Narratives of Change: Identity and Recognition Dynamics in the Process of Moving Away From a Life Dominated by Drug Use

The concepts of identity and recovery capital are recognized as being an embedded part of moving away from a life dominated by drug use. However, the link between these two concepts and the effect of broader social structures, and the normative assumptions underpinning the condition of recovery, is less explored. This article focuses on the social practices of everyday life in the foreground of identity formation, meaning that “who I am” is an inseparable part of “what I do.” A narrative approach was employed to analyze qualitative follow-up data extracted from 48 in-depth interviews with 17 males and females with drug-using experience that were conducted posttreatment on three separate occasions over a period of 2.5 years. Theories of identity formation were employed to analyze the interdependent dynamic between social structure, persona and social resources, and way of life and identity. The analyses identified four narratives related to how people present themselves through the process of changing practices. Following the work of Honneth, we argue that the positive identity formation revealed in these narratives is best understood as a struggle for recognition via the principle of achievement. However, the participants’ self-narratives reflected cultural stories—specified as formula stories—of “normality,” “addiction,” and the “addict,” which work into the concepts of self and confine options of storying experiences during the recovery process. This study demonstrate that the process of recovery is culturally embedded and constitutes a process of adaption to conventional social positions and roles. We suggest challenging dominant discourses related to “addiction as a disease” and “normality” in order to prevent stigma related to drug use and recovery. In so doing, it may contribute to broaden conditions for identity (trans)formation for people in recovery.publishedVersio

Science of Digital Libraries(SciDL)

Our purpose is to ensure that people and institutions better manage information through digital libraries (DLs). Thus we address a fundamental human and social need, which is particularly urgent in the modern Information (and Knowledge) Age. Our goal is to significantly advance both the theory and state-of-theart of DLs (and other advanced information systems) - thoroughly validating our approach using highly visible testbeds. Our research objective is to leverage our formal, theory-based approach to the problems of defining, understanding, modeling, building, personalizing, and evaluating DLs. We will construct models and tools based on that theory so organizations and individuals can easily create and maintain fully functional DLs, whose components can interoperate with corresponding components of related DLs. This research should be highly meritorious intellectually. We bring together a team of senior researchers with expertise in information retrieval, human-computer interaction, scenario-based design, personalization, and componentized system development and expect to make important contributions in each of those areas. Of crucial import, however, is that we will integrate our prior research and experience to achieve breakthrough advances in the field of DLs, regarding theory, methodology, systems, and evaluation. We will extend the 5S theory, which has identified five key dimensions or onstructs underlying effective DLs: Streams, Structures, Spaces, Scenarios, and Societies. We will use that theory to describe and develop metamodels, models, and systems, which can be tailored to disciplines and/or groups, as well as personalized. We will disseminate our findings as well as provide toolkits as open source software, encouraging wide use. We will validate our work using testbeds, ensuring broad impact. We will put powerful tools into the hands of digital librarians so they may easily plan and configure tailored systems, to support an extensible set of services, including publishing, discovery, searching, browsing, recommending, and access control, handling diverse types of collections, and varied genres and classes of digital objects. With these tools, end-users will for be able to design personal DLs. Testbeds are crucial to validate scientific theories and will be thoroughly integrated into SciDL research and evaluation. We will focus on two application domains, which together should allow comprehensive validation and increase the significance of SciDL's impact on scholarly communities. One is education (through CITIDEL); the other is libraries (through DLA and OCKHAM). CITIDEL deals with content from publishers (e.g, ACM Digital Library), corporate research efforts e.g., CiteSeer), volunteer initiatives (e.g., DBLP, based on the database and logic rogramming literature), CS departments (e.g., NCSTRL, mostly technical reports), educational initiatives (e.g., Computer Science Teaching Center), and universities (e.g., theses and dissertations). DLA is a unit of the Virginia Tech library that virtually publishes scholarly communication such as faculty-edited journals and rare and unique resources including image collections and finding aids from Special Collections. The OCKHAM initiative, calling for simplicity in the library world, emphasizes a three-part solution: lightweightprotocols, component-based development, and open reference models. It provides a framework to research the deployment of the SciDL approach in libraries. Thus our choice of testbeds also will nsure that our research will have additional benefit to and impact on the fields of computing and library and information science, supporting transformations in how we learn and deal with information

The Ursinus Weekly, February 23, 1906

Alumni meetings • Zwinglian declamation contest • Glee Club entertained • Honors awarded • Philadelphia letter • Charmidean Club • Society notes • Student Volunteer Convention • Alumni • Senior officers • Baseball schedule • Literary Supplement: The United States among the nations; Poe and his poetic works; The supernatural element in The Rime of the Ancient Mariner; Our national crime; Criticism on the works of Schubert and Schumann; Mutabilityhttps://digitalcommons.ursinus.edu/weekly/2970/thumbnail.jp

