Autoimmune-Associated Hemophagocytic Syndrome/Macrophage Activation Syndrome

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Late Ovarian and Intestinal Extramedullary Relapse of Acute Myeloid Leukemia with Inv 16 after Allogeneic Hematopoietic Stem Cell Transplantation

Treatment of acute myeloid leukemia (AML) extramedullary relapse (EMR) after allogenic hematopoietic stem cell transplantation (alloHSCT) is challenging. EMR pathogenesis of this entity is not clearly elucidated. Variety of factors affect clinical approaches in diagnostics, treatment and prognosis. Furthermore, there is no current consensus for post-transplant AML EMR treatment. We present here the case of young AML female patient with rare EMR presentation: ovary and large intestine infiltration. The treatment combined different strategies – conservative like surgery and chemotherapy, but also effective new approaches of targeted therapy - hypomethylating agent with tyrosine kinase inhibitor

Differences in the prognosis of HPV16-positive patients with squamous cell carcinoma of head and neck according to viral load and expression of P16

Purpose To evaluate the impact of HPV16 load (VL-the number of virus genome copies per cell) and P16 expression on prognosis of patients with squamous cell carcinomas (SCCs) of head and neck (HN). Materials and methods HPV16 presence was assessed in the group of 109 patients with HNSCCs by quantitative polymerase chain reaction (qPCR). VL (assessed by qPCR) and P16 expression (evaluated by immunohistochemistry) were analysed only in the subgroup of HPV16-positive tumours. These features were correlated with 5-year overall survival (OS) and disease-free survival (DFS). Results HPV16 infection was found in 36 tumours (33.0%). Virus-positive patients had better OS and DFS than those without infection (P = 0.041 and 0.005). Among HPV16-positive HNSCCs, 18 (50.0%) had higher VL (median value > 6764.3 copies/cell) and 25 (73.5%) P16 over expression. The significant differences in OS and DFS (P = 0.008 and 0.004) were noticed according to VL, wherein 100% DFS was found for patients with higher VL. According to P16 expression, significant difference was found only for OS (P = 0.020). In multivariate analysis, VL (P = 0.045; HR = 2.795; CI 0.121-1.060) and the level of smoking (P = 0.023, HR = 2.253; CI 1.124-4.514) were independent factors affecting DFS of HPV16-positive patients. Conclusion On the basis of viral load, it is possible to differentiate prognosis of patients with HPV16-positive HNSCCs. In this subgroup, viral load has stronger prognostic potential than P16 expression

Thalidomide, dexamethasone and lovastatin with autologous stem cell transplantation as a salvage immunomodulatory therapy in patients with relapsed and refractory multiple myeloma

The treatment of patients with multiple myeloma usually includes many drugs including thalidomide, lenalidomide and bortezomib. Lovastatin and other inhibitors of HMG-CoA reductase demonstrated to exhibit antineoplasmatic and proapoptotic properties in numerous in vitro studies involving myeloma cell lines. We treated 91 patients with relapsed or refractory multiple myeloma with thalidomide, dexamethasone and lovastatin (TDL group, 49 patients) or thalidomide and dexamethasone (TD group, 42 patients). A clinical response defined of at least 50% reduction of monoclonal band has been observed in 32% of TD patients and 44% of TDL patients. Prolongation of overall survival and progression-free survival in the TDL group as compared with the TD group has been documented. The TDL regimen was safe and well tolerated. The incidence of side effects was comparable in both groups. Plasma cells have been cultured in vitro with thalidomide and lovastatin to assess the impact of both drugs on the apoptosis rate of plasma cells. In vitro experiments revealed that the combination of thalidomide and lovastatin induced higher apoptosis rate than apoptosis induced by each drug alone. Our results suggest that the addition of lovastatin to the TD regimen may improve the response rate in patients with relapsed or refractory myeloma

Artistic activity of young adults in the field of music and citzenship

Celem pracy było poznanie związków, jakie mogą zachodzić między działalnością artystyczną – muzyczną i działalnością obywatelską.Analiza teoretyczna przybliżyła problematykę społeczeństwa obywatelskiego, zwłaszcza w ujęciu tradycji republikańskiej. Inny istotny aspekt poruszany w pracy dotyczył wartości w kontekście budowania postawy obywatelskości. Następnym ważnym teoretycznym zagadnieniem była działalność artystyczna – muzyczna jako środowisko pielęgnowania wartości oraz zaprezentowanie roli sztuki w kreowaniu społeczeństwa obywatelskiego. Podjęte były również rozważania z zakresu form, zasad i obszarów, wyżej wymienionych, dwóch typów działalności. Porównanie działalności z zakresu społeczeństwa obywatelskiego oraz działalności artystycznej – muzycznej wiązało się z próbą odpowiedzi na główny problem badawczy: „jak bliska postawie obywatelskości jest działalność młodych artystów muzyków, ze względu na wyznawane przez nich wartości?” Celem badań własnych było zebranie odpowiednio stopniowanych opinii, ocen w postaci wywiadu pisemnego. Grupa respondentów składała się z młodych artystów muzyków oraz młodych aktywnych obywateli, działających w różnych grupach formalnych lub nieformalnych.Na podstawie wyników badań zostały sformułowane wnioski związane z odpowiedzią na główny problem badawczy - działalność młodych artystów muzyków, ze względu na wyznawane przez nich wartości, takie jak: aktywność, zaufanie, współpraca, twórcze myślenie, poczucie wspólnotowości, wrażliwość, w końcu dbałość o dobro wspólne bliska jest postawie obywatelskości. Dalsze działania pedagogów w tym zakresie powinny dotyczyć nowych badań, teorii i pomysłów praktycznych, mających na celu połączyć działania w obszarach kultury i społeczeństwa obywatelskiego. Kształcenie i wychowanie estetyczne powinny stać się niepodważalnym elementem wychowania ogólnego.The aim of this thesis was to explore the possible relations between artistic and musical activities with activities of the civil society.The theoretical analysis of this work presents the issue of attitudes in a civil society, focusing principally on the republican tradition. Also essential in this work is the aspect of value in the context of creation of civil attitudes. Another important theoretical discussion is that of artistic – musical activity as a field of a value fostering and playing the role of representing the art in the process of building a civil society. Different forms, rules and fields of those two types of activity was also taken into consideration. The comparison between the civil society's activities and the artistic – musical activity, was done to answer the main scientific question: „How close are the activities of the young musicians to the civil attitude, in terms of values?” The aim of the research was to collect adequately graded opinions and marks by employing a written questionnaire. The group of respondents consisted of young artistic and young active civilians, working in various formal and informal groups.Conclusions derived from this work:Based on the findings, conclusions were formulated related to the response to the main research problem - the activity of young musicians because of their values, such as: activity, trust, cooperation, creative thinking, a sense of community, an appreciation in the end concern for the common good is close to the basis of citizenship. Follow-up of pedagogues in this area should involve new research, theory and practical ideas designed to bring together the efforts in the areas of culture and civil society. Aesthetic education should become an indisputable part of general education

The myth of Androgyny in late-century French literature and during the Young Poland movement on the example of selected works by Rachilde, J.-K. Huysmans, M. Komornicka and S. Przybyszewski

Cette étude vise à comparer les représentations du mythe de l’androgyne dans la littérature française fin-de-siècle et à l’époque de la Jeune Pologne sur l’exemple des œuvres choisies de Rachilde, Huysmans, Komornicka et Przybyszewski. La genèse de ce mythe reflète le caractère complexe et hétérogène de l’être à sexe indéterminé, mettant en valeur la continuité de la vie des mythes dans les textes littéraires. Néanmoins, son entrée dans la littérature marquerait la dégradation du mythe par rapport au mythe primaire. Autrement dit, l’androgyne fin-de-siècle de chair et d’os marque la rupture avec l’androgyne initial, incarnation de l’union harmonieuse, ce qui impose une certaine hiérarchie aux versions postérieures du récit mythique. L’objectif est d’adopter une nouvelle approche envers la figure du Double à l’aube du XXe siècle, en ajoutant un apport polonais. L’accent est mis sur le contexte et les sens polyvalents transmis par l’androgyne. Dans l’optique de la méthode du comparatisme différentiel, l’objectif est d’instaurer un rapport non hiérarchisant entre les versions du mythe de l’androgyne en France et en Pologne. La perspective de l’analyse s’étend sur les rapprochements entre les deux mondes littéraires, la réception, les influences partagées et le différentiel.This study aims to compare various depictions of the myth of androgyny in late-century French literature and during the Young Poland period on the example of selected works by Huysmans, Rachilde, Komornicka and Przybyszewski. The genesis of this myth reflects the complex and heterogeneous character of the figure of indeterminate sex, highlighting the continuity of the existence of myths in literary texts. Nevertheless, its entry into the literature would be perceived as a mark of degradation of the myth in comparison to the primordial one. In other words, the androgyny of flesh and bone demonstrates the break with the initial androgyny being the incarnation of the harmonious union, which imposes a certain hierarchy on the perception of later versions of the mythical narrative. The goal is to take a new approach to the figure of Double at the dawn of the twentieth century, by adding a Polish contribution. The focus is on the context and the versatile meanings conveyed. In the context of the differential comparatism method, the aim is to establish a non-hierarchical relationship between different versions of the myth of androgyne in the works of French and Polish authors. The perspective of the analysis extends to the connections between the two literary worlds, the reception, the shared influences and the differences

