Advances in mapping ice-free surfaces within the Northern Antarctic peninsula region using polarimetric RADARSAT-2 data

Ice-free areas within the Northern Antarctic Peninsula region are of interest for studying changes occurring to surface covers, including those related to glacial coverage, raised beach deposits and periglacial processes and permafrost. The objective of this work is to map the main surface covers within ice-free areas of King George Island, the largest island of the South Shetlands archipelago, using fully polarimetric RADARSAT-2 SAR data. Surface covers such as rock outcrops and glacial till, stone fields, patterned ground, and sand and gravel deposits form the most representative classes and account for 84 km2 of the ice-free areas on the island. A distribution of complex geomorphological features and landforms was obtained, being some of them considered indicators of periglacial processes and presence of permafrost.Published versio

La Resolución de problemas de energía en la formación inicial de maestros

Este artículo presenta una investigación sobre la introducción de la Metodología de Resolución de Problemas como una Investigación, para abordar el currículo de ciencias de la formación inicial de maestros, dentro de los planteamientos del Espacio Europeo de Educación Superior. Para ello, se diseñó la unidad didáctica «La energía, una realidad que nos envuelve», constituida por cuatro situaciones problemáticas abiertas. Los objetivos del estudio se refieren a la mejora del aprendizaje sobre los procedimientos involucrados en dicha metodología y sobre los contenidos científicos abordados en la unidad. Se contó con 35 futuros maestros de la Universidad Complutense de Madrid que resolvieron los problemas abiertos y que contestaron a cuestionarios de conocimientos (pretest-postest). Los resultados constatan mejoras en su capacidad para resolver problemas y aprender los contenidos científicos.This research aims to test the effectiveness of using the Methodology of Problem-Solving as an Investigation (MPSI) approach to teaching the science curriculum of prospective primary school teachers, in accordance with European Higher Education Area (EHEA) principles. Research began with the design of a didactic unit, "Energy, a Reality that Surrounds Us", composed of four open problematic situations. The target of the study is based on the supposition that there would be significant improvement both in learning of MPSI related procedures and in scientific knowledge. The sample consisted of 35 students of the UCM who performed the problem-solving activities and answered pre-test and post-test knowledge questionnaires. The results verify significant improvement in the application of MPSI procedures and positive evolution in scientific knowledge

An exploratory analysis of the implementation and use of an intelligent platform for learning in primary education

Smile and Learn is an intelligent platform with more than 4500 educational activities for children aged 3-12. The digital material developed covers all courses of primary education and most of the subjects with the different topic-related worlds with activities in the field of logics and mathematics, science, linguistics and tales, visual-spatial and cognitive skills, emotional intelligence, arts, and multiplayer games. This kind of material supports active learning and new pedagogical models for teachers to use in their lessons. The purpose of this paper is to explore the usage of the platform in three pilot groups schools from different regions of Spain, outlining future directions in the design of such digital materials. Usage is assessed via descriptive analysis and variance analysis, with data collected from users interacting with the intelligent platform. The results show a high use of STEM (Science, Technology, Engineering and Maths) activities among all the activities that could be chosen. Cross-curricular activities are also used. Continuation in the development of such materials is concluded necessary, focusing integration of different fields, accentuating games over quizzes, and the value of teacher training for improving their use in schools.This research was funded by Community of Madrid 'Industrial PhD grants' under project number IND2017/SOC-7874

Binding of retinoids to uteroglobin

AbstractUteroglobin, a progesterone-binding secretory protein, was shown to bind retinoic acid and retinol in a non-saturable manner, at least up to concentrations of retinoids of 20 μM. Binding is increased about 10-fold by previous reduction of uteroglobin with 10 mM dithothreitol and it is not affected by previous saturation of the progesterone binding site, suggesting different binding sites for the steroid and the retinoids. The results are discussed in relation to a possible physiological role for this protein

Accounting Profession in Mexico; Professional Accounting in Foreign Country Series

https://egrove.olemiss.edu/aicpa_guides/1685/thumbnail.jp

Assessment of the effects of digital educational material on executive function performance

The Learning Analytics system of the Smile and Learn platform recorded the students'use during class. According to the usage analysis, the results obtained show preference of using activities from Logic and Spatial worlds. In the external analysis of the effect of the learning material, the results record a significant effect using activities in Logic and Spatial worlds with the Gray Trails task, which involves spatial perception, processing speed, and working memory, among others. A second analysis to contrast the results with a post hoc design approaches relationships among executive functions as involved in tasks like Gray Trails, Interference, and Ring Tasks within the usage of Spatial and Logic activities. The need for further research to improve these materials for enhanced learning and the extrapolation of training from executive functions to other tasks is discussed. Likewise, limitations of the implementation and design of these materials are pointed out.This study is part of the project IND2017/SOC-7874 for assessment and improve the digital material design, funded by the Community of Madrid by 'Industrial Ph.D' grants

Gestión de la educación inclusiva para niños/niñas y adolescentes, asociadas a una discapacidad. Elaboración de una guía de buenas prácticas en educación inclusivas para los docentes de la unidad educativa fiscal patria.

