Developing through mentoring or being mentored: ALDinHE’s new mentoring scheme and certified mentor recognition

ALDinHE is launching its new mentoring scheme and mentorship recognition to acknowledge, promote and recognise the importance of mentoring for learning development as a field that does not offer an official route into the profession. This Professional Development session introduced the mentoring scheme, explaining how to get involved, what support mentors and mentees can receive from ALDinHE and what benefits both sides can get from mentoring or being mentored. If you’re new to learning development or keen to develop more experience in a specific area with the help of a mentor, the mentoring scheme will offer you a brilliant framework to broaden your expertise. If you’re an experienced learning developer or have specific expertise you could share, find out how you could become recognised as a Certified Mentor (CeM) in learning development by ALDinHE

Mentoring in learning development

Learning Development is still a relatively young field (Syska and Buckley, 2022), and despite a growing body of research, it remains strongly practice-oriented. This means that experience, in this case of individual Learning Developers, takes an even more central place than it does in more established fields, and sharing this experience through mentoring takes on a central role. This is why the mentoring working group has developed a Learning Development focused ALDinHE Mentoring Scheme, together with a Certified Mentor recognition that helps experienced mentors be recognised for their contribution to growing and sharing LD knowledge. This mini keynote briefly introduced the Mentoring Scheme and the CeM recognition before exploring the role mentoring can play in the professional development of Learning Developers with the audience. The questions we asked were: What benefits would you expect for mentees? What benefits would you expect for mentors? What kind of experience can be best shared through mentoring

Dense Ionized and Neutral Gas Surrounding Sgr A*

We present high resolution H41a hydrogen recombination line observations of the 1.2' (3 pc) region surrounding Sgr A* at 92 GHz using the OVRO Millimeter Array with an angular resolution of 7" x 3" and velocity resolution of 13 km/s. New observations of H31a, H35a, H41a, and H44a lines were obtained using the NRAO 12-m telescope, and their relative line strengths are interpreted in terms of various emission mechanisms. These are the most extensive and most sensitive observations of recombination line to date. Observations of HCO+ (1 - 0) transition at 89 GHz are also obtained simultaneously with a 40% improved angular resolution and 4-15 times improved sensitivity over previous observations, and the distribution and kinematics of the dense molecular gas in the circumnuclear disk (CND) are mapped and compared with those of the ionized gas. The line brightness ratios of the hydrogen recombination lines are consistent with purely spontaneous emission from 7000 K gas with n_e = 20,000 cm$^{-3}$ near LTE condition. A virial analysis suggests that the most prominent molecular gas clumps in the CND have mean densities of 10^7 cm^{-3}, sufficient to withstand the tidal shear in the Galactic Center region. Therefore, these clumps may survive over several dynamical times, and the CND may be a dynamically stable structure. We estimate a total gas mass of 3 x 10^5 solar mass for the CND. \Comment: 34 pages including 11 figures (4 jpgs), Latex, uses aastex. The full pdf format file including high resolution figures is available at http://www.astro.umass.edu/~myun/papers/SgrA.pdf . To appear in the 20 November 2004 (V616) issue of the Astrophysical Journa

The obscured hyper-energetic GRB 120624B hosted by a luminous compact galaxy at z = 2.20

Gamma-ray bursts are the most luminous explosions that we can witness in the Universe. Studying the most extreme cases of these phenomena allows us to constrain the limits for the progenitor models. In this Letter, we study the prompt emission, afterglow, and host galaxy of GRB 120624B, one of the brightest GRBs detected by Fermi, to derive the energetics of the event and characterise the host galaxy in which it was produced. Following the high-energy detection we conducted a multi-wavelength follow-up campaign, including near-infrared imaging from HAWKI/VLT, optical from OSIRIS/GTC, X-ray observations from the Chandra X-ray Observatory and at sub-millimetre/millimetre wavelengths from SMA. Optical/nIR spectroscopy was performed with X-shooter/VLT. We detect the X-ray and nIR afterglow of the burst and determine a redshift of z = 2.1974 +/- 0.0002 through the identification of emission lines of [OII], [OIII] and H-alpha from the host galaxy of the GRB. This implies an energy release of Eiso = (3.0+/-0.2)x10^54 erg, amongst the most luminous ever detected. The observations of the afterglow indicate high obscuration with AV > 1.5. The host galaxy is compact, with R1/2 < 1.6 kpc, but luminous, at L ~ 1.5 L* and has a star formation rate of 91 +/- 6 Msol/yr as derived from H-alpha. As other highly obscured GRBs, GRB 120624B is hosted by a luminous galaxy, which we also proof to be compact, with a very intense star formation. It is one of the most luminous host galaxies associated with a GRB, showing that the host galaxies of long GRBs are not always blue dwarf galaxies, as previously thought.Comment: 6 pages, 4 figures, 4 tables; accepted for publication in A&

