THE IMPACT OF BEAN RESEARCH IN HONDURAS

Since the mid-1980s, bean research in Honduras has focused on the development of improved varieties resistant to key diseases, principally Bean Golden Yellow Mosaic Virus (BGYMV), one of the main constraints to bean production in the country. This paper presents evidence of recent adoption rates of improved bean varieties, the farm-level economic impact of adoption, and the ex post rate of return to bean research in Honduras from 1982-2010. Results from a 2001 farm-level survey in the two principal bean-producing regions in Honduras show that 46 to 51% of bean farmers (depending upon the season) have adopted an improved variety, and that adoption is scale-neutral with respect to farm-size and market orientation. Due to the potential problem of sample selection bias in the adoption of disease-resistant varieties, the farm-level impact of the new varieties was estimated using experimental data to approximate the yield differential between resistant and non-resistant varieties under disease pressure, and survey data was used to approximate the frequency of disease incidence in farmers' fields. An expected utility framework assuming risk neutrality demonstrates that adopters gain an average of 20% in bean income from increased yield stability under disease pressure, although these gains are reduced by 7 to 16% due to market price discounts for the resistant varieties. Under base-level assumptions, the economic rate of return bean research in Honduras during the period 1982-2010 is 40 %.Crop Production/Industries, Research and Development/Tech Change/Emerging Technologies,

DFT modeling of the adsorption of trimethylphosphine oxide at the internal and external surfaces of zeolite MFI

The characterization of the acidity of zeolites allows a direct correlation with their catalytic activity. To this end, probe molecules are utilized to obtain a ranking of acid strengths. Trimethylphosphine oxide (TMPO) is a widely used probe molecule, which allows the sensing of solid acids by using 31P NMR. We have performed calculations based on the density functional theory to investigate the Brønsted acid (BA) sites in zeolite MFI by adsorbing TMPO as a probe molecule. We have considered the substitution of silicon at the T2 site by aluminum, both at the internal cavity and at the external surface. The different acid strengths observed in the zeolite MFI when probed by TMPO (very strong, strong, and weak) may depend on the basicity of the centers sharing the acid proton. If the proton lies between the TMPO and one of the framework oxygen atoms binding the Al, the acidity is strong. When the framework oxygen atom is not directly binding the Al, it is less basic and a shortening of the TMPO–H distance is observed, causing an acid response of very strong. Finally, if two TMPO molecules share the proton, the TMPO–H distance elongates, rendering a weak acid character

A density functional theory study of the structure of pure-silica and aluminium-substituted MFI nanosheets

The layered MFI zeolite allows a straightforward hierarchization of the pore system which accelerates mass transfer and increases its lifetime as a catalyst. Here, we present a theoretical study of the structural features of the pure-silica and aluminium-substituted MFI nanosheets. We have analysed the effects of aluminium substitution on the vibrational properties of silanols as well as the features of protons as counter-ions. The formation of the two-dimensional system did not lead to appreciable distortions within the framework. Moreover, the effects on the structure due to the aluminium dopants were the same in both the bulk and the slab. The principal differences were related to the silanol groups that form hydrogen-bonds with neighbouring aluminium-substituted silanols, whereas intra-framework hydrogen-bonds increase the stability of aluminium-substituted silanols toward dehydration. Thus, we have complemented previous experimental and theoretical studies, showing the lamellar MFI zeolite to be a very stable material of high crystallinity regardless of its very thin structure

Quasar-galaxy and AGN-galaxy cross-correlations

We compute quasar-galaxy and AGN-galaxy cross-correlation functions for samples taken from the \cite{VCV98} catalog of quasars and active galaxies, using tracer galaxies taken from the Edinburgh/Durham Southern Catalog. The sample of active galaxy targets shows positive correlation at projected separations $r_p < 6 h^{-1} Mpc$ consistent with the usual power-law. On the other hand, we do not find a statistically significant positive quasar-galaxy correlation signal except in the range $3 h^{-1} Mpc < r_p < 6 h^{-1} Mpc$ where we find similar AGN-galaxy and quasar-galaxy correlation amplitudes. At separations $r_p<3 h^{-1} Mpc$ a strong decline of quasar-galaxy correlations is observed, suggesting a significant local influence of quasars in galaxy formation. In an attempt to reproduce the observed cross-correlation between quasars and galaxies, we have performed CDM cosmological hydrodynamical simulations and tested the viability of a scenario based on the model developed by \cite{silkrees98}. In this scheme a fraction of the energy released by quasars is considered to be transferred into the baryonic component of the intergalactic medium in the form of winds. The results of the simulations suggest that the shape of the observed quasar-galaxy cross-correlation function could be understood in a scenario where a substantial amount of energy is transferred to the medium at the redshift of maximum quasar activity.Comment: 11 pages, 9 figures. Accepted for publication in Ap

Union after multiple anterior cervical fusion 21 cases followed for 1-6 years

With a mean follow-up of 3 (1-6) years, we report on 21 patients who underwent multiple level cervical fusion, using autologous iliac crest grafts. Dissectomies were performed in 14 patients and corpectomies in another 7. Instrumentation was used in all patients with corpectomies and in 2 patients who underwent 2-level and 3-level dissectomies. Non-union occurred in 1 patient at 1 level. Graft displacement requiring reoperation was observed in 2 patients with massive corpectomies, in 1 of them as a consequence of trauma. In both patients complete bony fusion was obtained after reoperation and no other complications were observed. We conclude that the success rate with multiple-level fusion is comparable to that of single-level fusion when adequate fixation is achieve

