The Relationship of Lateral Eye Movements to Field-Dependence-Independence and Verbal and Performance Skills

Lateral eye movements and handedness as indexes of hemisphere asymmetry were compared to field-dependence-independence, as measured by Rod-and-Frame Test errors, and to Wechsler Verbal and Performance IQs. Consistent with previous research, the hypotheses predicted that persons with inconsistent lateral eye movements (ambilaterality) would have greater Rod-and-Frame errors (field-dependence) and lower Wechsler Verbal and Performance IQs. Subjects were 41 male undergraduates who were grouped according to their lateral eye movements in response to 20 reflective questions consisting of ten verbal (left-hemisphere) and ten spatial (right-hemisphere) questions. The response scoring resulted in 12 subjects with 70% or more lateral eye movements to the right who were classified as right-movers (left hemisphere dominant), 12 subjects with 70% or more lateral eye movements to the left who were classified as left-movers (right hemisphere dominant), and 17 subjects with inconsistent lateral eye movements who were classified as bidirectionals (ambilateral). Ambilaterals are assumed to have verbal functions equally represented in both hemispheres of the brain rather than left hemisphere specialization for that function. In addition to the subsequent administration of the handedness questionnaire, Rod-and-Frame Test, and the Wechsler, the existence of immediate or extended-family sinistrality (left-handedness) was also questioned. Statistical analysis by means of one-way analysis of variance, stepwise regression, and discriminant analysis yielded no significant differences between the three groups on measures of LEMs, handedness, Verbal IQ, Performance IQ, or Full Scale IQ. Chi square analysis of absence or presence of immediate or extended family sinistrality likewise yielded no significant results

Incentivizing preventive services in primary care: perspectives on Local Enhanced Services

Background: General practitioners in the UK play a key role in prevention but provision of preventive services is variable. The 2004 General Medical Services contract allows Primary Care Trusts (PCTs) to address health needs through providing locally agreed payments for Local Enhanced Services (LESs). This study identifies how this contractual flexibility is used for preventive services and explores its perceived effectiveness. Methods: Semi-structured interviews were carried out (2008–09) in 10 purposively selected case study sites in England. Details of LESs for these sites were collected (2009) through Freedom of Information requests or local contacts. A national on-line survey of PCTs (2009) provided a national context for case study findings. Results: LESs were considered to be effective in incentivizing preventive activity. However, specifications and performance management were often weak, awareness of how to optimize incentives was low and, as optional services, LESs were perceived to be at risk in a financial downturn. Conclusions: Using LESs for preventive services highlights gaps in ‘core’ primary care responsibilities and in the national pay-for-performance framework. Current incentive arrangements are complex, could increase inequalities and provide only a partial, short-term solution to developing a proactive approach to prevention in primary care

PAX6 does not regulate Nfia and Nfib expression during neocortical development

The Nuclear factor I (NFI) family of transcription factors regulates proliferation and differentiation throughout the developing central nervous system. In the developing telencephalon of humans and mice, reduced Nfi expression is associated with agenesis of the corpus callosum and other neurodevelopmental defects. Currently, little is known about how Nfi expression is regulated during early telencephalic development. PAX6, a transcription factor important for telencephalic development, has been proposed as an upstream regulator of Nfi expression in the neocortex. Here we demonstrate that, in the developing neocortex of mice, NFIA and NFIB are endogenously expressed in gradients with high caudo-medial to low rostro-lateral expression and are most highly expressed in the cortical plate. We found that this expression pattern deviates from that of PAX6, suggesting that PAX6 does not drive Nfi expression. This is supported by in vitro reporter assays showing that PAX6 overexpression does not regulate Nfi promoter activity. Similarly, we also found that in the Pax6 Small Eye mutant, no changes in Nfi mRNA or protein expression are observed in the neocortical ventricular zone where PAX6 and the NFIs are expressed. Together these data demonstrate that in mice, PAX6 is not a transcriptional activator of Nfi expression during neocortical development

Your voice matters: Assessing the need for a resource center

With the transformation of the AGEP project initiative, identifying and preserving the knowledge created and making it available for re-use by other researchers and higher education institutions will require the development of a specific intervention. The current trajectory for the Alliances materials will fail to reach the larger audiences needed to realize their full promise and the materials will be lost over time due to the absence of infrastructure to provide ongoing access

The Materials Curation Inventory Toolkit: Interviewer\u27s Manual

The Interviewer’s Manual provides the framework for the interview. It contains text and questions to be read to the participating researcher over the course of the interview. It is meant to be used in conjunction with the Interview Worksheet

Directors of public health as ‘a protected species’: qualitative study of the changing role of public health professionals in England following the 2013 reforms

Background: The Health and Social Care Act 2012 gave councils in England responsibility for improving the health of their populations. Public health teams were transferred from the NHS, accompanied by a ring-fenced public health grant. This study examines the changing role of these teams within local government. Methods: In-depth case study research was conducted within 10 heterogeneous councils. Initial interviews (n=90) were carried out between October 2015 and March 2016, with follow-up interviews (n=21) 12 months later. Interviewees included elected members, directors of public health (DsPH) and other local authority officers, plus representatives from NHS commissioners, the voluntary sector and Healthwatch. Results: Councils welcomed the contribution of public health professionals, but this was balanced against competing demands for financial resources and democratic leverage. DsPH – seen by some as a ‘protected species’ – were relying increasingly on negotiating and networking skills to fulfil their role. Both the development of the existing specialist public health workforce and recruitment to, and development of, the future workforce were uncertain. This poses both threats and opportunities. Conclusions: Currently the need for staff to retain specialist skills and maintain UKPH registration is respected. However, action is needed to address how future public health professionals operating within local government will be recruited and developed