Measuring large topographic change with InSAR: lava thicknesses, extrusion rate and subsidence rate at Santiaguito volcano, Guatemala

Lava flows can produce changes in topography on the order of 10s-100s of metres. A knowledge of the resulting volume change provides evidence about the dynamics of an eruption. We present a method to measure topographic changes from the differential InSAR phase delays caused by the height differences between the current topography and a Digital Elevation Model (DEM). This does not require a pre-event SAR image, so it does not rely on interferometric phase remaining coherent during eruption and emplacement. Synthetic tests predicts that we can estimate lava thickness of as little as �9 m, given a minimum of 5 interferograms with suitably large orbital baseine separations. In the case of continuous motion, such as lava flow subsidence, we invert interferometric phase simultaneously for topographic change and displacement. We demonstrate the method using data from Santiaguito volcano, Guatemala, and measure increases in lava thickness of up to 140 m between 2000 and 2009, largely associated with activity between 2000 and 2005. We find a mean extrusion rate of 0.43 +/- 0.06 m3/s, which lies within the error bounds of the longer term extrusion rate between 1922-2000. The thickest and youngest parts of the flow deposit were shown to be subsiding at an average rate of �-6 cm/yr. This is the first time that flow thickness and subsidence have been measured simultaneously. We expect this method to be suitable for measurment of landslides and other mass flow deposits as well as lava flows

KLaF4 nanocrystallisation in oxyfluoride glass-ceramics

Nanocrystallisation of the cubic and hexagonal polymorphs of KLaF 4 in a 70SiO2-7Al2O3-16K 2O-7LaF3 (mol%) glass has been achieved by heat treatment above the glass transition temperature. For treatment at 580°C, only the cubic structure crystallises, with a maximum crystallite size of ~9 nm. At higher temperatures, crystallisation of the hexagonal structure also takes place. The crystallisation process has been analysed using several thermal and structural techniques and is revealed to occur from a constant number of nuclei. The formation of a viscous barrier which inhibits further crystal growth and limits the crystal size to the nanometric range is observed. The title materials doped with lanthanide ions may be good candidates for optical applications

KLaF4 nanocrystallisation in oxyfluoride glass-ceramics

Nanocrystallisation of the cubic and hexagonal polymorphs of KLaF 4 in a 70SiO2-7Al2O3-16K 2O-7LaF3 (mol%) glass has been achieved by heat treatment above the glass transition temperature. For treatment at 580°C, only the cubic structure crystallises, with a maximum crystallite size of ~9 nm. At higher temperatures, crystallisation of the hexagonal structure also takes place. The crystallisation process has been analysed using several thermal and structural techniques and is revealed to occur from a constant number of nuclei. The formation of a viscous barrier which inhibits further crystal growth and limits the crystal size to the nanometric range is observed. The title materials doped with lanthanide ions may be good candidates for optical applications

Review and meta-analysis of genetic polymorphisms associated with exceptional human longevity

Background Many factors contribute to exceptional longevity, with genetics playing a significant role. However, to date, genetic studies examining exceptional longevity have been inconclusive. This comprehensive review seeks to determine the genetic variants associated with exceptional longevity by undertaking meta-analyses. Methods Meta-analyses of genetic polymorphisms previously associated with exceptional longevity (85+) were undertaken. For each variant, meta-analyses were performed if there were data from at least three independent studies available, including two unpublished additional cohorts. Results Five polymorphisms, ACE rs4340, APOE ε2/3/4, FOXO3A rs2802292, KLOTHO KL-VS and IL6 rs1800795 were significantly associated with exceptional longevity, with the pooled effect sizes (odds ratios) ranging from 0.42 (APOE ε4) to 1.45 (FOXO3A males). Conclusion In general, the observed modest effect sizes of the significant variants suggest many genes of small influence play a role in exceptional longevity, which is consistent with results for other polygenic traits. Our results also suggest that genes related to cardiovascular health may be implicated in exceptional longevity. Future studies should examine the roles of gender and ethnicity and carefully consider study design, including the selection of appropriate controls

Production and dilution of gravitinos by modulus decay

We study the cosmological consequences of generic scalar fields like moduli which decay only through gravitationally suppressed interactions. We consider a new production mechanism of gravitinos from moduli decay, which might be more effective than previously known mechanisms, and calculate the final gravitino-to-entropy ratio to compare with the constraints imposed by successful big bang nucleosynthesis (BBN) etc., taking possible hadronic decays of gravitinos into account. We find the modulus mass smaller than $\sim 10^4$ TeV is excluded. On the other hand, inflation models with high reheating temperatures $T_{R,\rm inf} \sim 10^{16}$ GeV can be compatible with BBN thanks to the late-time entropy production from the moduli decay if model parameters are appropriately chosen.Comment: 18 pages, 4 figures, to appear in Phys. Rev.

