Double Play: The Need for 4-H to Partner in Youth Sports

Fewer children in the United States are playing team-based sports, and the trend is making national headlines. While there is no complete agreement as to the predominant reason for this trend, it is clear that a national conversation on this problem has begun, and Cooperative Extension holds the potential for getting kids back in the game. At its core, this conversation is about the healthful development of our children and their advancement as contributors to society. Cooperative Extension has decades of experience creating a playbook for youth development, and it is time to put that playbook into action

Computational Docking Simulations of Nitroanisole and Nitrophenol with CYP2E1

Studies have shown that CYP2E1, a cytochrome P450 enzyme containing two primary binding sites, plays a substantial role in the oxidative metabolism of many foreign substances, including the detoxification reaction of 4-nitroanisole to 4-nitrophenol. Through the advancements of the computational docking software Tripos Sybyl7.2, it has been possible to investigate the mechanism of oxidation of 4-nitroanisole. Docking modules of Sybyl7.2 software, including Surflext and molecular dynamics, have created the ability to ascertain the likely binding configurations of 4-nitranisole and its constitutional isomers in either the distal or proximal binding sites of CYP2E1. Knowing the relative binding relationships of 4-nitroanisole to the heme of the CYP2E1 plays in human oxidative metabolism of xenobiotic substances. The goal in this research was to observe the configuration of nitroanisole and its derivatives in relation to the heme of the enzyme and possibly determine a cause for the unconventional reaction kinetics of CYP2E1

Calculation of receiver sensitivities in (orthogonal) subcarrier multiplexing microwave-optical links

Microwave-based all-analogue (orthogonal) subcarrier multiplexing (SCM) permits a direct processing of baseband data at Gbit/s while achieving low power consumption, low latency, low cost, and tolerance to dispersion. A key figure of merit in any SCM link is the sensitivity in the receiver, which depends on the transmitter, the link and the receiver. By analysing the impact of the nonlinearities of an optical IQ modulator in the presence of optical noise, sensitivities are mathematically estimated as a function of the optical modulation index (OMI) at the transmitter. The results are verified with simulations achieving a good agreement with the mathematical model. The theoretical model provided can be employed as a tool to predict the best achievable sensitivities and the optimum OMI in broadband SCM and orthogonal SCM links

MMWB 001 Hansen Capley McLeod McBride Martin 5-12-1992

Acc #: 268; MMWB 001 This interview with Jean Hansen, Ethel M. “Perry” Capley, Irene McLeod, Doris D. McBride, and Mavis Martin was recorded by Martha Mercer on May 12, 1992 in Mrs. Hansen’s home. The main topic of the interview revolves around the women\u27s experiences marrying American GIs during World War II and moving to the United States. The interview begins with the women discussing their lives in Britain before the during the war, and how their families made their respective livings. They discuss their experiences traveling to America on ships, reflection on the immigration process itself and their interactions with immigration officials, and the difficulties of return travel to visit Britain afterward. They also discuss their adjustment to life in the American South as white women from the UK, and their first impressions of Mobile, and reflect on how living in Mobile has affected their sense of home. The interview concludes with discussion of the Mobile-based women’s club that they founded, originally named the British Brides’ Club. This interview is part of a collection of three audio cassette recordings and one written interview that Martha Mercer conducted with white World War II war brides from the UK and Australia in 1992-93. Mercer undertook the project for her master’s thesis in History, “British Brides, American Wives: The Immigration and Acculturation of War Brides in Mobile, Alabama, 1945-1993,” which she completed at the University of South Alabama in 1993

All-analogue real-time broadband filter bank multicarrier optical communications system

This paper studies the key aspects of an optical link which transmits a broadband microwave filter bank multicarrier (FBMC) signal. The study is presented in the context of creating an all-analogue real-time multigigabit orthogonal frequency division multiplexing electro-optical transceiver for short range and high-capacity data center networks. Passive microwave filters are used to perform the pulse shaping of the bit streams, allowing an orthogonal transmission without the necessity of digital signal processing (DSP). Accordingly, a cyclic prefix that would cause a reduction in the net data rate is not required. An experiment consisting of three orthogonally spaced 2.7 Gbaud quadrature phase shift keyed subchannels demonstrates that the spectral efficiency of traditional DSP-less subcarrier multiplexed links can be potentially doubled. A sensitivity of -29.5 dBm is achieved in a 1-km link

