Signalling pathways and gene expression profiles in prostate cancer

In general, cancer, encompassing prostate cancer (PCa), is a disease that utilises signalling pathways to progress through the uncontrolled proliferation of cancerous cells. Although the mechanisms of how the cells evade intrinsic or extrinsic signals of death and keep on dividing is not completely understood, there is a plethora of evidence that point to certain signalling molecules that are crucial conveyors of the fine tuning that slightly differs in cancer in comparison to control states. The present chapter provides a detailed description of the key regulators of PCa cell life and unveils their closely communicating proteins that aid in the fine tuning of the cancerous state

Implementing a Practice Doctorate Program at a Distance through an Urban-Rural Partnership

The purposes of this poster presentation are to 1) describe the implementation of a doctor of nursing practice (DNP) program by providing access to rigorous distance education to students living in rural Pennsylvania; 2) discuss building a critical mass of doctorally prepared advanced practice nurse experts in both urban and rural communities; and 3) share formative and summative evaluation information. Through funding from the U.S. Department of Health and Human Services, Health Resources and Services Administration, Bureau of Health Professions, Division of Nursing, the Jefferson School of Nursing (JSN) expanded its DNP program currently offered at the urban Philadelphia campus to the rural campus in Danville. Using the methodologies of live web-casting and live video over the Internet, distance students are afforded the opportunity to participate in a live classroom setting rather than experience the static distance methodology of reading through lectures themselves. For example, during the applied biostatistics course, the faculty teaches onsite in Philadelphia projecting the SPSS and the database on screen so that students on both campuses can simultaneously view, hear, and interact with the discussion. There is a doctorally prepared faculty member onsite in Danville as a resource for the students. These newer technologies make possible real-time faculty-student dialogue, student-to-student dialogue, and enhance socialization. Furthermore, the use of advanced technologies allows distance students to discuss with peers and faculty alike, in real time, the problems, successes, and questions which arise during class and clinical practica, thereby enhancing critical thinking and diagnostic reasoning skills. This unique urban-rural partnership, made possible through advanced technologies, addresses increasing demands for educating greater numbers of doctorally prepared advanced practice nurses to work in north and central rural Pennsylvania, thus promoting access to health care in rural underserved communities. Other than in academia, there are no doctorally prepared advanced practice nurses employed in practice in the area

Aktivitas Penghambatan Oksidasi Asam Linoleat Ekstrak Metanol Daun Soyogik (Saurauia bracteosa DC) dengan Metode Ferric Thiocyanate

Telah dilakukan penelitian untuk menentukan kandungan total fenolik dan aktivitas antioksidan ekstrak metanol daun soyogik (Saurauia bracteosa DC) sebagai peredam radikal bebas asam linoleat. Kandungan total fenolik diukur dengan metode Folin-Ciocalteu sedangkan aktivitas antioksidan diukur dengan metode FTC (Ferric Thiocyanate) untuk mengetahui kemampuan penghambatan peroksida pada tahap pertama oksidasi lipid.  Hasil penelitian menunjukkan bahwa ekstrak metanol memiliki kandungan total fenolik sebesar 99,67 mg/kg dan kemampuan dalam menghambat oksidasi asam linoleat sebesar 49,464%.This research has been conducted to measure the total phenolic compounds and the antioxidant activity of methanol extract of soyogik leaves (Saurauia bracteosa DC) as a reducer of free radicals linoleic acid. The total phenolic content was measured using folin-ciocalteu method, meanwhile the antioxidant activity was measured using FTC (Ferric Thiocyanate) method and to determine the peroxide inhibitory capability in the first stages of lipid peroxidation. The results showed that the methanol extract had a total phenolic content of 99, 67 mg/kg and peroxide inhibition of 49, 464

HUBUNGAN ANTARA PENGETAHUAN GIZI IBU DENGAN STATUS GIZI ANAK USIA 12-24 BULAN DI WILAYAH KERJA PUSKESMAS TATELI KECAMATAN MANDOLANG KABUPATEN MINAHASA

