1,399 research outputs found
Reducing the Cost of Being the Boss : Authentic Leadership Suppresses the Effect of Role Stereotype Conflict on Antisocial Behaviors in Leaders and Entrepreneurs
What drives entrepreneurs to engage in antisocial economic behaviors? Without dismissing entrepreneurs' agency in their decision-making processes, our study aims to answer this question by proposing that antisocial economic behaviors are a dysfunctional coping mechanism to reduce the psychological tension that entrepreneurs face in their day-to-day activities. Further, given the overlap between the male gender role stereotype and both leader and entrepreneur role stereotypes, this psychological tension should be stronger in female entrepreneurs (or any person who identifies with the female gender role). We argue that besides the well-established female gender role - leader role incongruence, female entrepreneurs also suffer a female gender role - entrepreneur role incongruence. Thus, we predicted that men (or those identifying with the male gender role) or entrepreneurs (regardless of their gender identity) that embrace these roles stereotypes to an extreme, are more likely to engage in antisocial economic behaviors. In this context, the term antisocial economic behaviors refers to cheating or trying to harm competitors' businesses. Finally, we predicted that embracing an authentic leadership style might mitigate this effect. We tested our predictions in two laboratory studies (Phase 1 and 2). For Phase 1 we recruited a sample of French Business school students (N = 82). For Phase 2 we recruited a sample of Costa Rican male and female entrepreneurs, using male and female managers as reference groups (N = 64). Our results show that authentic leadership reduced the likelihood of entrepreneurs and men of engaging in antisocial economic behaviors such as trying to harm one's competition or seeking an unfair advantage
On the Stellar Kinematics and Mass of the Virgo Ultra-Diffuse Galaxy VCC 1287
Here, we present a kinematical analysis of the Virgo cluster ultra-diffuse
galaxy (UDG) VCC 1287 based on data taken with the Keck Cosmic Web Imager
(KCWI). We confirm VCC 1287's association both with the Virgo cluster and its
globular cluster (GC) system, measuring a recessional velocity of $1116 \pm 2\
\mathrm{km\ s^{-1}}19 \pm 6\
\mathrm{km\ s^{-1}}1.11^{+0.81}_{-0.81}
\times 10^{9} \ \mathrm{M_{\odot}}13^{+11}_{-11}$)
within the half light radius (4.4 kpc). This places VCC 1287 slightly above the
well established relation for normal galaxies, with a higher mass to light
ratio for its dynamical mass than normal galaxies. We use our dynamical mass,
and an estimate of GC system richness, to place VCC 1287 on the GC number --
dynamical mass relation, finding good agreement with a sample of normal
galaxies. Based on a total halo mass derived from GC counts, we then infer that
VCC 1287 likely resides in a cored or low concentration dark matter halo. Based
on the comparison of our measurements to predictions from simulations, we find
that strong stellar feedback and/or tidal effects are plausibly the dominant
mechanisms in the formation of VCC 1287. Finally, we compare our measurement of
the dynamical mass with those for other UDGs. These dynamical mass estimates
suggest relatively massive halos and a failed galaxy origin for at least some
UDGs.Comment: 13 pages, 10 figures with an additional 5 pages and 5 figures in
appendices. Accepted for publication in MNRAS. v2: with small updates from
publication formatting and a minor plotting fix for Fig. 1
Hadronic aspects of exotic baryons
In this talk I look into three different topics, addressing first the
possibility that the is a bound state of , exploiting the
results of this study to find out the contribution of two meson and one baryon
components in the baryon antidecuplet and in the third place I present results
on a new resonant exotic baryonic state which appears as dynamically generated
by the Weinberg Tomozawa interaction.Comment: Talk at the International Workshop PENTAQUARK0
On the determination of quantum numbers and other topics of exotic baryons
In this talk I look into three different topics, addressing first a method to
determine the quantum numbers of the , then exploiting the
possibility that the is a bound state of and in the third
place I present results on a new resonant exotic baryonic state which appears
as dynamically generated by the Weinberg Tomozawa interaction.Comment: 9 pags. Talk in the NSTAR04 Workshop, Grenoble, march 200
INFOPrà cticum: i després del grau, què?
