New insights on the seismogenic potential of the Eastern Betic Shear Zone (SE Iberia): Quaternary activity and paleoseismicity of the SW segment of the Carrascoy Fault Zone

The Carrascoy Fault (CAF) is one of the main active faults that form part of the Eastern Betic Shear Zone, a 450 km fault system that accommodates most of the convergence between the Eurasian (Iberia) and Nubian plates in the Betic Cordillera, south Spain. Although the CAF represents a major earthquake threat to the nearby City of Murcia, studies on its Quaternary tectonics and seismogenic potential are scarce to date. We present evidence that supports the division of the CAF into two overlapping segments with contrasting tectonic structure, Quaternary activity, and landform control: a SW segment, characterized by a broad fold-and-thrust zone similar to the forebergs defined in the Gobi-Altai region, and a NE segment, characterized by a sharp mountain front controlled by strike-slip tectonics. We attribute the differentiation into these two segments to the stresses associated with topography, which in turn is a consequence of the shortening component, at the middle Pleistocene, after circa 217.4 ka. For the SW segment we infer the occurrence of 9 to 11, Mw 6.7 paleoearthquakes in the last 30.2 kyr, and a slip rate of 0.37 ± 0.08 m/kyr. We date the occurrence of the last surface rupture event after 2750 B.P., and we estimate an average recurrence period of major events of 3.3 ± 0.7 kyrThis work was supported by SISMOGEN (IGME, 2279) and FASEGEO (CGL2009-09726) research projects and a technical assistance of the Civil Protection Service of Murci

The effects of aerobic exercise and transcranial direct current stimulation on cognitive function in older adults with and without cognitive impairment:A systematic review and meta-analysis

Background: Aerobic exercise (AE) may slow age-related cognitive decline. However, such cognition-sparing effects are not uniform across cognitive domains and studies. Transcranial direct current stimulation (tDCS) is a form of non-invasive brain stimulation and is also emerging as a potential alternative to pharmaceutical therapies. Like AE, the effectiveness of tDCS is also inconsistent for reducing cognitive impairment in ageing. The unexplored possibility exists that pairing AE and tDCS could produce synergistic effects and reciprocally augment cognition-improving effects in older individuals with and without cognitive impairments. Previous research found such synergistic effects on cognition when cognitive training is paired with tDCS in older individuals with and without mild cognitive impairment (MCI) or dementia. Aim: The purpose of this systematic review with meta-analysis was to explore if pairing AE with tDCS could augment singular effects of AE and tDCS on global cognition (GC), working memory (WM) and executive function (EF) in older individuals with or without MCI and dementia. Methods: Using a PRISMA-based systematic review, we compiled studies that examined the effects of AE alone, tDCS alone, and AE and tDCS combined on cognitive function in older individuals with and without mild cognitive impairment (MCI) or dementia. Using a PICOS approach, we systematically searched PubMed, Scopus and Web of Science searches up to December 2021, we focused on ‘MoCA’, ‘MMSE’, ‘Mini-Cog’ (measures) and ‘cognition’, ‘cognitive function’, ‘cognitive’, ‘cognitive performance’, ‘executive function’, ‘executive process’, ‘attention’, ‘memory’, ‘memory performance’ (outcome terms). We included only randomized controlled trials (RTC) in humans if available in English full text over the past 20 years, with participants’ age over 60. We assessed the methodological quality of the included studies (RTC) by the Physiotherapy Evidence Database (PEDro) scale. Results: Overall, 68 studies were included in the meta-analyses. AE (ES = 0.56 [95% CI: 0.28–0.83], p = 0.01) and tDCS (ES = 0.69 [95% CI: 0.12–1.26], p = 0.02) improved GC in all three groups of older adults combined (healthy, MCI, demented). In healthy population, AE improved GC (ES = 0.46 [95% CI: 0.22–0.69], p = 0.01) and EF (ES = 0.27 [95% CI: 0.05–0.49], p = 0.02). AE improved GC in older adults with MCI (ES = 0.76 [95% CI: 0.21–1.32], p = 0.01). tDCS improved GC (ES = 0.69 [90% CI: 0.12–1.26], p = 0.02), all three cognitive function (GC, WM and EF) combined in older adults with dementia (ES = 1.12 [95% CI: 0.04–2.19], p = 0.04) and improved cognitive function in older adults overall (ES = 0.69 [95% CI: 0.20–1,18], p = 0.01). Conclusion: Our systematic review with meta-analysis provided evidence that beyond the cardiovascular and fitness benefits of AE, pairing AE with tDCS may have the potential to slow symptom progression of cognitive decline in MCI and dementia. Future studies will examine the hypothesis of this present review that a potentiating effect would incrementally improve cognition with increasing severity of cognitive impairment

