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Plasmonic and magnetoplasmonic interferometry for sensing

[Introduction and background] Nowadays, we are surrounded by sensors in our daily lives, in industrial processes, medical diagnosis systems, environmental monitoring, etc. The development of sensors with higher sensitivity and smaller dimensions to be integrated in miniaturized systems is then of highest importance for our society. Within all different kinds of sensors, optical sensors are advantageous because they are highly versatile, non-invasive and they can be used in aggressive conditions. In particular, sensors based on surface plasmons, known as surface plasmon resonance (SPR) sensors, have become increasingly popular in biosensing in recent decades due to their high sensitivity and ease of use. Different SPR configurations, such as modulation techniques, have been proposed and demonstrated in order to increase their sensitivity, and attempts to obtain miniaturized SPR sensors have been carried out, the development of plasmonic interferometry sensors being a promising path.[Main results] We have compared theoretically the performance of three implementations of plasmonic sensors: the standard SPR configuration, plasmonic interferometry and magnetically modulated plasmonic (magnetoplasmonic) interferometry. Our results show that the sensitivity of plasmonic interferometers surpasses that of standard SPR methods for long enough except the micrometer-sized interferometers. Moreover, when plasmonic interferometers are magnetically modulated, the direct measurement of the induced modulation in the surface plasmon wavevector allows one to further increase the system sensitivity.[Wider implications] These results show that the development of plasmonic interferometers for sensing, either plain or magnetically modulated, is an interesting route to obtain miniaturized surface plasmon based sensors with higher sensitivity. Moreover, the extended knowledge of immobilization protocols in gold already developed for standard SPR sensors will remain applicable.We acknowledge funding from the Spanish MINECO ('MAPS' MAT2011-29194-C02-01 and 'FUNCOAT' CONSOLIDER INGENIO 2010 CSD2008-00023) and the Comunidad de Madrid ('MICROSERES-CM' S2009/TIC-1476).Peer Reviewe

Optical and magneto-optical properties of Au:Conanoparticles and Co:Aunanoparticles doped magnetoplasmonic systems

© 2015 AIP Publishing LLC. We report a study of Au:CoNPs and Co:AuNPs doped magnetoplasmonic systems. In particular, we analyze the effect of adding different concentrations of Co (or Au) nanoparticles (NPs) in a Au (or Co) matrix on both the optical and magneto-optical constants. Through the use of a simple effective medium model, relevant changes in the optical properties of the Au NPs compared to those of bulk material have been identified. Such effects are not observed in the Co NPs system. However, in both systems, there is an increase of the effective diameter of the NPs as compared to the real diameter that can be due to interface effects surrounding the NPs. Moreover, the magneto-optical constants values of both systems are smaller (in absolute values) than expected, which could also be attributed to interface effects such as hybridization between Au and Co.This work was supported by the Spanish MINECO under Project Nos. MAT2011-29194-C02 (MAPS), CSD2007-00041 (NANOSELECT), and CSD2008-00023 (FUNCOAT). http://dx.doi.org/10.1063/1.4906946Peer Reviewe

Vitamin D3 Receptor (VDR) Gene rs2228570 (Fok1) and rs731236 (Taq1) Variants Are Not Associated with the Risk for Multiple Sclerosis: Results of a New Study and a Meta-Analysis

Background: Some epidemiological, genetic, and experimental data suggest a possible role of vitamin D in the pathogenesis of multiple sclerosis (MS) and in experimental autoimmune encephalomyelitis. Data on the possible contribution of several single nucleotide polymorphisms (SNP) in the vitamin D receptor (VDR) gene to the risk for MS are controversial. Several studies suggested an interaction between some SNPs in the VDR gene and HLADRB1*1501 in the risk for MS. Objectives: The aim of this study was to investigate a possible influence of the SNPs rs2228570 and rs731236 in the VDR gene in the risk for MS. A secondary objective was to address the possible interactions between VDR genes and HLADRB1*1501. Methods: We analyzed the allelic and genotype frequency of VDR rs2228570, rs731236, and HLADRB1*1501 (rs3135388) in 303 patients with MS and 310 healthy controls, using TaqMan Assays. We also conducted a meta-analysis, that was carried out by using the software Meta-Disc 1.1.1 (http://www.hrc.es/investigacion/metadisc.html; Unit of Clinical Statistics, Hospital Ramon y Cajal, Madrid, Spain). Heterogeneity between studies in terms of degree of association was tested using the Q-statistic. Results: VDR rs2228570 and rs731236 allelic and genotype frequencies did not differ significantly between MS patients and controls, and were unrelated with the age of onset of MS, gender, and course of MS. HLADRB1*1501 showed a high association with the risk of developing MS 4.76(95% C. I. = 3.14-7.27; p<0.0001). The meta-analysis, after excluding data of one study that was responsible of heterogeneity for rs731236 polymorphism, showed lack of relation of both SNPs with the risk for MS. HLADRB1*1501 showed lack of interaction with VDR rs2228570 and rs731236 in increasing MS risk. Conclusions: These results suggest that VDR rs2228570 and rs731236 polymorphisms are not related with the risk for MS, and did not confirm interaction between these VDR SNPs and HLADRB1 in the risk for MS.This work was supported in part by Grants FIS PS09/00943, PS09/00469, and RETICS RD07/0064/0016 from Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, Spain, and GR10068 from Junta de Extremadura, Spain.Peer Reviewe