Nurses\u27 Alumnae Association Bulletin - Volume 6 Number 10

Financial Report Calendar of Events Attention, Class of 1945! Miss Shafer Retires Review of the Alumnae Association Meetings Institutional Staff Nurses\u27 Section Report of Staff Activites - 1948-1949 The Staff Stockings! Stockings! Stockings! Pop-Up Toaster It\u27s Not Too Soon Any White Elephants? Private Duty Section The Jefferson Hospital Private Duty Nurses\u27 Register Report for Barton Memorial Hospital Progress of the Orthopedic Department Just Under the Date Line Pediatrics at Jefferson Controlled Respiration in Anesthesia Anesthesia Progress Physical Advances at Jefferson During the Past Year The White Haven Division The Clara Melville Scholarship Fund The Relief Fund The Busy Year for the Nurses\u27 Home Committee of the Women\u27s Board The Gray Ladies Memories Lost Miscellaneous Items Medical College News Marriages Births Deaths Condolences Prizes District No. 1 Dues Help! Help! Help! Jap Prison School Spurs Nurse to Win University Degree Twenty Ways to Kill an Organization The Bulletin Committee Attention, Alumnae New Addresse

Recombinant human activated protein C attenuates cardiovascular and microcirculatory dysfunction in acute lung injury and septic shock

Introduction: This prospective, randomized, controlled, experimental animal study looks at the effects of recombinant human activated protein C (rhAPC) on global hemodynamics and microcirculation in ovine acute lung injury (ALI) and septic shock, resulting from smoke inhalation injury

A Splicing Mutation in Slc4a5 Results in Retinal Detachment and Retinal Pigment Epithelium Dysfunction

Fluid and solute transporters of the retinal pigment epithelium (RPE) are core components of the outer blood-retinal barrier. Characterizing these transporters and their role in retinal homeostasis may provide insights into ocular function and disease. Here, we describe RPE defects in tvrm77 mice, which exhibit hypopigmented patches in the central retina. Mapping and nucleotide sequencing of tvrm77 mice revealed a disrupted 5\u27 splice donor sequence in Slc4a5, a sodium bicarbonate cotransporter gene. Slc4a5 expression was reduced 19.7-fold in tvrm77 RPE relative to controls, and alternative splice variants were detected. SLC4A5 was localized to the Golgi apparatus of cultured human RPE cells and in apical and basal membranes. Fundus imaging, optical coherence tomography, microscopy, and electroretinography (ERG) of tvrm77 mice revealed retinal detachment, hypopigmented patches corresponding to neovascular lesions, and retinal folds. Detachment worsened and outer nuclear layer thickness decreased with age. ERG a- and b-wave response amplitudes were initially normal but declined in older mice. The direct current ERG fast oscillation and light peak were reduced in amplitude at all ages, whereas other RPE-associated responses were unaffected. These results link a new Slc4a5 mutation to subretinal fluid accumulation and altered light-evoked RPE electrophysiological responses, suggesting that SLC4A5 functions at the outer blood-retinal barrier

Standardized, systemic phenotypic analysis reveals kidney dysfunction as main alteration of Kctd1 I27N mutant mice

Background: Increased levels of blood plasma urea were used as phenotypic parameter for establishing novel mouse models for kidney diseases on the genetic background of C3H inbred mice in the phenotype-driven Munich ENU mouse mutagenesis project. The phenotypically dominant mutant line HST014 was established and further analyzed. Methods: Analysis of the causative mutation as well as the standardized, systemic phenotypic analysis of the mutant line was carried out. Results: The causative mutation was detected in the potassium channel tetramerization domain containing 1 (Kctd1) gene which leads to the amino acid exchange Kctd1 I27N thereby affecting the functional BTB domain of the protein. This line is the first mouse model harboring a Kctd1 mutation. Kctd1 I27N homozygous mutant mice die perinatally. Standardized, systemic phenotypic analysis of Kctd1 I27N heterozygous mutants was carried out in the German Mouse Clinic (GMC). Systematic morphological investigation of the external physical appearance did not detect the specific alterations that are described in KCTD1 mutant human patients affected by the scalp-ear-nipple (SEN) syndrome. The main pathological phenotype of the Kctd1 I27N heterozygous mutant mice consists of kidney dysfunction and secondary effects thereof, without gross additional primary alterations in the other phenotypic parameters analyzed. Genome-wide transcriptome profiling analysis at the age of 4 months revealed about 100 differentially expressed genes (DEGs) in kidneys of Kctd1 I27N heterozygous mutants as compared to wild-type controls. Conclusions: In summary, the main alteration of the Kctd1 I27N heterozygous mutants consists in kidney dysfunction. Additional analyses in 9–21 week-old heterozygous mutants revealed only few minor effects