Dynamics and thermodynamics of linear quantum open systems

We analyze the behavior of a network of quantum oscillators coupled with a number of external environments. We show that the dynamics is such that the quantum state of the network always obeys a local master equation with a simple analytical solution. We use this to study the emergence of thermodynamical laws in the stationary regime, achieved for sufficiently long times if the environments are dissipative. We show that the validity of the second law implies the impossibility of building a quantum refrigerator without moving parts (therefore, a quantum absorption refrigerators requires non-linearity as an crucial ingredient, as recently proposed by Kosloff and others cite{Kosloff1,Kosloff2}). We also show that the third law imposes strong constraints on the low frequency behavior of the environmental spectral densities.Comment: 4 pages of main text, 6 pages of supplementary material, 1 figure; substantially modified, detailed derivations presented in the supplementary materia

Prospects for a Dark Matter annihilation signal towards the Sagittarius dwarf galaxy with ground based Cherenkov telescopes

Dwarf galaxies are widely believed to be among the best targets for indirect dark matter searches using high-energy gamma rays; and indeed gamma-ray emission from these objects has long been a subject of detailed study for ground-based atmospheric Cherenkov telescopes. Here, we update current exclusion limits obtained on the closest dwarf, the Sagittarius dwarf galaxy, in light of recent realistic dark matter halo models. The constraints on the velocity-weighted annihilation cross section of the dark matter particle are of a few 10$^{-23}$ cm$^{3}$s$^{-1}$ in the TeV energy range for a 50 h exposure. The limits are extrapolated to the sensitivities of future Cherenkov Telescope Arrays. For 200 h of observation time, the sensitivity at 95% C.L. reaches 10$^{-25}$ cm$^{3}$s$^{-1}$. Possible astrophysical backgrounds from gamma-ray sources dissembled in Sagittarius dwarf are studied. It is shown that with long-enough observation times, gamma-ray background from millisecond pulsars in a globular cluster contained within Sagittarius dwarf may limit the sensitivity to dark matter annihilations.Comment: 12 pages, 5 figures, 2 tables, accepted for publication in Ap

Effects of refrigeration and oxygen on the coffee brew composition

The aim of this work was to monitor the changes both in the composition and in some sensory parameters of Colombian Arabica coffee brews stored at room and refrigeration temperatures, with and without oxygen. Some nonvolatile compounds related to the taste of coffee brews were determined, in an attempt to study possible relationships between chemical and sensory changes. Storage time hardly affects the amounts of chlorogenic, caffeic and ferulic acids, reported to have some beneficial health effects, mainly due to their antioxidant activities. In contrast, pH decreases in all the coffee brews along the time, mainly in that stored at 25 degrees C with oxygen. The appearance of sourness and other non typical coffee tastes (rancid taste, aftertaste) and an increase in astringency leads to establish a shelf-life of 10 days for coffee brews stored at 25 degrees C with oxygen, 15 days for coffee brews stored at 4 degrees C with oxygen and at 25 degrees C without oxygen, and 20 days for coffee brews stored at 4 degrees C without oxygen. The behaviour of 5-caffeoylquinic acid, caffeic acid and 4-vinylguaiacol throughout time was different from other studies conducted at higher temperatures to accelerate the staling, what reveals that stability studies of coffee brews should be made in real time and temperature

Changes in volatile compounds and overall aroma profile during storage of coffee brews at 4 and 25 degrees C

In this work, the chemical changes occurring in the volatile fraction of Arabica coffee brews during storage at 4 and 25 degrees C for 30 days have been characterized for the first time by means of HS-GC-MS. A total of 47 compounds were identified and quantified: 2 sulfur compounds, 7 aldehydes, 3 esters, 15 furans, 5 ketones, 1 alcohol, 2 thiophenes, 4 pyrroles, 1 pyridine, 5 pyrazines, 1 alkene, and 1 acid. No new volatile compounds were detected at the end of the storage time. The changes observed are, in general, slower and less pronounced at refrigeration temperature. Storage also affects the sensory characteristics of the stored coffee brews, which lose part of their aroma intensity and freshness, acquiring some nondesirable notes such as rancid aroma, mainly during storage at 25 degrees C. Furthermore, seven aroma indices have been proposed as indicators of coffee brew staling, which show a good correlation with some sensory attributes, not only for aroma but also overall sensory quality. Consequently, they could be considered useful to monitor both the "age" and the sensory quality of stored coffee brews

