AVALIAÇÃO DO EQUILÍBRIO DE MULHERES COM CÂNCER DE MAMA

The objective of this study was to verify the balance of women with breast cancer. This cross-sectional study, tested balance of fifteen women, eight women with cancer and seven without cancer. The evaluation was performed through the Mini Balance Evaluation Systems (MiniBESTest), TUG with simple and dual- task. The mean of age was 59.2 ± 5 years for cancer group and 60.2 ± 5 years for the control group. Student's t-test for independent samples showed that there was no statistical difference (p> 0.05) between the groups for: MiniBESTest score, TUG with simple and dual-task. Women with cancer did not present balance impairments compared to control group according to MiniBESTest, and TUG with simple and dual-task.O objetivo desse estudo foi verificar o equilíbrio de mulheres com câncer de mama. Este estudo transversal avaliou o equilíbrio de quinze mulheres, sendo oito mulheres com câncer e sete sem câncer. Avaliação foi realizada através do Mini Balance Evaluation Systems (MiniBESTest), TUG simples e dupla tarefa. A média de idade foi de 59,2 ± 5 anos para o grupo de mulheres com câncer e 60,2 ± 5 anos para o grupo controle. Teste t Student para amostras independentes mostrou que não houve diferença estatística (p>0,05) entre os grupos para as variáveis: pontuação no MiniBESTest, tempo de realização do TUG simples e tempo de realização do TUG dupla tarefa. Mulheres com câncer não apresentaram alterações de equilíbrio comparadas ao grupo controle de acordo com o MiniBESTest, e TUG tarefa simples e dupla tarefa

Results of the COVID-19 mental health international for the general population (COMET-G) study.

INTRODUCTION: There are few published empirical data on the effects of COVID-19 on mental health, and until now, there is no large international study. MATERIAL AND METHODS: During the COVID-19 pandemic, an online questionnaire gathered data from 55,589 participants from 40 countries (64.85% females aged 35.80 ± 13.61; 34.05% males aged 34.90±13.29 and 1.10% other aged 31.64±13.15). Distress and probable depression were identified with the use of a previously developed cut-off and algorithm respectively. STATISTICAL ANALYSIS: Descriptive statistics were calculated. Chi-square tests, multiple forward stepwise linear regression analyses and Factorial Analysis of Variance (ANOVA) tested relations among variables. RESULTS: Probable depression was detected in 17.80% and distress in 16.71%. A significant percentage reported a deterioration in mental state, family dynamics and everyday lifestyle. Persons with a history of mental disorders had higher rates of current depression (31.82% vs. 13.07%). At least half of participants were accepting (at least to a moderate degree) a non-bizarre conspiracy. The highest Relative Risk (RR) to develop depression was associated with history of Bipolar disorder and self-harm/attempts (RR = 5.88). Suicidality was not increased in persons without a history of any mental disorder. Based on these results a model was developed. CONCLUSIONS: The final model revealed multiple vulnerabilities and an interplay leading from simple anxiety to probable depression and suicidality through distress. This could be of practical utility since many of these factors are modifiable. Future research and interventions should specifically focus on them

Cardiopathogenic mediators generated by GATA4 signaling upon co-activation with endothelin-1 and Trypanosoma cruzi infection

Trypanosoma cruzi (Tc), the etiological agent of Chagas disease, triggers multiple responses in the myocardium, a central organ of infection and pathology in the host. Parasite-driven induction of diverse regulators of cardiovascular function, including the vasoconstrictor endothelin-1 (ET-1), the inducible form of nitric oxide synthase (iNOS) and the B-type natriuretic peptide (BNP), has been linked to the development of severe chagasic cardiomyopathy. Our current goal was to analyze the participation of the zinc finger transcription factor GATA4, critically implicated in pathological cardiac hypertrophic response, in the generation of key mediators involved in the pathogenesis of Tc-elicited heart dysfunction. In this study, we found that the combined effects of Tc and ET-1 on atrial myocytes promoted the protein expression, phosphorylation and DNA-binding activity of GATA4, leading to augmented protein levels of iNOS and increased nitric oxide release. Moreover, Tc- and ET-1-co-activation of cardiomyocytes resulted in enhanced GATA4-dependent secretion of BNP. Accordingly, mice with chronic chagasic cardiomyopathy showed increased expression of GATA4, iNOS and BNP at inflammatory lesions in cardiac muscle. Our findings support a role for the GATA4 signaling pathway in the myocardial production of pathogenic mediators associated with Chagas heart disease, and may help define novel therapeutic targets.Fil: Rigazio, Cristina Sandra. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; ArgentinaFil: Hernandez, Matias. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; ArgentinaFil: Corral, Ricardo Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentin

Dual chemotherapy with benznidazole at suboptimal dose plus curcumin nanoparticles mitigates Trypanosoma cruzi-elicited chronic cardiomyopathy

Curcumin (Cur) is a natural polyphenolic flavonoid isolated from the rhizomes of Curcuma longa. Its anti-inflammatory and cardioprotective properties are increasingly considered to have beneficial effects on the progression of cardiomyopathy associated with Chagas disease, caused by Trypanosoma cruzi. However, the Cur therapeutic limitation is its bioavailability and new Cur nanomedicine formulations are developed to overcome this obstacle. In this research, we provide evidence showing that oral therapy with a suboptimal dose of the standard parasiticidal drug benznidazole (BZ) in combination with Cur-loaded nanoparticles is capable of reducing myocardial parasite load, cardiac hypertrophy, inflammation and fibrosis in mice with long-term infection by T. cruzi. Treatment with BZ plus Cur was highly effective in downregulating myocardial expression of proinflammatory cytokines/chemokines (IL-1β, TNF-α, IL-6, CCL5), and the level/activity of matrix metalloproteinases (MMP-2, MMP-9) and inducible enzymes (cyclooxygenase, nitric oxide synthase) implicated in leukocyte recruitment and cardiac remodeling. Oral administration of a Cur-based nanoformulation displays potential as a complementary strategy to the conventional BZ chemotherapy in the treatment of chronic Chagas heart disease.Fil: Hernandez, Matias. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaFil: Wicz, Susana. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaFil: Pérez Caballero, Eugenia. Centro de Estudios Metabólicos; EspañaFil: Santamaría, Miguel H.. Centro de Estudios Metabólicos; EspañaFil: Corral, Ricardo Santiago. Gobierno de la Ciudad de Buenos Aires. Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas; Argentin

