Multiage Classrooms: A New Way to Learn Math

Recent research supports Vygotsky\u27s zone of proximal development theory; children receiving peer assistance can stretch their learning beyond their individual accomplishment. A study of a multiage classroom revealed three strategies used by children working together to solve math problems--modeling, tutoring, and pairing/sharing activities. The multiage setting invites collaboration and sharing, while helping students meet mathematics learning standards. (MLH

The Iowa Homemaker vol.37, no.3

What Does a Dean Do?, Dean Helen LeBaron, page 5 Concerning Friendship, Noel BreDahl, page 6 If I Were a Freshman, Orma Herman, page 7 Look Where You’re Going, Martha Glenn, page 8 The New Core, Martha Glenn, page 9 Joe Jalope, the Car Without a Friend, Carole Boughton, page 9 Testing and Tasting, Rosalyn McBride, page 10 Young Iowans Face the Future, Sandra Schnur, page 12 I Hated Physics, Diane Rasmussen, page 13 We Present with Pride, Martha Burleigh, page 16 Follow the Dotted Line, Marilyn Jones, page 2

Estudio de la lengua popular utilizada por los hablantes del municipio de Niquinohomo y San Juan de Oriente, Masaya, durante el periodo 2015-2016

La presente investigación se generó a partir de la necesidad de contribuir a los estudios sobre la caracterización léxico-semántica del español, específicamente describe la lengua popular utilizada por los hablantes de Niquinohomo y San Juan de Oriente, pertenecientes al departamento de Masaya, Nicaragua. Para el cumplimiento de este objetivo se hace referencia a los estudios relacionadas con el tema en los que se refleja la variedad e innovación del habla. Con esta investigación se afirma que a pesar que varias personas pertenezcan a la misma ciudad, siempre habrá diferencias en la utilización del idioma. En la forma particular de expresarse, intervienen factores lingüísticos y extralingüísticos que colaboran a dicha variedad, es por esto que este estudio enfoca el análisis de algunas variables sociales como el nivel de instrucción escolar, la edad y el sexo. También se presenta un sustento teórico que sirvió para analizar y conceptualizar todos aquellos aspectos que se consideran válidos para el fortalecimiento del tema, a su vez se aplicaron entrevistas que fueron transcritas según etiquetas establecidas por PREESEA (Proyecto para el estudio sociolingüístico del español de España y América) y se identificaron lemas y locuciones a nivel de lengua popular. Se utilizaron procedimientos y métodos que contribuyeron a una mejor recopilación de datos, comprobándose así los objetivos propuestos. En los métodos generales se utilizaron el análisis, síntesis, comparativo, gramatical, sintáctico y semántico, la técnica de recopilación de la información fue la entrevista y el instrumento la descripción y aplicación, además de las técnicas de análisis de la información, siendo estas la comparación, contrastación y triangulación. Se elaboraron dos glosarios, uno por cada municipio, el de Niquinohomo está conformado por diecisiete y San Juan de Oriente con diez lemas y locuciones, dentro de las informaciones que contienen los artículos lexicográficos están: Información gramatical, información cronológica, información pragmática, información de locuciones, registros específicos, valoración social, estratificación social y estilo lingüística. A partir de todas las indagaciones realizadas en el transcurso de este análisis y de los datos obtenidos con su interpretación cualitativa y cuantitativa, se recogieron veintisiete lemas y locuciones, se afirma que la lengua coloquial y popular es una misma, se contrastó un municipio con el otro, identificando los campos semánticos que tienen en comú

Accuracy of intra-operative PTH measurement during subtotal parathyroidectomy for tertiary hyperparathyroidism after renal transplantation

Background and aims: Intra-operative parathyroid hormone (IOPTH) results are not known in the setting of tertiary hyperparathyroidism (HPT) after renal transplantation. Materials and methods: A retrospective analysis of 35 tertiary HPT patients who all underwent subtotal parathyroidectomy and IOPTH monitoring was conducted. Results: The mean follow-up time was 2.2±1.4years. Thirty-four patients were cured; one patient (2.8%) had a persistent disease and was cured after reoperation. Median parathyroid hormone (PTH) (median percent decrease from highest) at baseline and at 5, 10, 20, and 30min were 244, 78 (69%), 63 (75%), 53 (79%), and 49pg/ml (83%), respectively. Four patients who were cured had a decrease of 50% at 10min. The sensitivity of the test was 94% at 10min using the Miami criteria. Conclusion: This study shows that IOPTH in tertiary hyperparathyroidism has a high sensitivity. However, because of the low risk of persistent hyperparathyroidism when a subtotal parathyroidectomy is performed, its potential impact on the overall success rate is very small. We therefore do not recommend the routine use of IOPTH in tertiary hyperparathyroidis

Quality Control of Herbal Medicines with Spectrophotometry and Chemometric Techniques - Application to Baccharis L. Species Belonging to Sect - Caulopterae DC. (Asteraceae)