Podeu consultar la Vuitena trobada de professorat de Ciències de la Salut completa a: http://hdl.handle.net/2445/66524L'INFOPrà cticum és una jornada en que s'organitzen un conjunt d'activitats (xerrades, taula rodona, presentació de pòsters sobre les prà ctiques realitzades, etc.), pensades per orientar a l'alumnat de 4t. curs sobre les sortides professionals, i les possibilitats que té de seguir-se formant a l'INEFC.
És també el moment en que l'alumnat de 4t. de grau..
Two more things about compositional biplots: quality of projection and inclusion of supplementary elements
The biplot is a widely and powerful methodology used with multidimensional data sets to
describe and display the relationships between observations and variables in an easy way.
Compositional data consist of positive vectors each of which is constrained to have a constant sum;
due to this property standard biplots can not be performed with compositional data, instead of a
previous transformation of the data is performed. Due to this constant sum constraint, a
transformation of data is needed before performing a biplot and, consequently, special interpretation
rules are required. However, these rules can only be safely applied when the elements of a biplot
have a good quality of projection, for which a new measure is introduced in this paper. Also, we
extend the compositional biplot defined by Aitchison and Greenacre on 2002, in order to include
the display supplementary elements that are not used in the definition of the compositional biplot.
Different types of supplementary elements are considered: supplementary parts of the composition,
supplementary continuous variables external to the composition, supplementary categorical
variables and supplementary observations. The projection of supplementary parts of the
composition is done by means of the equivalence of clr and lr biplots. The other supplementary
projections are done by classical methodology. Both the qualities of projections and the
supplementary projections are explained using real geological data: a sample of 72 observations of
soil in an area about 20 km west of Kiev in the area south of Kiev Polessie
Measurements and analysis of microwave nonlinearities in ferroelectric thin film transmission lines
This work evaluates the microwave nonlinear properties of ferroelectric BaSrTiO thin films by measuring the frequency response of several coplanar transmission lines and interdigital capacitor structures as a function of the applied electric field from 150 Hz to 40 GHz. From these measurements, we obtain the distributed nonlinear capacitance C(Vdc) as a function of dc bias. We also measure the harmonic generation at microwave frequencies in ferroelectric transmission lines, and use an accurate circuit model to obtain C(Vrf), the nonlinear capacitance as a function of RF bias. Information about the tuning speed of the film is obtained from a comparison between the two nonlinear capacitances. Characterization of this mechanism is also required to assess the spurious signal generation in ferroelectric-based devicesPeer Reviewe
Differential Modulation of I-K and I-Ca,I-L Channels in High-Fat Diet-Induced Obese Guinea Pig Atria
