Mid-infrared two-octave spanning supercontinuum generation in a Ge-Se-Te glass suspended core fiber

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DMTs and Covid-19 severity in MS: a pooled analysis from Italy and France

We evaluated the effect of DMTs on Covid-19 severity in patients with MS, with a pooled-analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid-19 severity was assessed by multivariate ordinal-logistic models and pooled by a fixed-effect meta-analysis. 1066 patients with MS from Italy and 721 from France were included. In the multivariate model, anti-CD20 therapies were significantly associated (OR = 2.05, 95%CI = 1.39–3.02, p < 0.001) with Covid-19 severity, whereas interferon indicated a decreased risk (OR = 0.42, 95%CI = 0.18–0.99, p = 0.047). This pooled-analysis confirms an increased risk of severe Covid-19 in patients on anti-CD20 therapies and supports the protective role of interferon

Raymond Saleilles et au-delà

À l'occasion du centenaire du décès de Raymond Saleilles (1855-1912), des juristes et des politistes ont réuni leurs efforts pour revisiter, à la lumière des derniers apports de l'historiographie juridique, certains aspects de la vie professionnelle de cette grande figure des facultés de droit, ses engagements politiques et religieux, sa conception de la science du droit ainsi que la réception de son oeuvre. Cet ouvrage se propose ainsi, en premier lieu, de mettre en lumière tant la complexité de ses options politiques que l'impact de ses opinions religieuses sur sa pensée juridique. Il s'efforce, ensuite, d'explorer le rôle de Saleilles dans le renouvellement de la science du droit autour de 1900. Enfin, certaines contributions sont l'occasion d'évaluer non seulement l'intérêt de l'auteur pour les droits étrangers et le comparatisme, mais encore le retentissement de son oeuvre à travers le Monde ainsi que son apport à certaines branches du droit

Evaluation du modèle Caenorhabditis elegans pour estimer la qualité d’une eau eau. Application à l’eau de la Dordogne sur la Communauté de Communes de Sumène-Artense

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Biomimetic optoelectronic nose for analysis of volatile organic compounds

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Recent Advances on Peptide-Based Biosensors and Electronic Noses for Foodborne Pathogen Detection

International audienceFoodborne pathogens present a serious issue around the world due to the remarkably high number of illnesses they cause every year. In an effort to narrow the gap between monitoring needs and currently implemented classical detection methodologies, the last decades have seen an increased development of highly accurate and reliable biosensors. Peptides as recognition biomolecules have been explored to develop biosensors that combine simple sample preparation and enhanced detection of bacterial pathogens in food. This review first focuses on the selection strategies for the design and screening of sensitive peptide bioreceptors, such as the isolation of natural antimicrobial peptides (AMPs) from living organisms, the screening of peptides by phage display and the use of in silico tools. Subsequently, an overview on the state-of-the-art techniques in the development of peptide-based biosensors for foodborne pathogen detection based on various transduction systems was given. Additionally, limitations in classical detection strategies have led to the development of innovative approaches for food monitoring, such as electronic noses, as promising alternatives. The use of peptide receptors in electronic noses is a growing field and the recent advances of such systems for foodborne pathogen detection are presented. All these biosensors and electronic noses are promising alternatives for the pathogen detection with high sensitivity, low cost and rapid response, and some of them are potential portable devices for on-site analyses

An Overview of Artificial Olfaction Systems with a Focus on Surface Plasmon Resonance for the Analysis of Volatile Organic Compounds

International audienceThe last three decades have witnessed an increasing demand for novel analytical tools for the analysis of gases including odorants and volatile organic compounds (VOCs) in various domains. Traditional techniques such as gas chromatography coupled with mass spectrometry, although very efficient, present several drawbacks. Such a context has incited the research and industrial communities to work on the development of alternative technologies such as artificial olfaction systems, including gas sensors, olfactory biosensors and electronic noses (eNs). A wide variety of these systems have been designed using chemiresistive, electrochemical, acoustic or optical transducers. Among optical transduction systems, surface plasmon resonance (SPR) has been extensively studied thanks to its attractive features (high sensitivity, label free, real-time measurements). In this paper, we present an overview of the advances in the development of artificial olfaction systems with a focus on their development based on propagating SPR with different coupling configurations, including prism coupler, wave guide, and grating

Screening of specific aptamers for Bacillus cereus by Surface Plasmon Resonance imaging (SPRi)

International audienceBacillus cereus is a food poisoning bacterium present in dairy products. To detect it, antibody based biosensors are efficient but available antibodies are expensive and may cross-react with other Bacillus species. Aptamers are a good alternative to these issues. Herein, seven aptamer sequences derived from the literature (1,2) are compared and their specificity to B. cereus is assessed versus Escherichia coli and Bacillus subtilis by Surface Plasmon Resonance imaging (SPRi)

Screening of specific aptamers for Bacillus cereus by Surface Plasmon Resonance imaging (SPRi)

International audienceBacillus cereus is a food poisoning bacterium present in dairy products. To detect it, antibody based biosensors are efficient but available antibodies are expensive and may cross-react with other Bacillus species. Aptamers are a good alternative to these issues. Herein, seven aptamer sequences derived from the literature (1,2) are compared and their specificity to B. cereus is assessed versus Escherichia coli and Bacillus subtilis by Surface Plasmon Resonance imaging (SPRi)