Don’t Kick the Habit: The Role of Dependency in Habit Formation Apps

Habit formation apps are intended to help instigate and maintain new behaviors. Prior research has established that these apps mostly do not support the theoretical ‘habit’ construct defined in psychology, yet are generally popular and well reviewed in app stores. This apparent mismatch between theory and ‘in-the-wild’ usage has not been investigated to date. Through an in-depth qualitative study of a popular application Lift, this research establishes that common techniques such as reminders and streaks are effective at supporting repetition of new behaviors, but at the same time create a dependency: on-going app use is often required to achieve lasting change. This dependency introduces fragility in users’ attempts to change their behavior, as they often abandon the app and subsequently disengage with their new behaviors

The long-term effects of CVDs on economic development: the case of Bangalore

The aim of this paper is to demonstrate the economic and health burden of Cardiovascular diseases (CVDs) in the context of Bangalore during the period 2010-2013. A data set containing in excess of 1 million historic records corresponding to all-cause mortality was obtained from the central repository data register. After a data quality assessment, a dataset of n=183,893 was obtained. Spatial analysis was carried out to highlight the hotspots of CVD. Potential Years of Life Lost due to CVD and Present Value of Lifetime Earnings were computed. CVDs were responsible for 25% of the total of potential years of life lost. The potential value of lifetime earnings highlighted a loss in excess of 8 billion INR over the four years. CVD poses a tremendous challenge for socio-economic development, and there is an urgent need for a strategic action to promote CVD prevention and enable a sustainable development for the economy

Spatial Interpolation of Air Pollutants in Bangalore: 2010-2013

Air pollutants and their ill effects on the environment and health of populations are well known. However for informed decisions on the protection of the health of populations from elevated levels of air pollution, an understanding of spatial-temporal variance of air pollutant patterns is necessary. Bangalore and other similar developing cities do not have an adequate number of fixed monitoring stations that could provide a complete coverage of the air pollution levels for the entire city. This can be overcome by using geospatial interpolation techniques that provide a complete coverage of the levels of pollutants. The aim of this study is to locate sample points, characterise distribution patterns, map air pollutant distributions using interpolation techniques, highlight areas exceeding standard levels and in doing so determine spatial and temporal patterns of the levels of air pollutants. An air pollution map indicating levels of the variability of the pollutants will aid in the analysis of effects on health in populations due to elevated levels of pollutants

Air Pollution in Bangalore, India: A Six-Year Trend and Health Implication Analysis

Air pollution is increasingly becoming a global concern and is believed to be amongst the leading causes of death in the world today. Developing countries, with rapidly growing economies, are struggling between the focus on economic development and curbing air pollution emissions. Bangalore is one of India’s fastest growing metropolises and, although benefiting economically due to its rapid development, has a rapidly deteriorating environment. This paper provides a critical analysis of the air pollution trend in the city over the period 2005-2011 at 6 specific locations where measurements have been consistently recorded. It also discusses the potential health implications pertaining to exceeding levels of pollutants where these are applicable

K2: A new method for the detection of galaxy clusters based on CFHTLS multicolor images

We have developed a new method, K2, optimized for the detection of galaxy clusters in multicolor images. Based on the Red Sequence approach, K2 detects clusters using simultaneous enhancements in both colors and position. The detection significance is robustly determined through extensive Monte-Carlo simulations and through comparison with available cluster catalogs based on two different optical methods, and also on X-ray data. K2 also provides quantitative estimates of the candidate clusters' richness and photometric redshifts. Initially K2 was applied to 161 sq deg of two color gri images of the CFHTLS-Wide data. Our simulations show that the false detection rate, at our selected threshold, is only ~1%, and that the cluster catalogs are ~80% complete up to a redshift of 0.6 for Fornax-like and richer clusters and to z ~0.3 for poorer clusters. Based on Terapix T05 release gri photometric catalogs, 35 clusters/sq deg are detected, with 1-2 Fornax-like or richer clusters every two square degrees. Catalogs containing data for 6144 galaxy clusters have been prepared, of which 239 are rich clusters. These clusters, especially the latter, are being searched for gravitational lenses -- one of our chief motivations for cluster detection in CFHTLS. The K2 method can be easily extended to use additional color information and thus improve overall cluster detection to higher redshifts. The complete set of K2 cluster catalogs, along with the supplementary catalogs for the member galaxies, are available on request from the authors.Comment: Accepted in ApJ. 25 pages, including 10 figures. Latex with emulateapj v03/07/0

