Socio-Economic Determinants Of Abortion Rates

Abortion rates are increasing all around the world, especially for young women. Our proposals for public policies to reduce unwanted pregnancies are based on an analysis of the socio-economic determinants of abortion rates. Special attention is paid to regional levels of alcohol consumption, living conditions, and public spending on health and education. We carry out estimations using data on regions in Spain from 1999 to 2004. There is empirical evidence that socioeconomic conditions, lifestyles and regional characteristics determine regional abortion rates. Our results suggest that it is important to design public policies to reduce alcohol abuse, improve citizens’ working conditions and promote gender equality through government subsidized childcare.abortion rates; unplanned pregnancy; public policies.

El espacio marginal como núcleo autorreferencial (retórico, compositivo, conceptual) en La pícara Justina

La pícara Justina de Francisco López de Úbeda offre une explosion de virtualités textuelles. La fragmentation constitue l’une des caractéristiques formelles fondamentales de l’œuvre, véritable corpus de poèmes, de textes en prose, de paragraphes conclusifs moralisateurs, de notes à la marge ; autant de formes d’écriture combinées entre elles en un puzzle singulier. Nous explorons les notes marginales en tant que fil d’Ariane dans le labyrinthe de l’œuvre. Son histoire éditoriale permettra d’apporter un éclairage génétique aux notes. La présence des marginalia dans toutes les éditions du livre place l’autoréflexion au centre de la composition rhétorique de l’ensemble. L’instance narrative qui produit l’ensemble des textes apparaît de manière multiple, comme en diffraction. L’effet de style que produit l’inclusion des annotations, partie intégrante de l’œuvre, invite par ailleurs à considérer leur motivation au second degré : elles constituent un reflet du caractère marginal de la substance narrative. Ainsi s’offre-t-elle au lecteur s’il se montre disposé à mettre en question le caractère linéaire de la lecture.La pícara Justina de Francisco López de Úbeda ofrece una explosión de virtualidades textuales. Una de las características formales fundamentales del libro es su fragmentación, ya que se trata de un verdadero corpus, compuesto de poemas, prosas, aprovechamientos, notas marginales, formas de escritura de diversa índole combinadas entre sí en un curioso puzle. La apuesta de lectura consiste en explorar los apuntes marginales como uno de los hilos de Ariadna en el laberinto de la obra. Un repaso a la historia y fortuna editorial de la obra permitirá una aproximación genética a dichas notas. La fijación editorial de los marginalia los acuña como fruto de un proceso autorreflexivo dentro de la composición retórica del conjunto. La instancia narrativa de la que emanan los textos parece múltiple y como difractada. El efecto estilístico de la inclusión de las notas como parte íntegra de la obra invita además a considerarlas como una motivación en segundo grado: las notas marginales son un reflejo de lo marginal como sustancia narrativa. Como tal se ofrece al lector, a poco que éste se preste a romper con una lectura lineal

Le langage des larmes dans La Dorotea de Lope de Vega

Lope de Vega érige La Dorotea (1632) en tombeau de sa maîtresse Marta de Nevares, mais aussi à sa propre trajectoire poétique par l’utilisation du champ sémiotique des larmes.Lope de Vega writes ‘La Dorotea’ (1632) in honour of his last beloved mistress Marta de Nevares but also in honour of his own poetic career, through the use of the semiotic field of tears.Lope de Vega hace de La Dorotea (1632) un homenaje a su amada Marta de Nevares y también a su propia trayectoria poética utilizando el campo semiótico de las lágrimas

Mecanismos moleculares implicados en el desarrollo, crecimiento y funcionalidad de las células beta pancreáticas: factores implicados

La diabetes es una de las patologías con mayor prevalencia hoy en día, en la cual se centran gran parte de las investigaciones actuales en la búsqueda de nuevas estrategias terapéuticas. Se trata de relacionar la masa de las células β pancreáticas, su crecimiento, desarrollo y proliferación con posibles futuros tratamientos. Estos procesos se dan a cabo gracias a diversos factores transcripcionales, hormonas y moléculas de señalización, que serán el objetivo de estudio. La terapéutica de hoy en día supone una disminución de las afecciones de la enfermedad ya instaurada pero no alcanza una idea de calidad de vida del paciente diabético, por lo que en las nuevas estrategias terapéuticas se persigue rentabilizar tanto la salud del paciente como del sistema sanitario

Analysis of the concordance between scales of cardiovascular risk in patients with HIV