El Área Metropolitana de Guadalajara a través de sus viejos cines

En este proyecto se investigaron las historias de los viejos cines del Área Metropolitana de Guadalajara (AMG) que por distintas causas fueron abandonados, se transformaron en otro tipo de espacios o simplemente fueron demolidos para dar paso a la creación de nuevos edificios. Las disciplinas de la historia, el urbanismo y la sociología nos acercaron a nuevas reflexiones y miradas en torno a este tema. Como producto de este proyecto se creó un testimonio fotográfico–documental sobre estos espacios y los personajes que aún podamos encontrar vinculados a ellos. Además, creamos un sitio web que permite preservar la memoria y dotar de significado los sitios identificados en la investigación. Los motivos para emprender un proyecto relacionado con las viejas salas de cine, más allá de la añoranza nostálgica que éstas evocan en la biografía de muchos habitantes del AMG, es dar cuenta que estos cines de antaño han sido también testigos y ámbitos de los procesos de transformación sociocultural en el siglo XX. Se revisa su historia, la visión de sus protagonistas y se ofrecen referencias para una mejor comprensión de cómo la transformación (y en algunos casos, la extinción) de los cines, de esta ciudad, le ha 3 cambiado el rostro y sus señas de identidad a través de los años. Es innegable que estas y otras dinámicas de transformación en la vida urbana han propiciado cambios tanto en las relaciones que en el interior de las salas se desarrollan, como generado maneras diversas de aproximarse y percibir la experiencia cinematográfica.ITESO, A.C

CRB2 completes a fully expressed Crumbs complex in the Retinal Pigment Epithelium

The CRB proteins CRB1, CRB2 and CRB3 are members of the cell polarity complex Crumbs in mammals that together with Scribble and Par complexes stablish the polarity of a variety of cell types. Although many members of the Crumbs complex proteins are expressed in the retinal pigment epithelium (RPE), and even though the mRNA of CRB2 has been detected in ARPE-19 cells and in the RPE/Choroid, to date no CRB protein has yet been found in this tissue. To investigate this possibility, we generated an antibody that specifically recognize the mouse CRB2 protein, and we demonstrate the expression of CRB2 in mouse RPE. Confocal analysis shows that CRB2 is restricted to the apicolateral membrane of RPE cells, and more precisely, in the tight junctions. Our study identified CRB2 as the member of the CRB protein family that is present together with the rest of the components of the Crumbs complex in the RPE apico-lateral cell membrane. Considering that the functions of CRB proteins are decisive in the establishment and maintenance of cell-cell junctions in several epithelial-derived cell types, we believe that these findings are a relevant starting point for unraveling the functions that CRB2 might perform in the RPE.This study was supported by grants from Fundación Ramón Areces and Ministerio de Ciencia e Innovación (BFU2008-04490/BFI). S.H.M received support from the Junta de Castilla y León PhD Program.Peer Reviewe

Paleoseismological evidence of holocene activity of the Los Tollos fault (Murcia, se Spain): a lately formed quaternary tectonic feature of the eastern betic shear zone

The Los Tollos Fault is a recent and important feature of the Eastern Betic Shear Zone, one of the major tectonic structures in South Iberia accommodating the convergence between Nubian and Eurasian plates in the western Mediterranean. The Los Tollos Fault became active by the end of Middle Pleistocene introducing some paleogeographical modifications. Previously mapped as a secondary normal fault related to the Carrascoy Fault, recent research evidences that the Los Tollos Fault is an independent Holocene active left-lateral reverse fault extending for at least 15 km. Data analysis from 4 trenches dug across the fault has revealed the occurrence of at least two paleo-earthquake events during the Holocene. The most recent event is dated between 2,740 and 2,140 yr BP (8th to 2nd centuries BC). The size of the paleoevents is calculated to be Mw 6.3 – 6.6 following empirical regressions on surface rupture length. The recurrence interval is estimated to be between 2,200-6,860 years, fitting a slip rate for the fault between 0.12 and 0.17 mm/yr. Such parameters highlight the Los Tollos Fault as a tectonic structure with a considerable activity located relatively close to densely populated areas. These seismogenic parameters should be considered in future reassessments of the seismic hazard of the regionThis work forms part of the research activities carried out in the FASEGEO Project (CGL2009-09726) funded by the Spanish Ministry of Science and Innovatio

