Pre-Prosthetic Rehabilitation of the Lower Jaw Following Complex Dento-Alveolar Trauma with Multiple Avulsion of Teeth: Case Presentation

Traumatski gubitak zubi s defektom kosti u donjoj čeljusti težak je problem u protetskoj reha-bilitaciji. U ovome radu prikazuje se mogući način rehabilitacije nakon složene dentoalveolarne traume s gubitkom svih četiriju sjekutića, očnjaka, obaju pretkutnjaka i prvoga kutnjaka u desnoj strani donje čeljusti te gubitka alveolarne kosti, uz poremećene anatomsko morfološke odnose u tome području. Da bi se zadovoljila stabilnost, funkcija i estetika pro-tetskoga nadomjestka te prevenirala atrofija kosti, rehabilitacija je izvedena u nekoliko faza: pretpro-tetički kirurški pristup - vestibuloplastika i ugradnja usatka u područje defekta.Traumatic loss of teeth with bone defect in the lower jaw represents a serious problem in prosthetic rehabilitation. The paper presents a possible method of rehabilitation following complex dento-alveolar trauma with loss of four incisors, canines and both premolars, and the first molar on the right side of the lower jaw, and the loss of alveolar bone with impairment of anatomic morphological relations in this area. In order to satisfy stability, function and aesthetics of the prosthetic restoration, and to pre-vent bone atrophy, rehabilitation was carried out in several phases: prosthetic surgical approach -ves-tibuloplastics and insertion of an implant in the area of the defect

Hantavirus infections in forestry workers

Bjedov, L., Margaletić, J., Vucelja, M., Medved, M.M., Matijević, I., Krajinović, L.C., Markotic, A

N-ftaloil-glicin-hidroksamska kiselina kao kelator željeza u serumu štakora

The aim of this study was to investigate the activity of N-phthaloyl-glycine-hydroxamic acid (Phth-Gly-HA) as a new iron chelator in vivo to be used in iron overload diseases. After intraperitoneal application of Phth-Gly-HA to male rats (1 mg kg1 body mass) once a day for seven days, iron serum level decreased by 21%, whereas the iron value dropped by 32% in female rats (1.5 mg kg1 body mass). The results indicate that the tested substance has the ability to bind serum iron by complexation. Besides transferrin iron release, mobilization of ferritin iron is also possibleU cilju pronalaženja novog efikasnog kelatora koji bi mogao poslužiti u liječenju bolesti izazvanih viškom željeza, u ovom je radu ispitano djelovanje N-ftaloil-glicin-hidroksamske kiseline (Phth-Gly-HA) in vivo. Istraživan je utjecaj kelatora na razinu željeza u serumu štakora nakon intraperitonealne primjene vodene otopine Phth-Gly-HA (0,1 mg mL1) jednom dnevno tijekom 7 dana. Kontrolne su životinje primale fiziološku otopinu. Kod mužjaka injektiranje test supstancije (1 mg kg1) uzrokovalo je pad serumskog željeza za 21%. Kod ženki je nakon tretmana (1,5 mg kg1) izmjereno sniženje razine željeza za 35%. Rezultati pokazuju da ispitivana supstanca ima sposobnost kompleksiranja serumskog željeza, pretežno transferinskog, ali da postoji mogućnost mobilizacije željeza i iz feritinskih zaliha

Supplementary data for article: Matijević, B. M.; Vaštag, T. T.; Apostolov, S. L.; Milčić, M. K.; Marinković, A. D.; Petrović, S. D. N-(Substituted Phenyl)-2-Chloroacetamides: LSER and LFER Study, 2015. https://doi.org/10.1016/j.arabjc.2015.09.008

Supplementary material for: [https://doi.org/10.1016/j.arabjc.2015.09.008]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/293

Supplementary data for the article: Mrđan, G. S.; Vastag, G. G.; Škorić, D. Đ.; Radanović, M. M.; Verbić, T. Ž.; Milčić, M. K.; Stojiljković, I. N.; Marković, O. S.; Matijević, B. M. Synthesis, Physicochemical Characterization, and TD–DFT Calculations of Monothiocarbohydrazone Derivatives. Structural Chemistry 2021, 32 (3), 1231–1245. https://doi.org/10.1007/s11224-020-01700-y.

Supplementary material for: [https://doi.org/10.1007/s11224-020-01700-y]Related to published version: [https://cherry.chem.bg.ac.rs/handle/123456789/4453

Efficient fabrication of high-density ensembles of color centers via ion implantation on a hot diamond substrate

Nitrogen-Vacancy (NV) centers in diamond are promising systems for quantum technologies, including quantum metrology and sensing. A promising strategy for the achievement of high sensitivity to external fields relies on the exploitation of large ensembles of NV centers, whose fabrication by ion implantation is upper limited by the amount of radiation damage introduced in the diamond lattice. In this works we demonstrate an approach to increase the density of NV centers upon the high-fluence implantation of MeV N2+ ions on a hot target substrate (>550 {\deg}C). Our results show that, with respect to room-temperature implantation, the high-temperature process increases the vacancy density threshold required for the irreversible conversion of diamond to a graphitic phase, thus enabling to achieve higher density ensembles. Furthermore, the formation efficiency of color centers was investigated on diamond substrates implanted at varying temperatures with MeV N2+ and Mg+ ions revealing that the formation efficiency of both NV centers and magnesium-vacancy (MgV) centers increases with the implantation temperature.Comment: 12 pages, 5 figure

