5,827 research outputs found
Late movement of basin-edge lobate scarps on Mercury
Basin-edge lobate scarps are a sub-type of tectonic shortening structure on the surface of Mercury that have formed at the edge of volcanic units that fill or partly fill impact basins. We have performed a global survey of these features and find that they are widespread in basins across the planet. We obtained model ages from crater sizeâfrequency distribution analysis for a subset of our surveyed basins, for both the smooth plains infill and for the last resolvable tectonic activity on the associated basin-edge scarps. Our results indicate that some of these lobate scarps were still accumulating strain in the late Mansurian (approximately 1 Ga). From a photogeological assessment, we find that the orientations of these basin-edge lobate scarps are similar to those reported for the global population of lobate scarps in earlier studies, appearing to align âŒnorthâsouth at low latitudes and âŒeastâwest at higher latitudes. However, reassessing these landformsâ orientation with artificially illuminated topographic data does not allow us to rule out the effect of illumination bias. We propose that these landforms, the result of crustal shortening in response to global contraction, formed along the interface between the basin floor and the smooth plains unit, which acted as a mechanical discontinuity along which shortening strains were concentrated
Multispectral satellite imaging improves detection of large individual fossils
Palaeontological field surveys in remote regions are a challenge, because of uncertainty in finding new specimens, high transportation costs, risks for the crew and a long time commitment. The effort can be facilitated by using high-resolution satellite imagery. Here we present a new opportunity to investigate remote fossil localities in detail, mapping the optical signature of individual fossils. We explain a practical workflow for detecting fossils using remote-sensing platforms and cluster algorithms. We tested the method within the Petrified Forest National Park, where fossil logs are sparse in a large area with mixed lithologies. We ran both unsupervised and supervised classifications, obtaining the best estimations for the presence of fossil logs using the likelihood and spectral angle mapper algorithms. We recognized general constraints and described logical and physical pros and cons of each estimated map. We also explained how the outcomes should be critically evaluated with consistent accuracy tests. Instead of searching for fossiliferous outcrops, our method targets single fossil specimens (or highly condensed accumulations), obtaining a significant increase in potential efficiency and effectiveness of field surveys. When repeatedly applied to the same region over time, it could also be useful for monitoring palaeontological heritage localities. Most importantly, the method here described is feasible, easily applicable to both fossil logs and bones, and represents a step towards standard best practices for applying remote sensing in the palaeontological field
The effects of the target material properties and layering on the crater chronology: the case of Raditladi and Rachmaninoff basins on Mercury
In this paper we present a crater age determination of several terrains
associated with the Raditladi and Rachmaninoff basins. These basins were
discovered during the first and third MESSENGER flybys of Mercury,
respectively. One of the most interesting features of both basins is their
relatively fresh appearance. The young age of both basins is confirmed by our
analysis on the basis of age determination via crater chronology. The derived
Rachmaninoff and Raditladi basin model ages are about 3.6 Ga and 1.1 Ga,
respectively. Moreover, we also constrain the age of the smooth plains within
the basins' floors. This analysis shows that Mercury had volcanic activity
until recent time, possibly to about 1 Ga or less. We find that some of the
crater size-frequency distributions investigated suggest the presence of a
layered target. Therefore, within this work we address the importance of
considering terrain parameters, as geo-mechanical properties and layering, into
the process of age determination. We also comment on the likelihood of the
availability of impactors able to form basins with the sizes of Rachmaninoff
and Raditladi in relatively recent times.Comment: Accepted by PSS, to appear on MESSENGER Flybys special issu
Suspended Multifunctional Nanocellulose as Additive for Mortars