MicroRNA-24 regulates vascularity after myocardial infarction

BACKGROUND: Myocardial infarction leads to cardiac remodeling and development of heart failure. Insufficient myocardial capillary density after myocardial infarction has been identified as a critical event in this process, although the underlying mechanisms of cardiac angiogenesis are mechanistically not well understood. METHODS AND RESULTS: Here, we show that the small noncoding RNA microRNA-24 (miR-24) is enriched in cardiac endothelial cells and considerably upregulated after cardiac ischemia. MiR-24 induces endothelial cell apoptosis, abolishes endothelial capillary network formation on Matrigel, and inhibits cell sprouting from endothelial spheroids. These effects are mediated through targeting of the endothelium-enriched transcription factor GATA2 and the p21-activated kinase PAK4, which were identified by bioinformatic predictions and validated by luciferase gene reporter assays. Respective downstream signaling cascades involving phosphorylated BAD (Bcl-XL/Bcl-2-associated death promoter) and Sirtuin1 were identified by transcriptome, protein arrays, and chromatin immunoprecipitation analyses. Overexpression of miR-24 or silencing of its targets significantly impaired angiogenesis in zebrafish embryos. Blocking of endothelial miR-24 limited myocardial infarct size of mice via prevention of endothelial apoptosis and enhancement of vascularity, which led to preserved cardiac function and survival. CONCLUSIONS: Our findings indicate that miR-24 acts as a critical regulator of endothelial cell apoptosis and angiogenesis and is suitable for therapeutic intervention in the setting of ischemic heart disease. [KEYWORDS: Animals, Apoptosis/drug effects, Arterioles/pathology, Capillaries/pathology, Cell Hypoxia, Cells, Cultured/drug effects/metabolism, Collagen, Drug Combinations, Drug Evaluation, Preclinical, Endothelial Cells/ metabolism/pathology, GATA2 Transcription Factor/biosynthesis/genetics, Gene Expression Profiling, Heart Failure/etiology, Heme Oxygenase-1/biosynthesis/genetics, Laminin, Male, Mice, Mice, Inbred C57BL, MicroRNAs/antagonists & inhibitors/genetics/ physiology, Myocardial Infarc

Renormalization for Discrete Optimization

The renormalization group has proven to be a very powerful tool in physics for treating systems with many length scales. Here we show how it can be adapted to provide a new class of algorithms for discrete optimization. The heart of our method uses renormalization and recursion, and these processes are embedded in a genetic algorithm. The system is self-consistently optimized on all scales, leading to a high probability of finding the ground state configuration. To demonstrate the generality of such an approach, we perform tests on traveling salesman and spin glass problems. The results show that our ``genetic renormalization algorithm'' is extremely powerful.Comment: 4 pages, no figur

A Transient New Coherent Condition of Matter: The Signal for New Physics in Hadronic Diffractive Scattering

We demonstrate the existence of an anomalous structure in the data on the diffractive elastic scattering of hadrons at high energies and small momentum transfer. We analyze five sets of experimental data on $p(\overline{p})-p$ scattering from five different experiments with colliding beams, ranging from the first-- and second--generation experiments at $\sqrt{s} = 53$ GeV to the most recent experiments at 546 GeV and at 1800 GeV. All of the data sets exhibit a localized anomalous structure in momentum transfer. We represent the anomalous behavior by a phenomenological formula. This is based upon the idea that a transient coherent condition of matter occurs in some of the intermediate inelastic states which give rise, via unitarity, to diffractive elastic scattering. The Fourier--Bessel transform into momentum--transfer space of a spatial oscillatory behavior of matter in the impact--parameter plane results in a small piece of the diffractive amplitude which exhibits a localized anomalous behavior near a definite value of $-t$. In addition, we emphasize possible signals coming directly from such a new condition of matter that may be present in current experiments on inelastic processes.Comment: 25 pages, LaTeX (12 figures, not included). A complete postscript file (except figures 1 and 11, which are available upon request) is available via anonymous ftp at ttpux2.physik.uni-karlsruhe.de (129.13.102.139) as /ttp94-03 /ttp94-03.ps, Local preprint# TTP94-03 (March 1994

Cosmological Perturbations in Flux Compactifications

Kaluza-Klein compactifications with four-dimensional inflationary geometry combine the attractive idea of higher dimensional models with the attempt to incorporate four-dimensional early-time or late-time cosmology. We analyze the mass spectrum of cosmological perturbations around such compactifications, including the scalar, vector, and tensor sector. Whereas scalar perturbations were discussed before, the spectrum of vector and tensor perturbations is a new result of this article. Moreover, the complete analysis shows, that possible instabilities of such compactifications are restricted to the scalar sector. The mass squares of the vector and tensor perturbations are all non-negative. We discuss form fields with a non-trivial background flux in the extra space as matter degrees of freedom. They provide a source of scalar and vector perturbations in the effective four-dimensional theory. We analyze the perturbations in Freund-Rubin compactifications. Although it can only be considered as a toy model, we expect the results to qualitatively generalize to similar configurations. We find that there are two possible channels of instabilities in the scalar sector of perturbations, whose stabilization has to be addressed in any cosmological model that incorporates extra dimensions und form fields. One of the instabilities is associated with the perturbations of the form field.Comment: 16 pages, v2 figure and references added, accepted version for JCA

Implementation of on-site velocity boundary conditions for D3Q19 lattice Boltzmann

On-site boundary conditions are often desired for lattice Boltzmann simulations of fluid flow in complex geometries such as porous media or microfluidic devices. The possibility to specify the exact position of the boundary, independent of other simulation parameters, simplifies the analysis of the system. For practical applications it should allow to freely specify the direction of the flux, and it should be straight forward to implement in three dimensions. Furthermore, especially for parallelized solvers it is of great advantage if the boundary condition can be applied locally, involving only information available on the current lattice site. We meet this need by describing in detail how to transfer the approach suggested by Zou and He to a D3Q19 lattice. The boundary condition acts locally, is independent of the details of the relaxation process during collision and contains no artificial slip. In particular, the case of an on-site no-slip boundary condition is naturally included. We test the boundary condition in several setups and confirm that it is capable to accurately model the velocity field up to second order and does not contain any numerical slip.Comment: 13 pages, 4 figures, revised versio