Weighted inequalities and vector-valued Calderón-Zygmund operators on non-homogeneous spaces

Recently, F. Nazarov, S. Treil and A. Volberg (and independently X. Tolsa) have extended the classical theory of Calderón-Zygmund operators to the context of a "non-homogeneous" space (X, d, µ), where, in particular, the measure µ may be non-doubling. In the present work we study weighted inequalities for these operators. Specifically, for 1 < p < [infinity], we identify sufficient conditions for the weight on one side, which guarantee the existence of another weight in the other side, so that the weighted Lp inequality holds. We deal with this problem by developing a vector-valued theory for Calderón-Zygmund operators on non-homogeneous spaces which is interesting in its own right. For the case of the Cauchy integral operator, which is the most important example, we even prove that the conditions for the weights are also necessary

Comprehensive study of Leon-Queretaro area

There are no author-identified significant results in this report

Properties of the phi meson at high temperatures and densities

We calculate the spectral density of the phi meson in a hot bath of nucleons and pions using a general formalism relating self-energy to the forward scattering amplitude (FSA). In order to describe the low energy FSA, we use experimental data along with a background term. For the high energy FSA, a Regge parameterization is employed. We verify the resulting FSA using dispersion techniques. We find that the position of the peak of the spectral density is slightly shifted from its vacuum position and that its width is considerably increased. The width of the spectral density at a temperature of 150 MeV and at normal nuclear density is more than 90 MeV.Comment: 4 pages, 5 figures, Poster presented at Quark Matter 200

Supersensitive PSA-Monitored neoadjuvant hormone treatment of clinically localized prostate cancer: Effects on positive margins, tumor detection and epithelial cells in bone marrow

Objective: The present study was done to investigate the effects of supersensitive PSA-controlled inductive treatment on positive margins, detection of tumor and epithelial cells in bone marrow of 101 patients with untreated and clinically localized prostatic carcinoma (cT1-3N0M0). Methods: Hormonal treatment was given until PSA (DPD Immulite(R) third-generation assay) reached 0.3 ng/ml in only 1 case. Of the 101 patients, 82 had a measurable hypoic lesion on initial transrectal ultrasound. 84% of these became smaller, 7.5% remained unchanged and 8.5% increased. Of the 101 prostatectomy specimens, 20 (20%) were margin-positive. The incidence of affected margins was relatively high (35% from 55 patients) with cT3 tumors, but almost negligible (2% from 46 patients) in cT1-2 tumor. Our pathologists, despite their great experience in evaluating hormonally treated prostates (>500 cases) and using immunohistochemical staining, were unable to detect carcinoma in 15 (15%) specimens. Whereas only 2 (4%) of the 55 cT3 specimens were without detectable tumor, this incidence rised to 28% (13 of 46 prostates) in patients with cT1-2 tumors. Of the initial 29 patients with epithelial cells in bone marrow, only 4 (14%) remained positive after controlled induction and all of them had fewer cells than before. Conclusion: Endocrine induction controlled by a supersensitive PSA assay and continued until reaching PSA nadir is highly effective in clearing surgical margins and eliminating tumor cells from bone marrow. It seems to be clearly superior to the conventional 3 months of pretreatment at least in cT1-2 tumors in respect to surgical margins and detectability of tumor in the resected prostate. A definitive statement about the value of endocrine induction can only be given by prospective randomized studies, with optimal drugs, doses and treatment time. But the conventional 3 months of pretreatment are far from exploiting the possibilities of this therapeutic option

Determining yttrium in plutonium by anion-exchange x-ray fluorescence

This report describes a method for determining yttrium in plutonium using an anion-exchange separation and x-ray fluorescence. We add zirconium to the plutonium solution as an internal standard. We oxidize the plutonium to Pu + 4 and pass the solution through an anion-exchange column with 8M HCl. The Pu + 4 sorbs to the resin and the yttrium and zirconium pass through completely. We evaporate the eluate solution containing the yttrium and zirconium and transfer it to a 10-ml volumetric flask. We add a portion of this solution to an x-ray cell and measure the Ka x-ray line for both yttrium and zirconium. The ratio of yttrium to zirconium is then compared with standards. This method has a precision of 0.84% relative standard deviation for yttrium over a concentration range of 0.5 to 3.5 mg in a 10-ml volume. 1 ref., 2 figs., 2 tabs

Microcanonical treatment of black hole decay at the Large Hadron Collider

This study of corrections to the canonical picture of black hole decay in large extra dimensions examines the effects of back-reaction corrected and microcanonical emission at the LHC. We provide statistical interpretations of the different multiparticle number densities in terms of black hole decay to standard model particles. Provided new heavy particles of mass near the fundamental Planck scale are not discovered, differences between these corrections and thermal decay will be insignificant at the LHC.Comment: small additions and clarifications, format for J. Phys.

