The MSSM prediction for W+/- H-/+ production by gluon fusion

We discuss the associated W+/- H-/+ production in p p collision for the Large Hadron Collider. A complete one-loop calculation of the loop-induced subprocess g g -> W+/- H-/+ is presented in the framework of the Minimal Supersymmetric Standard Model (MSSM), and the possible enhancement of the hadronic cross section is investigated under the constraint from the squark direct-search results and the low-energy precision data. Because of the large destructive interplay in the quark-loop contributions between triangle-type and box-type diagrams, the squark-loop contributions turn out to be comparable with the quark-loop ones. In particular, the hadronic cross section via gluon fusion can be extensively enhanced by squark-pair threshold effects in the box-type diagrams, so that it can be as large as the hadronic cross section via the b b-bar -> W+/- H-/+ subprocess which appears at tree level.Comment: 35 pages, 7 figures, version to appear in Physical Review

Normatividad internacional de contabilidad pública y su aplicación en la contabilización de activos fijos en las municipalidades de Tumbes, 2023

En el presente trabajo, se ejecutó con el objetivo de determinar en que inciden la normatividad internacional de contabilidad aplicadas en la gestión pública (NIC SP 17 PPE) y el proceso contable de los activos fijos, estudio aplicado en 3 municipalidades provinciales y 10 distritales de la región de Tumbes, 2023; la metodología aplicada en el estudio es descriptivo trasversal, se aplicaron pruebas de confiabilidad al instrumento el cual se aplicó a la totalidad de la población de los servidores públicos que laboran bajo el régimen laboral del DL 276, DL 728, DL 1057 y terceros; de las áreas de Gerencia general, Oficina de Administración, Subgerencia de Contabilidad, Sub gerencia de Abastecimiento y Gerencia de Infraestructura (Obras); sumando un total de 196 servidores. Bajo el proceso estadístico se efectuó la prueba de Chi cuadrado de Pearson; donde se determinó un valor de valor p = 0.000< 0.05; por lo que podemos concluir que las variables investigadas se asocian, así se rechaza la hipótesis nula Ho y se acepta la hipótesis alterna Ha. Se propone la implementación de las Normas Internacionales de Contabilidad para el Sector público en las Municipalidades de la Región de Tumbes

Modulation fonctionnelle des cellules dendritiques par les Neutrophil Extracellular Traps

