315 research outputs found
Increase in the magnitude of the energy barrier distribution in Ni nanoparticles due to dipolar interactions
The energy barrier distribution Eb of five samples with different
concentrations x of Ni nanoparticles using scaling plots from ac magnetic
susceptibility data has been determined. The scaling of the imaginary part of
the susceptibility Chi"(nu, T) vs. Tln(t/tau_0) remains valid for all samples,
which display Ni nanoparticles with similar shape and size. The mean value
increases appreciably with increasing x, or more appropriately with
increasing dipolar interactions between Ni nanoparticles. We argue that such an
increase in constitutes a powerful tool for quality control in magnetic
recording media technology where the dipolar interaction plays an important
role.Comment: 3 pages, 3 figures, 1 tabl
Role of dipolar interactions in a system of Ni nanoparticles studied by magnetic susceptibility measurements
The role of dipolar interactions among Ni nanoparticles (NP) embedded in an
amorphous SiO2/C matrix with different concentrations has been studied
performing ac magnetic susceptibility Chi_ac measurements. For very diluted
samples, with Ni concentrations < 4 wt % Ni or very weak dipolar interactions,
the data are well described by the Neel-Arrhenius law. Increasing Ni
concentration to values up to 12.8 wt % Ni results in changes in the
Neel-Arrhenius behavior, the dipolar interactions become important, and need to
be considered to describe the magnetic response of the NPs system. We have
found no evidence of a spin-glasslike behavior in our Ni NP systems even when
dipolar interactions are clearly present.Comment: 7 pages, 5 figures, 3 table
Tumour enhancement with newly developed Mn-metalloporphyrin (HOP-9P) in magnetic resonance imaging of mice
The purpose of the study is to evaluate the tumour enhancing characteristics and biodistribution of a newly developed metalloporphyrin derivative, HOP-9P (13, 17-bis (1-carboxypropionyl) carbamoylethyl-3, 8-bis (1-phenylpropyloxyethyl)-2,7,12,18-tetra- methyl-porphynato manganese (III)). Seven mice bearing SCC VII tumours were imaged using T1-weighted conventional spin echo magnetic resonance images before and 5 min, 2 h and 24 h after intravenous injection of 0.1 mmol/kg of HOP-9P. For the acquired images, signal intensities of the tumour, muscle and oil-phantom were measured. Then, tumor/oil and tumor/muscle signal intensity ratios were calculated. Nineteen mice were sacrificed before or after the administration of HOP-9P (at 5 min, 2 h and 24 h), and the biodistribution of manganese in the tumour, muscle, liver, blood and kidneys was measured using optical emission spectrometers and was expressed as micrograms of manganese per gram of tissue. The tumour/muscle signal intensity ratio at 24 h (3.18 ± 0.34) was significantly higher than precontrast ratio (1.77 ± 0.20) (P < 0.05). The biodistribution assessment of manganese demonstrated that HOP-9P gradually and consistently accumulated in the tumour to reach the highest concentration at 24 h (3.49 ± 1.22 μ gMn/g). It is concluded that HOP-9P is a potential tumour-specific MR contrast agent. © 2001 Cancer Research Campaign http://www.bjcancer.co
Gravitational Collapse and Fragmentation in Molecular Clouds with Adaptive Mesh Refinement
We describe a powerful methodology for numerical solution of 3-D
self-gravitational hydrodynamics problems with extremely high resolution. Our
method utilizes the technique of local adaptive mesh refinement (AMR),
employing multiple grids at multiple levels of resolution. These grids are
automatically and dynamically added and removed as necessary to maintain
adequate resolution. This technology allows for the solution of problems in a
manner that is both more efficient and more versatile than other fixed and
variable resolution methods. The application of AMR to simulate the collapse
and fragmentation of a molecular cloud, a key step in star formation, is
discussed. Such simulations involve many orders of magnitude of variation in
length scale as fragments form. In this paper we briefly describe the
methodology and present an illustrative application for nonisothermal cloud
collapse. We describe the numerical Jeans condition, a criterion for stability
of self-gravitational hydrodynamics problems. We show the first well-resolved
nonisothermal evolutionary sequence beginning with a perturbed dense molecular
cloud core that leads to the formation of a binary system consisting of
protostellar cores surrounded by distinct protostellar disks. The scale of the
disks, of order 100 AU, is consistent with observations of gaseous disks