Photosensitizer potential of doped and undoped nanostructured TiO2

Treating cancer remains a major challenge, despite the development of many therapies and advances in general knowledge about the disease. The treatments commonly used are invasive and non-selective, leading to severe side effects and unsatisfactory long-term outcomes. Nevertheless, external stimuli activating therapeutic agents in the affected area can be more beneficial than these aggressive therapies. Photodynamic therapy (PDT) is a minimally invasive, selective treatment that uses photosensitizer (PS) to damage cancer cells. The PS is activated by light, triggering a series of processes that produce reactive oxygen species (ROS), ultimately leading to cancer cell death. Numerous types of nanomaterial possess the capability to act as PS, one of which is TiO2 [1]. Although nanostructured TiO2 is biocompatible in the absence of light, its valence band electrons can be stimulated only by ultraviolet (UV) light irradiation. Since the penetration of UV light into tissue is limited, for application in PDT, nanostructured TiO2 can be doped with heteroatoms like N or C to allow visible light responsiveness [2,3]. This work evaluated the PS properties of unmodified nanostructured TiO2 (spherical nanoparticles TiO2 NPs and prolate nanospheroids, TiO2 PNSs) and doped TiO2 (N- and C-TiO2 NPs). After the synthesis, the size of TiO2 was confirmed to be in the nanoscale range (5-104 nm) by transmission electron microscopy [3,4]. The doped TiO2 was found to absorb visible light, as demonstrated by UV-Vis spectroscopy and bandgap calculations. Additionally, hydroxyl radicals were detected in water suspensions of TiO2 PNSs by electron paramagnetic resonance (EPR) spectroscopy, both with and without UV light illumination [4]. However, this radical was observed only with blue light stimulation of the water suspensions of N- and C-TiO2 NPs [3]. Cell experiments further revealed the internalization process of nanostructured TiO2 within cells, their cytotoxicity profiles, and the different death modalities triggered by their uptake. After confocal microscopy indicated the successful internalization of the investigated TiO2, viability tests on different cell lines confirmed their good biocompatibility without light [3,4]. The PDT's efficacy using nanostructured TiO2 and appropriate light stimuli was evaluated on various cancer cell lines. The most significant viability reduction (60 %) was observed in the HeLa cell line with the combined treatment of C-TiO2 NPs-blue light. In addition to EPR results, blue light-induced C-TiO2 NPs-catalyzed generation of ROS was confirmed intracellularly, implying that oxidative stress was the leading cause of HeLa cell death. Fluorescent labeling allowed distinguishing morphological changes inside the cells after the C-TiO2 NPs, blue light, and the combined C-TiO2 NPs-blue light treatment. Blue light exposure led to the appearance of large necrotic cells with deformed nuclei, cytoplasm swelling, and membrane blebbing. In contrast, the combined therapy with C-TiO2 NPs-blue light resulted in controlled cell death, such as autophagy. Since programmed cell death is the desired cancer cell death mechanism, the combined treatment presented here can provide a better outcome of local anticancer therapy.IX International School and Conference on Photonics : PHOTONICA2023 : book of abstracts; August 28 - September 1, 2023; Belgrad

In search of conditions for Gd-TiO2 activation by light irradiation in photodynamic treatment of pancreatic cancer cells

With difficulty in early diagnosis, inaccessibility for the surgical approach, and high resistance to radio and chemotherapies, the resulting low treatment success rates are calling for new approaches in treating pancreatic cancer [1]. Photodynamic therapy (PDT), with the use of light or X-rays, is a method that has the potential to help overcome the problems that existing approaches meet [2,3]. Through activation of photo-sensitive particles with irradiation, PDT helps the production of reactive oxygen species, consequently stimulating cell death. We have synthesized and characterized Gadolinium-doped titanium dioxide nanoparticles (Gd-TiO2 NPs) and tested them as photosensitizers on two pancreatic cancer cell lines, MIA PaCa-2 and PANC-1. Different concentrations of NP treatment, irradiation powers, and times of irradiation were trialed as parameters of activation. Cell viability was measured 48h after treatments, and although some results implied a slight decrease in the viability of treated cells, we have met difficulties in obtaining consistency in results. Statistical significance in the decrease of the viability of treated cells in most cases was not attained, suggesting that higher concentrations or irradiation power and longer illumination time might be needed to achieve a positive PDT effect with this NP system.IX International School and Conference on Photonics : PHOTONICA2023 : book of abstracts; August 28 - September 1, 2023; Belgrad

Supplementary data for article: Matijević, B. M.; Vaštag, T. T.; Apostolov, S. L.; Milčić, M. K.; Marinković, A. D.; Petrović, S. D. N-(Substituted Phenyl)-2-Chloroacetamides: LSER and LFER Study, 2015. https://doi.org/10.1016/j.arabjc.2015.09.008

Supplementary material for: [https://doi.org/10.1016/j.arabjc.2015.09.008]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/293