Guia farmacològica en VIH

Tractament antiretrovirals (TARV); Pacients de sida; VacunesRetroviral treatment (HAART); AIDS patients; VaccinesTratamiento antirretrovirales (TARAA); Pacientes de sida; VacunasEn aquesta guia es vol donar una visió pràctica dels aspectes diaris del tractament del pacient amb infecció per VIH. D’una manera pràctica es revisen aspectes relacionats amb el tractament antiretroviral, posologia, potencials interaccions amb altres fàrmacs, valorant de forma breu els principals i més freqüents que es fan servir en diferents situacions de la pràctica clínica diària en els pacients amb infecció pel VIH en tractament antiretroviral i, finalment, les diferents vacunes, analitzant-ne els aspectes generals, les indicacions i les contraindicacions.This guide is to give a practical view of the daily aspects of the treatment of patients with HIV infection. From a practical manner of antiretroviral treatment, dosage, potential interactions with other drugs, valuing briefly are review the main and most frequently used in different situations of daily clinical practice in patients with HIV infection in antiretroviral treatment and finally the different vaccines, analyzing the general aspects, indications and contraindications.En esta guía se quiere dar una visión práctica de los aspectos diarios del tratamiento del paciente con infección por VIH. De una manera práctica se revisan aspectos relacionados con el tratamiento antirretroviral, posología, potenciales interacciones con otros fármacos, valorando de forma breve los principales y más frecuentes que se utilizan en diferentes situaciones de la práctica clínica diaria en los pacientes con infección por el VIH en tratamiento antirretroviral y, finalmente, las diferentes vacunas, analizando los aspectos generales, las indicaciones y las contraindicaciones

Constraining the X-ray reflection in low accretion rate AGN using XMM-Newton, NuSTAR and Swift

An interesting feature in active galactic nuclei (AGN) accreting at low rate is the weakness of the reflection features in their X-ray spectra, which can result from the gradual disappearance of the torus with decreasing accretion rates. It has been suggested that low luminosity AGN (LLAGN) would have a different reflector configuration compared with high luminosity AGN, either covering a smaller fraction of the sky or simply having less material. Additionally, we note that the determination of the spectral index ($\Gamma$) and the cut-off energy of the primary power-law emission is affected by the inclusion of reflection models, showing the importance of using them to study the accretion mechanism, especially in the case of the LLAGN that have previously shown a high dispersion on the relation between $\Gamma$ and the accretion rate. Our purpose is to constrain the geometry and column density of the reflector in a sample of LLAGN covering a broad X-ray range of energy combining data from XMM-Newton + NuSTAR + Swift of a hard X-ray-flux limited sample of 17 LLAGN from BASS/DR2 with accretion rates $\lambda_{Edd}$=L$_{\rm Bol}$/L$_{\rm Edd}$<10$^{-3}$. We fit all spectra using the reflection model for torus (borus02) and accretion disk (Xillver) reflectors. We found a tentative correlation between the torus column density and the accretion rate, LLAGN shows a lower column density compared with the high-luminosity objects. We also confirm the relation between $\Gamma$ and $\lambda_{Edd}$, with a smaller scatter than previously reported, thanks to the inclusion of high-energy data and the reflection models. Our results are consistent with a break at $\lambda_{Edd}\sim10^{-3}$, suggestive of a different accretion mechanism compared with higher accretion AGN.Comment: Accepted for publication in Astronomy & Astrophysic

Constraining X-ray reflection in the low-luminosity AGN NGC 3718 using NuSTAR and XMM--Newton

One distinctive feature of low-luminosity active galactic nuclei (LLAGN) is the relatively weak reflection features they may display in the X-ray spectrum, which can result from the disappearance of the torus with decreasing accretion rates. Some material, however, must surround the active nucleus, i.e., the accretion flow itself and, possibly, a flattened-out or thinned torus. In this work, we study whether reflection is indeed absent or undetectable due to its intrinsically weak features together with the low statistics inherent to LLAGN. Here we focus on NGC 3718 ($L/L_{\rm Edd}\sim10^{-5}$) combining observations from XMM--Newton and the deepest to date NuSTAR (0.5--79 keV) spectrum of a LLAGN, to constrain potential reflectors, and analyze how the fitted coronal parameters depend on the reflection model. We test models representing both an accretion disc (Relxill) and a torus-like (MYTorus and Borus) neutral reflector. From a statistical point of view, reflection is not required, but its inclusion allows to place strong constraints on the geometry and physical features of the surroundings: both neutral reflectors (torus) tested should be Compton thin ($N_H<10^{23.2}$cm$^{-2}$) and preferentially cover a large fraction of the sky. If the reflected light instead arises from an ionized reflector, a highly ionized case is preferred. These models produce an intrinsic power-law spectral index in the range [1.81--1.87], where the torus models result in steeper slopes. The cut-off energy of the power-law emission also changes with the inclusion of reflection models, resulting in constrained values for the disc reflectors and unconstrained values for torus reflectors.Comment: 15 pages and 16 Figure