Experimental use of nonhuman primates is not a simple problem.

To the Editor: The recent Nature Medicine editorial on the use of nonhuman primates in research1 presented some of the many sound scientific arguments for why such studies continue to be an essential component of medical research. The article also discussed some aspects of the ethical dilemma surrounding this work: such experiments may be scientifically justified, but is it 'right' that we do them? On this issue, the editorial concluded that "the solid scientific case that can be made to support the use of monkeys and apes in research must take precedence over ethical arguments until the latter can be settled for good." This position is somewhat unrealistic—the history of both this debate and many others in medical ethics tells us that such a resolution is unlikely. Even if a resolution is reached within the scientific community, it may be more difficult to achieve one amongst the wider public, who, after all, are the principal stakeholders. Furthermore, adopting such a position may give rise to a reality or at least a perception in which scientists are distanced from the ethical arguments. This is problematic, because the pivotal point for decisions over whether or not to use animals in research is a cost-benefit analysis, where the 'cost' is principally couched in terms of probable animal suffering. Ethical issues are therefore involved in decision making at every stage of the research process, from grant applications to local ethical review committees and specific experimental designs. Most importantly, as scientists, we must continue to have an active and vociferous presence in this debate. It is not that the scientific case should take precedence over 'unsettled' ethical arguments; rather, the scientific case must remain an inextricable part of the ongoing ethical debate

Dardinger v. Anthem Blue Cross & Blue Shield: Judicial Redistribution of Punitive Damage Awards

This Casenote examines the role of punitive damages in tort law and the actions of the Ohio Supreme Court in Dardinger v. Anthem Blue Cross & Blue Shield. The author begins by describing the anomalous nature of punitive damages, which are a form of punishment, being given to a plaintiff in a tort system that is compensatory in nature. The author then gives an overview of the punitive damages doctrine historically and as it exists today. Next, the author discusses the Dardinger case and analyzes the implications of the court\u27s decision to remit a portion of the punitive damages on condition that the award be given to a third party beneficiary. The analysis takes into consideration several important factors, including the separation of powers doctrine, the Eight Amendment, the Fifth Amendment, and possible undesirable consequences. The author concludes that the judiciary is the proper branch to distribute punitive damages to worthy third party beneficiaries so long as there are some restrictions to prevent judges from rewarding their own pet projects

Cultivation and anaerobic digestion of Scenedesmus spp. grown in a pilot-scale open raceway

Digestibility of a micro-algal mixture was evaluated by mesophilic anaerobic digestion in continuously-stirred tank reactors. The culture consisted primarily of Scenedesmus spp. continuously cultivated over a 6-month period in a 100 m2 raceway reactor instrumented to record pH, dissolved oxygen and temperature. The raceway received supplementary carbon in the form of flue gas from a diesel boiler (10% CO2) injected into a 1-m deep sump to control pH in the range 7.8–8.0. Dilution was optimised to biomass productivity and gave values of 10–15 and 20–25 g total suspended solids (TSS) m? 2 day? 1 in winter (December–February) and spring (April–May), respectively. The culture for the anaerobic digestion trial was harvested in February by centrifugation to give an algal paste containing 4.3% volatile solids (VS). Semi-continuous digestion at organic loading rates of 2.00, 2.75 and 3.50 g VS l? 1 day? 1 gave volumetric biogas productions of ~ 0.66, ~ 0.83 and ~ 0.99 l l? 1 day? 1, respectively. Specific methane yield ranged from 0.13 to 0.14 l CH4 g? 1 VSadded with biogas methane content ~ 62%. Overall the digestion process was stable, but only ~ 30% VS destruction was achieved indicating low biodegradability, due to the short retention times and the recalcitrant nature of this type of biomas

When Media Are New: Understanding the Dynamics of New Media Adoption and Use

The world of communication media has undergone massive changes since the mid-1980s. Along with the extraordinary progress in technological capability, it has experienced stunning decreases in costs; a revolutionary opening up of markets (a phenomenon exemplified by but not limited to the rise of the Internet); the advent of new business models; and a striking acceleration in the rate of change. These technological, regulatory, and economic changes have attracted the attention of a large number of researchers, from industry and academe, and given rise to a substantial body of research and data. Significantly less attention has been paid to the people who use new media—whose own rate of adoption and assimilation often lags notably behind the technologies themselves. When Media Are New addresses this research and publishing gap by investigating the human factors involved in technological change and their implications for current and future media. It will find a broad audience ranging from media and communication scholars to historians and organizational theorists to industry professionals

