3 research outputs found
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Global Grazinglands and Greenhouse Gas Fluxes
Grazinglands, vegetated land that is grazed or has the potential to be grazed by wild and/or domestic ungulates, occupy about half of the world’s surface, provide livelihoods to almost one billion people, and constitute a major component of the global carbon stock and cycle. Grazinglands have significant potential for mitigation of climate change in the short term, and management practices that lead to mitigation are fairly well known. However, the degree to which this mitigation potential is realized pivots on our ability to design cost-effective protocols to promote the implementation of such management practices. In order to create efficient protocols we need a deeper and more precise knowledge of the processes and factors that affect greenhouse gas (GHG; mainly CO2, N2O, and CH4) fluxes and carbon (C) stocks in grazinglands. The Rangeland Ecology & Management archives are made available by the Society for Range Management and the University of Arizona Libraries. Contact [email protected] for further information.Migrated from OJS platform August 202
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer
<p>TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOG, we analyzed similar to 480 SNPs at the TERT locus in breast (n = 103,991), ovarian (n = 39,774) and BRCA1 mutation carrier (n = 11,705) cancer cases and controls. Leukocyte telomere measurements were also available for 53,724 participants. Most associations cluster into three independent peaks. The minor allele at the peak 1 SNP rs2736108 associates with longer telomeres (P = 5.8 x 10(-7)), lower risks for estrogen receptor (ER)-negative (P = 1.0 x 10(-8)) and BRCA1 mutation carrier (P = 1.1 x 10(-5)) breast cancers and altered promoter assay signal. The minor allele at the peak 2 SNP rs7705526 associates with longer telomeres (P = 2.3 x 10(-14)), higher risk of low-malignant-potential ovarian cancer (P = 1.3 x 10(-15)) and greater promoter activity. The minor alleles at the peak 3 SNPs rs10069690 and rs2242652 increase ER-negative (P = 1.2 x 10(-12)) and BRCA1 mutation carrier (P = 1.6 x 10-14) breast and invasive ovarian (P = 1.3 x 10(-11)) cancer risks but not via altered telomere length. The cancer risk alleles of rs2242652 and rs10069690, respectively, increase silencing and generate a truncated TERT splice variant.</p>