Application of multivariate analysis to the effects of additives on chemical and sensory quality of stored coffee brew

The aim of this work was to obtain a black coffee brew to be consumed hot by extension of its shelf life, by addition of additives. Four pH-regulator agents (sodium and potassium carbonates and bicarbonates), one pH regulator and antioxidant (sodium citrate), three antioxidants [sodium ascorbate, ethylenediaminetetracetic acid (EDTA), and sodium sulfite], and lactoserum were tested by sensory analysis. Sodium carbonate and bicarbonate were selected for a study of the physicochemical (soluble and volatile compounds related to the sensory properties) and sensorial quality of coffee brew stored for 90 days at 4 degrees C. Although both additives extended the shelf life of the coffee brew up to 60 days, sodium carbonate was the chosen additive because it was the most useful in limiting the pH decrease and perception of sourness, which are some of the main factors involved in the rejection of stored coffee brews, and it better maintained the aroma and taste/flavor. Moreover, the application of multivariate analysis facilitated first the description of the global changes of the coffee brews with or without additives throughout the storage using principal component analysis and second the obtainment of a simple equation only with pH and caffeic acid parameters to discriminate the three types of coffee brews and simplify the analytical process, by means of the stepwise discriminant analysis

Impact of the COVID-19 pandemic on the care of cancer patients in Spain

Background: Studies evaluating the effects of the COVID-19 pandemic on public healthcare systems are limited, particularly in cancer management. As no such studies have been carried out in Spain, our objective is to describe and quantify the impact of the COVID-19 pandemic on cancer patients in Spanish hospitals during the first wave of the pandemic. Materials and methods: This retrospective, multicenter, nationwide study collected information from hospital departments treating oncology patients. An electronic questionnaire comparing outcomes and management of oncohematological patients for the March-June 2019 and March-June 2020 periods was used. Results: Information from 78 departments (36 tertiary hospitals) was analyzed. Forty-four departments implemented adapted protocols during March 2020. Most of these (n = 38/44; 86.4%) carried out COVID-19 triage, while 26 of 44 (59.1%) carried out onsite polymerase chain reaction tests for clinically suspected cases. A shift from in-person to telephone visits was observed in 43 of 44 (97.7%) departments. Comparing the March-June 2019 and March-June 2020 periods, the number of new patients decreased by 20.8% (from 160.2 to 126.4). Decreases were also seen in the mean number of total (2858.2 versus 1686.1) and cancer (465.5 versus 367.2) biopsies, as well as the mean number of bone marrow biopsies (30.5 versus 18.6). Concerning the number of patients visiting specific cancer care departments, a decrease from 2019 to 2020 was seen for mean number of chemotherapy treatments (712.7 versus 643.8) and radiation therapy (2169.9 versus 2139.9). Finally, a reduction from 2019 to 2020 of 12.9% (from 8.6 to 7.4) in the mean number of patients included in clinical trials was noted. Conclusions: This study provides the first comprehensive data concerning the impact of COVID-19 on cancer care in Spain. The pandemic caused a 20.8% decrease in newly diagnosed patients, which may impact future outcomes. Measures must be taken to ensure cancer management receives priority in times of healthcare emergencies

Effect of ultra high temperature (UHT) treatment on coffee brew stability

In this work, the influence of an Ultra High Temperature (UHT) treatment on chemical and sensory composition of Arabica coffee brews for a longer shelf-life has been studied. A temperature of 120 degrees C for 2 s allows to obtain a microbiologically safe coffee brew, good valued from the sensory point of view. The behavior of the UHT vs non UHT treated coffee brew was followed throughout 120 days of storage at 4 degrees C. The UHT treatment keeps the typical acidity of the brews longer, delaying and softening the pH decrease and the development of sourness, which is one of the main causes for the rejection of stored coffee brews. The UHT treatment hardly affects the concentrations of caffeine and trigonelline, and of some phenolic compounds such as 5-caffeoylquinic (5-CQA), caffeic or ferulic acids. Sixteen key odorants and staling volatiles were analyzed by HS-GC-MS and lower changes were observed in the UHT treated coffee brew throughout storage. Higher DPPH center dot scavenging activity was observed in the UHT treated coffee brew from days 60 to 120. In conclusion, the application of an UHT treatment is proposed to extend the shelf-life (up to 60 days) of stored coffee brews