Introducción: La infección por el virus de la inmunodeficina humana (VIH) supone un aumento del riesgo cardiovasular (RCV). Este hecho junto al desarrollo de nuevos tratamientos antirretrovirales que alargan la esperanza de vida de estos pacientes, ha hecho que aumente la incidencia de las enfermedades cardiovasculares. Es por ello que se necesitan métodos precisos de evaluación del RCV de estos pacientes con el objetivo de establecer una correcta prevención primaria de estos eventos. Material y métodos: Estudio descriptivo transversal. Se calculó el RCV de los pacientes con VIH de la consulta de Enfermedades Infecciosas del HGU de Elda mediante las ecuaciones de SCORE, REGICOR, ACC/AHA, COMVIH-COR y GEAM. Resultados: Según la escala REGICOR, SCORE, ACC/AHA, COMVIH-COR y GEAM el 2,3%, el 9,2%, el 4,6%, el 13,3% y el 54,1% de los pacientes presentaba un RCV alto respectivamente. El mayor nivel de concordancia obtenido entre escalas fue de k=0,412 (p=0,000) entre COMVIH-COR y ACC/AHA. El menor nivel de concordancia fue de k= - 0,004 (p=0,819) entre las escalas REGICOR y GEAM. Conclusión: El análisis de la concordancia entre las diferentes escalas fue pobre a excepción de ACC/AHA y COMVIH-COR que fue moderado.Introduction: The infection with the Human Immunodeficiency Virus (HIV) increases the cardiovascular risk (CVR). This fact together with the development of new antiretroviral treatments that extend the life expectancy of these patients, has increased the incidence of cardiovascular diseases. That is why precise methods of cardiovascular risk assessment are needed in order to establish a correct primary prevention of these events. Methods: Descriptive cross-sectional study. The CVR of patients with HIV infection from the Elda HGU Infectious Diseases consultation was calculated using the equations of SCORE, REGICOR, ACC/AHA, COMVIH-COR and GEAM. Results: According to the REGICOR, SCORE, ACC / AHA, COMVIH-COR and GEAM scale, 2.3%, 9.2%, 4.6%, 13.3% and 54.1% of the patients presented a high RCV respectively. The highest level of agreement obtained between scales was k = 0.412 (p = 0.000) between COMVIH-COR and ACC / AHA. The lowest level of concordance was k = - 0.004 (p = 0.819) between the REGICOR and GEAM scales. Conclusion: The concordance analysis between the different scales was poor except for ACC / AHA and COMVIH-COR which was moderate

Representing Trauma in American Women’s Literature

[Abstract] This round table aimed at exploring how different female traumatic experiences have found expression through literature. For that purpose, the session began with an introduction to the question of trauma in the field of the humanities. Then the discussion focused on the representation of individual trauma through the poems of Anne Sexton. After that, the debate explored how social trauma was transmitted transgenerationally by analyzing Nora Okja Keller’s novel Comfort Woman. Finally, the work of Arab American women writers served to illustrate the issue of collective trauma caused by September 11, 2001

Redesigning a case study for the assessment of ethical responsibility

[EN] This work presents the redesign of an activity (case study) that has been carried out over the last three years in the course Deontology and Professionalism for 2nd year students of the Informatics Engineering Degree at the Universitat Politecnica de Valencia (UPV) -Spain-. The aim of the activity is to encourage students to face ethical dilemmas that they may encounter in the exercise of their profession. Specifically, the case is about autonomous cars where decisions that must be taken imply a challenge, and even more when the programmers of the car deal with situations where human lives are endangered. The UPV has defined some general scoring rubrics in order to assess transversal competences of students. One of these rubrics deals with Ethics. Indicators included in this rubric are: The student: Becomes aware of other ways of seeing and perceiving things Critically accepts new perspectives, although this requires questioning your own perspective Differentiates facts from opinions in the arguments of other people Reflects on the consequences and effects (practical implications) that decisions and proposals have on people Recognizes the ethical and deontological aspects of the profession The case is introduced in a progressive way facilitating the development of the ethical competence and includes the required elements to assess the indicators established in the rubric. Thus, all the indicators proposed in the rubric can be evaluated by means of this activity. As a conclusion, the high degree of participation of the students in the activity is remarkable, which is on the one hand due to the transcendence of the theme and on the other hand because it is a very current topic closely linked to the computer science. Furthermore, the redesign of the case guided by the rubric allows an adequate evaluation.This research has been carried out under the project of innovation and educational improvement (PIME/A15) 'DAICE - Design of activities for the Innovation, Creativity and Entrepreneurship Competence' funded by the Universitat Politecnica de Valencia, and the Escola Tecnica Superior d'Enginyeria Informatica.Boza, A.; Fernández-Diego, M.; Cuenca, L.; Ruiz Font, L. (2017). Redesigning a case study for the assessment of ethical responsibility. INTED proceedings (Online). 6677-6682. doi:10.21125/inted.2017.1545S6677668

Ly9 (CD229) Cell-Surface Receptor is Crucial for the Development of Spontaneous Autoantibody Production to Nuclear Antigens

The Signaling Lymphocyte Activation Molecule Family (SLAMF) genes, which encode cell-surface receptors that modulate innate and adaptive immune responses, lay within a genomic region of human and mouse chromosome 1 that confers a predisposition for the development of systemic lupus erythematosus (SLE). Herein, we demonstrate that the SLAMF member Ly9 arises as a novel receptor contributing to the reinforcement of tolerance. Specifically, Ly9-deficient mice spontaneously developed features of systemic autoimmunity such as the production of anti-nuclear antibodies (ANA), -dsDNA, and -nucleosome autoantibodies, independently of genetic background [(B6.129) or (BALB/c.129)]. In aged (10- to 12-month-old) Ly9−/− mice key cell subsets implicated in autoimmunity were expanded, e.g., T follicular helper (Tfh) as well as germinal center (GC) B cells. More importantly, in vitro functional experiments showed that Ly9 acts as an inhibitory receptor of IFN-γ producing CD4+ T cells. Taken together, our findings reveal that the Ly9 receptor triggers cell intrinsic safeguarding mechanisms to prevent a breach of tolerance, emerging as a new non-redundant inhibitory cell-surface receptor capable of disabling autoantibody responses