L’ontologie des vertus dans l’Inquiry (1726) de Hutcheson

Hutcheson fonde sa théorie morale sur un « sens moral ». Ce sens nous permet de faire des distinctions morales (bien et mal). Cette théorie donnera lieu à un débat sur la réalité des valeurs morales. Selon certains commentateurs, nos distinctions morales portent sur des faits moraux réels que l’on peut connaître empiriquement grâce à notre sens moral. Inversement, certains soutiendront que le sens moral ne produit pas de connaissance morale. Les jugements moraux issus de ce sens sont des réponses émotionnelles plus ou moins fiables que l’on ressent face à des motivations qui nous semblent être vertueuses. Nous montrerons que, selon Hutcheson, nos jugements moraux sont bien des réponses émotionnelles, mais qu’ils ont néanmoins un critère d’objectivité. Notre sens moral, grâce à la Providence divine, a pour fonction de préserver le bien-être de l’humanité. Cette fonction du sens moral sert de critère pour évaluer le bon fonctionnement de ce sens moral

On Words with the Zero Palindromic Defect

We study the set of finite words with zero palindromic defect, i.e., words rich in palindromes. This set is factorial, but not recurrent. We focus on description of pairs of rich words which cannot occur simultaneously as factors of a longer rich word

Evaluation of building envelope retrofit techniques for reducing energy needs for space cooling.

One of the fastest growing sources of new energy demand is space cooling. According to EU-studies a four-fold growth in air-conditioned space is likely to take place between 1990 and 2020. The energy savings achievable in the end-use space cooling depend on a number of variables related to the building envelope, the plants and to some extent the behaviour of occupants. They are hence complex to evaluate and consequently often underrepresented in energy efficiency programmes and National Plans. This paper is based on some preliminary results of the IEE project KeepCool 2. It discusses in particular: a methodology for bottom-up assessment of the energy savings related to "sustainable summer comfort" solutions; reference base case building typologies are analyzed in 5 European climates, and dynamic simulations are used to calculate the reductions in the energy need for cooling which can be achieved by specific retrofit actions (e.g. additions of effective solar protections, increased thermal insulation, night ventilation, increase of active mass by PCM, low solar absorbance surfaces,...); situations where mechanical cooling can be avoided are evaluated using the Adaptive Comfort model, according to the norm EN 15251. case studies of buildings with good summer comfort and low energy consumption performances, according to the ten steps of the KC2 procedure. the analysis of case studies of "comfort policies" adopted by public and private bodies to ensure summer comfort with low energy consumption (commitments to give priority to heat load reductions instead of introducing mechanical cooling, relaxed dress codes, low thermal insulation chairs, local air velocity increase)

An Optimal Algorithm for Tiling the Plane with a Translated Polyomino

We give a $O(n)$-time algorithm for determining whether translations of a polyomino with $n$ edges can tile the plane. The algorithm is also a $O(n)$-time algorithm for enumerating all such tilings that are also regular, and we prove that at most $\Theta(n)$ such tilings exist.Comment: In proceedings of ISAAC 201

Vitamin B6 deficiency experimentally-induced bone and joint disorder: microscopic, radiographic and biochemical evidence

In the present study the effect of pyridoxine deficiency on the utrastructure and morphology of bone and its metabolism was examined in the rapidly growing chick. Pyridoxine-deficient animals had tibias of reduced dry weight and cortical thickness. Histomorphometry demonstrated a disproportionately high eroded surface, lower amount of osteoid tissue and reduced mineralized trabecular width. Anterior-posterior radiographs of the tibiotarsometatarsal joint showed reduced secondary ossification centres and coarse trabeculation. Decalcified metaphyseal cartilage showed irregular trabeculas and a markedly reduced amount of Fast-green counterstain matrix suggesting that there is less collagen present and in turn less availability for matrix to be laid down for later calcification. Plasma activity of the bone alkaline phosphatase isoenzyme (EC) 3. 1.3.1) was decreased. Plasma Ca and PO4 levels did not vary. The present bone study referring to a pseudo-lathyritic state in which collagen maturation is not completely achieved supports the hypothesis that pyridoxine is an essential nutrient for the connective tissue matri