This research project considers the management of inclusive education at Unidad Educativa Fiscal “Patria”, the main objective is to develop a Good Inclusive Practices Guide, addressed to those who are part of the educational community it will consist of specific orientations and activities for each of them, so the analytical and descriptive methodology were used, based on a qualitative approach by interview and observation sheet to school authorities, individual perception results will be achieved in addition, the quantitative approach will be carried out through a survey, and the percentages obtained will allow the analysis of the results, reaching to identify strategies that permit the optimal development of the teachers’ guide and helping the entire educational community to strengthen the processes of educational inclusion; thus reaching the following results insofar as these practices can be effective, the student will be able to reach his learning objectives, access in a better way to the contents proposed for him and his skills can be developed more quickly and adequately for performing in the school and his life.En el presente trabajo de investigación se plantío la gestión de la educación inclusiva en la Unidad Educativa Fiscal “Patria”, que tiene como objetivo principal elaborar una Guía de Buenas prácticas en educación inclusivas dirigido a quienes forman parte de la comunidad educativa, la que consta de orientaciones y actividades específicas para cada uno de ellos, para la cual se utilizó la metodología descriptiva, analítica, basándose a un enfoque cuali-cuantitativo, mismo que mediante la ficha de observación y entrevista a las autoridades del plantel se consiguió resultados de percepción individual, así también, se realizó la encuesta y se obtuvo porcentajes que permitió el análisis de resultados, alcanzando así estrategias que permitan la óptima elaboración de la guía, con el fin de fortalecer los recursos necesarios para desarrollar las buenas prácticas requeridas para la inclusión educativa; llegando a los siguientes resultados en la medida en que estas prácticas sean eficaces, el estudiante en cuestión podrá lograr más fácilmente sus objetivos de aprendizaje, acceder de mejor manera a los contenidos que se ha propuesto para él y desarrollar más rápida y adecuadamente las destrezas que necesita para desenvolverse en la escuela y en la vida en general

Estudio biológico y anatomopatológico del tumor solido de Ehrlich injertado a ratones sometidos a quimioterapia simple y multiple

Tesis Univ. Complutense de Madrid.Fac. de VeterinariaTRUEProQuestpu

Hamiltonian Noether theorem for gauge systems and two time physics

The Noether theorem for Hamiltonian constrained systems is revisited. In particular, our review presents a novel method to show that the gauge transformations are generated by the conserved quantities associated with the first class constraints. We apply our results to the relativistic point particle, to the Friedberg et al. model and, with special emphasis, to two time physics.Comment: 20 pages, Latex, references added, the "massless" sense of (87) is clarifie

Inhibition of RNA Binding in SND1 Increases the Levels of miR-1-3p and Sensitizes Cancer Cells to Navitoclax

SND1 is an RNA-binding protein overexpressed in large variety of cancers. SND1 has been proposed to enhance stress tolerance in cancer cells, but the molecular mechanisms are still poorly understood. We analyzed the expression of 372 miRNAs in the colon carcinoma cell line and show that SND1 silencing increases the expression levels of several tumor suppressor miRNAs. Furthermore, SND1 knockdown showed synergetic effects with cancer drugs through MEK-ERK and Bcl-2 family-related apoptotic pathways. To explore whether the SND1-mediated RNA binding/degradation is responsible for the observed effect, we developed a screening assay to identify small molecules that inhibit the RNA-binding function of SND1. The screen identified P2X purinoreceptor antagonists as the most potent inhibitors. Validation confirmed that the best hit, suramin, inhibits the RNA binding ability of SND1. The binding characteristics and mode of suramin to SND1 were characterized biophysically and by molecular docking that identified positively charged binding cavities in Staphylococcus nuclease domains. Importantly, suramin-mediated inhibition of RNA binding increased the expression of miR-1-3p, and enhanced sensitivity of cancer cells to Bcl-2 inhibitor navitoclax treatment. Taken together, we demonstrate as proof-of-concept a mechanism and an inhibitor compound for SND1 regulation of the survival of cancer cells through tumor suppressor miRNAs