The legacy of nineteenth-century replicas for object cultural biographies : lessons in duplication from 1830s Fife

Peer reviewedPostprin

Fast recognition of alternating groups of unknown degree

We present a constructive recognition algorithm to decide whether a given black-box group is isomorphic to an alternating or a symmetric group without prior knowledge of the degree. This eliminates the major gap in known algorithms, as they require the degree as additional input. Our methods are probabilistic and rely on results about proportions of elements with certain properties in alternating and symmetric groups. These results are of independent interest; for instance, we establish a lower bound for the proportion of involutions with small support.Comment: 31 pages, submitted to Journal of Algebr

Physicians’ Perceptions of Facilitators and Barriers in Electronic Health Record Education

A significant focus in health care is quality documentation to lower patient safety risks. The local problem at a healthcare organization in the northeastern United States is that some physicians are falling short with quality documentation of patient care in athenaNet, a cloud-based electronic health record (EHR). This qualitative case study was conducted to explore physicians\u27 perceptions of the facilitators and barriers that impact the educational process for quality documentation in EHRs. Attention also focused on identifying physicians\u27 recommendations for enhancing the educational process for quality documentation. Knowles’ adult learning theory served as the conceptual framework. Purposeful sampling was used to select participants who had a minimum of 5 years’ experience as a physician and had worked with multiple EHRs in the past. Individual interviews with 11 physicians were supplemented with review of documents in athenaNet on milestones in physician documentation. Data analysis included coding of interview transcripts and information from documents to identify common themes: (a) preparation for implementation, (b) specialty-specific training, (c) hands-on practice, (d) time limitations on completing training, (e) preparedness for EHR go-live, and (f) additional training resources. Findings of the study were used to develop a white paper to increase the quality of the documentation entered into an EHR, and to lower patient safety risks through more effective continuing education. The study contributes to positive social change through modifications to the current training methodology for the EHR as a solution to assisting physicians to complete quality documentation

The Kinematics of CIV in Star-Forming Galaxies at z~1.2

We present the first statistical sample of rest-frame far-UV spectra of star-forming galaxies at z~1. These spectra are unique in that they cover the high-ionization CIV{\lambda}{\lambda}1548, 1550 doublet. We also detect low-ionization features such as SiII{\lambda}1527, FeII{\lambda}1608, AlII{\lambda}1670, NiII{\lambda}{\lambda}1741, 1751 and SiII{\lambda}1808, and intermediate-ionization features from AlIII{\lambda}{\lambda}1854, 1862. Comparing the properties of absorption lines of lower- and higher- ionization states provides a window into the multi-phase nature of circumgalactic gas. Our sample is drawn from the DEEP2 survey and spans the redshift range 1.01 < z < 1.35 ( = 1.25). By isolating the interstellar CIV absorption from the stellar P-Cygni wind profile we find that 69% of the CIV profiles are blueshifted with respect to the systemic velocity. Furthermore, CIV shows a small but significant blueshift relative to FeII (offset of the best-fit linear regression -76 $\pm$ 26 km/s). At the same time, the CIV blueshift is on average comparable to that of MgII{\lambda}{\lambda}2796, 2803. At this point, in explaining the larger blueshift of CIV absorption at the ~ 3-sigma level, we cannot distinguish between the faster motion of highly-ionized gas relative to gas traced by FeII, and filling in on the red side from resonant CIV emission. We investigate how far-UV interstellar absorption kinematics correlate with other galaxy properties using stacked spectra. These stacking results show a direct link between CIV absorption and the current SFR, though we only observe small velocity differences among different ionization states tracing the outflowing ISM.Comment: 21 pages, 14 figures, ApJ, accepte

All Great and Precious Things

Includes: The Girls in the Photographs; The Woman with the Scar; The Walking Joke; HitchedBachelor of Art

Connexin communication compartments and wound repair in epithelial tissue

Epithelial tissues line the lumen of tracts and ducts connecting to the external environment. They are critical in forming an interface between the internal and external environment and, following assault from environmental factors and pathogens, they must rapidly repair to maintain cellular homeostasis. These tissue networks, that range from a single cell layer, such as in airway epithelium, to highly stratified and differentiated epithelial surfaces, such as the epidermis, are held together by a junctional nexus of proteins including adherens, tight and gap junctions, often forming unique and localised communication compartments activated for localised tissue repair. This review focuses on the dynamic changes that occur in connexins, the constituent proteins of the intercellular gap junction channel, during wound-healing processes and in localised inflammation, with an emphasis on the lung and skin. Current developments in targeting connexins as corrective therapies to improve wound closure and resolve localised inflammation are also discussed. Finally, we consider the emergence of the zebrafish as a concerted whole-animal model to study, visualise and track the events of wound repair and regeneration in real-time living model systems

Addressing the challenges of modeling the scattering from bottlebrush polymers in solution

Small‐angle scattering measurements of complex macromolecules in solution are used to establish relationships between chemical structure and conformational properties. Interpretation of the scattering data requires an inverse approach where a model is chosen and the simulated scattering intensity from that model is iterated to match the experimental scattering intensity. This raises challenges in the case where the model is an imperfect approximation of the underlying structure, or where there are significant correlations between model parameters. We examine three bottlebrush polymers (consisting of polynorbornene backbone and polystyrene side chains) in a good solvent using a model commonly applied to this class of polymers: the flexible cylinder model. Applying a series of constrained Monte‐Carlo Markov Chain analyses demonstrates the severity of the correlations between key parameters and the presence of multiple close minima in the goodness of fit space. We demonstrate that a shape‐agnostic model can fit the scattering with significantly reduced parameter correlations and less potential for complex, multimodal parameter spaces. We provide recommendations to improve the analysis of complex macromolecules in solution, highlighting the value of Bayesian methods. This approach provides richer information for understanding parameter sensitivity compared to methods which produce a single, best fit