UNDERSTANDING THE SCALAR MESON qqˉq\bar q NONET

It is shown that one can fit the available data on the a0(980), f0(980), f0(1300) and K*0(1430) mesons as a distorted 0++ qq bar nonet using very few (5-6) parameters and an improved version of the unitarized quark model. This includes all light two-pseudoscalar thresholds, constraints from Adler zeroes, flavour symmetric couplings, unitarity and physically acceptable analyticity. The parameters include a bare uu bar or dd bar mass, an over-all coupling constant, a cutoff and a strange quark mass of 100 MeV, which is in accord with expectations from the quark model. It is found that in particular for the a0(980) and f0(980) the KK bar component in the wave function is large, i.e., for a large fraction of the time the qq bar state is transformed into a virtual KK bar pair. This KK bar component, together with a similar component of eta' pi for the a0(980) , and eta eta, eta eta' and eta' eta' components for the f0(980), causes the substantial shift to a lower mass than what is naively expected from the qq bar component alone. Mass, width and mixing parameters, including sheet and pole positions, of the four resonances are given, with a detailed pedagogical discussion of their meaning.Comment: 35 pages in plain latex (ZPC in press), 10 figures obtainable from the author ([email protected]) with regular mail or as a large PS fil

Silicon Drift Detector Readout Electronics for a Compton Camera

A prototype detector for Compton camera imaging is under development. A monolithic array of 19 channel Silicon drift detector with on-chip electronics is going to be used as a scatter detector for the prototype system. Custom designed analog and digital readout electronics for this detector was first tested by using a single cell Silicon drift detector. This paper describes the readout architecture and presents the results of the measurement.Comment: 10 pages, 9 figures, submitted to Nucl. Instr. Meth.

A Statistical Mechanical Problem in Schwarzschild Spacetime

We use Fermi coordinates to calculate the canonical partition function for an ideal gas in a circular geodesic orbit in Schwarzschild spacetime. To test the validity of the results we prove theorems for limiting cases. We recover the Newtonian gas law subject only to tidal forces in the Newtonian limit. Additionally we recover the special relativistic gas law as the radius of the orbit increases to infinity. We also discuss how the method can be extended to the non ideal gas case.Comment: Corrected an equation misprint, added four references, and brief comments on the system's center of mass and the thermodynamic limi

Modification of the ground state in Sm-Sr manganites by oxygen isotope substitution

The effect of $^{16}$O $\to$ $^{18}$O isotope substitution on electrical resistivity and magnetic susceptibility of Sm$_{1-x}$Sr$_x$MnO$_3$ manganites is analyzed. It is shown that the oxygen isotope substitution drastically affects the phase diagram at the crossover region between the ferromagnetic metal state and that of antiferromagnetic insulator (0.4 $< x <$ 0.6), and induces the metal-insulator transition at for $x$ = 0.475 and 0.5. The nature of antiferromagnetic insulator phase is discussed.Comment: 4 pages, 3 eps figures, RevTeX, submitted to Phys. Rev. Let

Simulation and validation of injection-compression filling stage of liquid moulding with fast curing resins

Very short manufacture cycle times are required if continuous carbon fibre and epoxy composite components are to be economically viable solutions for high volume composite production for the automotive industry. Here, a manufacturing process variant of resin transfer moulding (RTM), targets a reduction of in-mould manufacture time by reducing the time to inject and cure components. The process involves two stages; resin injection followed by compression. A flow simulation methodology using an RTM solver for the process has been developed. This paper compares the simulation prediction to experiments performed using industrial equipment. The issues encountered during the manufacturing are included in the simulation and their sensitivity to the process is explored

Retraction Notice of the Article: The DYRK-family kinase Pom1 phosphorylates the F-BAR protein Cdc15 to prevent division at cell poles

Division site positioning is critical for both symmetric and asymmetric cell divisions. In many organisms, positive and negative signals cooperate to position the contractile actin ring for cytokinesis. In rod-shaped fission yeast Schizosaccharomyces pombe cells, division at midcell is achieved through positive Mid1/anillin-dependent signaling emanating from the central nucleus and negative signals from the dual-specificity tyrosine phosphorylation-regulated kinase family kinase Pom1 at the cell poles. In this study, we show that Pom1 directly phosphorylates the F-BAR protein Cdc15, a central component of the cytokinetic ring. Pom1-dependent phosphorylation blocks Cdc15 binding to paxillin Pxl1 and C2 domain protein Fic1 and enhances Cdc15 dynamics. This promotes ring sliding from cell poles, which prevents septum assembly at the ends of cells with a displaced nucleus or lacking Mid1. Pom1 also slows down ring constriction. These results indicate that a strong negative signal from the Pom1 kinase at cell poles converts Cdc15 to its closed state, destabilizes the actomyosin ring, and thus promotes medial septation