Permasalahan anak saat ini pada umumnya yaitu masalah kesulitan makan diantaranya kurangnya pengetahuan ibu mengenai gizi yang harus dipemuhi pada masa pertumbuhan anak. Tujuan dari penelitian ini untuk mengetahui apakah ada hubungan antara pengetahuan gizi ibu dengan status gizi anak usia 12- 24 bulan di Wilayah Kerja Puskesmas Tateli Kecamatan Mandolang Kabupaten Minahasa. Penelitian ini menggunakan Desain Penelitian Survey Analitik dengan pendekatan Cross Sectional, dilaksanakan pada bulan Juli-September 2019 di Wilayah Kerja Puskesmas Tateli Kecamatan Mandolang Kabupaten Minahasa. Sampel yang digunakan sebesar 70 anak. Instrumen penelitian: Kuesioner, timbangan berat badan dan microtoise. Pengolahan data menggunakan uji korelasi Spearman. Hasil uji statistik dalam penelitian menunjukkan status gizi dengan indikator BB/U gizi baik 68,6%, gizi kurang 28,6% dan gizi lebih 2,9%. Indikator TB/U tinggi 4,3%, normal 62,9%, pendek 30,0% dan sangat pendek 2,9%. Indikator BB/TB normal 70,0%, gemuk 86%, kurus 15,7% dan sangat kurus 5,7%. Sedangkan, Pengetahuan gizi ibu yang baik berjumlah 62,9%, cukup berjumlah 24,3% dan kurang 12,9%. Berdasarkan hasil uji Spearman menujukkan terdapat hubungan antara pengetahuan gizi ibu dengan (BB/U) nilai p =  0,006 tetapi tidak terdapat hubungan antara pengetahuan gizi ibu dengan (TB/U) nilai p = 0,244 dan (BB/TB) tidak terdapat hubungan dengan nilai p = 0,240  pada anak 12- 24 bulan di Wilayah Kerja Puskesmas Tateli Kecamatan Mandolang Kabupaten Minahasa. Kesimpulan diharapkan bagi ibu yang memiliki pengetahuan yang kurang baik untuk sering ke Posyandu saat kegiatan Posyandu berlangsung atau sudah dijadwalkan untuk mendapatkan penimbangan anak. Saran agar ibu juga mendapat penyuluhan dari petugas kesehatan agar dapat menambah pengetahuan agar dapat memenuhi kebutuhan nutrisisi anak. Kata Kunci: Pengetahuan Gizi Ibu dan Status Gizi ABSTRACTThe problem of children today in general is the problem of eating difficulties including lack of maternal knowledge about nutrition that must be met during the child's growing period. The purpose of this research was to determine whether there is a Relationship Between Mother's Nutrition Knowledge and The Nutritional Status of Children 12-24 Months In The Working Area of The Tateli Community Health Center, Mandolang District, Minahasa Regency. This research used an Analytical Survey research design with a Cross Sectional approach, carried out in July-September 2019 in the Tateli Community Health Center, Mandolang District, Minahasa Regency. The sample used was 70 children. Research instruments: Questionnaires, Weight Scales and Microtoise. Data processing using the Spearman Correlation test. The results of statistical tests in the research indicate that the nutritional status with an indicator of Body Weight/Age is 68.6% good nutrition, 28.6% malnutrition and 2.9% over nutrition. Indicator Height/Age, high 4.3%, normal 62.9%, short 30.0% and very short 2.9%. Indicator of Body Weight/Height is 70.0% normal, 86% fat, 15.7% thin and very thin 5.7%. Meanwhile, good knowledge of maternal nutrition is amount 62.9%, enough amounted to 24.3% and less 12.9%. Based on the results of the Spearman test shows there is a relationship between maternal nutrition knowledge with (BB/U) p value = 0,006 but there is no relationship between maternal nutritional knowledge with (TB/U) p value = 0,244 and (BB/TB) value of p = 0,240 in children 12-24 months in the working are of the Tateli Community Health Center, Mandolang District, Minahasa Regency. It is expected that mothers who have inadequate knowledge often go to integrated healthcare post when they doing activities take place or have been scheduled to get a child's weighing. So that mothers also receive counseling from health workers in order to increase knowledge in order to meet the nutritional needs of children. Keywords: Mother’s Nutritional Knowledge and Nutritional Statu

Gambaran Pengetahuan, Sikap, dan Praktik Gizi Seimbang Remaja di Jemaat GMIM Kalvari Kombos Timur

Peran penting yang sangat memengaruhi derajat kesehatan masyarakat adalah gizi. Kondisi gizi dari seseorang dipengaruhi beberapa faktor yaitu pengetahuan, sikap, dan praktik terkait gizi seimbang. Penerapan terkait gizi seimbang masih kurang dilakukan salah satunya karena penyampaian informasi yang tidak maksimal. Tujuan dari penelitian ini ialah untuk mengetahui gambaran pengetahuan, sikap, dan praktik gizi seimbang dari remaja di jemaat GMIM Kalvari Kombos Timur. Penelitian ini menggunakan survei deskriptif dengan sampel penelitian adalah seluruh anggota remaja GMIM Kalvari Kombos Timur dan menggunakan data primer atau data yang didapatkan langsung dari lapangan serta data sekunder mendukung gambaran umum wilayah. Penelitian ini menggunakan analisis univariat. Hasil dari penelitian menunjukkan bahwa mayoritas responden yaitu 72,5% memiliki pengetahuan baik, 97,8% memiliki sikap baik, dan 73,6% memiliki praktik baik terhadap gizi seimbang.  Kata Kunci: Pengetahuan, Sikap, Praktik ABSTRACTAn important aspect that significantly affects the degree of public health is nutrition. The nutritional condition of a person is influenced by several factors, namely knowledge, attitudes, and practices related to balanced nutrition. Applications related to balanced nutrition are still lacking, one of which is because the delivery of information is not optimal. The purpose of this study is to describe the knowledge, attitudes, and practices of balanced nutrition among the adolescents in the GMIM Kalvari Kombos Timur congregation. This study uses a descriptive survey with the research sample being all members of the GMIM Kalvari Timur Kombos adolescents and using primary data or data obtained directly and secondary data to support the general description of the area. This study used univariate analysis. The results of the study showed that the majority of respondents which is 72.5% have good knowledge, 97.8% have good attitudes, and 73.6% have good practices towards balanced nutrition.  Keywords: Knowledge, Attitudes, Practices

Clinical and psychosocial correlates of post-herpetic neuralgia

Post-herpetic neuralgia is the most challenging and debilitating complication of herpes zoster in the immunocompetent host. Because the effect of treatment is disappointing once the syndrome has developed, it is important to know which factors predict post-herpetic neuralgia occurrence to facilitate selection of herpes zoster patients with a higher risk of developing neuralgia and undertake preventative strategies. The present study aimed at identifying demographic, clinical and psychosocial correlates of post-herpetic neuralgia in a sample of 219 immunocompetent patients, who were examined by dermatologists in private practice in Italy and who completed a questionnaire designed to evaluate their clinical and psychosocial profile at the time of clinical diagnosis of herpes zoster and at a follow-up visit 6 months later. In a univariate analysis, post-herpetic neuralgia was associated significantly with older age, longer duration of prodromal pain, greater acute pain intensity, greater extent of rash, presence of abnormal sensations and use of systemic antiviral therapy. Compared to the values at herpes zoster onset, at the follow-up visit patients with post-herpetic neuralgia presented with similar high mean scores of pain intensity, anxiety and depression and greatly reduced quality of life, whereas patients without neuralgia presented with improved scores. In a multivariate model, older age, greater acute pain intensity, greater extent of rash and longer duration of prodromal pain were independently associated with post-herpetic neuralgia. The results of this study may help physicians to identify patients with a higher risk of developing post-herpetic neuralgia and undertaking preventative strategies

APPLICATION OF LASER SCANNING SURVEYING TO ROCK SLOPES RISK ASSESSMENT ANALYSIS

The methods for understanding rock instability mechanisms and for evaluating potential destructive scenarios are of great importance in risk assessment analysis dedicated to the establishment of appropriate prevention and mitigation actions. When the portion of the unstable rock mass is very large, effective actions to counteract the risks are complex and expensive. In these conditions, an optimal risk management cannot ignore procedures able to faster and accurately acquire i) geometrical data for modeling the geometry of the rock walls and implementing reliable forecasting models and ii) monitoring data able to describe the magnitude and the direction of deformation processes. These data contributes to the prediction of the behavior of a landslide if the measurements are acquired frequently and reliable numerical models can be implemented. Innovative geomatic techniques, based on GPS, Terrestrial Laser Scanning Surveying (TLS), automated total station and satellite and ground SAR Interferometry, have been recently applied to define the geometry and monitoring the displacements of unstable slopes. Among these, TLS is mainly adopted to generate detailed 3D models useful to reconstruct rock wall geometry by contributing to the estimation of geo-mechanical parameters, that is orientation, persistence and apparent spacing of rock discontinuities. Two examples of applications of TLS technique to the analysis of a large front in a quarry and of a rock shoulder of a dam are presented