Theoretical analysis of magnetoplasmonic interferometers for sensing

Comunicación presentada en la Conferencia Española de Nanofotónica (CEN2012), celebrada en Carmona (Sevilla) del 1 al 4 de octubre de 2012.Peer Reviewe

Probabilistic meta-analysis of risk from the exposure to Hg in artisanal gold mining communities in Colombia

Colombia is one of the largest per capita mercury polluters in the world as a consequence of its artisanal gold mining activities. The severity of this problem in terms of potential health effects was evaluated by means of a probabilistic risk assessment carried out in the twelve departments (or provinces) in Colombia with the largest gold production. The two exposure pathways included in the risk assessment were inhalation of elemental Hg vapors and ingestion of fish contaminated with methyl mercury. Exposure parameters for the adult population (especially rates of fish consumption) were obtained from nation-wide surveys and concentrations of Hg in air and of methyl-mercury in fish were gathered from previous scientific studies. Fish consumption varied between departments and ranged from 0 to 0.3 kg d?1. Average concentrations of total mercury in fish (70 data) ranged from 0.026 to 3.3 lg g?1. A total of 550 individual measurements of Hg in workshop air (ranging from menor queDL to 1 mg m?3) and 261 measurements of Hg in outdoor air (ranging from menor queDL to 0.652 mg m?3) were used to generate the probability distributions used as concentration terms in the calculation of risk. All but two of the distributions of Hazard Quotients (HQ) associated with ingestion of Hg-contaminated fish for the twelve regions evaluated presented median values higher than the threshold value of 1 and the 95th percentiles ranged from 4 to 90. In the case of exposure to Hg vapors, minimum values of HQ for the general population exceeded 1 in all the towns included in this study, and the HQs for miner-smelters burning the amalgam is two orders of magnitude higher, reaching values of 200 for the 95th percentile. Even acknowledging the conservative assumptions included in the risk assessment and the uncertainties associated with it, its results clearly reveal the exorbitant levels of risk endured not only by miner-smelters but also by the general population of artisanal gold mining communities in Colombia

Empathy for others' suffering and its mediators in mental health professionals

Empathy is a complex cognitive and affective process that allows humans to experience concern for others, comprehend their emotions, and eventually help them. In addition to studies with healthy subjects and various neuropsychiatric populations, a few reports have examined this domain focusing on mental health workers, whose daily work requires the development of a saliently empathic character. Building on this research line, the present population-based study aimed to (a) assess different dimensions of empathy for pain in mental health workers relative to general-physicians and non-medical workers; and (b) evaluate their relationship with relevant factors, such as moral profile, age, gender, years of experience, and workplace type. Relative to both control groups, mental health workers exhibited higher empathic concern and discomfort for others' suffering, and they favored harsher punishment to harmful actions. Furthermore, this was the only group in which empathy variability was explained by moral judgments, years of experience, and workplace type. Taken together, these results indicate that empathy is continuously at stake in mental health care scenarios, as it can be affected by contextual factors and social contingencies. More generally, they highlight the importance of studying this domain in populations characterized by extreme empathic demands.Fil: Santamaria Garcia, Hernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Báez Buitrago, Sandra Jimena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: García, Adolfo Martín. Instituto de Neurología Cognitiva. Laboratorio de Psicología Experimental y Neurociencia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentina. Universidad Nacional de Cuyo. Facultad de Educación Elemental y Especial; ArgentinaFil: Flichtentrei, Daniel. Intramed; ArgentinaFil: Prats, Lucía María. Intramed; Argentina. Centro de Educaciones Médicas e Investigación Clínica "Norberto Quirno"; ArgentinaFil: Mastandueno, Ricardo. Intramed; ArgentinaFil: Sigman, Mariano. Universidad Torcuato di Tella; ArgentinaFil: Matallana, Diana. Pontificia Universidad Javeriana; ColombiaFil: Cetkovich Bakmas, Marcelo Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; ArgentinaFil: Ibanez Barassi, Agustin Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Neurociencia Cognitiva. Fundación Favaloro. Instituto de Neurociencia Cognitiva; Argentin

