Comparison of on-wafer calibrations using the concept of reference impedance

A novel method that allows to compare different calibration techniques has been developed. It is based on determining the reference impedance of a given Network Analyzer calibration from the reflection coefficient measurement of a physical open circuit. The method has been applied to several on-wafer calibrations.Peer ReviewedPostprint (published version

Current perspectives of the signaling pathways directing neural crest induction.

The neural crest is a migratory population of embryonic cells with a tremendous potential to differentiate and contribute to nearly every organ system in the adult body. Over the past two decades, an incredible amount of research has given us a reasonable understanding of how these cells are generated. Neural crest induction involves the combinatorial input of multiple signaling pathways and transcription factors, and is thought to occur in two phases from gastrulation to neurulation. In the first phase, FGF and Wnt signaling induce NC progenitors at the border of the neural plate, activating the expression of members of the Msx, Pax, and Zic families, among others. In the second phase, BMP, Wnt, and Notch signaling maintain these progenitors and bring about the expression of definitive NC markers including Snail2, FoxD3, and Sox9/10. In recent years, additional signaling molecules and modulators of these pathways have been uncovered, creating an increasingly complex regulatory network. In this work, we provide a comprehensive review of the major signaling pathways that participate in neural crest induction, with a focus on recent developments and current perspectives. We provide a simplified model of early neural crest development and stress similarities and differences between four major model organisms: Xenopus, chick, zebrafish, and mouse

Pax7 lineage contributions to the mammalian neural crest.

BackgroundNeural crest cells are vertebrate-specific multipotent cells that contribute to a variety of tissues including the peripheral nervous system, melanocytes, and craniofacial bones and cartilage. Abnormal development of the neural crest is associated with several human maladies including cleft/lip palate, aggressive cancers such as melanoma and neuroblastoma, and rare syndromes, like Waardenburg syndrome, a complex disorder involving hearing loss and pigment defects. We previously identified the transcription factor Pax7 as an early marker, and required component for neural crest development in chick embryos. In mammals, Pax7 is also thought to play a role in neural crest development, yet the precise contribution of Pax7 progenitors to the neural crest lineage has not been determined.Methodology/principal findingsHere we use Cre/loxP technology in double transgenic mice to fate map the Pax7 lineage in neural crest derivates. We find that Pax7 descendants contribute to multiple tissues including the cranial, cardiac and trunk neural crest, which in the cranial cartilage form a distinct regional pattern. The Pax7 lineage, like the Pax3 lineage, is additionally detected in some non-neural crest tissues, including a subset of the epithelial cells in specific organs.Conclusions/significanceThese results demonstrate a previously unappreciated widespread distribution of Pax7 descendants within and beyond the neural crest. They shed light regarding the regionally distinct phenotypes observed in Pax3 and Pax7 mutants, and provide a unique perspective into the potential roles of Pax7 during disease and development

Economic growth and investment in the Arab world

This paper analyses the economic growth performance in the Arab world over the last forty years. The Arab world has managed to reduce poverty performance despite its relatively disappointing growth performance. We relate this poor performance of both oil and non-oil producers to investment. Contrary to widespread belief, we do not find evidence that low quantity of investment is the main of low growth. The decline in the investment rate followed rather than preceded the reduction in the aggregate growth rate. We conclude that the low quality of investment projects is the key determinant of growth. The excessive reliance on public investment, the low quality of financial institutions, the bad business environment (due to political and social instability and to excessive public intervention and overregulation) and the low quality of human capital are important determinants of systematically unproductive investment decisions and, thus, low economic growth.Economic growth, investment, the Arab World

Social security, retirement, and the single-mindedness of the electorate

We propose a positive theory that is consistent with two important features of social security programs around the world: (1) they redistribute income from young to old and (2) they induce retirement. We construct a voting model that includes a “political campaign” or “debate” prior to the election. The model incorporates “single-mindedness” of the groups that do not work: while the workers divide their political capital between their “age concerns” and “occupational concerns”, the retired concentrate all their political capital to support their age group. In our model, the elderly end up getting transfers from the government (paid by the young) and distortionary labor income taxes induce the retirement of the elderly. In addition, our model predicts that occupational groups that work more will tend to have more political power. The opposite is true for non-occupational groups (such as the elderly). We provide some evidence that supports these additional predictions.Social Security, retirement, retirement incentives, single-mindedness, political theories of Social Security

The economic tragedy of the XXth Century: Growth in Africa

The dismal growth performance of Africa is the worst economic tragedy of the XXth century. We document the evolution of per capita GDP for the continent as a whole and for subset of countries south of the Sahara desert. We document the worsening of various income inequality indexes and we estimate poverty rates and headcounts. We then analyze some of the central robust determinants of economic growth reported by Sala-i-Martin, Doppelhofer and Miller (2003) and project the annual growth rates Africa would have enjoyed if these key determinants had taken OECD rather than African values. Expensive investment goods, low levels of education, poor health, adverse geography, closed economies, too much public expenditure and too many military conflicts are seen as key explanations of the economic tragedy.Africa, determinants of growth, economic developement

Quantum Singular Value Decomposer

We present a variational quantum circuit that produces the Singular Value Decomposition of a bipartite pure state. The proposed circuit, that we name Quantum Singular Value Decomposer or QSVD, is made of two unitaries respectively acting on each part of the system. The key idea of the algorithm is to train this circuit so that the final state displays exact output coincidence from both subsystems for every measurement in the computational basis. Such circuit preserves entanglement between the parties and acts as a diagonalizer that delivers the eigenvalues of the Schmidt decomposition. Our algorithm only requires measurements in one single setting, in striking contrast to the $3^n$ settings required by state tomography. Furthermore, the adjoints of the unitaries making the circuit are used to create the eigenvectors of the decomposition up to a global phase. Some further applications of QSVD are readily obtained. The proposed QSVD circuit allows to construct a SWAP between the two parties of the system without the need of any quantum gate communicating them. We also show that a circuit made with QSVD and CNOTs acts as an encoder of information of the original state onto one of its parties. This idea can be reversed and used to create random states with a precise entanglement structure.Comment: 6 + 1 pages, 5 figure

Information content versus word length in random typing

Recently, it has been claimed that a linear relationship between a measure of information content and word length is expected from word length optimization and it has been shown that this linearity is supported by a strong correlation between information content and word length in many languages (Piantadosi et al. 2011, PNAS 108, 3825-3826). Here, we study in detail some connections between this measure and standard information theory. The relationship between the measure and word length is studied for the popular random typing process where a text is constructed by pressing keys at random from a keyboard containing letters and a space behaving as a word delimiter. Although this random process does not optimize word lengths according to information content, it exhibits a linear relationship between information content and word length. The exact slope and intercept are presented for three major variants of the random typing process. A strong correlation between information content and word length can simply arise from the units making a word (e.g., letters) and not necessarily from the interplay between a word and its context as proposed by Piantadosi et al. In itself, the linear relation does not entail the results of any optimization process