Spatio-Temporal Analysis of the Effects of Air Pollution Hazards on Cardiovascular Health Outcomes in Bangalore, India

Recent research has established a link between exposure to certain pollutants and exacerbation or onset of cardiac diseases. Diseases have a spatial context and the evolution of computer applications, such as Geographical Information Systems (GIS), has favoured the studies of environment and their effects on health and populations. To aid in understanding the extent of air pollution and cardiac diseases in the city of Bangalore (India), this research explores the data requirements and GIS analysis tools that could be used to undertake a spatio-temporal analysis by developing a web based GIS application. The ultimate goal is to identify hotspots of air pollution, explore the relationships between environmental pollution hazards and cardiovascular diseases, integrate the available data to enable sharing among decision makers and disseminate information

Trends in prevalence, mortality, and disability-adjusted life-years relating to chronic obstructive pulmonary disease in Europe: an observational study of the global burden of disease database, 2001-2019

Introduction Chronic Obstructive Pulmonary Disease (COPD) is associated with significant mortality and well-defined aetiological factors. Previous reports indicate that mortality from COPD is falling worldwide. This study aims to assess the burden of COPD using prevalence, mortality, and disability-adjusted life years (DALYs) between 2001 and 2019 in 28 European countries (the European Union and the United Kingdom). Methods We extracted COPD data from the Global Burden of Disease database based on the International Classification of Diseases versions 10 (J41, 42, 43, 44 and 47). Age-standardised prevalence rates (ASPRs), age-standardised mortality rates (ASMRs), and DALYs were analysed for European countries by sex for each year (2001–2019) and reported per 100,000 population. We used Joinpoint regression analysis to quantify changing trends in the burden of COPD. Results In 2019, the median ASPR across Europe was 3230/100,000 for males and 2202/100,000 for females. Between 2001 and 2019, the median percentage change in ASPR was − 9.7% for males and 4.3% for females. 23/28 countries demonstrated a decrease in ASPRs in males, and 11/28 demonstrated a decrease in females. The median percentage change in ASMR between 2001 and 2019 was − 27.5% for males and − 10.4% for females. 25/28 and 19/28 countries demonstrated a decrease in ASMR in males and females, respectively. Conclusion In the EU between 2001 and 2019 COPD prevalence has overall increased in females but continues to decrease in males and in some countries, female prevalence now exceeds that of males. COPD mortality in the EU has decreased overall between 2001 and 2019; however, this decrease is not universal, particularly in females, and therefore remains a substantial source of amenable mortality

DNA content of a functioning chicken kinetochore

© The Author(s) 2014. In order to understand the three-dimensional structure of the functional kinetochore in vertebrates, we require a complete list and stoichiometry for the protein components of the kinetochore, which can be provided by genetic and proteomic experiments. We also need to know how the chromatin-containing CENP-A, which makes up the structural foundation for the kinetochore, is folded, and how much of that DNA is involved in assembling the kinetochore. In this MS, we demonstrate that functioning metaphase kinetochores in chicken DT40 cells contain roughly 50 kb of DNA, an amount that corresponds extremely closely to the length of chromosomal DNA associated with CENP-A in ChIP-seq experiments. Thus, during kinetochore assembly, CENP-A chromatin is compacted into the inner kinetochore plate without including significant amounts of flanking pericentromeric heterochromatin. © 2014 The Author(s).Wellcome Trust [grant number 073915]; Wellcome Trust Centre for Cell Biology (core grant numbers 077707 and 092076); Darwin Trust of Edinburg

A Novel Mutation in the Upstream Open Reading Frame of the CDKN1B Gene Causes a MEN4 Phenotype

PubMed ID: 23555276This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited