Cyberbullying Profiles: Differences in Anxiety, Depression, and Stress in a Sample of Spanish Students

The increased prevalence and significant negative consequences associated with cyberbullying justify the need for empirical research that helps provide a deeper understanding of the problem. The objective of this study was to identify the existence of different cyberbullying profiles (according to degree of cybervictimization and cyberaggression of students) and whether these profiles vary with regard to anxiety, depression, and stress. The sample consisted of 1,185 students aged 12 to 18 (M = 14.01; DT = 2.36). A latent class analysis and ANOVA were carried out. The data showed four profiles: not-involved (low scores for cybervictimization and cyberaggression), cybervictims (moderately high scores for cybervictimization and low scores for cyberaggression), cyberbullies (low scores for cybervictimization and moderately high scores for cyberaggression), and cybervictims-cyberbullies (high scores for cybervictimization and cyberaggression). Statistically significant differences in anxiety, depression, and stress were found between the profiles. The group of cybervictims and cybervictims-cyberbullies presented higher anxiety than the not-involved group and cyberbullies. The cybervictims-cyberbullies group showed higher depression and stress levels than the other groups, and the cyberbully group showed a higher level of depression than the not-involved group.This research was financed by the Ministry of Science and Innovation, the Agency and the European Regional Development Fund (Proyect PID123118NA-100 funded by MCIN /AEI /10.13039/501100011033 / FEDER, UE

Molecular signature of response and potential pathways related to resistance to the HSP90 inhibitor, 17AAG, in breast cancer

<p>Abstract</p> <p>Background</p> <p>HSP90 may be a favorable target for investigational therapy in breast cancer. In fact, the HSP90 inhibitor, 17AAG, currently has entered in phase II clinical trials as an anticancer agent in breast and other tumors. Since HSP90 inhibition leads to global depletion of oncogenic proteins involved in multiple pathways we applied global analysis using gene array technology to study new genes and pathways involved in the drug response in breast cancer.</p> <p>Methods</p> <p>Gene expression profiling using Whole Human Genome Agilent array technology was applied to a total of six sensitive and two resistant breast cancer cell lines pre-treatment and treated with the 17AAG for 24 and 48 hours.</p> <p>Results</p> <p>We have identified a common molecular signature of response to 17AAG composed of 35 genes which include novel pharmacodynamic markers of this drug. In addition, different patterns of HSP90 client transcriptional changes after 17AAG were identified associated to the sensitive cell lines, which could be useful to evaluate drug effectiveness. Finally, we have found differentially expressed pathways associated to resistance to 17AAG. We observed significant activation of NF-κB and MAPK pathways in resistant cells upon treatment, indicating that these pathways could be potentially targeted to overcome resistance.</p> <p>Conclusions</p> <p>Our study shows that global mRNA expression analysis is a useful strategy to examine molecular effects of drugs, which allowed us the discovery of new biomarkers of 17AAG activity and provided more insights into the complex mechanism of 17AAG resistance.</p

Multiple Genome Sequences of Lactobacillus pentosus Strains Isolated from Biofilms on the Skin of Fermented Green Table Olives

The draft genome sequences of five Lactobacillus pentosus strains isolated from biofilms on the skin of green table olives are presented here. These genome sequences will assist in revealing the potential probiotic properties of these strains, as the intake of fermented olives implicates the passage of millions of Lactobacillus spp. throughout a consumer’s gastrointestinal tract.This work was funded by the Junta de Andalucía through the P11-AGR-7051 project and by the Spanish Government through MICIIN projects AGL2013-48300-R/ALI (OliFilm project: www.olifilm.science.com.es) and BFU2016-77297-P

Personality Traits and Aggression as Explanatory Variables of Cyberbullying in Spanish Preadolescents

There is a growing interest in preventing cyberbullying in youth. However, multiple questions remain as to the relationship between cyberbullying and psychosocial variables. This study examines the relationship between personality traits, aggression and cyberbullying (victims, bullies, victimized bullies and not involved) in 548 Spanish students aged 10 to 13 (50.2% boys). To do so, the Screening of Peer Harassment, the Big Five Questionnaire for Children and the Aggression Questionnaire were used. Logistic regression analyses indicated that the extraversion trait is an explanatory factor for being a victim and openness is a protective factor against being a cyberbully. Agreeableness was found to be a positive predictor of being a cyberbullying victim. Only verbal aggression and anger were included as explanatory factors of being a victim and a victimized bully, respectively. The results are discussed, suggesting their potential implications in the development of preventive programs.This research was funded by the Regional Ministry of Culture, Education and Sport of Region of Valencia (Spain), grant number GV/2015/111, with Beatriz Delgado as the Principal Researcher

Relationship between Cyberbullying, Motivation and Learning Strategies, Academic Performance, and the Ability to Adapt to University

Cyberbullying has become a frequent relational problem among young people, which has made it necessary to evaluate and prevent it in the university setting. The aim of this study is to examine the relationship between cyberbullying, motivation and learning strategies, the ability to adapt to university, and academic performance. A sample of 1368 Spanish university students (64% female) was administered a battery consisting of the European Bullying Intervention Project Questionnaire, the Learning and Study Strategies Inventory Short version, and the Student Adaptation to College Questionnaire, with their academic performance also being studied. The results found that the victimized bullies have greater difficulties in their organization and planning for study and exams, have fewer control and consolidation strategies, and are less able to adapt to university. Logistic regression analyses show that the greater the difficulties in organization and planning, and the greater the difficulties experienced in exams, the greater the probability of a person being a victim and a victimized bully. In addition, students are less likely to be victims, bullies, and victimized bullies as their ability to adapt to university increases. The findings have been discussed and it has been noted that there is a need to address academic adjustment and the ability to adapt to the university environment as a preventive measure for cyberbullying in university students

Fibrosis, the Bad Actor in Cardiorenal Syndromes: Mechanisms Involved

Cardiorenal syndrome is a term that defines the complex bidirectional nature of the interaction between cardiac and renal disease. It is well established that patients with kidney disease have higher incidence of cardiovascular comorbidities and that renal dysfunction is a significant threat to the prognosis of patients with cardiac disease. Fibrosis is a common characteristic of organ injury progression that has been proposed not only as a marker but also as an important driver of the pathophysiology of cardiorenal syndromes. Due to the relevance of fibrosis, its study might give insight into the mechanisms and targets that could potentially be modulated to prevent fibrosis development. The aim of this review was to summarize some of the pathophysiological pathways involved in the fibrotic damage seen in cardiorenal syndromes, such as inflammation, oxidative stress and endoplasmic reticulum stress, which are known to be triggers and mediators of fibrosis

Relationship between suicidal thinking, anxiety, depression and stress in university students who are victims of cyberbullying

The objective of this study is to analyze the predictive capacity of cybervictimization with regards to suicidal thinking and anxiety, depression and stress in university students. The European Cyberbullying Intervention Project Questionnaire, the Depression Anxiety Stress Scale-21 and the Suicidality Scale were administered to a sample of 1282 university students (594 men and 688 women) aged between 18 and 46 (M = 21.65; SD = 4.25). The results suggest that being a cybervictim increases the probability of suicidal thinking and presenting high levels of anxiety, depression and stress. This study highlights the high prevalence rates of cyberbullying in the university environment and how this issue is associated with emotional problems and suicidal thinking. The identification of these relationships may allow for the development of effective preventive intervention measures to respond to this problem

Cyberbullying in the University Setting. Relationship With Emotional Problems and Adaptation to the University

Little scientific attention has been paid to the problem of cyberbullying in the university environment, compared to similar studies conducted on adolescents. This study attempts to analyze the predictive capacity of certain emotional problems (anxiety, depression, and stress) and university adaptation with respect to cyberbullying in victims and aggressors. The European Cyberbullying Intervention Project Questionnaire, the Depression Anxiety Stress Scale-21 and the Student Adaptation to College Questionnaire were administered to a sample of 1282 university students (46.33% male) aged between 18 and 46. The results suggest that high levels of depression and stress increase the probability of being a cyberbullying victim, while high levels of depression increase the probability of being a cyberbullying aggressor. Similarly, the personal–emotional and social adaptation of students are found to be predictor variables of being a cyberbullying victim, in that high levels of personal–emotional and social adaptation decrease the probability of being a victim, while high levels of personal–emotional, academic and institutional adaptation decrease the probability of being a cyberbullying victim. The results of this study are of special relevance, since they indicate that intervention programs should consider the influence of emotional intelligence, as well as the relevance students’ adaptation to university

Cyberbullying in the university setting. Relationship with family environment and emotional intelligence

Currently, the enormous quantity of research on cyberbullying during adolescence contrasts with those studies carried out in the university environment. The objective of this study was to analyze the predictive capacity of family environment and emotional intelligence with regard to cyberbullying in university students. The European Cyberbullying Intervention Project Questionnaire, the Social Climate in the Family Scale and the Trait Meta-Mood Scale-24 were administered to a sample of 1282 university students (594 men and 688 women) between the ages of 18 and 46 (M = 21.65; DT = 4.25). The results revealed that a deteriorated family environment increases the probability of being both a victim and an aggressor of cyberbullying, whereas a favorable family environment decreases this probability. Likewise, the dimensions of emotional intelligence were predictive variables of participation as victims or aggressors of cyberbullying. The conclusions of this study are of special relevance given that they do not only bring about a problem that has a little knowledge of the university setting, but because they also note that intervention programs should consider the influence of the family environment during the early adulthood period, as well as the relevance of emotional level of these university students

La educación energética en la secundaria básica: una alternativa para su desarrollo /Power‐saving education in junior high school. An alternative for its development

The article approaches the need of given instruction on energy‐saving as a constituent of a comprehensive education al high school. The aim is to describe a developmental strategy, devised on the basis of specially tailored theoretical framework, observation, questionnaires and interviews. The main finding is the proposal of an alternative to achieve educational objectives on this area