SPOC: A widely distributed domain associated with cancer, apoptosis and transcription

BACKGROUND: The Split ends (Spen) family are large proteins characterised by N-terminal RNA recognition motifs (RRMs) and a conserved SPOC (Spen paralog and ortholog C-terminal) domain. The aim of this study is to characterize the family at the sequence level. RESULTS: We describe undetected members of the Spen family in other lineages (Plasmodium and Plants) and localise SPOC in a new domain context, in a family that is common to all eukaryotes using profile-based sequence searches and structural prediction methods. CONCLUSIONS: The widely distributed DIO (Death inducer-obliterator) family is related to cancer and apoptosis and offers new clues about SPOC domain functionality

Acute exacerbations of chronic obstructive pulmonary disease are associated with decreased CD4+ & CD8+ T cells and increased growth & differentiation factor-15 (GDF-15) in peripheral blood

Abstract Background Although T cells, especially CD8+, have been implicated in chronic obstructive pulmonary disease (COPD) pathogenesis, their role during acute exacerbations (AE-COPD) is uncertain. Methods We recruited subjects with COPD and a history of previous AE-COPD and studied them quarterly to collect blood and spontaneously expectorated sputum while stable. During exacerbations (defined by a change in symptoms plus physician diagnosis and altered medications), we collected blood and sputum before administering antibiotics or steroids. We used flow cytometry to identify leukocytes in peripheral blood, plus Luminex® analysis or ELISA to determine levels of inflammatory biomarkers in serum and sputum supernatants. Results Of 33 enrolled subjects, 13 participated in multiple stable visits and had ≥1 AE-COPD visit, yielding 18 events with paired data. Flow cytometric analyses of peripheral blood demonstrated decreased CD4+ and CD8+ T cells during AE-COPD (both absolute and as a percentage of all leukocytes) and significantly increased granulocytes, all of which correlated significantly with serum C-reactive protein (CRP) concentrations. No change was observed in other leukocyte populations during AE-COPD, although the percentage of BDCA-1+ dendritic cells expressing the activation markers CD40 and CD86 increased. During AE-COPD, sICAM-1, sVCAM-1, IL-10, IL-15 and GDF-15 increased in serum, while in sputum supernatants, CRP and TIMP-2 increased and TIMP-1 decreased. Conclusions The decrease in CD4+ and CD8+ T cells (but not other lymphocyte subsets) in peripheral blood during AE-COPD may indicate T cell extravasation into inflammatory sites or organized lymphoid tissues. GDF-15, a sensitive marker of cardiopulmonary stress that in other settings independently predicts reduced long-term survival, is acutely increased in AE-COPD. These results extend the concept that AE-COPD are systemic inflammatory events to which adaptive immune mechanisms contribute. Trial registration NCT00281216 , ClinicalTrials.gov.http://deepblue.lib.umich.edu/bitstream/2027.42/112169/1/12931_2015_Article_251.pd

Increased responsiveness of murine eosinophils to MIPâ 1β (CCL4) and TCAâ 3 (CCL1) is mediated by their specific receptors, CCR5 and CCR8

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141970/1/jlb1019.pd

Acute exacerbations of chronic obstructive pulmonary disease are associated with decreased CD4+ & CD8+ T cells and increased growth & differentiation factor-15 (GDF-15) in peripheral blood

Abstract Background Although T cells, especially CD8+, have been implicated in chronic obstructive pulmonary disease (COPD) pathogenesis, their role during acute exacerbations (AE-COPD) is uncertain. Methods We recruited subjects with COPD and a history of previous AE-COPD and studied them quarterly to collect blood and spontaneously expectorated sputum while stable. During exacerbations (defined by a change in symptoms plus physician diagnosis and altered medications), we collected blood and sputum before administering antibiotics or steroids. We used flow cytometry to identify leukocytes in peripheral blood, plus Luminex® analysis or ELISA to determine levels of inflammatory biomarkers in serum and sputum supernatants. Results Of 33 enrolled subjects, 13 participated in multiple stable visits and had ≥1 AE-COPD visit, yielding 18 events with paired data. Flow cytometric analyses of peripheral blood demonstrated decreased CD4+ and CD8+ T cells during AE-COPD (both absolute and as a percentage of all leukocytes) and significantly increased granulocytes, all of which correlated significantly with serum C-reactive protein (CRP) concentrations. No change was observed in other leukocyte populations during AE-COPD, although the percentage of BDCA-1+ dendritic cells expressing the activation markers CD40 and CD86 increased. During AE-COPD, sICAM-1, sVCAM-1, IL-10, IL-15 and GDF-15 increased in serum, while in sputum supernatants, CRP and TIMP-2 increased and TIMP-1 decreased. Conclusions The decrease in CD4+ and CD8+ T cells (but not other lymphocyte subsets) in peripheral blood during AE-COPD may indicate T cell extravasation into inflammatory sites or organized lymphoid tissues. GDF-15, a sensitive marker of cardiopulmonary stress that in other settings independently predicts reduced long-term survival, is acutely increased in AE-COPD. These results extend the concept that AE-COPD are systemic inflammatory events to which adaptive immune mechanisms contribute. Trial registration NCT00281216 , ClinicalTrials.gov.http://deepblue.lib.umich.edu/bitstream/2027.42/134660/1/12931_2015_Article_251.pd