Phytohemagglutinin-Induced Mitotic Index in Blood Lymphocytes: A Potential Biomarker for Breast Cancer Risk

Background Cell proliferation is associated with the pathogenesis of cancer because it provides opportunities for accumulating genetic mutations. However, biomarkers of cell proliferation in response to environmental stimuli have not been adequately explored for breast cancer risk. Methods In a case-control study of 200 breast cancer patients and 360 healthy controls, we investigated the association between phytohemagglutinin (PHA)-induced mitotic index in blood lymphocyte and breast cancer risk. Results Having high mitotic index (>3.19%) was associated with an increased risk of breast cancer, with adjusted odds ratios (95% confidence interval) of 1.54 (1.03–2.30) and 2.03 (1.18–3.57) for all women and post-menopausal women, respectively. Mitotic index was correlated with some reproductive factors and body mass index in controls. Conclusions Our data suggest increased PHA-induced mitotic index in blood lymphocytes is associated with an increased breast cancer risk and that this association may be modulated by reproductive and other hormones

Model thrombi formed under flow reveal the role of factor XIII-mediated cross-linking in resistance to fibrinolysis

Background: Activated factor XIII (FXIIIa), a transglutaminase, introduces fibrin-fibrin and fibrin-inhibitor cross-links, resulting in more mechanically stable clots. The impact of cross-linking on resistance to fibrinolysis has proved challenging to evaluate quantitatively. Methods: We used a whole blood model thrombus system to characterize the role of cross-linking in resistance to fibrinolytic degradation. Model thrombi, which mimic arterial thrombi formed in vivo, were prepared with incorporated fluorescently labeled fibrinogen, in order to allow quantification of fibrinolysis as released fluorescence units per minute. Results: A site-specific inhibitor of transglutaminases, added to blood from normal donors, yielded model thrombi that lysed more easily, either spontaneously or by plasminogen activators. This was observed both in the cell/platelet-rich head and fibrin-rich tail. Model thrombi from an FXIII-deficient patient lysed more quickly than normal thrombi; replacement therapy with FXIII concentrate normalized lysis. In vitro addition of purified FXIII to the patient's preprophylaxis blood, but not to normal control blood, resulted in more stable thrombi, indicating no further efficacy of supraphysiologic FXIII. However, addition of tissue transglutaminase, which is synthesized by endothelial cells, generated thrombi that were more resistant to fibrinolysis; this may stabilize mural thrombi in vivo. Conclusions: Model thrombi formed under flow, even those prepared as plasma 'thrombi', reveal the effect of FXIII on fibrinolysis. Although very low levels of FXIII are known to produce mechanical clot stability, and to achieve ?-dimerization, they appear to be suboptimal in conferring full resistance to fibrinolysis

Experimental Control and Characterization of Autophagy in Drosophila

Insects such as the fruit fly Drosophila melanogaster, which fundamentally reorganize their body plan during metamorphosis, make extensive use of autophagy for their normal development and physiology. In the fruit fly, the hepatic/adipose organ known as the fat body accumulates nutrient stores during the larval feeding stage. Upon entering metamorphosis, as well as in response to starvation, these nutrients are mobilized through a massive induction of autophagy, providing support to other tissues and organs during periods of nutrient deprivation. High levels of autophagy are also observed in larval tissues destined for elimination, such as the salivary glands and larval gut. Drosophila is emerging as an important system for studying the functions and regulation of autophagy in an in vivo setting. In this chapter we describe reagents and methods for monitoring autophagy in Drosophila, focusing on the larval fat body. We also describe methods for experimentally activating and inhibiting autophagy in this system and discuss the potential for genetic analysis in Drosophila to identify novel genes involved in autophagy

On the consistency of de Sitter vacua

In this paper the consistency of the de Sitter invariant $\alpha$-vacua, which have been introduced as simple tools to study the effects of transplanckian physics, is investigated. In particular possible non renormalization problems are discussed, as well as non standard properties of Greens functions. We also discuss the non thermal properties of the $\alpha$-vacua and the necessity of $\alpha$ to change. The conclusion is that non of these problems necessarily exclude an application of the $\alpha$-vacua to inflation.Comment: 12 pages, v2: minor clarifications and corrections to reference