6,802 research outputs found
The Real Constitutional Problem with State Judicial Selection: Due Process, Judicial Retention, and the Dangers of Popular Constitutionalism
In Caperton v. A.T. Massey Coal Co., decided in 2009, the Supreme Court held for the first time that conduct related to a judicial election campaign violated a litigantâs right to procedural due process because the opposing litigant had contributed an inordinate amount of money to the campaign of one of the justices ruling on the case. The due process danger recognized in Caperton rests on a fear of retrospective gratitudeâthat is, the fear that the Justice would decide his contributorâs case differently because he was grateful for the litigantâs generous support. The Courtâs focus on retrospective gratitude is simultaneously overinclusive and underinclusive. It is overinclusive because it proves far too much: all judgesâeven federal judges protected by Article IIIâowe their selection to someone, whether it is a president or a senator, and that has never been deemed to threaten their independence. Yet the due process rule that derives from the decision is also underinclusive, because it makes no reference to the real due process danger of state court elections. This Article argues that the key constitutional problem with the selection of state court judges is for the most part not the initial selection process, but rather the use of majoritarian processes (either retention elections or gubernatorial appointment) to determine judicial retention. It is in this context that all of the constitutional concerns about judicial independence converge because this is the context in which the very real threat to decisional independence arises. A judgeâs fears that deciding a particular case in a particular manner could threaten her continued employment could easily skew the decision from a neutral decision grounded in the judgeâs independent assessment of the facts and law. This Article argues that life tenure, or, at the very least, some form of formal term limit is required by the Due Process Clause to assure constitutionally required judicial independence. As radical as this recommendation may be, we argue that there is no other way to assure the appearance or reality of fairness, both of which lie at the core of the due process guarantee
Userâs Guide to C2R: A Set of C Language Output Routines Compatible with the R Statistics Language
C2R is a collection of C routines for saving complex data structures into a file that can be read in the R statistics environment with a single command.1 C2R provides both the means to transfer data structures significantly more complex than simple tables, and an archive mechanism
to store data for future reference.
We developed this software because we write and run computationally intensive numerical models in Fortran, C++, and AD Model Builder. We then analyse results with R. We desired to automate data transfer to speed diagnostics during working-group meetings.
We thus developed the C2R interface to write an R data object (of type list) to a plain-text file. The master list can contain any number of matrices, values, dataframes, vectors or lists, all of which can be read into R with a single call to the dget function. This allows easy transfer
of structured data from compiled models to R.
Having the capacity to transfer model data, metadata, and results has sharply reduced the time spent on diagnostics, and at the same time, our diagnostic capabilities have improved tremendously. The simplicity of this interface and the capabilities of R have enabled us to automate graph and table creation for formal reports. Finally, the persistent storage in files makes it easier to treat model results in analyses or meta-analyses devised monthsâor even yearsâlater.
We offer C2R to others in the hope that they will find it useful. (PDF contains 27 pages
Daily Sleep Quality is Associated with Daily Cognition in Late-Life
Background: Older adults often face sleep disturbance or cognitive decline that goes beyond the scope of normal aging. The present study examined the relationship between self-reported sleep quality and self-reported daytime attention in a community-dwelling sample of older men at the between-persons and within-persons levels of association.
Methods: Thirty-eight participants (M age =75.36 years, SD age =7.51 years, range=66-90 years) completed a twice-daily sleep diary for one week. Sleep quality and attention were assessed using a single-item 0-10 rating scales from the morning diary (âHow was the quality of your sleep last night?â) and from the evening diary (âHow was your attention today?â). A two-level multilevel model was parameterized with days nested within individuals to examine whether nightly sleep quality predicts an individualâs daily attention rating.
Results: A multilevel model predicting self-reported attention revealed (1) older individuals who reported better sleep quality reported having better daily attention [Beta=0.64, t(248.15)=10.12, p\u3c0.001] and (2) following a day of above-average sleep quality, older individuals experienced above-average attention [Beta=0.16, t(259.79)=2.75, p=.006].
Conclusion: Not only was overall sleep quality associated with self-reported attention, but a good night\u27s sleep was associated with better self-reported next-day attention. Results point to the potential importance of fluctuations in sleep quality for daytime functioning. Interventions aimed at improving nightly sleep consistency may be worth exploring as methods to improve daytime cognitive functioning in older adults.
Support: This work was supported by the Sleep Research Society Foundation/Jazz Pharmaceuticals (001JP13, PI: Dzierzewski) and by the National Institute on Aging of the National Institutes of Health under Award Number K23AG049955 (PI: Dzierzewski), and National Heart Lung and Blood Institute at the National Institutes of Health under award number K24HL143055 (PI: Martin). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the Department of Veterans Affairs.https://scholarscompass.vcu.edu/gradposters/1089/thumbnail.jp
Userâs Guide to For2R: A Module of Fortran 95 Output Routines Compatible with the R Statistics Language
For2R is a collection of Fortran routines for saving complex data structures into a file that can be read in the R statistics environment with a single command.1 For2R provides both the means to transfer data structures significantly more complex than simple tables, and an
archive mechanism to store data for future reference.
