Misurazione dell'angolo γ ottenuta attraverso una combinazione bayesiana di risultati dell'esperimento LHCb

L'esperimento LHCb si occupa di realizzare misure di precisione nell'ambito della fisica del flavour, al fine di verificare la validità delle previsioni del Modello Standard. Nel Modello Standard, le trasformazioni degli stati di flavour dei quark sono descritti mediante la matrice CKM (Cabibbo-Kobayashi-Maskawa). Uno degli obiettivi principali di LHCb è la misura del parametro γ associato a questa matrice. La misura di γ è ottenuta combinando i risultati dell'analisi di vari decadimenti dei mesoni B. La combinazione è complicata dal fatto che molti degli osservabili di ciascuba misura sono legati a γ solo tramite equazioni non lineari. Inoltre sono presenti molti parametri addizionali (parametri "nuisance") che devono essere determinati insieme a γ. In questa tesi si fornisce una stima di γ ottenuta tramite una combinazione bayesiana di dodici misurazioni realizzate da LHCb. Questa combinazione verrà chiamata "DK only", in quanto contiene solo osservabili misurate nei decadimenti del tipo B->DK

Immunoscintigraphy for therapy decision making and follow-up of biological therapies

With the availability of new biological therapies there is the need of more accurate diagnostic tools to noninvasively assess the presence of their targets. In this scenario nuclear medicine offers many radiopharmaceuticals for SPECT or PET imaging of many pathological conditions. The availability of monoclonal antibodies provides tools to target specific antigens involved in angiogenesis, cell cycle or modulation of the immune systems. The radiolabelling of such therapeutic mAbs is a promising method to evaluate the antigenic status of each cancer lesion or inflamed sites before starting the therapy. It may also allow to perform follow-up of such biological therapies. In the present review we provide an overview of the most studied radiolabelled antibodies for therapy decision making and follow-up of patients affected by cancer and other pathological conditions

Tickling the CMB damping tail: scrutinizing the tension between the ACT and SPT experiments

The Atacama Cosmology Telescope (ACT) and the South Pole Telescope (SPT) have recently provided new, very precise measurements of the cosmic microwave background (CMB) anisotropy damping tail. The values of the cosmological parameters inferred from these measurements, while broadly consistent with the expectations of the standard cosmological model, are providing interesting possible indications for new physics that are definitely worth of investigation. The ACT results, while compatible with the standard expectation of three neutrino families, indicate a level of CMB lensing, parametrized by the lensing amplitude parameter A_L, that is about 70% higher than expected. If not a systematic, this anomalous lensing amplitude could be produced by modifications of general relativity or coupled dark energy. Vice-versa, the SPT experiment, while compatible with a standard level of CMB lensing, prefers an excess of dark radiation, parametrized by the effective number of relativistic degrees of freedom N_eff. Here we perform a new analysis of these experiments allowing simultaneous variations in both these, non-standard, parameters. We also combine these experiments, for the first time in the literature, with the recent WMAP9 data, one at a time. Including the Hubble Space Telescope (HST) prior on the Hubble constant and information from baryon acoustic oscillations (BAO) surveys provides the following constraints from ACT: N_eff=3.23\pm0.47, A_L=1.65\pm0.33 at 68% c.l., while for SPT we have N_eff=3.76\pm0.34, A_L=0.81\pm0.12 at 68% c.l.. In particular, the A_L estimates from the two experiments, even when a variation in N_eff is allowed, are in tension at more than 95% c.l..Comment: 7 pages, 7 figures, v.2. some typos and sentences correcte

Assessment for sonographic grading scales of the body fat changes related to the lipoatrophic findings of HIV patients in treatment with HAART

Methods We enrolled non-obese HIV patients (73 males and 42 females; body mass index <27 kg/m2). Clinical assessments of BFCs were defined by correspondence between the self-reports of patients and medical examinations. Fat redistribution was scored separately for face, arm and lower limbs on a scale ranging from 0 (absence) to 1 (mid) and 2–3 (severe BFCs). US scans of subcutaneous fat thickness (SFT) were performed at 3 reference points: transversal scan at the deepest point of Bichat pad (facial SFT), long dorsal scan of arm (brachial SFT), and long scan of anterior face of thigh (crural SFT)

Kinematics Adaptation and Inter-Limb Symmetry during Gait in Obese Adults

The main purpose of this study is to characterize lower limb joint kinematics during gait in obese individuals by analyzing inter-limb symmetry and angular trends of lower limb joints during walking. To this purpose, 26 obese individuals (mean age 28.5 years) and 26 normal-weight age- and sex-matched were tested using 3D gait analysis. Raw kinematic data were processed to derive joint-specific angle trends and angle-angle diagrams (synchronized cyclograms) which were characterized in terms of area, orientation and trend symmetry parameters. The results show that obese individuals exhibit a kinematic pattern which significantly differs from those of normal weight especially in the stance phase. In terms of inter-limb symmetry, higher values were found in obese individuals for all the considered parameters, even though the statistical significance was detected only in the case of trend symmetry index at ankle joint. The described alterations of gait kinematics in the obese individuals and especially the results on gait asymmetry are important, because the cyclic uneven movement repeated for hours daily can involve asymmetrical spine loading and cause lumbar pain and could be dangerous for overweight individuals

Is HAART based on newest active antiretroviral drugs influenced by GSS

Methods Major enrollment criterion was the administration of maraviroc, enfuvirtide, raltegravir, etravirine, darunavir/r or tipranavir/r, alone or in combination, in the latest antiretroviral regimen, decided upon the last genotypic RNA resistance test. This allowed us to assess the genotypic sensitivity score (GSS) at the same time. We also recorded previous presence of specific mutations in all available genotypic resistance tests, their persistence in time and their correlation to the last GSS

