Child and Parent Perceptions of Participating in Multimethod Research in the Acute Aftermath of Pediatric Injury

Background: Despite growing evidence that participation in psychological trauma research is well tolerated by children and parents, ethics boards may voice concerns regarding research with families with recent acute trauma exposure. Factors impacting child and parent experiences of research participation are not well documented, particularly for methodologies including observational components. Objectives: This study describes child and parent perceptions of research participation involving an observational task following an acute traumatic event and explores potential relationships between research experience and selected demographic factors (race/ethnicity, sex, age, prior trauma exposure), and post-traumatic stress symptoms. Methods: As part of a larger study on the role of biopsychosocial factors in post-traumatic stress symptoms, 96 child–parent dyads (ages 8–12 years, M = 10.6) participated in a three–time point study following hospitalization for pediatric injury. At baseline, children and parents completed measures of reactions to research participation, post-traumatic stress symptoms, and trauma history. Measures of post-traumatic stress symptoms were repeated at 6- and 12-week follow-up assessments. Results: The majority of families reported they were glad they participated in the research study (61% children; 72% parents) and felt good about helping others (74% children; 93% parents). Negative feelings were uncommon (\u3c 10% of families). Perceptions of participation were not related to race, sex, or trauma history, but child age significantly factored into trust of the research team and informed consent (Spearman’s ρ = .289, p \u3c .01). Reactions to research were not significantly related to child or parent post-traumatic stress symptoms at any time point. Conclusions: Current results extend past research to suggest that most children’s and parents’ research experience is positive, even when completing an observational task during hospitalization for an injury. Children under the age of 10 years may perceive their participation as less voluntary, supporting prior findings that additional steps be taken to ensure their understanding of their choice in participation

Acoustically induced and controlled micro-cavitation bubbles as active source for transcranial adaptive focusing

The skull bone is a strong aberrating medium for ultrasound in the low MHz range. Brain treatment with High Intensity Focused Ultrasound (HIFU) can however be achieved through the skull by multichannel arrays using an adaptive focusing technique. Time-reversal is a robust adaptive technique for correction of aberrations. It achieves moreover a matched filter and then allows the optimal energy concentration for thermal therapy. Nevertheless, this method requires a reference signal sent by a source embedded in brain tissues. Acoustically generated cavitation bubbles are active acoustic sources which can be remotely generated. Therefore, they are suited for this non-invasive time reversal aberration correction. We report here in vitro experiments where micro-cavitation was induced transcranially in agar gel at targeted positions using a coarse aberration correction either obtained from CT-scan based simulations or conventional steering. The bubbles' ultrasonic signature received by the array were then successfully used to optimally focus at the designated locations.http://deepblue.lib.umich.edu/bitstream/2027.42/84308/1/CAV2009-final134.pd

A Parent-Led Intervention to Promote Recovery Following Pediatric Injury: Study Protocol for a Randomized Controlled Trial

Background: Injury is one of the most prevalent potentially emotionally traumatic events that children experience and can lead to persistent impaired physical and emotional health. There is a need for interventions that promote full physical and emotional recovery and that can be easily accessed by all injured children. Based on research evidence regarding post-injury recovery, we created the Cellie Coping Kit for Children with Injury intervention to target key mechanisms of action and refined the intervention based on feedback from children, families, and experts in the field. The Cellie Coping Kit intervention is parent-guided and includes a toy (for engagement), coping cards for children, and a book for parents with evidence-based strategies to promote injury recovery. This pilot research trial aims to provide an initial evaluation of the impact of the Cellie Coping Kit for Children with Injury on proximal targets (coping, appraisals) and later child health outcomes (physical recovery, emotional health, health-related quality of life). Method / Design: Eighty children (aged 8–12 years) and their parents will complete a baseline assessment (T1) and then will be randomly assigned to an immediate intervention group or waitlist group. The Cellie Coping Kit for Injury Intervention will be introduced to the immediate intervention group after the T1 assessment and to the waitlist group following the T3 assessment. Follow-up assessments of physical and emotional health will be completed at 6 weeks (T2), 12 weeks (T3), and 18 weeks (T4). Discussion: This will be one of the first randomized controlled trials to examine an intervention tool intended to promote full recovery after pediatric injury and be primarily implemented by children and parents. Results will provide data on the feasibility of the implementation of the Cellie Coping Intervention for Injury as well as estimations of efficacy. Potential strengths and limitations of this design are discussed. Trial Registration: Clinicaltrials.gov, NCT03153696. Registered on 15 May 2017

An Initial Application of a Biopsychosocial Framework to Predict Posttraumatic Stress Following Pediatric Injury

Objectives—Each year millions of children suffer from unintentional injuries that result in poor emotional and physical health. This study examined selected biopsychosocial factors (i.e., child heart rate, peritrauma appraisals, early coping, trauma history) to elucidate their roles in promoting emotional recovery following injury. The study evaluated specific hypotheses that threat appraisals (global and trauma-specific) and coping would predict subsequent posttraumatic stress symptoms (PTSS), that coping would mediate the association between early and later PTSS, and that heart rate would predict PTSS and appraisals would mediate this association. Method—Participants were 96 children hospitalized for injury and assessed at 3 time points: T1 (within 2 weeks of injury), T2 (6-week follow-up), and T3 (12-week follow-up). Participants completed measures of trauma history and appraisals at T1, coping at T2, and PTSS at T1, T2, and T3. Heart rate was abstracted from medical records. Structural equation modeling was employed to evaluate study hypotheses. Results—Heart rate was not associated with PTSS or appraisals. Models including trauma history, appraisals, coping, and PTSS were constructed to test other study hypotheses and fit the data well. T1 global and trauma-specific threat appraisals were associated with T1 PTSS; T2 avoidant coping was a significant mediator of the relation between T1 and T3 PTSS. Conclusions—Findings confirm a role for appraisals and coping in the development of PTSS over the weeks following pediatric injury. Early appraisals and avoidant coping may be appropriate targets for prevention and early intervention. Future researchers should further explicate the utility of a biopsychosocial framework in predicting PTSS

Accounting for fishing days without a fishing set in the CPUE standardization of yellowfin tuna in free schools for the EU purse seine fleet operating in the eastern Atlantic Ocean during the 1993-2018 period

The time series of EU purse seine fleet catches per unit effort (CPUE) of yellowfin tuna (YFT) from the Atlantic Ocean were standardized using an extension of the Delta-lognormal GLMM to three components. The aim was to depict the trend in abundance for adult YFT observed in free schools (FSC). The originality of this work relied on the inclusion of i) null sets, considered as presence of YFT FSC, ii) fishing days without set, considered as absence of FSC, iii) EU fishing agreement in the exclusive economic zones driving EU purse seine fleet presence in these areas, and iv) time spent by centroid cell by boat by day to constrain detectability. Standardized CPUE for FSC was thus defined as the product of the number of set (positive and null) by spatio-temporal strata, the proportion of sets with large YFT (>10 kg) and the catch per large YFT set. To detect strata without sets, all activities recorded in captain logbooks were used for the period 1993-2018. This new standardization approach, therefore, represents a significant advance over previous efforts, though there are a number of avenues for future progress.Versión del edito