2,071 research outputs found
Long-Term Safety of Tedizolid in a Patient With Spondilodiscitis After Switch From Linezolid Due to Toxicity
The patient is a 57-year-old man with liver cirrhosis, Bricker anastomosis after a radical cystoprostatectomy and, a history of bacteremias caused by extended-spectrum -lactamase-positive Escherichia coli, Enterococcus faecium, and Candida albicans. He presented with persistent low back pain and was diagnosed with vertebral osteomyelitis, for which he received ertapenem-linezolid treatment. However, after 20 days, linezolid had to be discontinued because of myelotoxicity and metabolic acidosis. The patient was switched to tedizolid, which, in combination with ertapenem, was successfully given for 114 days until biopsy showed no growth of gram-positive cocci. We conclude that tedizolid can be an alternative to linezolid in case of toxicity, especially in long-term treatments
The psychosocial burden of hidradenitis suppurativa: the patients' perspectives
We designed a qualitative study to interview 12 patients with Hidradenitis Suppurativa. This was done by means of a semistructured interview. Questions on quality of life, the impact of their skin disease on family, friends, work, intimate relationships, treatments, etc. were asked. Patients consented to be interviewed and to be video taped to facilitate the transcription of the interviews. The interviews lasted between 30 and 60 minutes and were carried out by a psychologist and a social worker. The dermatologist had previously seen the patients and filled in a form with the Hurley Stage, years of evolution and treatment..
Predictors of weight gain in a Mediterranean cohort: the Seguimiento Universidad de Navarra Study 1
BACKGROUND:
High consumption of sugar-sweetened drinks has been associated with weight gain and obesity in the United States. This trend may also be affecting populations with different eating patterns who increasingly are adopting typical US dietary patterns.
OBJECTIVE:
We assessed whether the consumption of sweetened drinks and other food items increased the likelihood of weight gain in a Mediterranean population.
DESIGN:
This was a prospective cohort analysis of 7194 men and women with a mean age of 41 y who were followed-up for a median of 28.5 mo with mailed questionnaires. Dietary exposure was assessed with a previously validated semiquantitative food-frequency questionnaire.
RESULTS:
During follow-up, we observed that 49.5% of the participants increased their weight (x weight gain: 0.64 kg; 95% CI: 0.55, 0.73 kg). In the participants who had gained > or =3 kg in the 5 y before baseline, the adjusted odds ratio of subsequent weight gain for the fifth quintile compared with the first quintile of sugar-sweetened soft drink consumption was 1.6 (95% CI: 1.2, 2.1; P for trend = 0.02). This association was absent in the participants who had not gained weight in the 5-y period before baseline. The consumption of hamburgers, pizza, and sausages (as a proxy for fast-food consumption) was also independently associated with weight gain (adjusted odds ratio for the fifth compared with the first quintile = 1.2; 95% CI: 1.0, 1.4; P for trend = 0.05). We also found a significant, but weaker, association between weight gain and both red meat and sweetened fruit juice consumption.
CONCLUSION:
In a Mediterranean cohort, particularly in the participants who had already gained weight, an increased consumption of sugar-sweetened soft drinks and of hamburgers, pizza, and sausages was associated with a higher risk of additional subsequent weight gain
Applications of a New Proposal for Solving the "Problem of Time" to Some Simple Quantum Cosmological Models
We apply a recent proposal for defining states and observables in quantum
gravity to simple models. First, we consider a Klein-Gordon particle in an ex-
ternal potential in Minkowski space and compare our proposal to the theory ob-
tained by deparametrizing with respect to a time slicing prior to quantiza-
tion. We show explicitly that the dynamics of the deparametrization approach
depends on the time slicing. Our proposal yields a dynamics independent of the
choice of time slicing at intermediate times but after the potential is turned
off, the dynamics does not return to the free particle dynamics. Next we apply
our proposal to the closed Robertson-Walker quantum cosmology with a massless
scalar field with the size of the universe as our time variable, so the only
dynamical variable is the scalar field. We show that the resulting theory has
the semi-classical behavior up to the classical turning point from expansion to
contraction, i.e., given a classical solution which expands for much longer
than the Planck time, there is a quantum state whose dynamical evolution
closely approximates this classical solution during the expansion. However,
when the "time" gets larger than the classical maximum, the scalar field be-
comes "frozen" at its value at the maximum expansion. We also obtain similar
results in the Taub model. In an Appendix we derive the form of the Wheeler-
DeWitt equation for the Bianchi models by performing a proper quantum reduc-
tion of the momentum constraints; this equation differs from the usual one ob-
tained by solving the momentum constraints classically, prior to quantization.Comment: 30 pages, LaTeX 3 figures (postscript file or hard copy) available
upon request, BUTP-94/1
Granular discharge and clogging for tilted hoppers
We measure the flux of spherical glass beads through a hole as a systematic
function of both tilt angle and hole diameter, for two different size beads.
