Are We Insane? The Quest for Proportionality in the Discovery Rules of the Federal Rules of Civil Procedure

Atrial fibrillation is a common heart arrhythmia which is characterized by a missing or irregular contraction of the atria. The disease is a risk factor for other more serious diseases and the total medical costs in society are extensive. Therefore it would be beneficial to improve and optimize the prevention and detection of the disease.   Pulse palpation and heart auscultation can facilitate the detection of atrial fibrillation clinically, but the diagnosis is generally confirmed by an ECG examination. Today there are several algorithms that detect atrial fibrillation by analysing an ECG. A common method is to study the heart rate variability (HRV) and by different types of statistical calculations find episodes of atrial fibrillation which deviates from normal sinus rhythm.   Two algorithms for detection of atrial fibrillation have been evaluated in Matlab. One is based on the coefficient of variation and the other uses a logistic regression model. Training and testing of the algorithms were done with data from the Physionet MIT database. Several steps of signal processing were used to remove different types of noise and artefacts before the data could be used.   When testing the algorithms, the CV algorithm performed with a sensitivity of 91,38%, a specificity of 93,93% and accuracy of 92,92%, and the results of the logistic regression algorithm was a sensitivity of 97,23%, specificity of 93,79% and accuracy of 95,39%. The logistic regression algorithm performed better and was chosen for implementation in Java, where it achieved a sensitivity of 97,31%, specificity of 93,47% and accuracy of 95,25%.Förmaksflimmer är en vanlig hjärtrytmrubbning som kännetecknas av en avsaknad eller oregelbunden kontraktion av förmaken. Sjukdomen är en riskfaktor för andra allvarligare sjukdomar och de totala kostnaderna för samhället är betydande. Det skulle därför vara fördelaktigt att effektivisera och förbättra prevention samt diagnostisering av förmaksflimmer.   Kliniskt diagnostiseras förmaksflimmer med hjälp av till exempel pulspalpation och auskultation av hjärtat, men diagnosen brukar fastställas med en EKG-undersökning. Det finns idag flertalet algoritmer för att detektera arytmin genom att analysera ett EKG. En av de vanligaste metoderna är att undersöka variabiliteten av hjärtrytmen (HRV) och utföra olika sorters statistiska beräkningar som kan upptäcka episoder av förmaksflimmer som avviker från en normal sinusrytm.   I detta projekt har två metoder för att detektera förmaksflimmer utvärderats i Matlab, en baseras på beräkningar av variationskoefficienten och den andra använder sig av logistisk regression. EKG som kommer från databasen Physionet MIT används för att träna och testa modeller av algoritmerna. Innan EKG-signalen kan användas måste den behandlas för att ta bort olika typer av brus och artefakter.   Vid test av algoritmen med variationskoefficienten blev resultatet en sensitivitet på 91,38%, en specificitet på 93,93% och en noggrannhet på 92,92%. För logistisk regression blev sensitiviteten 97,23%, specificiteten 93,79% och noggrannheten 95,39%. Algoritmen med logistisk regression presterade bättre och valdes därför för att implementeras i Java, där uppnåddes en sensitivitet på 91,31%, en specificitet på 93,47% och en noggrannhet på 95,25%

Bioinformatics service reconciliation by heterogeneous schema transformation

This paper focuses on the problem of bioinformatics service reconciliation in a generic and scalable manner so as to enhance interoperability in a highly evolving field. Using XML as a common representation format, but also supporting existing flat-file representation formats, we propose an approach for the scalable semi-automatic reconciliation of services, possibly invoked from within a scientific workflows tool. Service reconciliation may use the AutoMed heterogeneous data integration system as an intermediary service, or may use AutoMed to produce services that mediate between services. We discuss the application of our approach for the reconciliation of services in an example bioinformatics workflow. The main contribution of this research is an architecture for the scalable reconciliation of bioinformatics services

Experimental Verification of the Number Relation at Room and Elevated Temperatures

The accuracy of the Neuber equation for predicting notch root stress-strain behavior at room temperature and at 650 C was experimentally investigated. Strains on notched specimens were measured with a non-contacting, interferometric technique and stresses were simulated with smooth specimens. Predictions of notch root stress-strain response were made from the Neuber Equation and smooth specimen behavior. Neuber predictions gave very accurate results at room temperature. However, the predicted interaction of creep and stress relaxation differed from experimentally measured behavior at 650 C

The roundtable: an abstract model of conversation dynamics

Is it possible to abstract a formal mechanism originating schisms and governing the size evolution of social conversations? In this work a constructive solution to such problem is proposed: an abstract model of a generic N-party turn-taking conversation. The model develops from simple yet realistic assumptions derived from experimental evidence, abstracts from conversation content and semantics while including topological information, and is driven by stochastic dynamics. We find that a single mechanism - namely the dynamics of conversational party's individual fitness, as related to conversation size - controls the development of the self-organized schisming phenomenon. Potential generalizations of the model - including individual traits and preferences, memory effects and more elaborated conversational topologies - may find important applications also in other fields of research, where dynamically-interacting and networked agents play a fundamental role.Comment: 18 pages, 4 figures, to be published in Journal of Artificial Societies and Social Simulatio

The Roundtable: An Abstract Model of Conversation Dynamics

Is it possible to abstract a formal mechanism originating schisms and governing the size evolution of social conversations? In this work we propose a constructive solution to this problem: an abstract model of a generic N-party turn-taking conversation. The model develops from simple yet realistic assumptions derived from experimental evidence, abstracts from conversation content and semantics while including topological information, and is driven by stochastic dynamics. We find that a single mechanism, namely the dynamics of conversational party\'s individual fitness as related to conversation size, controls the development of the self-organized schisming phenomenon. Potential generalizations of the model - including individual traits and preferences, memory effects and more elaborated conversational topologies - may find important applications also in other fields of research, where dynamically-interacting and networked agents play a fundamental role.ABM, Complexity, Turn-Taking Dynamics, Schism, Stochastic Dynamics