Cyclogram-based evaluation of inter-limb gait symmetry in Prader-Willi Syndrome

Background Prader-Willi syndrome (PWS) is characterized by a complex clinical condition, whose typical features lead to impaired motor and functional skills. To date, limited data is available as regards symmetry of gait in PWS. Research question The aim of this study was to characterize lower-limb asymmetry during gait in a group of Prader-Willi Syndrome (PWS) individuals by using the synchronized cyclograms and to compare it with those of two different control groups, a normal-weight group and an obese group. Methods A total of 18 PWS, 30 normal weight (NW) and 28 obese individuals (OG) matched for age, sex and height were assessed via 3D gait analysis. Gait spatio-temporal parameters were computed together with angle-angle diagrams, characterized in terms of their geometric features (i.e. area, orientation, and trend symmetry index). Results Individuals with PWS exhibit reduced speed, stride length and cadence and increased duration of both stance and double support phase than the other groups. OG was characterized by the same pattern when compared to NW. With respect to inter-limb symmetry, individuals with PWS exhibited significantly larger cyclogram areas at hip joint with respect to the other two groups (203.32 degrees2 vs. 130.73 degrees2 vs. 111.59 degrees2) and significantly higher orientation angle (4.17° vs. 2.11° vs. 1.22°) and Trend Symmetry (3.72 vs. 2.02 vs. 1.21) with respect to the other two groups at knee joint; no differences were found at ankle joint. Both individuals with PWS and those of OG exhibited reduced ROM at knee and ankle joints with respect with normal weight, but no statistically significant differences were observed between PWS and OG. Significance The obtained results may provide novel and useful insights to understand better the impairments in motor control associated with this pathological state, supporting clinics in the identification of the best rehabilitation program for this rare pathological state, aimed to improve stability and motor control

Synchronized Cyclograms to Assess Inter-Limb Symmetry during Gait in Women with Anorexia and Bulimia: A Retrospective Study

Anorexia nervosa (AN) and bulimia nervosa (BN) are eating diseases characterized by extreme eating behaviours impacting both mental and physical health. Aberrant musculoskeletal adaptations due to malnutrition affect motor abilities such as postural control and gait. To date, limited data is available with regards to gait symmetry in AN and BN. The aim of this study was to characterize inter-limb asymmetry during gait in two cohorts affected by AN and BN, respectively, using the synchronized cyclograms and to compare it with a healthy weight group. A total of 14 AN, 17 BN, and 11 healthy-weight females were assessed via 3D gait analysis. Gait spatio-temporal parameters were computed together with angle–angle diagrams, which were characterized in terms of their geometric features. Individuals with AN and BN were characterized by reduced speed and cadence and an abnormal increase in the duration of the double support phase with respect to the healthy controls. With respect to inter-limb symmetry, asymmetries were detected in both groups, with individuals with BN exhibiting significantly larger cyclogram areas at the hip joint with respect to the other groups (323.43 degrees2 vs. 253.74 degrees2 vs. 136.37 degrees2) and significantly higher orientation angle and Trend Symmetry at both knee and ankle joint. The cyclogram analysis suggests the presence of an altered gait symmetry in individuals with BN. In the AN group, it is possible to observe a similar trend; however, this is not statistically significant. Overall, the findings of this study may provide a novel perspective on the motor control dysfunction linked to eating disorders and aid clinicians in selecting a suitable rehabilitation scheme targeted at enhancing motor stability and control

Functional electrical stimulation for foot drop in post-stroke people: quantitative effects on step-to-step symmetry of gait using a wearable inertial sensor

The main purpose of the present study was to assess the effects of foot drop stimulators (FDS) in individuals with stroke by means of spatio-temporal and step-to-step symmetry, harmonic ratio (HR), parameters obtained from trunk accelerations acquired using a wearable inertial sensor. Thirty-two patients (age: 56.84 ± 9.10 years; 68.8% male) underwent an instrumental gait analysis, performed using a wearable inertial sensor before and a day after the 10-session treatment (PRE and POST sessions). The treatment consisted of 10 sessions of 20 min of walking on a treadmill while using the FDS device. The spatio-temporal parameters and the HR in the anteroposterior (AP), vertical (V), and mediolateral (ML) directions were computed from trunk acceleration data. The results showed that time had a significant effect on the spatio-temporal parameters; in particular, a significant increase in gait speed was detected. Regarding the HRs, the HR in the ML direction was found to have significantly increased (+20%), while those in the AP and V directions decreased (approximately 13%). Even if further studies are necessary, from these results, the HR seems to provide additional information on gait patterns with respect to the traditional spatio-temporal parameters, advancing the assessment of the effects of FDS devices in stroke patients

The Healthy Fatty Index Allows for Deeper Insights into the Lipid Composition of Foods of Animal Origin When Compared with the Atherogenic and Thrombogenicity Indexes

The aim of this research was to validate the effectiveness of the Healthy Fatty Index (HFI) regarding some foods of animal origin (meat, processed, fish, milk products, and eggs) typical of the Western diet and to compare these results with two consolidated indices (atherogenic-AI, and thrombogenic-TI) in the characterization of the nutritional features of their lipids. The fatty acids profile (% of total fatty acids and mg/100 g) of 60 foods, grouped in six subclasses, was used. The AI, TI, and HFI indexes were calculated, and the intraclass correlation coefficients and the degree of agreement were evaluated using different statistical approaches. The results demonstrated that HFI, with respect to AI and TI, seems better able to consider the complexity of the fatty acid profile and the different fat contents. HFI and AI are the two most diverse indices, and they can provide different food classifications. AI and IT exhibit only a fair agreement in regards to food classification, confirming that such indexes are always to be considered indissolubly and never separately, in contrast to the HFI, which can stand alone