Nanoformas de carbono moleculares quirales

Conferencias científicasCharla magistral sobre la química en fullerenos quirales y sus propiedades.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. Vicerrectorado de Investigación de la Universidad de Málag

Nanoforms for Photovoltaics: Myth or Reality?

Unión Europea. FP7Ministerio de Economía y Competitividad (MINECO)Comunidad de MadridEuropean Research Council (ERC)Depto. de Química OrgánicaFac. de Ciencias QuímicasTRUEpu

Journal of Materials Chemistry C Q123 top picks web collection: the many faces of carbon

Nazario Martı´n introduces this Journal of Materials Chemistry C top picks web collection on the many faces of carbon

Interaction and cooperative effort among scientific societies. Twelve years of COSCE

The evolution of knowledge and technology in recent decades has brought profound changes in science policy, not only in the countries but also in the supranational organizations. It has been necessary, therefore, to adapt the scientific institutions to new models in order to achieve a greater and better communication between them and the political counterparts responsible for defining the general framework of relations between science and society. The Federationon of Scientific Societies of Spain (COSCE, Confederación de Sociedades Científicas de España) was founded in October 2003 to respond to the urgent need to interact with the political institutions and foster a better orientation in the process of making decisions about the science policy. Currently COSCE consists of over 70 Spanish scientific societies and more than 40,000 scientists. During its twelve years of active life, COSCE has developed an intense work of awareness of the real situation of science in Spain by launching several initiatives (some of which have joined other organizations) or by joining initiatives proposed from other groups related to science both at the Spanish level and at the European and non-European scenarios

Graphene Nanoribbons Via Crystal Engineering

In this issue of Chem, Rubin and coworkers have developed a new approach for the bottom-up synthesis of graphene nanoribbons by efficiently combining crystal engineering and topochemical polymerization

Sobre Fullerenos, Nanotubos de Carbono y Grafenos

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An STM study of molecular exchange processes in organic thin film growth

The growth of a fullerene derivative (PCBM) on top of a layer of a tetrathiafulvalene (TTF) derivative previously deposited on Au(111) has been studied by scanning tunneling microscopy (STM). The results show that the preferential interaction with the gold substrate induces the exchange of PCBM molecules with the exTTF monolayer, expelling exTTF molecules to the outer surface. This exchange process is forbidden when the thickness of the exTTF layer increases above the monolayer, and the larger surface energy of PCBM leads to the growth of 3D islandsOur work was supported by the MICINN of Spain (FIS2010-18847, FIS2012-33011), Comunidad de Madrid (NanobiomagnetS2009/MAT-1726), CONSOLIDER-INGENIO on Molecular Nanoscience (CSD2007-00010) and European Union (SMALL PITN-GA- 2009-23884

Stereodivergent-at-Metal Synthesis of [60]Fullerene Hybrids

Chiral fullerene–metal hybrids with complete control over the four stereogenic centers, including the absolute configuration of the metal atom, have been synthesized for the first time. The stereochemistry of the four chiral centers formed during [60]fullerene functionalization is the result of both the chiral catalysts employed and the diastereoselective addition of the metal complexes used (iridium, rhodium, or ruthenium).DFT calculations underpin the observed configurational stability at the metal center, which does not undergo an epimerization process

A Peptide/Fullerene Hybrid for Multivalent Recognition of E-Selectin

Molecular recognition through ligand-receptor interactions is a very important mechanism for metastatic processes. Among all of them, multivalent protein-carbohydrate interactions play a fundamental role in tumor cell-endothelial cell recognition processes. In particular, the interaction between SLex and SLea expressed in circulating tumor cells and proteins of the family of selectins, overexpressed in endothelial cells. Unlike tumor cells, vascular endothelial cells receptors are a stable target not subjected to genetic modifications. In addition, the elimination of a single endothelial cell involves the death of hundreds of tumor cells. Targeting endothelial receptors cells offers a high potential in tumor diagnosis and therapy. SLex and SLea are the natural ligands of selectins, but their complicated chemical synthesis and their low affinity for selectins made difficult to continue with their development. Recently, through "phase display" it was identified a simple peptide with a linear sequence of seven amino acids (Ile-Glu-Leu-Leu-Gln-Ala-Arg) called IELLQAR that interacts specifically with selectins. IELLQAR is a very simple compound, which can be synthesized using SPPS. IELLQAR can be functionalized and easily conjugated to fullerenes for its multivalent presentation. In addition, it can be combined with diagnostic and therapeutic agents. References [1] Smith, B. A. H.; Bertozzi, C. Nat. Rev. Drug Discov. 2021, 20, 217.243. [2] Fukuda, M. N. et al. Cancer Res. 2000, 60, 450-456 [3] (a) Ramos-Soriano, J. et al. Chem. Commun. 2016, 52, 10544-10546; (b) Ramos-Soriano, J. et al. J. Org. Chem. 2018, 83, 1727-1736.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tec