WDM orthogonal subcarrier multiplexing

Electro-optical transceivers can be implemented employing all-analog signal processing in order to achieve low values of power consumption and latency. This paper shows that the spectral efficiency of such solutions can be increased by combining orthogonal multicarrier techniques and off-the-shelf microwave components. A real-time 108-Gbit/s experiment was performed emulating a wavelength division multiplexing (WDM) system composed of five optical channels. The optical carriers were provided by an externally injected gain switched optical frequency comb. Each optical channel transmitted a 21.6-Gbit/s orthogonal subcarrier multiplexing (SCM) signal that was modulated and demodulated in the electrical domain without the requirement for digital signal processing. The net data rate remained higher than 100 Gbit/s after taking into account forward error correction overheads. The use of orthogonally overlapping subchannels achieves an unprecedented spectral efficiency in all-analog real-time broadband WDM/SCM links

Ariel - Volume 8 Number 2

Executive Editor James W. Lockard , Jr. Issue Editor Doug Hiller Business Manager Neeraj K. Kanwal University News Richard J. Perry World News Doug Hiller Opinions Elizabeth A. McGuire Features Patrick P. Sokas Sports Desk Shahab S. Minassian Managing Editor Edward H. Jasper Managing Associate Brenda Peterson Photography Editor Robert D. Lehman, Jr. Graphics Christine M. Kuhnl

The Antiferromagnetic Band Structure of La2CuO4 Revisited

Using the Becke-3-LYP functional, we have performed band structure calculations on the high temperature superconductor parent compound, La2CuO4. Under the restricted spin formalism (rho(alpha) equal to rho(beta)), the R-B3LYP band structure agrees well with the standard LDA band structure. It is metallic with a single Cu x2-y2/O p(sigma) band crossing the Fermi level. Under the unrestricted spin formalism (rho(alpha) not equal to rho(beta)), the UB3LYP band structure has a spin polarized antiferromagnetic solution with a band gap of 2.0 eV, agreeing well with experiment. This state is 1.0 eV (per formula unit) lower than that calculated from the R-B3LYP. The apparent high energy of the spin restricted state is attributed to an overestimate of on-site Coulomb repulsion which is corrected in the unrestricted spin calculations. The stabilization of the total energy with spin polarization arises primarily from the stabilization of the x2-y2 band, such that the character of the eigenstates at the top of the valence band in the antiferromagnetic state becomes a strong mixture of Cu x2-y2/O p(sigma) and Cu z2/O' p(z). Since the Hohenberg-Kohn theorem requires the spin restricted and spin unrestricted calculations give exactly the same ground state energy and total density for the exact functionals, this large disparity in energy reflects the inadequacy of current functionals for describing the cuprates. This calls into question the use of band structures based on current restricted spin density functionals (including LDA) as a basis for single band theories of superconductivity in these materials.Comment: 13 pages, 8 figures, to appear in Phys. Rev. B, for more information see http://www.firstprinciples.co

On Duality in the Born-Infeld Theory

The $SL(2,R)$ duality symmetric action for the Born-Infeld theory in terms of two potentials, coupled with non-trivial backgroud fields in four dimensions is established. This construction is carried out in detail by analysing the hamiltonian structure of the Born-Infeld theory. The equivalence with the usual Born-Infeld theory is shown.Comment: revtex, 4 page

Inhibition of IL-34 Unveils Tissue-Selectivity and Is Sufficient to Reduce Microglial Proliferation in a Model of Chronic Neurodegeneration

The proliferation and activation of microglia, the resident macrophages in the brain, is a hallmark of many neurodegenerative diseases such as Alzheimer’s disease (AD) and prion disease. Colony stimulating factor 1 receptor (CSF1R) is critically involved in regulating microglial proliferation, and CSF1R blocking strategies have been recently used to modulate microglia in neurodegenerative diseases. However, CSF1R is broadly expressed by many cell types and the impact of its inhibition on the innate immune system is still unclear. CSF1R can be activated by two independent ligands, CSF-1 and interleukin 34 (IL-34). Recently, it has been reported that microglia development and maintenance depend on IL-34 signaling. In this study, we evaluate the inhibition of IL-34 as a novel strategy to reduce microglial proliferation in the ME7 model of prion disease. Selective inhibition of IL-34 showed no effects on peripheral macrophage populations in healthy mice, avoiding the side effects observed after CSF1R inhibition on the systemic compartment. However, we observed a reduction in microglial proliferation after IL-34 inhibition in prion-diseased mice, indicating that microglia could be more specifically targeted by reducing IL-34. Overall, our results highlight the challenges of targeting the CSF1R/IL34 axis in the systemic and central compartments, important for framing any therapeutic effort to tackle microglia/macrophage numbers during brain disease