Cellulose derivatives have found significant applications in composite materials, mainly because of the increased mechanical performance they ensure. When added to cement-based materials, either in the form of nanocrystals, nanofibrils or micro/nanofibers, cellulose acts on the mixture with fresh and hardened properties, affecting rheology, shrinkage, hydration, and the resulting mechanical properties, microstructure, and durability. Commercial cotton wool was selected as starting material to produce multifunctional nanocelluloses to test as additives for mortars. Cotton wool was oxidized to oxidized nanocellulose (ONC), a charged nanocellulose capable of electrostatic interaction, merging cellulose and nanoparticles properties. Oxidized nanocellulose (ONC) was further functionalized by a radical-based mechanism with glycidyl methacrylate (GMA) and with a mixture of GMA and the crosslinking agent ethylene glycol dimethacrylate (EGDMA) affording ONC-GMA and ONC-GMA-EGDMA, both multifunctional-charged nanocellulose merging cellulose and bound acrylates properties. In this work, only ONC was found to be properly suitable for suspension and addition to a commercial mortar to assess the variation in mechanical properties and water-mortar interactions as a consequence of the modified microstructure obtained. The addition of oxidized nanocellulose caused an alteration of mortar porosity, with a decreased percentage of porosity and pore size distribution shifted towards smaller pores, with a consequent increase in compressive resistance, decrease in water absorption coefficient, and increased percentage of micropores present in the material, indicating a potential improvement in mortar durability
Development and characterization of highly stable silver nanoparticles as novel potential antimicrobial agents for wound healing hydrogels
Recurrent microbial infections are a major cause of surgical failure and morbidity. Wound healing strategies based on hydrogels have been proposed to provide at once a barrier against pathogen microbial colonization, as well as a favorable environment for tissue repair. Nevertheless, most biocompatible hydrogel materials are more bacteriostatic than antimicrobial materials, and lack specific action against pathogens. Silver-loaded polymeric nanocomposites have efficient and selective activity against pathogenic organisms exploitable for wound healing. However, the loading of metallic nanostructures into hydrogels represents a major challenge due to the low stability of metal colloids in aqueous environments. In this context, the aim of the present study was the development of highly stable silver nanoparticles (AgNPs) as novel potential antimicrobial agents for hyaluronic acids hydrogels. Two candidate stabilizing agents obtained from natural and renewable sources, namely cellulose nanocrystals and ulvan polysaccharide, were exploited to ensure high stability of the silver colloid. Both stabilizing agents possess inherent bioactivity and biocompatibility, as well as the ability to stabilize metal nanostructures thanks to their supramolecular structures. Silver nitrate reduction through sodium borohydride in presence of the selected stabilizing agents was adopted as a model strategy to achieve AgNPs with narrow size distribution. Optimized AgNPs stabilized with the two investigated polysaccharides demonstrated high stability in phosphate buffer saline solution and strong antimicrobial activity. Loading of the developed AgNPs into photocrosslinked methacrylated hyaluronic acid hydrogels was also investigated for the first time as an effective strategy to develop novel antimicrobial wound dressing materials.This research was supported by the Portuguese Foundation for Science and Technology
(FCT) under the projects PTDC/BII-BIO/28870/2017 and POCI-01-0145-FEDER-007038 (UID/Multi/
50026/2013), and by the European Regional Development Fund (FEDER) through the âCOMPETEââ
Operational Program for Competitiveness factors (FCOMP-01-0124-FEDER-028120). A.R.F. thanks
FCT through the Post-Doctoral scholarship SFRH/BPD/100760/2014
Mapping and Monitoring Urban Environment through Sentinel-1 SAR Data: A Case Study in the Veneto Region (Italy)
Focusing on a sustainable and strategic urban development, local governments and public
administrations, such as the Veneto Region in Italy, are increasingly addressing their urban and
territorial planning to meet national and European policies, along with the principles and goals of
the 2030 Agenda for the Sustainable Development. In this regard, we aim at testing a methodology
based on a semi-automatic approach able to extract the spatial extent of urban areas, referred to as
\u201curban footprint\u201d, from satellite data. In particular, we exploited Sentinel-1 radar imagery through
multitemporal analysis of interferometric coherence as well as supervised and non-supervised
classi\ufb01cation algorithms. Lastly, we compared the results with the land cover map of the Veneto
Region for accuracy assessments. Once properly processed and classi\ufb01ed, the radar images resulted
in high accuracy values, with an overall accuracy ranging between 85% and 90% and percentages of
urban footprint di\ufb00ering by less than 1%\u20132% with respect to the values extracted from the reference
land cover map. These results provide not only a reliable and useful support for strategic urban
planning and monitoring, but also potentially identify a solid organizational data\ufb02ow process to
prepare geographic indicators that will help answering the needs of the 2030 Agenda (in particular
the goal 11 \u201cSustainable Cities and Communities\u201d)
The Presence of Essential and Non-Essential Stratum Corneum Proteases: The Vital Need for Protease Inhibitors
Dry skin is one of the most important
concerns of consumers worldwide.