Medicinal plants constitute a rich cultural and biological heritage in many countries, which could be very useful in meeting the therapeutic needs of the population (Rodriguez, 2010a). Traditional herbal medicines have been widely used for many years in many eastern countries (Liang et al., 2004). However, little work has been done to validate and standardize these products properly in order to match phytotherapy to chemotherapy which currently receives almost unconditional support from formal systems of health care. For several years now activities have been undertaken to systematize the identification, validation, production and use of medicinal plants, for both primary health care as well as a semi-industrial or industrial process, which implies their transformation into safe, reliable and stable phytopharmaceutical products. Therefore it is suggested that medicinal plants and their derived products would be a viable option for national development as an agricultural and therapeutic alternative, but standardization and industrialization, involving sustained yields, a quality control system and honest and reliable marketing would be needed for widespread implementation and official support. Consequently, on account of the above, education and research should be in agreement if any advance is to be made in this area (Rodriguez, 2010a). However, the necessary criteria for data quality, safety and efficacy of traditional medicine that would support its use in the world do not exist. Appropriate, accepted research methodology for evaluating traditional medicine is also lacking (Liang et al., 2004).Fil: Rodriguez, María Victoria. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; ArgentinaFil: Martínez, María Laura. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Cortadi, Adriana Amalia. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Campagna, Maria Noel. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Di Sapio, Osvaldo Antonio. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Derita, Marcos Gabriel. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; ArgentinaFil: Zacchino, Susana Alicia Stella. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; ArgentinaFil: Gattuso, Martha Ana. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentin

Sustained Expression with Partial Correction of Neutrophil Defects 5 Years After Intramuscular rAAV1 Gene Therapy for Alpha-1 Antitrypsin Deficiency

Alpha-1 antitrypsin (AAT) deficiency is a common monogenic disorder resulting in emphysema, which is currently treated with weekly infusions of protein replacement. We previously reported achieving plasma wild-type (M) AAT concentrations at 2.5-3.8% of the therapeutic level at 1 year after intramuscular (IM) administration of 6×1012vg/kg of a recombinant adeno-associated virus serotype 1 (rAAV1)-AAT vector in AAT-deficient patients, with an associated regulatory T cell (Treg) response to AAV1 capsid epitopes in the absence of any exogenous immune suppression. Here, we report sustained expression at greater than 2% of the therapeutic level for 5 years after one-time treatment with rAAV1-AAT in an AAT-deficient patient from that study, with partial correction of neutrophil defects previously reported in AAT-deficient patients. There was also evidence of an active Treg response (FoxP3+, Helios+) and an exhausted cytotoxic T cell response (PD-1+, LAG-3+) to AAV1 capsid. These findings suggest that muscle-based AAT gene replacement is toleragenic and that very stable levels of M AAT may exert beneficial effects at lower concentrations than previously anticipated

Witness: The Modern Writer as Witness

Editor\u27s Note [Excerpt] The United States, as a society, is on the brink of profound and positive change. Demographically and culturally, things are improving, and the reason is obvious to people who study history: Conflict pushes us to be better, to strive for principled goals. Consider the inspired eco-advocacy of Greta Thunberg. Or the swearing in of most diverse class of lawmakers in history into the 116th Congress. Or billionaire Robert F. Smith’s pledge to pay off every Morehouse College (in Atlanta, Georgia) student’s debt. Indeed, there are many good people helping and great moments happening in spite of a bleak 24-hour news cycle designed to ruin happiness and to limit our understanding of our human potential. We at Witness see this yearning for transformation in the works we selected. The doorway must be crossed, and the voices and characters we featured in our Winter 2019 issue stand at the vestibule, ready for the light to warm them, primed to fight for that necessary illumination.https://digitalscholarship.unlv.edu/witness/1000/thumbnail.jp

Biological activities of Castela coccinea Griseb. extracts

Infusions of leaf and bark of Castela coccinea Griseb. (Simaroubaceae) were traditionally used against dysentery. In this work, anti-bacterial and antioxidant activity were studied in C. coccinea extracts. The higest DPPH scavenging activity was detected in ethanolic leaf extracts with an IC50= 0.015 mg/ml. Bark ethanolic extracts showed inhibition of lipoperoxidation and free radical scavenging. However, a previous work evidenced that this extract is toxic at a concentration needed to show antioxidant activity. It might be consider that wood could be used instead of bark extract as the first one showing higher scavenging activity (Wood 55 %, Bark 33 % of DPPH scavenging) and good inhibition of lipoperoxidation. It is a very interesting fact the high tannin and mucilage content, which are localized particularly in leaves. The high antioxidant activity and abundant mucilage and tannin contents could justify, at least in part, its popular use.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Looking beyond the exome: a phenotype-first approach to molecular diagnostic resolution in rare and undiagnosed diseases.

PurposeTo describe examples of missed pathogenic variants on whole-exome sequencing (WES) and the importance of deep phenotyping for further diagnostic testing.MethodsGuided by phenotypic information, three children with negative WES underwent targeted single-gene testing.ResultsIndividual 1 had a clinical diagnosis consistent with infantile systemic hyalinosis, although WES and a next-generation sequencing (NGS)-based ANTXR2 test were negative. Sanger sequencing of ANTXR2 revealed a homozygous single base pair insertion, previously missed by the WES variant caller software. Individual 2 had neurodevelopmental regression and cerebellar atrophy, with no diagnosis on WES. New clinical findings prompted Sanger sequencing and copy number testing of PLA2G6. A novel homozygous deletion of the noncoding exon 1 (not included in the WES capture kit) was detected, with extension into the promoter, confirming the clinical suspicion of infantile neuroaxonal dystrophy. Individual 3 had progressive ataxia, spasticity, and magnetic resonance image changes of vanishing white matter leukoencephalopathy. An NGS leukodystrophy gene panel and WES showed a heterozygous pathogenic variant in EIF2B5; no deletions/duplications were detected. Sanger sequencing of EIF2B5 showed a frameshift indel, probably missed owing to failure of alignment.ConclusionThese cases illustrate potential pitfalls of WES/NGS testing and the importance of phenotype-guided molecular testing in yielding diagnoses