The discharge increases with hole diameter in accord with the Beverloo relation
for both horizontal and vertical holes, but in the latter case with a larger
small-hole cutoff. For large holes the flux decreases linearly in cosine of the
tilt angle, vanishing smoothly somewhat below the angle of repose. For small
holes it vanishes abruptly at a smaller angle. The conditions for zero flux are
discussed in the context of a {\it clogging phase diagram} of flow state vs
tilt angle and ratio of hole to grain size
Formulation and Evaluation of Cephalexin Extended Release Matrix Tablets Using 32 Factorial Design
The aim of the present investigation was to prepare extended release film coated matrix tablets of cephalexin using binary mixture of two grades of hydrophilic polymer, hydroxypropyl methyl cellulose (HPMC), by direct compression method. Results of the preliminary trials indicated that the polymers used have significant release retarding effect on the formulation. To study the effect of concentration of polymers on drug release from matrix tablets, 32 full factorial design was applied. The concentration of HPMC K15M and HPMC 15cps were used as independent variables, while percentage drug release was selected as dependent variable. The dissolution data were fitted into zero-order, first-order, Higuchi and KorsemeyerâPeppas models to identify the pharmacokinetics and mechanism of drug release. Comparative study of dissolution profile of final batch F3 with market preparation (Sporidex AF 375) was done by similarity factor (f2) determination and it was concluded that final formulation F3 (10% HPMC K15M, 17.5% HPMC 15cps) shows good similarity with the market product. The results of the accelerated stability study of final formulation F3 for 1 month revealed that storage conditions were not found to have made any significant changes in final formulation F3. The release of cephalexin was prolonged for 6 h by using polymer combinations of HPMC and a twice daily matrix tablet was formulated
Casimir Effect, Achucarro-Ortiz Black Hole and the Cosmological Constant
We treat the two-dimensional Achucarro-Ortiz black hole (also known as (1+1)
dilatonic black hole) as a Casimir-type system. The stress tensor of a massless
scalar field satisfying Dirichlet boundary conditions on two one-dimensional
"walls" ("Dirichlet walls") is explicitly calculated in three different vacua.
Without employing known regularization techniques, the expression in each
vacuum for the stress tensor is reached by using the Wald's axioms. Finally,
within this asymptotically non-flat gravitational background, it is shown that
the equilibrium of the configurations, obtained by setting Casimir force to
zero, is controlled by the cosmological constant.Comment: 20 pages, LaTeX, minor corrections, comments and clarifications
added, version to appear in Phys. Rev.
The Milky Way Bulge: Observed properties and a comparison to external galaxies
The Milky Way bulge offers a unique opportunity to investigate in detail the
role that different processes such as dynamical instabilities, hierarchical
merging, and dissipational collapse may have played in the history of the
Galaxy formation and evolution based on its resolved stellar population
properties. Large observation programmes and surveys of the bulge are providing
for the first time a look into the global view of the Milky Way bulge that can
be compared with the bulges of other galaxies, and be used as a template for
detailed comparison with models. The Milky Way has been shown to have a
box/peanut (B/P) bulge and recent evidence seems to suggest the presence of an
additional spheroidal component. In this review we summarise the global
chemical abundances, kinematics and structural properties that allow us to
disentangle these multiple components and provide constraints to understand
their origin. The investigation of both detailed and global properties of the
bulge now provide us with the opportunity to characterise the bulge as observed
in models, and to place the mixed component bulge scenario in the general
context of external galaxies. When writing this review, we considered the
perspectives of researchers working with the Milky Way and researchers working
with external galaxies. It is an attempt to approach both communities for a
fruitful exchange of ideas.Comment: Review article to appear in "Galactic Bulges", Editors: Laurikainen
E., Peletier R., Gadotti D., Springer Publishing. 36 pages, 10 figure
Conserved Quasilocal Quantities and General Covariant Theories in Two Dimensions
General matterless--theories in 1+1 dimensions include dilaton gravity,
Yang--Mills theory as well as non--Einsteinian gravity with dynamical torsion
and higher power gravity, and even models of spherically symmetric d = 4
General Relativity. Their recent identification as special cases of
'Poisson--sigma--models' with simple general solution in an arbitrary gauge,
allows a comprehensive discussion of the relation between the known absolutely
conserved quantities in all those cases and Noether charges, resp. notions of
quasilocal 'energy--momentum'. In contrast to Noether like quantities,
quasilocal energy definitions require some sort of 'asymptotics' to allow an
interpretation as a (gauge--independent) observable. Dilaton gravitation,
although a little different in detail, shares this property with the other
cases. We also present a simple generalization of the absolute conservation law
for the case of interactions with matter of any type.Comment: 21 pages, LaTeX-fil
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