Breakdown of the semiclassical approximation at the black hole horizon

The definition of matter states on spacelike hypersurfaces of a 1+1 dimensional black hole spacetime is considered. The effect of small quantum fluctuations of the mass of the black hole due to the quantum nature of the infalling matter is taken into account. It is then shown that the usual approximation of treating the gravitational field as a classical background on which matter is quantized, breaks down near the black hole horizon. Specifically, on any hypersurface that captures both infalling matter near the horizon and Hawking radiation, quantum fluctuations in the background geometry become important, and a semiclassical calculation is inconsistent. An estimate of the size of correlations between the matter and gravity states shows that they are so strong that a fluctuation in the black hole mass of order exp[-M/M_{Planck}] produces a macroscopic change in the matter state.Comment: Latex, 31 pages + 5 uuencoded figure

Epigenetic inactivation of the splicing RNA-binding protein CELF2 in human breast cancer

Altres ajuts: This work was co-finaced by the European Development Regional Fund, "A way to achieve Europe" ERDF; the Cellex Foundation; and "la Caixa" Banking Foundation (LCF/PR/PR15/ 11100003).Human tumors show altered patterns of protein isoforms that can be related to the dysregulation of messenger RNA alternative splicing also observed in transformed cells. Although somatic mutations in core spliceosome components and their associated factors have been described in some cases, almost nothing is known about the contribution of distorted epigenetic patterns to aberrant splicing. Herein, we show that the splicing RNA-binding protein CELF2 is targeted by promoter hypermethylation-associated transcriptional silencing in human cancer. Focusing on the context of breast cancer, we also demonstrate that CELF2 restoration has growth-inhibitory effects and that its epigenetic loss induces an aberrant downstream pattern of alternative splicing, affecting key genes in breast cancer biology such as the autophagy factor ULK1 and the apoptotic protein CARD10. Furthermore, the presence of CELF2 hypermethylation in the clinical setting is associated with shorter overall survival of the breast cancer patients carrying this epigenetic lesion

Epidemiological characteristics and diagnostic approach in patients admitted to the emergency room for transient loos of consciousness: Group for Syncope Study in the Emergency Room (GESINUR) study

Aims: To assess the clinical presentation and acute management of patients with transient loss of consciousness (T-LOC) in the emergency department (ED). Methods and results: A multi-centre prospective observational study was carried out in 19 Spanish hospitals over 1 month. The patients included were 14 years old and were admitted to the ED because of an episode of T-LOC. Questionnaires and corresponding electrocardiograms (ECGs) were reviewed by a Steering Committee (SC) to unify diagnostic criteria, evaluate adherence to guidelines, and diagnose correctly the ECGs. We included 1419 patients (prevalence, 1.14%).ECG was performed in 1335 patients (94%) in the ED: 498 (37.3%) ECGs were classified as abnormal. The positive diagnostic yield ranged from 0% for the chest X-ray to 12% for the orthostatic test. In the ED, 1217 (86%) patients received a final diagnosis of syncope, whereas the remaining 202 (14%) were diagnosed of non-syncopal transient lossof consciousness (NST-LOC). After final review by the SC, 1080 patients (76%) were diagnosed of syncope, whereas 339 (24%) were diagnosed of NST-LOC (P , 0.001). Syncope was diagnosed correctly in 84% of patients. Only 25% of patients with T-LOC were admitted to hospitals. Conclusion Adherence to clinical guidelines for syncope management was low; many diagnostic tests were performed with low diagnostic yield. Important differences were observed between syncope diagnoses at the ED and by SC decision