[EN] Obesity mechanisms that make atrial tissue vulnerable to arrhythmia are poorly understood. Voltage-dependent potassium (I-K, I-Kur, and I-K1) and L-type calcium currents (I-Ca,I- L) are electrically relevant and represent key substrates for modulation in obesity. We investigated whether electrical remodeling produced by high-fat diet (HFD) alone or in concert with acute atrial stimulation were different. Electrophysiology was used to assess atrial electrical function after short-term HFD-feeding in guinea pigs. HFD atria displayed spontaneous beats, increased I-K (I-Kr + I-Ks) and decreased I-Ca,I- L densities. Only with pacing did a reduction in I-Kur and increased I-K1 phenotype emerge, leading to a further shortening of action potential duration. Computer modeling studies further indicate that the measured changes in potassium and calcium current densities contribute prominently to shortened atrial action potential duration in human heart. Our data are the first to show that multiple mechanisms (shortened action potential duration, early after depolarizations and increased incidence of spontaneous beats) may underlie initiation of supraventricular arrhythmias in obese guinea pig hearts. These results offer different mechanistic insights with implications for obese patients harboring supraventricular arrhythmias.This study was supported by an AHA (13SDG16850065 to AA), NIH (R01 HL147044 to AA), and Programa Prometeu de la Conselleria d Educació, Formació I Ocupació de la Generalitat Valenciana, award number PROMETEU/2016/088.MartÃnez-Mateu, L.; Saiz RodrÃguez, FJ.; Aromolaran, A. (2019). Differential Modulation of I-K and I-Ca,I-L Channels in High-Fat Diet-Induced Obese Guinea Pig Atria. Frontiers in Physiology. 10:1-18. https://doi.org/10.3389/fphys.2019.01212S11810Abed, H. S., & Wittert, G. A. (2013). Obesity and atrial fibrillation. Obesity Reviews, 14(11), 929-938. doi:10.1111/obr.12056Angelin, B., Olivecrona, H., Reihnér, E., Rudling, M., StÃ¥hlberg, D., Eriksson, M., … Einarsson, K. (1992). Hepatic cholesterol metabolism in estrogen-treated men. Gastroenterology, 103(5), 1657-1663. doi:10.1016/0016-5085(92)91192-7Aoki, Y., Hatakeyama, N., Yamamoto, S., Kinoshita, H., Matsuda, N., Hattori, Y., & Yamazaki, M. (2012). Role of ion channels in sepsis-induced atrial tachyarrhythmias in guinea pigs. British Journal of Pharmacology, 166(1), 390-400. doi:10.1111/j.1476-5381.2011.01769.xAromolaran, A. S., & Boutjdir, M. (2017). Cardiac Ion Channel Regulation in Obesity and the Metabolic Syndrome: Relevance to Long QT Syndrome and Atrial Fibrillation. Frontiers in Physiology, 8. doi:10.3389/fphys.2017.00431Aromolaran, A. S., Colecraft, H. M., & Boutjdir, M. (2016). High-fat diet-dependent modulation of the delayed rectifier K + current in adult guinea pig atrial myocytes. Biochemical and Biophysical Research Communications, 474(3), 554-559. doi:10.1016/j.bbrc.2016.04.113Aromolaran, A. S., Subramanyam, P., Chang, D. D., Kobertz, W. R., & Colecraft, H. M. (2014). LQT1 mutations in KCNQ1 C-terminus assembly domain suppress IKs using different mechanisms. Cardiovascular Research, 104(3), 501-511. doi:10.1093/cvr/cvu231Ashrafi, R., Yon, M., Pickavance, L., Yanni Gerges, J., Davis, G., Wilding, J., … Boyett, M. (2016). Altered Left Ventricular Ion Channel Transcriptome in a High-Fat-Fed Rat Model of Obesity: Insight into Obesity-Induced Arrhythmogenesis. Journal of Obesity, 2016, 1-12. doi:10.1155/2016/7127898Bai, J., Gladding, P. A., Stiles, M. K., Fedorov, V. V., & Zhao, J. (2018). Ionic and cellular mechanisms underlying TBX5/PITX2 insufficiency-induced atrial fibrillation: Insights from mathematical models of human atrial cells. Scientific Reports, 8(1). doi:10.1038/s41598-018-33958-yBarana, A., Matamoros, M., Dolz-Gaitón, P., Pérez-Hernández, M., Amorós, I., Núñez, M., … Caballero, R. (2014). Chronic Atrial Fibrillation Increases MicroRNA-21 in Human Atrial Myocytes Decreasing L-Type Calcium Current. Circulation: Arrhythmia and Electrophysiology, 7(5), 861-868. doi:10.1161/circep.114.001709Bar�, I., & Escande, D. (1989). A Ca2+-activated K+ current in guinea-pig atrial myocytes. Pfl�gers Archiv European Journal of Physiology, 414(S1), S168-S168. doi:10.1007/bf00582286Bar�, I., & Escande, D. (1989). A