Protocol for a randomized controlled trial examining multilevel prediction of response to behavioral activation and exposure-based therapy for generalized anxiety disorder.

BACKGROUND:Only 40-60% of patients with generalized anxiety disorder experience long-lasting improvement with gold standard psychosocial interventions. Identifying neurobehavioral factors that predict treatment success might provide specific targets for more individualized interventions, fostering more optimal outcomes and bringing us closer to the goal of "personalized medicine." Research suggests that reward and threat processing (approach/avoidance behavior) and cognitive control may be important for understanding anxiety and comorbid depressive disorders and may have relevance to treatment outcomes. This study was designed to determine whether approach-avoidance behaviors and associated neural responses moderate treatment response to exposure-based versus behavioral activation therapy for generalized anxiety disorder. METHODS/DESIGN:We are conducting a randomized controlled trial involving two 10-week group-based interventions: exposure-based therapy or behavioral activation therapy. These interventions focus on specific and unique aspects of threat and reward processing, respectively. Prior to and after treatment, participants are interviewed and undergo behavioral, biomarker, and neuroimaging assessments, with a focus on approach and avoidance processing and decision-making. Primary analyses will use mixed models to examine whether hypothesized approach, avoidance, and conflict arbitration behaviors and associated neural responses at baseline moderate symptom change with treatment, as assessed using the Generalized Anxiety Disorder-7 item scale. Exploratory analyses will examine additional potential treatment moderators and use data reduction and machine learning methods. DISCUSSION:This protocol provides a framework for how studies may be designed to move the field toward neuroscience-informed and personalized psychosocial treatments. The results of this trial will have implications for approach-avoidance processing in generalized anxiety disorder, relationships between levels of analysis (i.e., behavioral, neural), and predictors of behavioral therapy outcome. TRIAL REGISTRATION:The study was retrospectively registered within 21 days of first participant enrollment in accordance with FDAAA 801 with ClinicalTrials.gov, NCT02807480. Registered on June 21, 2016, before results

Upgrading short read animal genome assemblies to chromosome level using comparative genomics and a universal probe set

Most recent initiatives to sequence and assemble new species’ genomes de-novo fail to achieve the ultimate endpoint to produce a series of contigs, each representing one whole chromosome. Even the best-assembled genomes (using contemporary technologies) consist of sub-chromosomal sized scaffolds. To circumvent this problem, we developed a novel approach that combines computational algorithms to merge scaffolds into chromosomal fragments, scaffold verification by PCR and physical mapping to chromosomes. Multi genome-alignment-guided probe selection led to the development of a set of universal avian BAC clones that permit rapid anchoring of multiple scaffold loci to chromosomes on all avian genomes. As proof of principle we assembled genomes of the pigeon (Columbia livia) and peregrine falcon (Falco peregrinus) to chromosome level comparable, in continuity, to avian reference genomes. Both species are of interest for breeding, cultural, food and/or environmental reasons. Pigeon has a typical avian karyotype (2n=80) while falcon (2n=50) is highly rearranged compared to the avian ancestor. Using chromosome breakpoint data, we established that avian interchromosomal breakpoints appear in the regions of low density of conserved non-coding elements (CNEs) and that the chromosomal fission sites are further limited to long CNE “deserts”. This corresponds with fission being the rarest type of rearrangement in avian genome evolution. High-throughput multiple hybridization and rapid capture strategies using the current BAC set provide the basis for assembling numerous avian (and possibly other reptilian) species while the overall strategy for scaffold assembly and mapping provides the basis for an approach that could be applied to any animal genome

What does the rho-meson do? In-medium mass shift scenarios versus hadronic model calculations

The NA60 experiment has studied low-mass muon pair production in In-In collisions at $158 {\rm AGeV}$ with unprecedented precision. With these results there is hope that the in-medium modifications of the vector meson spectral function can be constrained more thoroughly than before. We investigate in particular what can be learned about collisional broadening by a hot and dense medium and what constrains the experimental results put on in-medium mass shift scenarios. The data show a clear indication of considerable in-medium broadening effects but disfavor mass shift scenarios where the $\rho$-meson mass scales with the square root of the chiral condensate. Scaling scenarios which predict at finite density a dropping of the $\rho$-meson mass that is stronger than that of the quark condensate are clearly ruled out since they are also accompanied by a sharpening of the spectral function.Comment: Proceeding contribution, Talk given by J. Ruppert at Workshop for Young Scientists on the Physics of Ultrarelativistic Nucleus-Nucleus Collisions (Hot Quarks 2006), Villasimius, Sardinia, Italy, 15-20 May 2006. To appear in EPJ