We developed this software because we write and run computationally intensive numerical models in Fortran, C++, and AD Model Builder. We then analyse results with R. We desired to automate data transfer to speed diagnostics during working-group meetings.
We thus developed the For2R interface to write an R data object (of type list) to a plain-text file. The master list can contain any number of matrices, values, dataframes, vectors or lists,
all of which can be read into R with a single call to the dget function. This allows easy transfer of structured data from compiled models to R.
Having the capacity to transfer model data, metadata, and results has sharply reduced the time spent on diagnostics, and at the same time, our diagnostic capabilities have improved tremendously. The simplicity of this interface and the capabilities of R have enabled us to automate graph and table creation for formal reports. Finally, the persistent storage in files makes it easier to treat model results in analyses or meta-analyses devised monthsâor even
yearsâlater.
We offer For2R to others in the hope that they will find it useful. (PDF contains 31 pages
Pharmacokinetics in neonatal prescribing: evidence base, paradigms and the future
Paediatric patients, particularly preterm neonates, present many pharmacological challenges. Due to the difficulty in conducting clinical trials in these populations dosing information is often extrapolated from adult populations. As the processes of absorption, distribution, metabolism and excretion of drugs change throughout growth and development extrapolation presents risk of over or underestimating the doses required. Information about the development these processes, particularly drug metabolism pathways, is still limited with weight based dose adjustment presenting the best method of estimating pharmacokinetic changes due to growth and development. New innovations in pharmacokinetic research, such as population pharmacokinetic modelling, present unique opportunities to conduct clinical trials in these populations improving the safety and effectiveness of the drugs used. More research is required into this area to ensure the best outcomes for our most vulnerable patients
The Star-Forming Dwarf Galaxy Populations of two z ~ 0.4 Clusters: MS1512.4+3647 and Abell 851
We present the results of a deep narrow-band [OII] 3727 \AA emission-line
search for faint ( 27), star-forming galaxies in the field of the
MS1512.4+3647 cluster. We find no evidence for an over-density of emission-line
sources relative to the field at 0.4 (Hogg et al. 1998), and therefore
conclude that the MS1512.4+3647 sample is dominated by field [OII]
emission-line galaxies which lie along the 180 Mpc line of sight
immediately in front and behind the cluster. This is surprising, given that the
previously surveyed cluster Abell 851 has 3-4 times the field
emission-line galaxy density (Martin et al. 2000). We find that the
MS1512.4+3647 sample is deficient in galaxies with intermediate colors (1.0 2.0) and implied star-formation exponential decay timescales
100 Myr - 1 Gyr that dominate the Abell 851 emission-line galaxy population.
Instead, the majority of [OII] emission-line galaxies surrounding the
MS1512.4+3647 cluster are blue () and forming stars in bursts
with 100 Myr. In both samples, galaxies with the shortest
star-formation timescales are preferentially among the faintest star-forming
objects. Their i luminosities are consistent with young stellar populations
\sim 10^8 - 10^9 \Msun, although an additional factor of ten in stellar mass
could be hiding in underlying old stellar populations. We discuss the
implications for the star-formation histories of dwarf galaxies in the field
and rich clusters.Comment: 26 pages, including 5 tables and 13 figures; accepted for publication
in the Astrophysical Journa
Effects of Sound Symbolism in Names on Personality Perception
We investigated effects of sound symbolism in names on personality perception. Participants were randomly assigned to a group that either had invented or non-invented round or sharp names. They were asked to fill out a BFI-10 and a BSRI-12 questionnaire for five different names followed by reading 10 descriptions of personality traits and circling either a round name or a sharp name that fit the description best. Results showed that sound type present in names affected perceptions of Extraversion and that name and sound type affected perceptions of Femininity. These results provide evidence of sound symbolic associations present in names
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Author Correction: Clustering and climate associations of Kawasaki Disease in San Diego County suggest environmental triggers.
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper
A fully automated procedure for the parallel, multidimensional purification and nucleotide loading of the human GTPases KRas, Rac1 and RalB
Small GTPases regulate many key cellular processes and their role in human disease validates many proteins in this class as desirable targets for therapeutic intervention. Reliable recombinant production of GTPases, often in the active GTP loaded state, is a prerequisite for the prosecution of drug discovery efforts. The preparation of these active forms can be complex and often constricts the supply to the reagent intensive techniques used in structure base drug discovery. We have established a fully automated, multidimensional protein purification strategy for the parallel production of the catalytic G-domains of KRas, Rac1 and RalB GTPases in the active form. This method incorporates a four step chromatography purification with TEV protease-mediated affinity tag cleavage and a conditioning step that achieves the activation of the GTPase by exchanging GDP for the non-hydrolyzable GTP analogue GMPPnP. We also demonstrate that an automated method is efficient at loading of KRas with mantGDP for application in a SOS1 catalysed fluorescent nucleotide exchange assay. In comparison to more conventional manual workflows the automated method offers marked advantages in method run time and operator workload. This reduces the bottleneck in protein production while generating products that are highly purified and effectively loaded with nucleotide analogues
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