long lasting Ca2+ -activated outward current in guinea-pig atrial myocytes. Pfl�gers Archiv European Journal of Physiology, 415(1), 63-71. doi:10.1007/bf00373142Bhuyan, R., & Seal, A. (2016). Dynamics and modulation studies of human voltage gated Kv1.5 channel. Journal of Biomolecular Structure and Dynamics, 35(2), 380-398. doi:10.1080/07391102.2016.1144528Boden, G., She, P., Mozzoli, M., Cheung, P., Gumireddy, K., Reddy, P., … Ruderman, N. (2005). Free Fatty Acids Produce Insulin Resistance and Activate the Proinflammatory Nuclear Factor- B Pathway in Rat Liver. Diabetes, 54(12), 3458-3465. doi:10.2337/diabetes.54.12.3458Bosch, R. F., Schneck, A. C., Csillag, S., Eigenberger, B., Gerlach, U., Brendel, J., … Kühlkamp, V. (2003). Effects of the chromanol HMR 1556 on potassium currents in atrial myocytes. Naunyn-Schmiedeberg’s Archives of Pharmacology, 367(3), 281-288. doi:10.1007/s00210-002-0672-5BOUTJDIR, M., HEUZEY, J. Y., LAVERGNE, T., CHAUVAUD, S., GUIZE, L., CARPENTIER, A., & PERONNEAU, P. (1986). Inhomogeneity of Cellular Refractoriness in Human Atrium: Factor of Arrhythmia?. Pacing and Clinical Electrophysiology, 9(6), 1095-1100. doi:10.1111/j.1540-8159.1986.tb06676.xBrundel, B. J. J. M., Van Gelder, I. C., Henning, R. H., Tieleman, R. G., Tuinenburg, A. E., Wietses, M., … Crijns, H. J. G. M. (2001). Ion Channel Remodeling Is Related to Intraoperative Atrial Effective Refractory Periods in Patients With Paroxysmal and Persistent Atrial Fibrillation. Circulation, 103(5), 684-690. doi:10.1161/01.cir.103.5.684Bünemann, M., Liliom, K., Brandts, B. K., Pott, L., Tseng, J. L., Desiderio, D. M., … Tigyi, G. (1996). A novel membrane receptor with high affinity for lysosphingomyelin and sphingosine 1-phosphate in atrial myocytes. The EMBO Journal, 15(20), 5527-5534. doi:10.1002/j.1460-2075.1996.tb00937.xCaballero, R., de la Fuente, M. G., Gómez, R., Barana, A., Amorós, I., Dolz-Gaitón, P., … Delpón, E. (2010). In Humans, Chronic Atrial Fibrillation Decreases the Transient Outward Current and Ultrarapid Component of the Delayed Rectifier Current Differentially on Each Atria and Increases the Slow Component of the Delayed Rectifier Current in Both. Journal of the American College of Cardiology, 55(21), 2346-2354. doi:10.1016/j.jacc.2010.02.028Caillier, B., Pilote, S., Patoine, D., Levac, X., Couture, C., Daleau, P., … Drolet, B. (2012). Metabolic syndrome potentiates the cardiac action potential-prolonging action of drugs: A possible ‘anti-proarrhythmic’ role for amlodipine. Pharmacological Research, 65(3), 320-327. doi:10.1016/j.phrs.2011.11.015Chiu, H.-C., Kovacs, A., Ford, D. A., Hsu, F.-F., Garcia, R., Herrero, P., … Schaffer, J. E. (2001). A novel mouse model of lipotoxic cardiomyopathy. Journal of Clinical Investigation, 107(7), 813-822. doi:10.1172/jci10947Christ, T., Boknik, P., Wöhrl, S., Wettwer, E., Graf, E. M., Bosch, R. F., … Dobrev, D. (2004). L-Type Ca2+Current Downregulation in Chronic Human Atrial Fibrillation Is Associated With Increased Activity of Protein Phosphatases. Circulation, 110(17), 2651-2657. doi:10.1161/01.cir.0000145659.80212.6aCourtemanche, M., Ramirez, R. J., & Nattel, S. (1998). Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model. American Journal of Physiology-Heart and Circulatory Physiology, 275(1), H301-H321. doi:10.1152/ajpheart.1998.275.1.h301Czick, M. E., Shapter, C. L., & Silverman, D. I. (2016). Atrial Fibrillation: The Science behind Its Defiance. Aging and Disease, 7(5), 635. doi:10.14336/ad.2016.0211Dan, G.