Generalised Lyndon-Schützenberger Equations

We fully characterise the solutions of the generalised Lyndon-Schützenberger word equations $u_1 \cdots u_\ell = v_1 cdots v_m w_1 \cdots w_n$, where $u_i \in \{u, \theta(u)\}$ for all $1 \leq i \leq \ell$, $v_j \in \{v, \theta(v)\}$ for all $1 \leq j \leq m$, $w_k \in \{w, \theta(w)\}$ for all $1 \leq k ?\leq n$, and $\theta$ is an antimorphic involution. More precisely, we show for which $\ell$, $m$, and $n$ such an equation has only $\theta$-periodic solutions, i.e., $u$, $v$, and $w$ are in $\{t, \theta(t)\}^\ast$ for some word $t$, closing an open problem by Czeizler et al. (2011)

Étude microsystémique des facteurs influençant l’anxiété de performance de l’élève athlète

Résumé Cette étude caractérise les facteurs de protection et de risque de l’anxiété de performance associés aux parents, aux entraîneurs et aux enseignants des élèves athlètes des programmes de Sport-études québécois. Le devis qualitatif interprétatif est ancré dans le modèle écologique de Bronfenbrenner. Seize entretiens semi-dirigés individuels documentent le point de vue de quatre trios (élève athlète, parent et entraîneur), celui d’une dyade (élève athlète et parent) et de deux personnes en direction sportive et scolaire. L’analyse thématique révèle plus de facteurs de protection que de facteurs de risque. Les résultats soulignent l’importance d’améliorer les savoirs des enseignants et de mieux définir les attentes académiques envers les élèves athlètes liées au programme de Sport-études. Ils mettent de l’avant la nécessité d’aider les élèves athlètes à modifier leurs schémas de pensées et de promouvoir l’apprentissage par erreur. Finalement, cette étude démontre l’importance de considérer les multiples sources d’influence de l’anxiété de performance. Abstract This study characterizes the protective and risk factors of performance anxiety associated with parents, coaches and teachers of student athletes in Quebec Sport-studies programs. The interpretative qualitative study is anchored in Bronfenbrenner's ecological model. Sixteen semi-structured individual interviews document the perspective of four trios (student athlete, parent and coach), that of a dyad (student athlete and parent) and two people in sports and school management. The thematic analysis reveals more protective factors than risk factors. The results underline the importance of improving the knowledge of teachers and of better defining the academic expectations of student athletes related to the Sport-studies program. They emphasize the need to help student athletes change their thought patterns and promote learning through mistake. Finally, this study demonstrates the importance of considering the multiple sources of influence of performance anxiety

Geometric control of cardiomyogenic induction in human pluripotent stem cells

Although it has been observed that aggregate size affects cardiac development, an incomplete understanding of the cellular mechanisms underlying human pluripotent stem cell-derived cardiomyogenesis has limited the development of robust defined-condition cardiac cell generation protocols. Our objective was thus to elucidate cellular and molecular mechanisms underlying the endogenous control of human embryonic stem cell (hESC) cardiac tissue development, and to test the hypothesis that hESC aggregate size influences extraembryonic endoderm (ExE) commitment and cardiac inductive properties. hESC aggregates were generated with 100, 1000, or 4000 cells per aggregate using microwells. The frequency of endoderm marker (FoxA2 and GATA6)-expressing cells decreased with increasing aggregate size during early differentiation. Cardiogenesis was maximized in aggregates initiated from 1000 cells, with frequencies of 0.49±0.06 cells exhibiting a cardiac progenitor phenotype (KDRlow/C-KITneg) on day 5 and 0.24±0.06 expressing cardiac Troponin T on day 16. A direct relationship between ExE and cardiac differentiation efficiency was established by forming aggregates with varying ratios of SOX7 (a transcription factor required for ExE development) overexpressing or knockdown hESCs to unmanipulated hESCs. We demonstrate, in a defined, serum-free cardiac induction system, that robust and efficient cardiac differentiation is a function of endogenous ExE cell concentration, a parameter that can be directly modulated by controlling hESC aggregate size. © 2011 Mary Ann Liebert, Inc