9 research outputs found
Psychopathological Predictors of Indirect Self-Destructiveness in Patients with Schizophrenia
Gender Differentiation in Indirect Self-Destructiveness and Suicide Attempt Methods (Gender, Indirect Self-Destructiveness, and Suicide Attempts)
Gender differentiation of indirect self-destructiveness
Objectives: The objective of this study was to examine the sex (gender) differentiation of indirect self-destructiveness intensity and its manifestations, as well as relationships between indirect self-destructiveness and its manifestations (categories) and the psychological dimensions of masculinity and femininity, also from the point of view of assessing occupational health and safety. Materials and Methods: A population of 558 individuals (399 females and 159 males) aged 19â25 (mean age: 22.6) was studied. The Polish version of the âChronic Self-Destructiveness Scaleâ (CS-DS) by Kelley adapted by SuchaĆska was used in order to examine indirect self-destructiveness and its manifestations. Gender testing applied the Polish version of the Bem Sex Role Inventory (BSRI) by Bem in its adaptation by KuczyĆska. Results: Malesâ scores are signifi cantly higher than those of females for the majority of CS-DS scales/indices: Indirect Self-Destructiveness (general index), Poor Health Maintenance (A2), Lack of Planfulness (A4), and Helplessness, Passiveness (A5). Moreover, there are statistically signifi cant correlations between CS-DS scales and the masculinity dimension (positive) as well as the femininity dimension (negative). Conclusions: Masculinity is a factor that may predispose towards indirectly self-destructive behaviors, while femininity is a factor protecting against those. The study results may prove useful in preventing indirectly and directly self-destructive behaviors as well as in therapy work with the individuals who display such tendencies or have made attempts on their own lives, in particular taking into account their being of a specifi c sex/gender and in the context of work (especially in diffi cult or dangerous conditions or both)
Psychopathological Predictors of Indirect Self-Destructiveness in Patients with Schizophrenia
Benefits of pH-responsive polyelectrolyte coatings for carboxymethyl cellulose-based microparticles in the controlled release of esculin
(Hydroxypropyl)methyl Cellulose-Chitosan Film as a Matrix for Lipase Immobilization. Part ÎÎ: Structural Studies
International audienceThe present work reports on the structural study of a film made of a hybrid blend of biopolymers used as an enzyme carrier. A cellulose derivative (HPMC) and chitosan (CS) were combined in order to formulate a film on which Mucor miehei lipase was immobilized. The film was successfully used as a biocatalyst; however, little is known about the structure of the system. Therefore, small-angle X-ray scattering, Fourier transform infrared spectroscopy (FTIR), optical microscopy, and scanning electron microscopy (SEM), as well as microindentation measurements, were used to shed light on the structure of the promising biocatalyst. Among the results, intermolecular hydrogen bonds were observed between the amide groups of the two polymers and the lipase. The presence of the enzyme does not seem to affect the mechanical properties of the matrix. The used film after 35 cycles of reaction seemed to be fatigued and had lost part of its humidity, explaining the reduction of the enzyme activity
Multilayered Curcumin-Loaded Hydrogel Microcarriers with Antimicrobial Function
The design of multifunctional microcarriers has attracted significant attention because they combine various functions within a single system. In this study, we developed a set of multilayered hydrogel microcarriers, which were first loaded with chemotherapeutic curcumin (CUR), then, using the layer-by-layer (LbL) technique, coated through a polyelectrolyte shell consisting of chitosan (CHIT) or poly(allylamine hydrochloride) (PAH). As an outer layer with antimicrobial function, newly synthesised alkylene quaternary ammonium salt functionalised polyelectrolytes (A-QAS-PEs) were applied. For this purpose, poly(acrylic acid) (PAA) was decorated with different hydrophobic side chains (n-hexane and n-dodecane side entities) and different degrees of substitution (m) of quaternary ammonium groups (abbreviated as PAA-C(O)O-(CH2)n-N+(CH3)3(m); n = 6, 12; m = 8â14%). The grafting approach of PAA with the alkylene quaternary ammonium salt moiety was performed under mild reaction conditions using Steglich esterification followed by quaternisation. The structure of antimicrobial decorated PAA was confirmed by 1H NMR and FTIR, and the mean diameter of all multifunctional microparticles was characterised by SEM. The viscoelastic properties of the functional layers were studied using quartz crystal microbalance with a dissipation (QCM-D). The release of CUR from the microcarriers was described using a hybrid model, i.e., a combination of first-order kinetics and the Korsmeyer-Peppas model. The antimicrobial activity of functionalised PAA and multilayered CUR-loaded hydrogel microcarriers with quaternary ammonium function was assessed against Staphylococcus aureus and Serratia marcescens by the agar diffusion assay method. Only a limited inhibition zone of PAA was observed, but in the case of both antimicrobial decorated PAA and the corresponding multilayered nanocarriers, the inhibitory activity increase was achieved against both strains of bacteria