-A., & Dobrev, D. (2018). Antiarrhythmic drugs for atrial fibrillation: Imminent impulses are emerging. IJC Heart & Vasculature, 21, 11-15. doi:10.1016/j.ijcha.2018.08.005Daoud, E. G., Knight, B. P., Weiss, R., Bahu, M., Paladino, W., Goyal, R., … Morady, F. (1997). Effect of Verapamil and Procainamide on Atrial Fibrillation–Induced Electrical Remodeling in Humans. Circulation, 96(5), 1542-1550. doi:10.1161/01.cir.96.5.1542De Sensi, F., Costantino, S., Limbruno, U., & Paneni, F. (2019). Atrial fibrillation in the cardiometabolic patient. Minerva Medica, 110(2). doi:10.23736/s0026-4806.18.05882-2Dey, S., DeMazumder, D., Sidor, A., Foster, D. B., & O’Rourke, B. (2018). Mitochondrial ROS Drive Sudden Cardiac Death and Chronic Proteome Remodeling in Heart Failure. Circulation Research, 123(3), 356-371. doi:10.1161/circresaha.118.312708Diness, J. G., Sørensen, U. S., Nissen, J. D., Al-Shahib, B., Jespersen, T., Grunnet, M., & Hansen, R. S. (2010). Inhibition of Small-Conductance Ca
2+
-Activated K
+
Channels Terminates and Protects Against Atrial Fibrillation. Circulation: Arrhythmia and Electrophysiology, 3(4), 380-390. doi:10.1161/circep.110.957407Djoussé, L., Benkeser, D., Arnold, A., Kizer, J. R., Zieman, S. J., Lemaitre, R. N., … Ix, J. H. (2013). Plasma Free Fatty Acids and Risk of Heart Failure. Circulation: Heart Failure, 6(5), 964-969. doi:10.1161/circheartfailure.113.000521Ehrlich, J. R., Ocholla, H., Ziemek, D., Rütten, H., Hohnloser, S. H., & Gögelein, H. (2008). Characterization of Human Cardiac Kv1.5 Inhibition by the Novel Atrial-selective Antiarrhythmic Compound AVE1231. Journal of Cardiovascular Pharmacology, 51(4), 380-387. doi:10.1097/fjc.0b013e3181669030Feng, J., Yue, L., Wang, Z., & Nattel, S. (1998). Ionic Mechanisms of Regional Action Potential Heterogeneity in the Canine Right Atrium. Circulation Research, 83(5), 541-551. doi:10.1161/01.res.83.5.541Fernandez, M. L., Conde, A. K., Ruiz, L. R., Montano, C., Ebner, J., & McNamara, D. J. (1995). Carbohydrate type and amount alter intravascular processing and catabolism of plasma lipoproteins in guinea pigs. Lipids, 30(7), 619-626. doi:10.1007/bf02536998Fretts, A. M., Mozaffarian, D., Siscovick, D. S., Djousse, L., Heckbert, S. R., King, I. B., … Lemaitre, R. N. (2014). Plasma Phospholipid Saturated Fatty Acids and Incident Atrial Fibrillation: The Cardiovascular Health Study. Journal of the American Heart Association, 3(3). doi:10.1161/jaha.114.000889Gaborit, N., Steenman, M., Lamirault, G., Le Meur, N., Le Bouter, S., Lande, G., … Demolombe, S. (2005). Human Atrial Ion Channel and Transporter Subunit Gene-Expression Remodeling Associated With Valvular Heart Disease and Atrial Fibrillation. Circulation, 112(4), 471-481. doi:10.1161/circulationaha.104.506857Garnvik, L. E., Malmo, V., Janszky, I., Wisløff, U., Loennechen, J. P., & Nes, B. M. (2018). Physical activity modifies the risk of atrial fibrillation in obese individuals: The HUNT3 study. European Journal of Preventive Cardiology, 25(15), 1646-1652. doi:10.1177/2047487318784365Gaspo, R., Bosch, R. F., Talajic, M., & Nattel, S. (1997). Functional Mechanisms Underlying Tachycardia-Induced Sustained Atrial Fibrillation in a Chronic Dog Model. Circulation, 96(11), 4027-4035. doi:10.1161/01.cir.96.11.4027Goette, A., Honeycutt, C., & Langberg, J. J. (1996). Electrical Remodeling in Atrial Fibrillation. Circulation, 94(11), 2968-2974. doi:10.1161/01.cir.94.11.2968González de la Fuente, M., Barana, A., Gómez, R., Amorós, I., Dolz-Gaitón, P., Sacristán, S., … Delpón, E. (2012). Chronic atrial fibrillation up-regulates β1-Adrenoceptors affecting repolarizing currents and action potential duration. Cardiovascular Research, 97(2), 379-388. doi:10.1093/cvr/cvs313Grandi, E., Dobrev, D., & Heijman, J. (2019). Computational modeling: What does it tell us about atrial fibrillation therapy? International Journal of Cardiology, 287, 155-161. doi:10.1016/j.ijcard.2019.01.077Grandi, E., Pandit, S. V., Voigt, N., Workman, A. J., Dobrev, D., Jalife, J., & Bers, D. M. (2011). Human Atrial Action Potential and Ca2+Model. Circulation Research, 109(9), 1055-1066. doi:10.1161/circresaha.111.253955HADIAN, D., ZIPES, D. P., OLGIN, J. E., & MILLER, J. M. (2002). Short-Term Rapid Atrial Pacing Produces Electrical Remodeling of Sinus Node Function in Humans. Journal of Cardiovascular Electrophysiology, 13(6), 584-586. doi:10.1046/j.1540-8167.2002.00584.xHeijman, J., Guichard, J.