Les polynucléaires neutrophiles (PN) sont des cellules essentielles au cours de la réponse immunitaire innée ; recrutés rapidement au site inflammatoire où ils participent à la phase aigüe, ils vont aussi contribuer à la résolution de l inflammation. Ils peuvent en effet moduler la réponse adaptative par interaction avec les lymphocytes (Ly) ou les cellules dendritiques (DC) via des médiateurs solubles ou des interactions cellulaires directes. Les Neutrophil Extracellular Traps (NETs) libérés par les PN activés pourraient jouer un rôle important dans ce contexte. Les NETs sont des filaments de chromatine décondensée associés à des protéines issues principalement des granulations et du cytoplasme. Ils sont essentiels dans la réponse anti-infectieuse mais semblent également impliqués dans la physiopathologie de certaines maladies auto-immunes et inflammatoires. L objectif de ce travail a été d évaluer les effets des NETs sur la maturation des DC dans un contexte inflammatoire au cours duquel les PN et les DC peuvent co-exister, assurant ainsi un pont entre immunité innée et immunité adaptative. La première partie de ce travail a consisté à développer un modèle de production, isolement et caractérisation des NETs issus de PN sanguins humains. L ionophore de calcium A23187 a été choisi pour induire les NETs et l'enzyme de restriction AluI a permis la récupération de fragments de NETs de taille hétérogène. Certains des composants de ces NETs sont quantifiables (ADN, élastase, histone 3 en particulier), et nous avons montré qu ils conservaient leurs capacités bactéricides in vitro. Ces échantillons de NETs constituent donc un outil biologique standardisé, permettant d évaluer leurs effets sur des cellules ou des tissus. Dans la deuxième partie de ce travail, nous avons mis en évidence que ces NETs purifiés régulaient négativement la maturation de moDC induites par le LPS (expression de HLA-DR, CD80, CD83, CD86 et production de TNFa, IL-12, IL-6, IL-23). De plus, les NETs diminuent la capacité de ces moDC à induire la prolifération des LyT, et leur polarisation est modulée en favorisant la production de cytokines de type Th2 (IL-5 et IL-13) aux dépens de cytokines de types Th1 (INFg) et Th17 (IL-17). De manière intéressante, la capacité de migration des moDC activées par le LPS n est pas modifiée en présence de NETs. En résumé, ces résultats suggèrent que les NETs pourraient jouer un rôle immunorégulateur sur la maturation des moDC dans des conditions inflammatoires. Les NETs produits par les PN activés pourraient ainsi participer à la régulation indispensable de la réponse inflammatoire.Polymorphonuclear neutrophils (PMN) are innate immune cells rapidly recruited to the inflammatory sites where they play a major role during the acute phase response but also contribute to resolution and repair. They can also modulate the adaptive response by interacting with lymphocytes (Ly) or dendritic cells (DC) via soluble mediators or cell-cell contacts. Activated PMN release Neutrophil Extracellular Traps (NETs) that could play a role in this context. NETs are decondensed chromatin fibers associated with granule and cytoplasmic proteins. As they are mainly involved in host defense against infection, they contribute to some autoimmune and inflammatory diseases. The aim of this work was to evaluate NET effects on DC maturation in an inflammatory context where PMN and DC co-exist, thus bridging innate and adaptive immunity. We first developed a model to induce, isolate and characterize NETs from human PMN. Calcium ionophore A23187 was chosen to induce NETs and the restriction enzyme AluI allowed the recovery of heterogeneous-sized fragments of NETs. Some of their components were quantified (DNA, elastase, histone 3, in particular) and we found that they retained their bactericidal activity. These NETs samples thus constitute a new and important biological tool to study their effects on immune cells or tissues. In the second part of this work, we found that isolated NETs were able to down-regulate LPS-induced moDC maturation as evidenced by the expressions of HLA-DR, CD80, CD83, CD86 and cytokine release (TNFa, Il-6, IL-12, Il-23). Moreover, the presence of NETs during moDC maturation lead to a decrease capacity of these moDC to induce T lymphocyte proliferation and modulated polarization by promoting the production of Th2 cytokines (IL-5 and IL-13) and decreasing Th1 cytokines (INFg) and Th17 (IL- 17). Interestingly, moDC migration capacity was not modified when moDC maturation was done in the presence of NETs. In summary, these data suggest that NETs could downregulate DC activation. NETs produced by activated PMN could thus participate to the regulation of inflammation.PARIS11-SCD-Bib. électronique (914719901) / SudocSudocFranceF

Addressing Racial and Socioeconomic Disparities Through Patient Education and Increasing Healthcare Professionals’ Cultural Competency to Reduce Maternal Mortality in the United States

Pregnancy-related deaths in the United States continue to increase with a notable disparity for women of color and/or low socioeconomic status. Hundreds of women die each year due to pregnancy or delivery complications as researchers and healthcare providers remain unclear on the solution. The mortality rate is the result of pregnancy complications, the aggravation of preexisting comorbidities, methods of intervention, or events precipitated by the pregnancy.https://openworks.mdanderson.org/rmps/1002/thumbnail.jp

Propuesta de intervención de seguridad vial en la carretera san pedro de la progresiva 0+000 a la 3+050 Las Peñitas, Talara, Piura 2022

