UN TENTATIVO DI RICOSTRUZIONE DEL CIBORIO DELLA CATTEDRALE DI KOTOR

Na temelju novih nalaza autor donosi rekonstrukciju košare ciborija iz Kotora, te ga morfološkom i epigrafskom analizom datira u 11. stoljeće. Također predlaže da je ciborij poklonio kotorski plemić Nikifor crkvi Petilovrijenci u Kotoru, koja je podignuta 1026. godine, te da je poslije dospio u katedralu sv. Tripuna.In occasione del restauro dell\u27edificio sulla piazza di fronte alla cattedrale di S. Trifone a Kotor (Cattaro), dopo il catastrofico terremoto dell\u27anno 1979, sono stati ritrovati diversi frammenti di un arco di ciborio con iscrizione. L\u27analisi dei motivi decorativi, il tipo di lavorazione e i caratteri epigrafici confermano che si tratta del già noto arco di ciborio della cattedrale e della parte corrispondente alla terza faccia con l \u27iscrizione relativa proveniente dalla collezione della cattedrale. La quarta faccia, sebbene con la decorazione scalpellata e l \u27iscrizione abrasa, è stata riconosciuta dall\u27autore sulla porta laterale dell\u27edificio del Vescovato. Nonostante la presenza di elementi decorativi dell\u27alto preromanico (intreccio a tre vimini con oculi, intreccio a otto e losanghe) che rinviano agli inizi del IX secolo, parlano a favore del tardo preromanico i motivi del viticcio con foglie cuoriformi e dell\u27evoluto tralcio protoromanico e in particolare la morfologia e il ductus delle lettere. Le lettere regolari con le terminazioni allargate presentano al centro dei tratti verticali una decorazione eseguita con il trapano a forma di punto. Analizzando l\u27iscrizione l\u27autore presenta una nuova interpretazione, e ritiene che non vi siano ricordati né l\u27imperatore bizantino né il vescovo di Cattaro come sostenevano, le letture precedenti di alcuni studiosi, bensi il donatore, il nobile cattarino Nikifor (Nikiforius). L\u27iscrizione, secondo la nuova ricostruzione, dice: t HOC OPVS EST LABO(r) /X/ T AM PVLCHRE DE( coratum) /quod donavit N/IKIFORIVS N/obilis Cathari/ ANDREE S(an)C(t)I AD HONOREM SOCIORVMQ(ue) MAIOREM† In confronto al restante materiale epigrafico a Cattaro, è evidente che il ductus di questa iscrizione è di qualità superiore, e si possono trovare analogie solo in un gruppo di iscrizioni spalatine dell\u27XI secolo. Considerate le dimensioni del ciborio (le cui facce misurano ognuna 130 cm), esso non poteva sicuramente stare nella chiesa originaria di S. Trifone, ma era probabilmente stato costruito per un\u27altra chiesa di Cattaro. Essendo citato S. Andrea sull\u27iscrizione, la chiesa è quella di Petilovrijenci, innalzata nel 1026, e dedicata ai martiri cattarini Andrea, Pietro e Lorenzo

Influence of the damage level during quenching on thermal shock behavior of low cement castable

In the recent decades, the use of unshaped monolithic refractories has been increasing greatly because of their significant advantages over other shaped refractory bricks of the same class. A low cement high alumina castable was synthetised and sintered at 1300°C in order to investigate thermal and mechanical properties, as well as thermal shock behavior. The water quench test was applied as an experimental method for thermal stability testing. Modification of the water quench test was performed by additional monitoring of the samples behavior during the water quench test such as implementation of image analysis and ultrasonic measurements. The image analysis program was applied on samples in order to measure the level of surface damage before and during the water quench test. Ultrasonic measurements were performed with the aim to measure the Young modulus of elasticity during the testing. Strength deterioration of the samples was calculated by the model based on ultrasonic velocity changes during the water quench test. The influence of monitoring the damage level before and during the quench experiment and its influence on thermal shock behavior will be discussed

Accidental intoxications among children. A five-year analytical study

A analitičkoj studiji 340 slučajeva trovanja dece kojoj je u razdoblju 1974-78 godine u Dečjoj klinici u Beogradu pružena neodložna i intenzivna terapija date su osnovne posebnosti, kao uzrast i pol dece, vrste trovanja, okolnosti zadesa. Trovanja dece ingestijom medikamenata, u prvom redu sa psihotropnim delovanjem, najčešća su i u porastu, kao i ingestijom destilatima petroleuma. Izneti su i aspekti uspešnih preventivnih mera (edukacija roditelja, dece školskog uzrasta i dr.).The results of an analytical study of 340 accidental poisonings in children treated in the Children\u27s Hospital in Beograd in the 1974-1978 period are discussed from the point of view of the age and sex of the children and the type and circumstances of poisoning. The poisonings caused by ingestion of medicaments, particularly psychotropic drugs, as well as by ingestion of petroleum distillates were found to be the most frequent. Some preventive measures such as education of parents and school age children are suggested

Synthesis of 5-azaandrostane-3β,17β-diol protected at the 17β-hydroxyl group

In the present paper, the preparation of 3β-hydroxy-17β-dimethyl- tert-butylsilyloxy-5-azaandrostane (15) in fourteen steps is described. B-nor-17-oxoandrost-5-en-3β-yl acetate (1) 1,2 was used as the starting material, which was transformed to the key intermediate of the synthesis, B-nor-17β-dimethyl-tert-butylsilyloxyandrost-4-en-3β-yl acetate (7)