Benthic biomass size spectra in shelf and deep-sea sediments

The biomass distributions of marine benthic metazoans (meio- to macro-fauna, 1 ?g–32 mg wet weight) across three contrasting sites were investigated to test the hypothesis that allometry can consistently explain observed trends in biomass spectra. Biomass (and abundance) size spectra were determined from observations made at the Faroe–Shetland Channel (FSC) in the Northeast Atlantic (water depth 1600 m), the Fladen Ground (FG) in the North Sea (150 m), and the hypoxic Oman Margin (OM) in the Arabian Sea (500 m). Observed biomass increased with body size as a power law at FG (scaling exponent, b = 0.16) and FSC (b = 0.32), but less convincingly at OM (b = 0.12 but not significantly different from 0). A simple model was constructed to represent the same 16 metazoan size classes used for the observed spectra, all reliant on a common detrital food pool, and allowing the three key processes of ingestion, respiration and mortality to scale with body size. A micro-genetic algorithm was used to fit the model to observations at the sites. The model accurately reproduces the observed scaling without needing to include the effects of local influences such as hypoxia. Our results suggest that the size-scaling of mortality and ingestion are dominant factors determining the distribution of biomass across the meio- to macrofaunal size range in contrasting marine sediment communities. Both the observations and the model results are broadly in agreement with the "metabolic theory of ecology" in predicting a quarter power scaling of biomass across geometric body size classes

Gravitational radiation from monopoles connected by strings

Monopole-antimonopole pairs connected by strings can be formed as topological defects in a sequence of cosmological phase transitions. Such hybrid defects typically decay early in the history of the universe but can still generate an observable background of gravitational waves. We study the spectrum of gravitational radiation from these objects both analytically and numerically, concentrating on the simplest case of an oscillating pair connected by a straight string.Comment: 18 pages, RevTex and 2 postscript figures. Submitted to Phys. Rev.

Effective dose in medicine

The International Commission on Radiological Protection (ICRP) developed effective dose as a quantity related to risk for occupational and public exposure. There was a need for a similar dose quantity linked to risk for making everyday decisions relating to medical procedures. Coefficients were developed to enable the calculation of doses to organs and tissues, and effective doses for procedures in nuclear medicine and radiology during the 1980s and 1990s. Effective dose has provided a valuable tool that is now used in the establishment of guidelines for patient referral and justification of procedures, choice of appropriate imaging techniques, and providing dose data on potential exposure of volunteers for research studies, all of which require the benefits from the procedure to be weighed against the risks. However, the approximations made in the derivation of effective dose are often forgotten, and the uncertainties in calculations of risks are discussed. An ICRP report on protection dose quantities has been prepared that provides more information on the application of effective dose, and concludes that effective dose can be used as an approximate measure of possible risk. A discussion of the way in which it should be used is given here, with applications for which it is considered suitable. Approaches to the evaluation of risk and methods for conveying information on risk are also discussed

Operationalising factors that explain the emergence of infectious diseases : A case study of the human campylobacteriosis epidemic

Peer reviewedPublisher PD

Antibiotics Alter Pocillopora Coral-Symbiodiniaceae-Bacteria Interactions and Cause Microbial Dysbiosis During Heat Stress

Symbioses between eukaryotes and their associated microbial communities are fundamental processes that affect organisms’ ecology and evolution. A unique example of this is reef-building corals that maintain symbiotic associations with dinoflagellate algae (Symbiodiniaceae) and bacteria that affect coral health through various mechanisms. However, little is understood about how coral-associated bacteria communities affect holobiont heat tolerance. In this study, we investigated these interactions in four Pocillopora coral colonies belonging to three cryptic species by subjecting fragments to treatments with antibiotics intended to suppress the normal bacteria community, followed by acute heat stress. Separate treatments with only antibiotics or heat stress were conducted to compare the effects of individual stressors on holobiont transcriptome responses and microbiome shifts. Across all Pocillopora species examined, combined antibiotics and heat stress treatment significantly altered coral-associated bacteria communities and caused major changes in both coral and Cladocopium algal symbiont gene expression. Individually, heat stress impaired Pocillopora protein translation and activated DNA repair processes, while antibiotics treatments caused downregulation of Pocillopora amino acid and inorganic ion transport and metabolism genes and Cladocopium photosynthesis genes. Combined antibiotics-heat stress treatments caused synergistic effects on Pocillopora and Cladocopium gene expression including enhanced expression of oxidative stress response genes, programed cell death pathways and proteolytic enzymes that indicate an exacerbated response to heat stress following bacteria community suppression. Collectively, these results provide further evidence that corals and their Symbiodiniaceae and bacteria communities engage in highly coordinated metabolic interactions that are crucial for coral holobiont health, homeostasis, and heat tolerance