Despite huge efforts over several decades,
the personal care industry still
does not offer complete solutions that
satisfy the unmet needs of consumers
for moisturizing treatments. The
paucity of data for the underlying biochemical
problems in and the effects
of moisturizers on facial skin biology
and physiology may partly explain
this. Our recent color mapping studies
based on bio-instrumental evaluations
of skin capacitance and transepidermal
water loss have revealed the
complexity of facial skin. However,
the biomolecular reasons for these
subtle differences in the different
zones of the face are unknown so
far. As the maturation of the stratum
corneum is vital for skin moisturization
and optimal barrier function, we
believe that the protease / proteaseinhibitor
balance particularly of the
plasminogen system may be key in
these processes. Thus, our aim was
to develop a specific dual plasmin and
urokinase inhibitor for topical application
to barrier-impaired skin and
demonstrate its efficac
Extra-small gold nanospheres decorated with a thiol-functionalized biodegradable and biocompatible linear polyamidoamine as nanovectors of anticancer molecules
Gold nanoparticles are elective candidate for cancer therapy. Current efforts are devoted to developing innovative methods for their synthesis. Besides, understanding their interaction with cells have become increasingly important for their clinical application. This work aims to describe a simple approach for the synthesis of extra-small gold nanoparticles for breast cancer therapy. In brief, a biocompatible and biodegradable polyamidoamine (named AGMA1-SH), bearing 20%, on a molar basis, thiol-functionalized repeat units, is employed to stabilize and coat extra-small gold nanospheres of different sizes (2.5, 3.5, and 5 nm in gold core), and to generate a nanoplatform for the link with Trastuzumab monoclonal antibody for HER2-positive breast cancer targeting. Dynamic light scattering, transmission electron microscopy, ultraviolet visible spectroscopy, X-ray powder diffraction, circular dichroism, protein quantification assays are used for the characterization. The targeting properties of the nanosystems are explored to achieve enhanced and selective uptake of AGMA1-SH-gold nanoparticles by in vitro studies against HER-2 overexpressing cells, SKBR-3 and compared to HER-2 low expressing cells, MCF-7, and normal fibroblast cell line, NIH-3T3. In vitro physicochemical characterization demonstrates that gold nanoparticles modified with AGMA1-SH are more stable in aqueous solution than the unmodified ones. Additionally, the greater gold nanoparticles size (5-nm) is associated with a higher stability and conjugation efficiency with Trastuzumab, which retains its folding and anticancer activity after the conjugation. In particular, the larger Trastuzumab functionalized nanoparticles displays the highest efficacy (via the pro-apoptotic protein increase, anti-apoptotic components decrease, survival-proliferation pathways downregulation) and internalization (via the activation of the classical clathrin-mediated endocytosis) in HER-2 overexpressing SKBR-3 cells, without eliciting significant effects on the other cell lines. The use of biocompatible AGMA1-SH for producing covalently stabilized gold nanoparticles to achieve selective targeting, cytotoxicity and uptake is completely novel, offering an important advancement for developing new anticancer conjugated-gold nanoparticles
Morphometric analysis of a fresh simple crater on the Moon
In this research we are proposing an innovative method to determine and quantify the morphology of a simple fresh impact crater. Linné is a well preserved impact crater of 2.2 km in diameter, located at 27.7oN 11.8oE, near the western edge of Mare Serenitatis on the Moon. The crater was photographed by the Lunar Orbiter and the Apollo space missions. Its particular morphology may place Linné as the most striking example of small fresh simple crater. Morphometric analysis, conducted on recent high resolution DTM from LROC (NASA), quantitatively confirmed the pristine morphology of the crater, revealing a clear inner layering which highlight a sequence of lava emplacement events
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