Supplementary data for article : Kolarević, S.; Milovanović, D.; Kračun-Kolarević, M.; Kostić, J.; Sunjog, K.; Martinović, R.; Đorđević, J.; Novaković, I.; Sladić, D.; Vuković-Gačić, B. Evaluation of Genotoxic Potential of Avarol, Avarone, and Its Methoxy and Methylamino Derivatives in Prokaryotic and Eukaryotic Test Models. Drug and Chemical Toxicology 2019, 42 (2), 130–139. https://doi.org/10.1080/01480545.2017.1413108

Supplementary material for: [https://doi.org/10.1080/01480545.2017.1413108]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/322

Direct Effects, Compensation, and Recovery in Female Fathead Minnows Exposed to a Model Aromatase Inhibitor

BackgroundSeveral chemicals in the environment have the potential to inhibit aromatase, an enzyme critical to estrogen synthesis.ObjectivesThe objective of this study was to provide a detailed characterization of molecular and biochemical responses of female fathead minnows to a model aromatase inhibitor, fadrozole (FAD).MethodsFish were exposed via water to 0, 3, or 30 microg FAD/L for 8 days and then held in clean water for 8 days, with samples collected at four time points during each 8-day period. We quantified ex vivo steroid production, plasma steroids, and plasma vitellogenin (Vtg) concentrations and analyzed relative transcript abundance of 10 key regulatory genes in ovaries and 3 in pituitary tissue by real-time polymerase chain reaction.ResultsEx vivo 17beta-estradiol (E2) production and plasma E2 and Vtg concentrations were significantly reduced after a single day of exposure to 3 microg or 30 microg FAD/L. However, plasma E2 concentrations recovered by the eighth day of exposure in the 3-microg/L group and within 1 day of cessation of exposure in the 30-microg/L group, indicating concentration- and time-dependent physiologic compensation and recovery. Concentration-dependent increases in transcripts coding for aromatase (A isoform), cytochrome P450 side-chain cleavage, steroidogenic acute regulatory protein, and follicle-stimulating hormone receptor all coincided with increased E2 production and recovery of plasma E2 concentrations.ConclusionsResults of this research highlight the need to consider compensation/adaptation and recovery when developing and interpreting short-term bioassays or biomarkers or when trying to predict the effects of chemical exposures based on mode of action

Long-term Effects of Oxidative Stress in Volleyball Players

The aim of this study was to determine the impact of long-term training on elite female volleyball players and to determine parameters that could discriminate them according to the level of oxidative stress-associated adaptation. Fifty-four elite female volleyball players were divided into 3 groups (1: below-average training experience lt 8.0 years, 2: average training experience between 8.0 and 10.5 years and 3: above-average training experience > 10.5 years). The measured parameters were reactive oxygen metabolites, biological anti-oxidative potential, superoxide anion, malondialdehyde, advanced oxidation protein products, lipid hydroperoxides, paraoxonase activity, superoxide-dismutase activity and sulphydryl groups. Multiple discriminant analysis of the oxidative stress status parameters between the three groups of athletes indicated a statistically significant difference (Wilks' lambda=0.458, X-2=35.898, p=0.031). The most important discriminant variables, superoxide-dismutase and superoxide anion, were the best indicators of differences between groups with different training experience. The significantly higher values were found in Group 3 compared with Group 1 in superoxide-dismutase activity (141 +/- 32 vs. 86 +/- 46; p=0.002), sulphydryl groups (p=0.031), and reactive oxygen metabolites (p = 0.042). The significantly lower superoxide anion was found between Group 3 and Group 1 (377 +/- 187 vs. 1183 +/- 905; p=0.001). Oxidative stress status parameters adequately discriminated 68.5% of athletes with different training experience

Modest protective effects of progesterone treatment in hippocampus of male rats submitted to cerebral hypoperfusion

In the brain, three isoforms of nitric oxide synthase (NOS) regulate production of nitric oxide (NO), a signalling molecule with a role in cerebral blood flow regulation. Depending on the stimulus, NO exerts dual nature, from neuroprotective to neurodestructive. Given the scarcity of literature data on the involvement of nitrosative stress indicators in the rat hippocampal response to 7-day lasting progesterone (P4) treatment following permanent occlusion of both common carotid arteries, we assessed NO level and protein expressions of endothelial nitric oxide synthase (eNOS, including its total (t-eNOS) and phosphorylated at Ser1177 isoform (p-eNOS Ser1177)). According to obtained results, elevated NO levels occurred due to activity of other NOS forms since eNOS expressions were similar between experimental groups. Although NO level was downscaled it was still elevated in occluded animals treated with P4, showing modest anti-nitrosative effect of this potent steroid in the hippocampus

HLA Class I and Class II Polymorphism in the Population of Rijeka, Croatia

The aim of the study was to examine frequencies of HLA-A, -B, -DR antigens and haplotypes in population of Rijeka and to compare them with general Croatian and European populations. The subjects were 117 unrelated healthy blood donors. The antigens with the highest frequencies were: A2 (27.2%), A9 (16.3%), B5 (14.8%), B12 (11.8%), B18 (11.8%), DR5 (21.6%) and DR6 (13.8%). Comparison of HLA antigens frequencies has shown statistically significant difference in 1 antigen with Croatian population and in 8 antigens with European population. The HLA haplotypes with high frequencies included HLA-A2, B5 (6.84%), HLA-A2, B12 (6.84%), HLA-A2, B18 (6.84%), HLA-B12, DR2 (9.78%) and HLA-B18, DR5 (6.84%). The antigen B5 showed strongest association with DR5 (6.41%; LD = 1.30) as in general Croatian and in some European populations. The results have shown great diversity of HLA haplotypes in Rijeka population which can be the result of admixture with neighborhood immigrating populations during the history