Oxygen in metabolic dysfunction and its therapeutic relevance

Significance: In recent years, a number of studies have shown altered oxygen partial pressure at a tissue level in metabolic disorders, and some researchers have considered oxygen to be a (macro) nutrient. Oxygen availability may be compromised in obesity and several other metabolism-related pathological conditions, including sleep apnea-hypopnea syndrome, the metabolic syndrome (which is a set of conditions), type 2 diabetes, cardiovascular disease, and cancer. Recent Advances: Strategies designed to reduce adiposity and its accompanying disorders have been mainly centered on nutritional interventions and physical activity programs. However, novel therapies are needed since these approaches have not been sufficient to counteract the worldwide increasing rates of metabolic disorders. In this regard, intermittent hypoxia training and hyperoxia could be potential treatments through oxygen-related adaptations. Moreover, living at a high altitude may have a protective effect against the development of abnormal metabolic conditions. In addition, oxygen delivery systems may be of therapeutic value for supplying the tissue-specific oxygen requirements. Critical Issues: Precise in vivo methods to measure oxygenation are vital to disentangle some of the controversies related to this research area. Further, it is evident that there is a growing need for novel in vitro models to study the potential pathways involved in metabolic dysfunction to find appropriate therapeutic targets. Future Directions: Based on the existing evidence, it is suggested that oxygen availability has a key role in obesity and its related comorbidities. Oxygen should be considered in relation to potential therapeutic strategies in the treatment and prevention of metabolic disorders

Blockchain Architecture Based on Decentralised PoW Algorithm

Blockchain has gained increasing popularity across various industries due to its decentralized, stable, and secure nature. Consensus algorithms play a crucial role in maintaining the security and efficiency of Blockchain systems and selecting the right algorithm can lead to significant performance improvements. This article aims to provide a comparative review of the most used Blockchain consensus algorithms, highlighting their strengths and weaknesses. Additionally, we propose a dissociated architecture for an efficient Blockchain system that doesn't compromise on security. A comparison is made between this architecture and the reviewed algorithms, considering aspects such as algorithm performance, energy consumption, mining, decentralization level, and vulnerability to security threats. The research findings demonstrate that the proposed architecture can support complex algorithms with high security while addressing issues related to efficiency, processing performance, and energy consumption

Understanding the importance of animation in human-computer interfaces and its relation to user experience

Animation is increasingly used in multimedia user interfaces (UI). Ever more applications are including animation to improve their UI and user experience (UX). Animation seems to play a key role to develop user-friendly, easy-to-use and easy-to-understand apps that achieve a satisfactory UX. This work attempts to explain animation performance in multimedia UI and how this affects the UX. We found that: (1) animation is a key element of multimedia UI that strongly affects UX and can improve it, if applied correctly; (2) animation enhances: reduced perceived waiting time, explanatory and cognitive support, efficient feedback and increased user attention; (3) animation's major properties lie in adapting its intensity, function, time and aesthetics to the context of action. Additionally, we identified two categories of animation aspects in multimedia UI: internal aspects and external features. Furthermore, this study demonstrates that the design of animated multimedia interfaces does not have a standardised methodology. Animation is incorporated ad-hoc, under the individual empirical experience of the creators, and without any a priori guarantee of usefulness or success. Therefore, our future work aims to generate an integral model where the variables related to animation in multimedia UI that modulate UX are analysed, and thus improve human-computer interfaces

Cerium oxide nanoparticles regulate insulin sensitivity and oxidative markers in 3T3-L1 adipocytes and C2C12 myotubes

Insulin resistance is associated with oxidative stress, mitochondrial dysfunction, and a chronic low-grade inflammatory status. In this sense, cerium oxide nanoparticles (CeO2 NPs) are promising nanomaterials with antioxidant and anti-inflammatory properties. Thus, we aimed to evaluate the effect of CeO2 NPs in mouse 3T3-L1 adipocytes, RAW 264.7 macrophages, and C2C12 myotubes under control or proinflammatory conditions. Macrophages were treated with LPS, and both adipocytes and myotubes with conditioned medium (25% LPS-activated macrophages medium) to promote inflammation. CeO2 NPs showed a mean size of ≤25.3 nm (96.7%) and a zeta potential of mV, suitable for cell internalization. CeO2 NPs reduced extracellular reactive oxygen species (ROS) in adipocytes with inflammation while increased in myotubes with control medium. The CeO2 NPs increased mitochondrial content was observed in adipocytes under proinflammatory conditions. Furthermore, the expression of Adipoq and Il10 increased in adipocytes treated with CeO2 NPs. In myotubes, both Il1b and Adipoq were downregulated while Irs1 was upregulated. Overall, our results suggest that CeO2 NPs could potentially have an insulin-sensitizing effect specifically on adipose tissue and skeletal muscle. However, further research is needed to confirm these findings