-B., Dobrev, D., & Nattel, S. (2018). Translational Challenges in Atrial Fibrillation. Circulation Research, 122(5), 752-773. doi:10.1161/circresaha.117.311081Huang, H., Amin, V., Gurin, M., Wan, E., Thorp, E., Homma, S., & Morrow, J. P. (2013). Diet-induced obesity causes long QT and reduces transcription of voltage-gated potassium channels. Journal of Molecular and Cellular Cardiology, 59, 151-158. doi:10.1016/j.yjmcc.2013.03.007Hume, J. R., & Uehara, A. (1985). Ionic basis of the different action potential configurations of single guinea-pig atrial and ventricular myocytes. The Journal of Physiology, 368(1), 525-544. doi:10.1113/jphysiol.1985.sp015874INOUE, M., INOUE, D., ISHIBASHI, K., SAKAI, R., OMORI, I., YAMAHARA, Y., … NAKAGAWA, M. (1993). Effects of Pilsicainide on the Atrial Fibrillation Threshold in Guinea Kg Atria. A Comparative Study with Disopyramide, Lidocaine and Flecainide. Japanese Heart Journal, 34(3), 301-312. doi:10.1536/ihj.34.301Inoue, D., Shirayama, T., Omori, I., Inoue, M., Sakai, R., Ishibashi, K., … Nakagawa, M. (1993). Electrophysiological effects of flecainide acetate on stretched guinea pig left atrial muscle fibers. Cardiovascular Drugs and Therapy, 7(3), 373-378. doi:10.1007/bf00880161Iwasaki, Y., Nishida, K., Kato, T., & Nattel, S. (2011). Atrial Fibrillation Pathophysiology. Circulation, 124(20), 2264-2274. doi:10.1161/circulationaha.111.019893Jensen, M. D., Ryan, D. H., Apovian, C. M., Ard, J. D., Comuzzie, A. G., Donato, K. A., … Yanovski, S. Z. (2013). 2013 AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults. Circulation, 129(25 suppl 2), S102-S138. doi:10.1161/01.cir.0000437739.71477.eeJi, Y., Varkevisser, R., Opacic, D., Bossu, A., Kuiper, M., Beekman, J. D. M., … van der Heyden, M. A. G. (2017). The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models. British Journal of Pharmacology, 174(15), 2576-2590. doi:10.1111/bph.13869Kanner, S. A., Jain, A., & Colecraft, H. M. (2018). Development of a High-Throughput Flow Cytometry Assay to Monitor Defective Trafficking and Rescue of Long QT2 Mutant hERG Channels. Frontiers in Physiology, 9. doi:10.3389/fphys.2018.00397Killeen, M. J., Sabir, I. N., Grace, A. A., & Huang, C. L.-H. (2008). Dispersions of repolarization and ventricular arrhythmogenesis: Lessons from animal models. Progress in Biophysics and Molecular Biology, 98(2-3), 219-229. doi:10.1016/j.pbiomolbio.2008.10.008Killeen, M. J., Thomas, G., Sabir, I. N., Grace, A. A., & Huang, C. L.-H. (2008). Mouse models of human arrhythmia syndromes. Acta Physiologica, 192(4), 455-469. doi:10.1111/j.1748-1716.2007.01822.xKoivumäki, J. T., Korhonen, T., & Tavi, P. (2011). Impact of Sarcoplasmic Reticulum Calcium Release on Calcium Dynamics and Action Potential Morphology in Human Atrial Myocytes: A Computational Study. PLoS Computational Biology, 7(1), e1001067. doi:10.1371/journal.pcbi.1001067LAU, C.-P., TSE, H.-F., SIU, C.