Control and Alignment of Segmented-Mirror Telescopes: Matrices, Modes, and Error Propagation

Starting from the successful Keck telescope design, we construct and analyze the control matrix for the active control system of the primary mirror of a generalized segmented-mirror telescope, with up to 1000 segments and including an alternative sensor geometry to the one used at Keck. In particular we examine the noise propagation of the matrix and its consequences for both seeing-limited and diffraction-limited observations. The associated problem of optical alignment of such a primary mirror is also analyzed in terms of the distinct but related matrices that govern this latter problem

Phasing the Mirror Segments of the Keck Telescopes: The Broadband Phasing Algorithm

To achieve its full diffraction limit in the infrared, the primary mirror of the Keck telescope (now telescopes) must be properly phased: The steps or piston errors between the individual mirror segments must be reduced to less than 100 nm. We accomplish this with a wave optics variation of the Shack–Hartmann test, in which the signal is not the centroid but rather the degree of coherence of the individual subimages. Using filters with a variety of coherence lengths, we can capture segments with initial piston errors as large as ± 30 µm and reduce these to 30 nm—a dynamic range of 3 orders of magnitude. Segment aberrations contribute substantially to the residual errors of ~75 nm

The Design of the Keck Observatory and Telescope

This report describes the design of the Ten Meter Telescope and Observatory. Since 1977 the University of California has been actively designing a ten meter telescope for visible and infrared ground-based astronomy. The University of California and the California Institute of Technology have now joined in a collaboration to construct and operate this telescope and observatory. A generous gift of seventy million dollars to Caltech from the W. M. Keck Foundation, announced in January 1985, will provide funds for the construction of the facility. In recognition the facility will be named the W. M. Keck Telescope and Observatory. The University of California will provide funds for its operation. We expect construction to be completed by 1990. The design of the telescope and observatory continues to be improved as the detailed design progresses. The description given here is current as of January 1985. Although many design details will change before construction, this description is accurate in the general concept and in many particulars. The details of the design are described in an ongoing series of Reports and Technical Notes. An index to this series is given in the Reference Section of this report

It's not what you do it's the way that it's measured: quality assessment of minor ailment management in community pharmacies:Quality assessment of minor ailment management in community pharmacies

Background: Effective management of minor ailments in community pharmacies could reduce the burden on alternative high-cost services (general practices, Emergency Departments). Evidence is needed regarding the appropriateness of management of these conditions in community pharmacies. Objective: To explore the appropriateness of minor ailment management in community pharmacies. Setting: Prospective, observational study of simulated patient (SP) visits to community pharmacies in Grampian (Scotland) and East Anglia (England). Method: Eighteen pharmacies (nine per centre) were recruited within a 25-mile radius of Aberdeen or Norwich. Consultations for four minor ailments were evaluated: back pain; vomiting/diarrhoea; sore throat; and eye discomfort. Each pharmacy received one SP visit per ailment (four visits/pharmacy; 72 visits total). Visits were audio-recorded and SPs completed a data collection form immediately after each visit. Primary Outcome Measure: Each SP consultation was assessed for appropriateness against product licence, practice guidelines and study-specific consensus standards developed by a multi-disciplinary consensus panel. Results: Evaluable data were available for 68/72 (94.4%) visits. Most (96%) visits resulted in the sale of a product; advice alone was the outcome of three visits. All product sales complied with the product licence, 52 (76%) visits complied with practice guidelines and seven visits achieved a ‘basic’ standard according to the consensus standard. Conclusion: Appropriateness of care varied according to the standard used. Pharmacy-specific quality standards are needed which are realistic and relevant to the pharmacy context and which reflect legal and clinical guidelines to promote the safe and effective management of minor ailments in this setting

Finding Our Way through Phenotypes

Despite a large and multifaceted effort to understand the vast landscape of phenotypic data, their current form inhibits productive data analysis. The lack of a community-wide, consensus-based, human- and machine-interpretable language for describing phenotypes and their genomic and environmental contexts is perhaps the most pressing scientific bottleneck to integration across many key fields in biology, including genomics, systems biology, development, medicine, evolution, ecology, and systematics. Here we survey the current phenomics landscape, including data resources and handling, and the progress that has been made to accurately capture relevant data descriptions for phenotypes. We present an example of the kind of integration across domains that computable phenotypes would enable, and we call upon the broader biology community, publishers, and relevant funding agencies to support efforts to surmount today's data barriers and facilitate analytical reproducibility

A Search for Low-mass Dark Matter via Bremsstrahlung Radiation and the Migdal Effect in SuperCDMS

We present a new analysis of previously published of SuperCDMS data using a profile likelihood framework to search for sub-GeV dark matter (DM) particles through two inelastic scattering channels: bremsstrahlung radiation and the Migdal effect. By considering these possible inelastic scattering channels, experimental sensitivity can be extended to DM masses that are undetectable through the DM-nucleon elastic scattering channel, given the energy threshold of current experiments. We exclude DM masses down to $220~\textrm{MeV}/c^2$ at $2.7 \times 10^{-30}~\textrm{cm}^2$ via the bremsstrahlung channel. The Migdal channel search provides overall considerably more stringent limits and excludes DM masses down to $30~\textrm{MeV}/c^2$ at $5.0 \times 10^{-30}~\textrm{cm}^2$.Comment: Submitted to PR

Finding Our Way through Phenotypes

Despite a large and multifaceted effort to understand the vast landscape of phenotypic data, their current form inhibits productive data analysis. The lack of a community-wide, consensus-based, human- and machine-interpretable language for describing phenotypes and their genomic and environmental contexts is perhaps the most pressing scientific bottleneck to integration across many key fields in biology, including genomics, systems biology, development, medicine, evolution, ecology, and systematics. Here we survey the current phenomics landscape, including data resources and handling, and the progress that has been made to accurately capture relevant data descriptions for phenotypes. We present an example of the kind of integration across domains that computable phenotypes would enable, and we call upon the broader biology community, publishers, and relevant funding agencies to support efforts to surmount today's data barriers and facilitate analytical reproducibility