Plugin for Drawing Recording and Reconstruction in Graphics Editor

The goal of this thesis is to explore the possibilities of observing brush strokes inside a graphics editor, recording them, and finally, allowing the user to edit each individual stroke or play them out in a sequence. These features are then implemented in a form of a plugin module for a selected suitable graphics editor

Plugin for Drawing Recording and Reconstruction in Graphics Editor

Cieľom tejto práce je preskúmať možnosť sledovania ťahov štetca v grafickom editore, ukladať ich a následne ponúknuť možnosť tieto ťahy individuálne upravovať alebo prehrať ako sekvenciu. Tieto vlastnosti sú následne implementované formou zásuvného modulu pre vybraný vhodný grafický editor.The goal of this thesis is to explore the possibilities of observing brush strokes inside a graphics editor, recording them, and finally, allowing the user to edit each individual stroke or play them out in a sequence. These features are then implemented in a form of a plugin module for a selected suitable graphics editor.

Apolipoprotein E controls the risk and age at onset of Parkinson disease

Background: Similarities between Alzheimer disease (AD) and Parkinson disease (PD) suggest a possible role for apolipoprotein E (APOE) in PD. Most previous studies seeking to establish such a link used case-control datasets and results have been inconsistent. Objective: To investigate APOE’s role in PD using family-based association analyses. Methods: APOE functional polymorphisms were genotyped for 658 PD affected families, including 282 multiplex and 376 singleton families. The pedigree disequilibrium test (PDT) and the genotype-PDT were used to test the risk effect of APOE. The Monks-Kaplan test was used to evaluate the effect of APOE on age at onset of PD. Results: APOE was significantly associated with risk of developing PD. Stratified analysis revealed that APOE was most strongly associated with families with a positive PD family history (global p = 0.003). Like AD, the APOE-4 allele increases disease risk while the APOE-3 allele decreases risk. We detected a positive association of APOE-3 (p = 0.019) and a negative association of APOE-4 (p = 0.015) with age at onset in PD. Conclusions: The APOE-4 allele increases risk and decreases age at onset of PD, an association that may not be dependent upon cognitive impairment

Association study of parkin gene polymorphisms with idiopathic Parkinson disease

Background Previously, we detected linkage of idiopathic Parkinson disease (PD) to the region on chromosome 6 that contains the Parkin gene (D6S305; logarithm of odds score, 5.47) in families with at least one individual with age at onset younger than 40 years (families with early-onset disease). Further study demonstrated the presence of Parkin mutations in this data set. However, previous case-control studies have reported conflicting results regarding the role of more common Parkin polymorphisms as susceptibility alleles for idiopathic PD. Objective To investigate the association of 7 previously studied Parkin single-nucleotide polymorphisms (SNPs) throughout the promoter and most of the open reading frame with PD in a large cohort of patients with primarily late-onset PD. Methods One promoter, 3 intronic, and 3 exonic Parkin SNPs were genotyped in 1580 individuals belonging to 397 families, and their association with PD was evaluated using family-based association tests. Results No significant association (P>.05) between PD and any Parkin SNP allele or genotype was detected. Haplotype analysis and stratification by age at onset or family history also failed to produce significant results. Conclusions These results suggest that these common variants of Parkin are not associated with PD in white patients, although Parkin mutations are known to cause early- and late-onset PD

Ohio History 2014

https://kent-islandora.s3.us-east-2.amazonaws.com/node/10128/OH-v121-thumb.jpgOHIO HISTORY Contents for Volume 121, 2014 Time Not Ripe: Black Women’s Quest for Citizenship and the Battle for Full Inclusion at Ohio State University Tyran Kai Steward ...... 4 “The Most Free of the Free States”: Politics, Slavery, Race, and Regional Identity in Early Ohio, 1790–1820 John Craig Hammond ...... 35 James A. Shedd to Dr. David Jordon: A Documentary Perspective on the Dayton Mob of 1841 Hans C. Rasmussen ...... 58 The Ohio Constitution of 1803, Jefferson’s Danbury Letter, and Religion in Education David Scott ...... 73 Memories of Work and the Definition of Community: The Making of Italian Americans in the Mahoning Valley Donna M. DeBlasio and Martha I. Pallante ...... 89 Germans, Jubilee Singers, and Axe Men: James A. Garfield and the Original Front-Porch Campaign for the Presidency Jeffrey Normand Bourdon ...... 112 &nbsp; Book Reviews ......&nbsp;130 On the cover: Niles Fire Brick workers, ca. 1896.</p