-W., & GBADEBO, D. (2012). Atrial Electrical and Structural Remodeling: Implications for Racial Differences in Atrial Fibrillation. Journal of Cardiovascular Electrophysiology, 23, s36-s40. doi:10.1111/jce.12022Leopoldo, A. S., Lima-Leopoldo, A. P., Sugizaki, M. M., Nascimento, A. F. do, de Campos, D. H. S., Luvizotto, R. de A. M., … Cicogna, A. C. (2011). Involvement of L-type calcium channel and serca2a in myocardial dysfunction induced by obesity. Journal of Cellular Physiology, 226(11), 2934-2942. doi:10.1002/jcp.22643Lima-Leopoldo, A. P., Leopoldo, A. S., Silva, D. C. T., Nascimento, A. F. do, Campos, D. H. S. de, Luvizotto, R. de A. M., … Cicogna, A. C. (2013). Influence of Long-Term Obesity on Myocardial Gene Expression. Arquivos Brasileiros de Cardiologia, 100(3). doi:10.5935/abc.20130045Lima-Leopoldo, A. P., Sugizaki, M. M., Leopoldo, A. S., Carvalho, R. F., Nogueira, C. R., Nascimento, A. F., … Cicogna, A. C. (2008). Obesity induces upregulation of genes involved in myocardial Ca2+ handling. Brazilian Journal of Medical and Biological Research, 41(7), 615-620. doi:10.1590/s0100-879x2008000700011Liu, T., Takimoto, E., Dimaano, V. L., DeMazumder, D., Kettlewell, S., Smith, G., … O’Rourke, B. (2014). Inhibiting Mitochondrial Na
+
/Ca
2+
Exchange Prevents Sudden Death in a Guinea Pig Model of Heart Failure. Circulation Research, 115(1), 44-54. doi:10.1161/circresaha.115.303062Mancarella, S., Yue, Y., Karnabi, E., Qu, Y., El-Sherif, N., & Boutjdir, M. (2008). Impaired Ca2+ homeostasis is associated with atrial fibrillation in the α1D L-type Ca2+ channel KO mouse. American Journal of Physiology-Heart and Circulatory Physiology, 295(5), H2017-H2024. doi:10.1152/ajpheart.00537.2008Mangoni, M. E., Couette, B., Bourinet, E., Platzer, J., Reimer, D., Striessnig, J., & Nargeot, J. (2003). Functional role of L-type Cav1.3 Ca2+ channels in cardiac pacemaker activity. Proceedings of the National Academy of Sciences, 100(9), 5543-5548. doi:10.1073/pnas.0935295100Martinez-Mateu, L., Romero, L., Ferrer-Albero, A., Sebastian, R., RodrÃguez Matas, J. F., Jalife, J., … Saiz, J. (2018). Factors affecting basket catheter detection of real and phantom rotors in the atria: A computational study. PLOS Computational Biology, 14(3), e1006017. doi:10.1371/journal.pcbi.1006017Matafome, P., & Seiça, R. (2017). Function and Dysfunction of Adipose Tissue. Obesity and Brain Function, 3-31. doi:10.1007/978-3-319-63260-5_1Matsimra, H., & Ehara, T. (1997). Selective Enhancement of the Slow Component of Delayed Rectifier K+Current in Guinea-Pig Atrial Cells by External ATP. The Journal of Physiology, 503(1), 45-54. doi:10.1111/j.1469-7793.1997.045bi.xMichael, G., Xiao, L., Qi, X.-Y., Dobrev, D., & Nattel, S. (2008). Remodelling of cardiac repolarization: how homeostatic responses can lead to arrhythmogenesis. Cardiovascular Research, 81(3), 491-499. doi:10.1093/cvr/cvn266Mickelson, A. V., & Chandra, M. (2017). Hypertrophic cardiomyopathy mutation in cardiac troponin T (R95H) attenuates length-dependent activation in guinea pig cardiac muscle fibers. American Journal of Physiology-Heart and Circulatory Physiology, 313(6), H1180-H1189. doi:10.1152/ajpheart.00369.2017Nakaya, H., Furusawa, Y., Ogura, T., Tamagawa, M., & Uemura, H. (2000). Inhibitory effects of JTV-519, a novel cardioprotective drug, on potassium currents and experimental atrial fibrillation in guinea-pig hearts. British Journal of Pharmacology, 131(7), 1363-1372. doi:10.1038/sj.bjp.0703713Nattel, S. (2002). New ideas about atrial fibrillation 50 years on. Nature, 415(6868), 219-226. doi:10.1038/415219aNattel, S., & Dobrev, D. (2017). Controversies About Atrial Fibrillation Mechanisms. Circulation Research, 120(9), 1396-1398. doi:10.1161/circresaha.116.310489Nattel, S., & Harada, M. (2014). Atrial Remodeling and Atrial Fibrillation. Journal of the American College of Cardiology, 63(22), 2335-2345. doi:10.1016/j.jacc.2014.02.555Nerbonne, J. M., & Kass, R. S. (2005). Molecular Physiology of Cardiac Repolarization. Physiological