surrounding single T-Tauri stars and debris disks surrounding systems such as
Pictoris.Comment: 10 pages, 6 figures (color postscript). To appear in the proceedings
of Numerical Astrophysics 1998, Tokyo, March 10-13, 199
Outcome of Reoperation for Local Recurrence Following En Bloc Resection for Bone Giant Cell Tumor of the Extremity
En bloc resection is typically performed to treat giant cell tumors of bone (GCTB), particularly when curettage can be challenging owing to extensive bone cortex destruction with soft tissue extension. Few reports have addressed the clinical outcomes after reoperation for local recurrence in patients with GCTB who underwent en bloc resection. In this multicenter retrospective study, we investigated local recurrence, distant metastasis, malignant transformation, mortality, and limb function in patients treated for local recurrence following en bloc resection for GCTB. Among 205 patients who underwent en bloc resection for GCTB of the extremities between 1980 and 2021, we included 29 with local recurrence. En bloc resection was performed for large tumors with soft tissue extension, pathological fractures with joint invasion, complex fractures, and dispensable bones, such as the proximal fibula and distal ulna. Local re-recurrence, distant metastasis, malignant transformation, and mortality rates were 41.4% (12/29), 34.5% (10/29), 6.9% (2/29), and 6.9% (2/29), respectively. The median Musculoskeletal Tumor Society score was 26 (interquartile range, 23–28). The median follow-up period after surgery for local recurrence was 70.1 months (interquartile range, 40.5–123.8 months). Local recurrence following en bloc resection for GCTB could indicate an aggressive GCTB, necessitating careful follow-up
Radiosensitivity of pimonidazole-unlabelled intratumour quiescent cell population to γ-rays, accelerated carbon ion beams and boron neutron capture reaction.
[Objectives] To detect the radiosensitivity of intratumour quiescent (Q) cells unlabelled with pimonidazole to accelerated carbon ion beams and the boron neutron capture reaction (BNCR). [Methods] EL4 tumour-bearing C57BL/J mice received 5-bromo-2′-deoxyuridine (BrdU) continuously to label all intratumour proliferating (P) cells. After the administration of pimonidazole, tumours were irradiated with γ-rays, accelerated carbon ion beams or reactor neutron beams with the prior administration of a [10]B-carrier. Responses of intratumour Q and total (P+Q) cell populations were assessed based on frequencies of micronucleation and apoptosis using immunofluorescence staining for BrdU. The response of pimonidazole-unlabelled tumour cells was assessed by means of apoptosis frequency using immunofluorescence staining for pimonidazole. [Results] Following γ-ray irradiation, the pimonidazole-unlabelled tumour cell fraction showed significantly enhanced radiosensitivity compared with the whole tumour cell fraction, more remarkably in the Q than total cell populations. However, a significantly greater decrease in radiosensitivity in the pimonidazole-unlabelled cell fraction, evaluated using a delayed assay or a decrease in radiation dose rate, was more clearly observed among the Q than total cells. These changes in radiosensitivity were suppressed following carbon ion beam and neutron beam-only irradiaton. In the BNCR, the use of a[10]B-carrier, especially L-para-boronophenylalanine-[10]B, enhanced the sensitivity of the pimonidazole-unlabelled cells more clearly in the Q than total cells. [Conclusion] The radiosensitivity of the pimonidazole-unlabelled cell fraction depends on the quality of radiation delivered and characteristics of the [10]B-carrier used in the BNCR
Horizontally and Vertically Aligned Polymeric Nanosheets: CO2-Induced Morphological Changes of Block Copolymer Thin Films
Recently, the carbon dioxide (CO2) Process with sphere forming block copolymer (bcp) templates successfully introduced nanometer cells into polymeric materials. CO2 selectively swells CO2-philic domains of fluorinated blocks and introduces nanometer voids in the CO2-philic domains. We extended the same methodology to bcp templates with nonspherical domains. Depending on the initial morphologies controlled by selectivity of casting solvents, vertically or horizontally aligned polymer nanosheets spontaneously appeared after the CO2 process and were confirmed by scanning electron microscopy and grazing incident small-angle X-ray scattering. Selective swelling of minority domains with CO2 induces transition to lamellar morphology during the process and results in stacking sheet structure after depressurization of CO2
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