El presente proyecto de investigación “Propuesta de intervención de seguridad vial en la carretera san pedro de la progresiva 0+000 a la 3+050 Las Peñitas, Talara, Piura 2022” tiene como objetivo Proponer un estudio de seguridad vial e implementación en la carretera san pedro de la progresiva 0+000 a la 3+050 las peñitas, talara, Piura 2022; para lo cual se hicieron los trabajos correspondientes de campo y gabinetes correspondientes. Se aplicaron la técnica de la encuesta para la obtención de datos a un total de 187 personas obtenidas gracias a la muestra. Además, para la recopilación de dicha información se usó el instrumento de recolección de datos, basándonos en la ficha de observación. El tipo de investigación realizado es aplicada y no experimental con un enfoque cualitativo. La base de datos obtenida se analizó mediante un programa de cálculo estadísticos donde se desarrolló una estadística descriptiva a través de frecuencias, porcentajes, media, mediana, moda y su representación gráfica. Como resultados se obtuvieron planos con la distribución correcta de señales tantos verticales como horizontales la cuales al implementar la señalización adecuada en una calle o carretera se puede reducir los accidentes de tránsito

Arctic Ocean benthic foraminifera Mg/Ca ratios and global Mg/Ca-temperature calibrations: New constraints at low temperatures

We explore the use of Mg/Ca ratios in six Arctic Ocean benthic foraminifera species as bottom water palaeothermometers and expand published Mg/Ca-temperature calibrations to the coldest bottom temperatures (<1 °C). Foraminifera were analyzed in surface sediments at 27 sites in the Chukchi Sea, East Siberian Sea, Laptev Sea, Lomonosov Ridge and Petermann Fjord. The sites span water depths of 52–1157 m and bottom water temperatures (BWT) of −1.8 to +0.9 °C. Benthic foraminifera were alive at time of collection, determined from Rose Bengal (RB) staining. Three infaunal and three epifaunal species were abundant enough for Mg/Ca analysis. As predicted by theory and empirical evidence, cold water Arctic Ocean benthic species produce low Mg/Ca ratios, the exception being the porcelaneous species Quinqueloculina arctica. Our new data provide important constraints at the cold end (<1 °C) when added to existing global datasets. The refined calibrations based on the new and published global data appear best supported for the infaunal species Nonionella labradorica (Mg/Ca = 1.325 ± 0.01 × e^(0.065 ± 0.01 × BWT), r2 = 0.9), Cassidulina neoteretis (Mg/Ca = 1.009 ± 0.02 × e^(0.042 ± 0.01 × BWT), r2 = 0.6) and Elphidium clavatum (Mg/Ca = 0.816 ± 0.06 + 0.125 ± 0.05 × BWT, r2 = 0.4). The latter is based on the new Arctic data only. This suggests that Arctic Ocean infaunal taxa are suitable for capturing at least relative and probably semi-quantitative past changes in BWT. Arctic Oridorsalis tener Mg/Ca data are combined with existing O. umbonatus Mg/Ca data from well saturated core-tops from other regions to produce a temperature calibration with minimal influence of bottom water carbonate saturation state (Mg/Ca = 1.317 ± 0.03 × e^(0.102 ± 0.01 BWT), r2 = 0.7). The same approach for Cibicidoides wuellerstorfi yields Mg/Ca = 1.043 ± 0.03 × e^(0.118 ± 0.1 BWT), r2 = 0.4. Mg/Ca ratios of the porcelaneous epifaunal species Q. arctica show a clear positive relationship between Mg/Ca and Δ[CO32−] indicating that this species is not suitable for Mg/Ca-palaeothermometry at low temperatures, but may be useful in reconstructing carbonate system parameters through time

Pair production of neutral Higgs bosons at the CERN Large Hadron Collider

We study the hadroproduction of two neutral Higgs bosons in the minimal supersymmetric extension of the standard model, which provides a handle on the trilinear Higgs couplings. We include the contributions from quark-antiquark annihilation at the tree level and those from gluon-gluon fusion, which proceeds via quark and squark loops. We list compact results for the tree-level partonic cross sections and the squark loop amplitudes, and we confirm previous results for the quark loop amplitudes. We quantitatively analyze the hadronic cross sections at the CERN Large Hadron Collider assuming a favorable supergravity-inspired scenario.Comment: 22 pages (Latex), 16 figures (Postscript). Discussion of theoretical uncertainties and background processes added. Accepted for publication in Phys. Rev.