Reviews, 85(4), 1205-1253. doi:10.1152/physrev.00002.2005Ni, H., Whittaker, D. G., Wang, W., Giles, W. R., Narayan, S. M., & Zhang, H. (2017). Synergistic Anti-arrhythmic Effects in Human Atria with Combined Use of Sodium Blockers and Acacetin. Frontiers in Physiology, 8. doi:10.3389/fphys.2017.00946O’Connell, R. P., Musa, H., Gomez, M. S. M., Avula, U. M., Herron, T. J., Kalifa, J., & Anumonwo, J. M. B. (2015). Free Fatty Acid Effects on the Atrial Myocardium: Membrane Ionic Currents Are Remodeled by the Disruption of T-Tubular Architecture. PLOS ONE, 10(8), e0133052. doi:10.1371/journal.pone.0133052OCHI, R., MOMOSE, Y., OYAMA, K., & GILES, W. (2006). Sphingosine-1-phosphate effects on guinea pig atrial myocytes: Alterations in action potentials and K+ currents. Cardiovascular Research, 70(1), 88-96. doi:10.1016/j.cardiores.2006.01.010O’Hara, T., & Rudy, Y. (2012). Quantitative comparison of cardiac ventricular myocyte electrophysiology and response to drugs in human and nonhuman species. American Journal of Physiology-Heart and Circulatory Physiology, 302(5), H1023-H1030. doi:10.1152/ajpheart.00785.2011Osadchii, O. E. (2012). Electrophysiological determinants of arrhythmic susceptibility upon endocardial and epicardial pacing in guinea-pig heart. Acta Physiologica, 205(4), 494-506. doi:10.1111/j.1748-1716.2012.02428.xPatoine, D., Levac, X., Pilote, S., Drolet, B., & Simard, C. (2013). Decreased CYP3A Expression and Activity in Guinea Pig Models of Diet-Induced Metabolic Syndrome: Is Fatty Liver Infiltration Involved? Drug Metabolism and Disposition, 41(5), 952-957. doi:10.1124/dmd.112.050641Paulino, E. C., Ferreira, J. C. B., Bechara, L. R., Tsutsui, J. M., Mathias, W., Lima, F. B., … Negrão, C. E. (2010). Exercise Training and Caloric Restriction Prevent Reduction in Cardiac Ca
2+
-Handling Protein Profile in Obese Rats. Hypertension, 56(4), 629-635. doi:10.1161/hypertensionaha.110.156141Pérez-Hernández, M., Matamoros, M., Barana, A., Amorós, I., Gómez, R., Núñez, M., … Caballero, R. (2015). Pitx2c increases in atrial myocytes from chronic atrial fibrillation patients enhancingIKsand decreasingICa,L. Cardiovascular Research, 109(3), 431-441. doi:10.1093/cvr/cvv280A, P., H, C., MC, F., L, B., JN, W., & HS, K. (2018). Atrial Fibrillation Initiated by Early Afterdepolarization-Mediated Triggered Activity during Acute Oxidative Stress: Eff
Dominant Color Extraction with K-Means for Camera Characterization in Cultural Heritage Documentation
The camera characterization procedure has been recognized as a convenient methodology to correct color recordings in cultural heritage documentation and preservation tasks. Instead of using a whole color checker as a training sample set, in this paper, we introduce a novel framework named the Patch Adaptive Selection with K-Means (P-ASK) to extract a subset of dominant colors from a digital image and automatically identify their corresponding chips in the color chart used as characterizing colorimetric reference. We tested the methodology on a set of rock art painting images captured with a number of digital cameras. The characterization approach based on the P-ASK framework allows the reduction of the training sample size and a better color adjustment to the chromatic range of the input scene. In addition, the computing time required for model training is less than in the regular approach with all color chips, and obtained average color differences ΔE∗ab lower than two CIELAB units. Furthermore, the graphic and numeric results obtained for the characterized images are encouraging and confirms that the P-ASK framework based on the K-means algorithm is suitable for automatic patch selection for camera characterization purposes
- …