Economic impact of improving patient safety using Sugammadex for routine reversal of neuromuscular blockade in Spain

Background: Neuromuscular blocking (NMB) agents are often administered to facilitate tracheal intubation and prevent patient movement during surgical procedures requiring the use of general anesthetics. Incomplete reversal of NMB, can lead to residual NMB, which can increase the risk of post-operative pulmonary complications. Sugammadex is indicated to reverse neuromuscular blockade induced by rocuronium or vecuronium in adults. The aim of this study is to estimate the clinical and economic impact of introducing sugammadex to routine reversal of neuromuscular blockade (NMB) with rocuronium in Spain. Methods: A decision analytic model was constructed reflecting a set of procedures using rocuronium that resulted in moderate or deep NMB at the end of the procedure. Two scenarios were considered for 537, 931 procedures using NMB agents in Spain in 2015: a scenario without sugammadex versus a scenario with sugammadex. Comparators included neostigmine (plus glycopyrrolate) and no reversal agent. The total costs for the healthcare system were estimated from the net of costs of reversal agents and overall cost offsets via reduction in postoperative pneumonias and atelectasis for which incidence rates were based on a Spanish real-world evidence (RWE) study. The model time horizon was assumed to be one year. Costs were expressed in 2019 euros (€) and estimated from the perspective of a healthcare system. One-way sensitivity analysis was carried out by varying each parameter included in the model within a range of +/- 50%. Results: The estimated budget impact of the introduction of sugammadex to the routine reversal of neuromuscular blockade in Spanish hospitals was a net saving of €57.1 million annually. An increase in drug acquisition costs was offset by savings in post-operative pulmonary events, including 4806 post-operative pneumonias and 13, 996 cases of atelectasis. The total cost of complications avoided was €70.4 million. All parameters included in the model were tested in sensitivity analysis and were favorable to the scenario with sugammadex. Conclusions: This economic analysis shows that sugammadex can potentially lead to cost savings for the reversal of rocuronium-induced moderate or profound NMB compared to no reversal and reversal with neostigmine in the Spanish health care setting. The economic model was based on data obtained from Spain and from assumptions from clinical practice and may not be valid for other countries

LFI 30 and 44 GHz receivers Back-End Modules

The 30 and 44 GHz Back End Modules (BEM) for the Planck Low Frequency Instrument are broadband receivers (20% relative bandwidth) working at room temperature. The signals coming from the Front End Module are amplified, band pass filtered and finally converted to DC by a detector diode. Each receiver has two identical branches following the differential scheme of the Planck radiometers. The BEM design is based on MMIC Low Noise Amplifiers using GaAs P-HEMT devices, microstrip filters and Schottky diode detectors. Their manufacturing development has included elegant breadboard prototypes and finally qualification and flight model units. Electrical, mechanical and environmental tests were carried out for the characterization and verification of the manufactured BEMs. A description of the 30 and 44 GHz Back End Modules of Planck-LFI radiometers is given, with details of the tests done to determine their electrical and environmental performances. The electrical performances of the 30 and 44 GHz Back End Modules: frequency response, effective bandwidth, equivalent noise temperature, 1/f noise and linearity are presented

Cholera forecast for Dhaka, Bangladesh, with the 2015-2016 El Nino: Lessons learned

A substantial body of work supports a teleconnection between the El Nino-Southern Oscillation (ENSO) and cholera incidence in Bangladesh. In particular, high positive anomalies during the winter (Dec-Feb) in sea surface temperatures (SST) in the tropical Pacific have been shown to exacerbate the seasonal outbreak of cholera following the monsoons from August to November. Climate studies have indicated a role of regional precipitation over Bangladesh in mediating this long-distance effect. Motivated by this previous evidence, we took advantage of the strong 2015-2016 El Nino event to evaluate the predictability of cholera dynamics for the city in recent times based on two transmission models that incorporate SST anomalies and are fitted to the earlier surveillance records starting in 1995. We implemented a mechanistic temporal model that incorporates both epidemiological processes and the effect of ENSO, as well as a previously published statistical model that resolves space at the level of districts (thanas). Prediction accuracy was evaluated with "out-of-fit" data from the same surveillance efforts (post 2008 and 2010 for the two models respectively), by comparing the total number of cholera cases observed for the season to those predicted by model simulations eight to twelve months ahead, starting in January each year. Although forecasts were accurate for the low cholera risk observed for the years preceding the 2015-2016 El Nino, the models also predicted a high probability of observing a large outbreak in fall 2016. Observed cholera cases up to Oct 2016 did not show evidence of an anomalous season. We discuss these predictions in the context of regional and local climate conditions, which show that despite positive regional rainfall anomalies, rainfall and inundation in Dhaka remained low. Possible explanations for these patterns are given together with future implications for cholera dynamics and directions to improve their prediction for the city