A genomic portrait of the emergence, evolution, and global spread of a methicillin-resistant staphylococcus aureus pandemic

The widespread use of antibiotics in association with high-density clinical care has driven the emergence of drug-resistant bacteria that are adapted to thrive in hospitalized patients. Of particular concern are globally disseminated methicillin-resistant Staphylococcus aureus (MRSA) clones that cause outbreaks and epidemics associated with health care. The most rapidly spreading and tenacious health-care-associated clone in Europe currently is EMRSA-15, which was first detected in the UK in the early 1990s and subsequently spread throughout Europe and beyond. Using phylogenomic methods to analyze the genome sequences for 193 S. aureus isolates, we were able to show that the current pandemic population of EMRSA-15 descends from a health-care-associated MRSA epidemic that spread throughout England in the 1980s, which had itself previously emerged from a primarily community-associated methicillin-sensitive population. The emergence of fluoroquinolone resistance in this EMRSA-15 subclone in the English Midlands during the mid-1980s appears to have played a key role in triggering pandemic spread, and occurred shortly after the first clinical trials of this drug. Genome-based coalescence analysis estimated that the population of this subclone over the last 20 yr has grown four times faster than its progenitor. Using comparative genomic analysis we identified the molecular genetic basis of 99.8% of the antimicrobial resistance phenotypes of the isolates, highlighting the potential of pathogen genome sequencing as a diagnostic tool. We document the genetic changes associated with adaptation to the hospital environment and with increasing drug resistance over time, and how MRSA evolution likely has been influenced by country-specific drug use regimens

Extragalactic Foregrounds of the Cosmic Microwave Background: Prospects for the MAP Mission

(Abridged) While the major contribution to the Cosmic Microwave Background (CMB) anisotropies are the sought-after primordial fluctuations produced at the surface of last scattering, other effects produce secondary fluctuations at lower redshifts. Here, we study the extragalactic foregrounds of the CMB in the context of the upcoming MAP mission. We first survey the major extragalactic foregrounds and show that discrete sources, the Sunyaev-Zel'dovich (SZ) effect, and gravitational lensing are the most dominant ones for MAP. We then show that MAP will detect (>5 sigma) about 46 discrete sources and 10 SZ clusters directly with 94 GHz fluxes above 2 Jy. The mean SZ fluxes of fainter clusters can be probed by cross-correlating MAP with cluster positions extracted from existing catalogs. For instance, a MAP-XBACs cross-correlation will be sensitive to clusters with S(94GHz)>200mJy, and will thus provide a test of their virialization state and a measurement of their gas fraction. Finally, we consider probing the hot gas on supercluster scales by cross-correlating the CMB with galaxy catalogs. Assuming that galaxies trace the gas, we show that a cross-correlation between MAP and the APM catalog should yield a marginal detection, or at least a four-fold improvement on the COBE upper limits for the rms Compton y-parameter.Comment: 27 LaTeX pages, including 5 ps figures and 2 tables. To appear in ApJ. Minor revisions to match accepted version. Color figures and further links available at http://www.astro.princeton.edu/~refreg

Signatures of Relativistic Neutrinos in CMB Anisotropy and Matter Clustering

We present a detailed analytical study of ultra-relativistic neutrinos in cosmological perturbation theory and of the observable signatures of inhomogeneities in the cosmic neutrino background. We note that a modification of perturbation variables that removes all the time derivatives of scalar gravitational potentials from the dynamical equations simplifies their solution notably. The used perturbations of particle number per coordinate, not proper, volume are generally constant on superhorizon scales. In real space an analytical analysis can be extended beyond fluids to neutrinos. The faster cosmological expansion due to the neutrino background changes the acoustic and damping angular scales of the cosmic microwave background (CMB). But we find that equivalent changes can be produced by varying other standard parameters, including the primordial helium abundance. The low-l integrated Sachs-Wolfe effect is also not sensitive to neutrinos. However, the gravity of neutrino perturbations suppresses the CMB acoustic peaks for the multipoles with l>~200 while it enhances the amplitude of matter fluctuations on these scales. In addition, the perturbations of relativistic neutrinos generate a *unique phase shift* of the CMB acoustic oscillations that for adiabatic initial conditions cannot be caused by any other standard physics. The origin of the shift is traced to neutrino free-streaming velocity exceeding the sound speed of the photon-baryon plasma. We find that from a high resolution, low noise instrument such as CMBPOL the effective number of light neutrino species can be determined with an accuracy of sigma(N_nu) = 0.05 to 0.09, depending on the constraints on the helium abundance.Comment: 38 pages, 7 figures. Version accepted for publication in PR

The BOOMERanG experiment and the curvature of the Universe

We describe the BOOMERanG experiment and its main result, i.e. the measurement of the large scale curvature of the Universe. BOOMERanG is a balloon-borne microwave telescope with sensitive cryogenic detectors. BOOMERanG has measured the angular distribution of the Cosmic Microwave Background on $\sim 3$ of the sky, with a resolution of $\sim 10$ arcmin and a sensitivity of $\sim 20 \mu K$ per pixel. The resulting image is dominated by hot and cold spots with rms fluctuations $\sim 80 \mu K$ and typical size of $\sim 1^o$. The detailed angular power spectrum of the image features three peaks and two dips at $\ell = (213^{+10}_{-13}), (541^{+20}_{-32}), (845^{+12}_{-25})$ and $\ell = (416^{+22}_{-12}), (750^{+20}_{-750})$, respectively. Such very characteristic spectrum can be explained assuming that the detected structures are the result of acoustic oscillations in the primeval plasma. In this framework, the measured pattern constrains the density parameter $\Omega$ to be $0.85 < \Omega < 1.1$ (95% confidence interval). Other cosmological parameters, like the spectral index of initial density fluctuations, the density parameter for baryons, dark matter and dark energy, are detected or constrained by the BOOMERanG measurements and by other recent CMB anisotropy experiments. When combined with other cosmological observations, these results depict a new, consistent, cosmological scenario.Comment: Proc. of the Erice School on "Neutrinos in Astro, Particle and Nuclear Physics", 18.-26. September 2001, Amand Faessler, Jan Kuckei eds, "Progress in Particle and Nuclear Physics", vol. 4