Evaluación de competencias genéricas instrumentales en la asignatura de Sistemas Operativos I

Una de las directrices emanadas del proceso de convergencia hacia el Espacio Europeo de Educación Superior (EEES) hace referencia al desarrollo de competencias transversales (genéricas) de nuestros estudiantes. Nos estamos refiriendo a aquellas habilidades instrumentales, personales y sistémicas que van más allá de las específicas de cada materia. En 2005, un grupo de profesores de la Universidad Politécnica de Madrid (UPM) constituimos el Grupo de Innovación Educativa DMAE-DIA que fue reconocido como tal por la UPM en 2006. Las líneas de actuación prioritarias del grupo son la evaluación de competencias transversales y el desarrollo de metodologías de aprendizaje activo. Desde entonces y en colaboración con dos profesoras del Departamento de Metodología de las Ciencias del Comportamiento de la Facultad de Psicología de la Universidad Complutense de Madrid estamos realizando evaluaciones sobre la adquisición de algunas de las citadas competencias. En este trabajo presentamos el procedimiento, los resultados y un análisis de los mismos en relación con la evaluación de una competencia genérica instrumental: la capacidad de organización y planificación del estudio. Se considera el estudio como una conducta psicopedagógica compleja, en la que se delimitan 3 fases: antes, durante y después. En este trabajo se han evaluado estrategias durante el estudio. Los sujetos del estudio fueron los alumnos de la asignatura de Sistemas Operativos I, en el curso académico 2006/2007. Como quedará puesto de manifiesto, nuestros estudiantes están en un percentil muy bajo en relación con esta competencia lo que influye sobremanera sobre el rendimiento académico final. En este trabajo también describimos algunas acciones que pensamos ejecutar para intentar paliar este problema

Magnetoplasmonic Interferometers and Applications

Comunicación presentada en el 2nd Early Stage Researchers Workshop in Nanoscience, celebrado en Madrid el 28 y 29 de junio de 2012.Surface plasmons polaritons (SPP) are evanescent waves that propagate along a dielectric-metal interface. They can be confined in subwavelength metal structures, i.e. below the diffraction limit, which leads to many possible applications, including miniaturized optical devices. Within that context, the development of active plasmonics is important to achieve nanophotonic devices with advanced functionalities. This requires a system where the plasmon properties can be manipulated using an external agent. Among the different control agents considered so far, the magnetic field seems a promising candidate, since it is able to modify the dispersion relation of SPP at reasonable magnetic field strengths, and with a high switching speed. This modulation comes from the non-diagonal elements of the dielectric tensor, εij, appearing when the magnetic field is turned on. For noble metals, the ones typically used in plasmonics, these elements are proportional to the applied magnetic field but, unfortunately, very small at field values reasonable for developing applications. On the other hand, ferromagnetic metals have sizeable εij values at small magnetic fields (proportional to their magnetization), but are optically too absorbent. A smart system to develop magnetic field tunable plasmonic devices is the use of multilayers of noble and ferromagnetic metals. That is the framework of the present work, where we analyze the magnetic field induced SPP wavevector modulation (Ak) in Au/Co/Au films as a function of the wavelength and its possible application as a sensor.N

A method for automatically extracting infectious disease-related primers and probes from the literature

BACKGROUND: Primer and probe sequences are the main components of nucleic acid-based detection systems. Biologists use primers and probes for different tasks, some related to the diagnosis and prescription of infectious diseases. The biological literature is the main information source for empirically validated primer and probe sequences. Therefore, it is becoming increasingly important for researchers to navigate this important information. In this paper, we present a four-phase method for extracting and annotating primer/probe sequences from the literature. These phases are: (1) convert each document into a tree of paper sections, (2) detect the candidate sequences using a set of finite state machine-based recognizers, (3) refine problem sequences using a rule-based expert system, and (4) annotate the extracted sequences with their related organism/gene information. RESULTS: We tested our approach using a test set composed of 297 manuscripts. The extracted sequences and their organism/gene annotations were manually evaluated by a panel of molecular biologists. The results of the evaluation show that our approach is suitable for automatically extracting DNA sequences, achieving precision/recall rates of 97.98% and 95.77%, respectively. In addition, 76.66% of the detected sequences were correctly annotated with their organism name. The system also provided correct gene-related information for 46.18% of the sequences assigned a correct organism name. CONCLUSIONS: We believe that the proposed method can facilitate routine tasks for biomedical researchers using molecular methods to diagnose and prescribe different infectious diseases. In addition, the proposed method can be expanded to detect and extract other biological sequences from the literature. The extracted information can also be used to readily update available primer/probe databases or to create new databases from scratch