La guardia específica de Neurología en la formación del médico residente en España

Resumen: Introducción: La formación en urgencias neurológicas es fundamental en el programa formativo de los residentes de Neurología. La Comisión Nacional de Neurología (CNN), decidió obtener información sobre el grado en que la Unidades Docentes de Neurología acreditadas posibilitan la realización de guardias específicas de Neurología y su grado de tutorización. Métodos: Realización de una encuesta a los tutores de las Unidades Docentes de Neurología para comprobar que se cumplen los criterios de la formación en guardias de neurología indicados en el programa oficial de formación. Resultados: Se obtuvo respuesta del 98,5% de las unidades docentes de Neurología que existen. En el 47% el médico de plantilla de Neurología tiene guardias de presencia física de 24 horas supervisando directamente al médico residente de Neurología. En el resto existe una diversidad de modelos que no cumplen de manera completa los criterios establecidos por el programa de especialidad. La distribución de los distintos modelos de guardias de Neurología varía mucho entre las distintas unidades docentes y entre las distintas Comunidades Autónomas. Sólo el 65% de los médicos residentes de Neurología realizan su formación en unidades docentes de Neurología que tienen guardias de Neurología autorizadas de manera correcta. Conclusiones: Hay una variabilidad injustificada en el cumplimiento de los criterios de formación en guardias de Neurología en las distintas unidades docentes distribuidas por todo nuestro país, habiendo diferencias de formación entre unos médicos residentes en Neurología y otros. Abstract: Introduction: Training in emergency neurological illness is very important for the neurologist today. The Neurology National Commission has decided to obtain information on the work duties of neurologist residents in the different neurology units of the hospitals of our country and the supervision of the training in urgent pathology. Method: A survey of adult neurology program directors to find out if their hospital fulfils the program criteria for the residents duty work. Results: A response rate of 98.5% was obtained. In 47% of the neurology training units a neurologist supervised resident duty work 24 hours a day. In the rest of the neurology training units they did not fulfil all the training program criteria. We analysed the differences between the neurologist training units, and there are great differences between the hospitals and all regions and communities in our country. Only 65% of neurology residents do their education in neurology units who fullfill the national program criteria on training on urgent neurology pathology Conclusions: There is too much diversity in resident duty work in neurologist training units and not all the units meet the national training program requirements Palabras clave: Formación, Guardias, Guardias tutorizadas, Programa residencia, Residentes, Keywords: Training, Residents, Training program, Duty work, Duty work supervisio

Specific neurology emergency training of medical residents in Spain

Introduction: Training in emergency neurological illness is very important for the neurologist today. The Neurology National Commission has decided to obtain information on the work duties of neurologist residents in the different neurology units of the hospitals of our country and the supervision of the training in urgent pathology. Method: A survey of adult neurology program directors to find out if their hospital fulfils the program criteria for the residents duty work. Results: A response rate of 98.5% was obtained. In 47% of the neurology training units a neurologist supervised resident duty work 24hours a day. In the rest of the neurology training units they did not fulfil all the training program criteria. We analysed the differences between the neurologist training units, and there are great differences between the hospitals and all regions and communities in our country. Only 65% of neurology residents do their education in neurology units who fullfill the national program criteria on training on urgent neurology pathology. Conclusions: There is too much diversity in resident duty work in neurologist training units and not all the units meet the national training program requirements. Resumen: Introducción: La formación en urgencias neurológicas es fundamental en el programa formativo de los residentes de Neurología. La Comisión Nacional de Neurología (CNN) decidió obtener información sobre el grado en que la Unidades Docentes de Neurología acreditadas posibilitan la realización de guardias específicas de Neurología y su grado de tutorización. Métodos: Realización de una encuesta a los tutores de las Unidades Docentes de Neurología para comprobar que se cumplen los criterios de la formación en guardias de neurología indicados en el programa oficial de formación. Resultados: Se obtuvo respuesta del 98,5% de las unidades docentes de Neurología que existen. En el 47% el médico de plantilla de Neurología tiene guardias de presencia física de 24 horas supervisando directamente al médico residente de Neurología. En el resto existe una diversidad de modelos que no cumplen de manera completa los criterios establecidos por el programa de especialidad. La distribución de los distintos modelos de guardias de Neurología varía mucho entre las distintas unidades docentes y entre las distintas Comunidades Autónomas. Sólo el 65% de los médicos residentes de Neurología realizan su formación en unidades docentes de Neurología que tienen guardias de Neurología autorizadas de manera correcta. Conclusiones: Hay una variabilidad injustificada en el cumplimiento de los criterios de formación en guardias de Neurología en las distintas unidades docentes distribuidas por todo nuestro país, habiendo diferencias de formación entre unos médicos residentes en Neurología y otros. Keywords: Training, Residents, Training program, Duty work, Duty work supervision, Palabras clave: Formación, Guardias, Guardias tutorizadas, Programa residencia, Residente