Mit androgyne w literaturze francuskiej fin-de- siècle i literaturze młodopolskiej na przykładzie wybranych dzieł Rachilde, Joris-Karl Huysmansa, Marii Komornickiej oraz Stanisława Przybyszewskiego

Założeniem pracy doktorskiej jest przyjrzenie się przedstawieniom mitu androgyne w literaturze francuskiej fin-de-siècle i w literaturze młodopolskiej na podstawie wybranych dzieł literackich Huysmansa, Rachilde, Komornickiej oraz Przybyszewskiego. Geneza mitu androgyne odzwierciedla złożony i niejednorodny charakter postaci o bliżej nieokreślonej płci, podkreślając zarazem kontynuację trwania mitów w literaturze. Przejście mitu do domeny literackiej odbywa się jednak pod znakiem degradacji mitycznej tekstu Platona, uważanego za założycielski. Innymi słowy, androgyne findesieklowska z krwi i kości zaznacza zerwanie z pierwszą androgyne, będącą uosobieniem harmonijnej Dwójjedni coincidentia oppositorum. To z kolei narzuca swego rodzaju hierarchiczność kolejnym wersjom mitu pierwotnego. Celem niniejszej pracy jest nowe spojrzenie na figurę androgyne schyłku XIX poprzez dodanie polskiego wariantu. Autorska metoda komparatystyki różnicowej Ute Heidmann pozwala skupić się na plastyczności dwoistej figury zamiast postrzegać ją głównie przez pryzmat rzekomego mitu założycielskiego. Intencją niniejszej pracy jest zbliżenie do siebie dwóch światów literackich za pośrednictwem symbolu Dwójjedni oraz ustanowienie między poszczególnymi jej przedstawieniami relacji opierającej się na równości, a nie na hierarchiczności

Does Mixing Tree Species Affect Water Storage Capacity of the Forest Floor? Laboratory Test of Pine-Oak and Fir-Beech Litter Layers

During the last decade, tree species mixing has been widely supported as a silvicultural approach to reduce drought stress. However, little is known on the influence of tree species mixing on physical properties and the water storage capacity of forest soils (including the forest floor). Thus, the study aimed to analyze the effect of mixing pine needles and oak leaves and mixing fir needles and beech leaves on hydro-physical properties of the litter layer during laboratory tests. We used fir-beech and pine-oak litter containing various shares of conifer needles (i.e., 0, 5, 10, 20, 30, 40, 50, 60, 70, 80, 90 and 100%) to determine the influence of the needle admixture on bulk density, total porosity, macroporosity, water storage capacity, the amount of water stored in pores between organic debris and the degree of saturation of mixed litter compared to broadleaf litter (oak or beech). We found that the admixture of fir needles increased the bulk density of litter from 7.9% with a 5% share of needles to 55.5% with a 50% share (compared to pure beech litter), while the share of pine needles < 40% caused a decrease in bulk density by an average of 3.0–11.0% (compared to pure oak litter). Pine needles decreased the water storage capacity of litter by about 13–14% with the share of needles up to 10% and on average by 28% with the 40 and 50% shares of pine needles in the litter layer. Both conifer admixtures reduced the amount of water stored in the pores between organic debris (pine needles more than fir needles)

Does Mixing Tree Species Affect Water Storage Capacity of the Forest Floor? Laboratory Test of Pine-Oak and Fir-Beech Litter Layers

During the last decade, tree species mixing has been widely supported as a silvicultural approach to reduce drought stress. However, little is known on the influence of tree species mixing on physical properties and the water storage capacity of forest soils (including the forest floor). Thus, the study aimed to analyze the effect of mixing pine needles and oak leaves and mixing fir needles and beech leaves on hydro-physical properties of the litter layer during laboratory tests. We used fir-beech and pine-oak litter containing various shares of conifer needles (i.e., 0, 5, 10, 20, 30, 40, 50, 60, 70, 80, 90 and 100%) to determine the influence of the needle admixture on bulk density, total porosity, macroporosity, water storage capacity, the amount of water stored in pores between organic debris and the degree of saturation of mixed litter compared to broadleaf litter (oak or beech). We found that the admixture of fir needles increased the bulk density of litter from 7.9% with a 5% share of needles to 55.5% with a 50% share (compared to pure beech litter), while the share of pine needles < 40% caused a decrease in bulk density by an average of 3.0–11.0% (compared to pure oak litter). Pine needles decreased the water storage capacity of litter by about 13–14% with the share of needles up to 10% and on average by 28% with the 40 and 50% shares of pine needles in the litter layer. Both conifer admixtures reduced the amount of water stored in the pores between organic debris (pine needles more than fir needles)