Effects of hyperoxia on oxygen-related inflammation with a focus on obesity

Several studies have shown a pathological oxygenation (hypoxia/hyperoxia) on the adipose tissue in obese subjects. Additionally, the excess of body weight is often accompanied by a state of chronic low-degree inflammation.The inflammation phenomenon is a complex biological response mounted by tissues to combat injurious stimuli in order to maintain cell homeostasis. Furthermore, it is believed that the abnormal oxygen partial pressure occurring in adipose tissue is involved in triggering inflammatory processes. In this context, oxygen is used in modern medicine as a treatment for several diseases with inflammatory components. Thus, hyperbaric oxygenation has demonstrated beneficial effects, apart from improving local tissue oxygenation, on promoting angiogenesis, wound healing, providing neuroprotection, facilitating glucose uptake, appetite, and others. Nevertheless, an excessive hyperoxia exposure can lead to deleterious effects such as oxidative stress, pulmonary edema, and maybe inflammation. Interestingly, some of these favorable outcomes occur under high and low oxygen concentrations. Hereby, we review a potential therapeutic approach to the management of obesity as well as the oxygen-related inflammation accompanying expanded adipose tissue, based on elevated oxygen concentrations. To conclude, we highlight at the end of this review some areas that need further clarification

KinOath Kinship Archiver Version 1.4

This talk will introduce a new tool for Humanities research, in particular Ethnology, Linguistics, Law, History, but also Genetics and Archiving. This tool is KinOath Kinship Archiver which is an application for collecting and analysing kinship data. It is designed to be flexible and culturally nonspecific, which is important to prevent extraneous concepts being imposed onto the data being recorded. The kinship data can be linked to external resources such as archive data. Graphical representation of the data is a key feature, it produces publishable quality diagrams that can be exported to SVG, PDF and JPG formats. Data can be imported from GEDCOM, CSV and TIP files. Data can be exported into CSV format, with additional formats becoming available as plugins. KinOath provides very flexible data fields for each individual / entity recorded in the kinship data, this is combined with customisable relation types, customisable symbols and customisable kin types. This means, for example, that any number of genders and kinship relations can be defined and represented on a diagram. The most common format, GEDCOM (Family History Department, 1999), can be imported into KinOath. However this GEDCOM format exhibits cultural specificities because it has a predetermined set of kinship types, genders and initiation ceremonies. We know that there is a wider array of kinship types (e.g. suckling relations (Altorki, 1980)) and genders (e.g. the Māhū of Hawaiʻi (Matzner, 2001)). There are also initiation ceremonies beyond the Christian and Jewish ceremonies that are predefined in GEDCOM. However once this data is imported, all the flexibility of KinOath will be available. KinOath has project based diagrams and freeform diagrams. Freeform diagrams are like a quick sketch; while project diagrams each have a database of kinship data which can be shared across multiple diagrams. Project based diagrams also allow kin type string queries, such that individuals to be found based on their relations to others. Individuals in a project diagram can be duplicated and merged, which can be useful, for example, in correcting data, or merging multiple data sets where some individuals overlap. In freeform diagrams kin terms can be defined with kin type strings and shown on the diagram, organised in groups, imported and exported. In the future it will be possible to overlay these kin terms onto project diagrams. In order to perform statistical analysis, the kinship data for each project or freeform diagram can be exported for use in R or SPSS. This combined with queries based on kin types and other search parameters, provides great potential in the analysis of both the kin data and the archive data that has been recorded. The intended users of Kinoath are any researchers that collect data in a context of social relations. Kinship data is often not systematically included in the metadata of archives, however these kin relations provide a context that enriches that archived data. KinOath is in active development and new features are regularly being added. The plugin framework that KinOath shares with Arbil has made it possible for external developers to add features. The various versions and the manual are available at: http://tla.mpi.nl/tools/tlatools/kinoath/ REFERENCES Family History Department of The Church of Jesus Christ of Latterday Saints, 1999, THE GEDCOM STANDARD DRAFT Release 5.5.1 http://www.phpgedview.net/ged551¬5.pdf Matzner, Andrew. 2001. 'O au no keia: voices from Hawaii's Mahu and transgender communities. Bloomington, Indiana: Xlibris. Altorki, Soraya. 1980. MilkKinship in Arab Society: An Unexplored Problem in the Ethnography of Marriage. Ethnology 19(2): 233-24