ACTIVE HOUSE PROTOCOL APPLICATION IN MEDITERRANEAN CLIMATE : an energy-efficient kindergarden in Coppito

La U.E. intende raggiungere la neutralità climatica entro il 2050. Questo articolo mira a colmare il divario nella scelta di soluzioni migliorative delle condizioni di vita negli assetti territoriali (SDG n.11) per il raggiungimento delle prestazioni energetiche attese (SDG n.7) e diffondere l’adozione di nuovi approcci e misure per la progettazione sostenibile (SDG n.13). Tali obiettivi sono stati conseguiti mediante l’applicazione di un processo di reverse engineering all’asilo Ape Tau, L’Aquila, località Coppito, dopo il sisma del 2009. Le soluzioni progettuali impiegate nell’edificio sono state analizzate secondo livelli quantitativi suggeriti dall’approccio olistico del protocollo Active House, che fornisce la metodologia per verificare le prestazioni dell’edificio secondo criteri di comfort, energia e ambiente. I risultati evidenziano elevate prestazioni dell’edificio costruito con tecnologia stratificata a secco e l’efficacia del metodo basato su analisi process- oriented a utente, ambiente e territorio. L’articolo propone un paradigma innovativo per la riqualificazione degli edifici, replicabile in numerosi contesti e differenti condizioni climaticheThe E.U. aims to achieve climate neutrality by 2050. This article aims to fill the gap in the selection of solutions to improve living conditions in territorial assets (SDG n.11) to achieve the expected energy performance (SDG n.7) and disseminate the adoption of new approaches and measures for sustainable design (SDG n.13). These objectives were met through the application of a reverse engineering process to the Ape Tau kindergarten in L'Aquila, Coppito area, after the 2009 earthquake. The building's design solutions were investigated according to quantitative levels suggested by the holistic approach of the Active House protocol, which provides the methodology to verify the building's performance according to comfort, energy and environmental criteria. The results highlight the high performance of the building constructed with multilayer dry technology and the method's effectiveness based on process-oriented analysis to user, environment and territory. The article proposes an innovative paradigm for building requalification replicable in numerous contexts and different climatic conditions

ACTIVE HOUSE PROTOCOL APPLICATION IN MEDITERRANEAN CLIMATE An energy-efficient kindergarten in Coppito

The E.U. aims to achieve climate neutrality by 2050. This article aims to fill the gap in the selection of solutions to improve living conditions in territorial assets (SDG n.11) to achieve the expected energy performance (SDG n.7) and disseminate the adoption of new approaches and measures for sustainable design (SDG n.13). These objectives were met through the application of a reverse engineering process to the Ape Tau kindergarten in L'Aquila, Coppito area, after the 2009 earthquake. The building's design solutions were investigated according to quantitative levels suggested by the holistic approach of the Active House protocol, which provides the methodology to verify the building's performance according to comfort, energy and environmental criteria. The results highlight the high performance of the building constructed with multilayer dry technology and the method's effectiveness based on process-oriented analysis to user, environment and territory. The article proposes an innovative paradigm for building requalification replicable in numerous contexts and different climatic conditions

LoCuSS: A Comparison of Sunyaev-Zel'dovich Effect and Gravitational Lensing Measurements of Galaxy Clusters

We present the first measurement of the relationship between the Sunyaev-Zel'dovich effect signal and the mass of galaxy clusters that uses gravitational lensing to measure cluster mass, based on 14 X-ray luminous clusters at z~0.2 from the Local Cluster Substructure Survey. We measure the integrated Compton y-parameter, Y, and total projected mass of the clusters (M_GL) within a projected clustercentric radius of 350 kpc, corresponding to mean overdensities of 4000-8000 relative to the critical density. We find self-similar scaling between M_GL and Y, with a scatter in mass at fixed Y of 32%. This scatter exceeds that predicted from numerical cluster simulations, however, it is smaller than comparable measurements of the scatter in mass at fixed T_X. We also find no evidence of segregation in Y between disturbed and undisturbed clusters, as had been seen with T_X on the same physical scales. We compare our scaling relation to the Bonamente et al. relation based on mass measurements that assume hydrostatic equilibrium, finding no evidence for a hydrostatic mass bias in cluster cores (M_GL = 0.98+/-0.13 M_HSE), consistent with both predictions from numerical simulations and lensing/X-ray-based measurements of mass-observable scaling relations at larger radii. Overall our results suggest that the Sunyaev-Zel'dovich effect may be less sensitive than X-ray observations to the details of cluster physics in cluster cores.Comment: Minor changes to match published version: 2009 ApJL 701:114-11

Joint analysis of X-ray and Sunyaev Zel'dovich observations of galaxy clusters using an analytic model of the intra-cluster medium

We perform a joint analysis of X-ray and Sunyaev Zel'dovich (SZ) effect data using an analytic model that describes the gas properties of galaxy clusters. The joint analysis allows the measurement of the cluster gas mass fraction profile and Hubble constant independent of cosmological parameters. Weak cosmological priors are used to calculate the overdensity radius within which the gas mass fractions are reported. Such an analysis can provide direct constraints on the evolution of the cluster gas mass fraction with redshift. We validate the model and the joint analysis on high signal-to-noise data from the Chandra X-ray Observatory and the Sunyaev-Zel'dovich Array for two clusters, Abell 2631 and Abell 2204.Comment: ApJ in pres

Sunyaev Zel'dovich Effect Observations of Strong Lensing Galaxy Clusters: Probing the Over-Concentration Problem

We have measured the Sunyaev Zel'dovich (SZ) effect for a sample of ten strong lensing selected galaxy clusters using the Sunyaev Zel'dovich Array (SZA). The SZA is sensitive to structures on spatial scales of a few arcminutes, while the strong lensing mass modeling constrains the mass at small scales (typically < 30"). Combining the two provides information about the projected concentrations of the strong lensing clusters. The Einstein radii we measure are twice as large as expected given the masses inferred from SZ scaling relations. A Monte Carlo simulation indicates that a sample randomly drawn from the expected distribution would have a larger median Einstein radius than the observed clusters about 3% of the time. The implied overconcentration has been noted in previous studies with smaller samples of lensing clusters. It persists for this sample, with the caveat that this could result from a systematic effect such as if the gas fractions of the strong lensing clusters are substantially below what is expected.Comment: submitte

Comparison of Pressure Profiles of Massive Relaxed Galaxy Clusters using Sunyaev-Zel'dovich and X-ray Data

We present Sunyaev-Zel'dovich (SZ) effect observations of a sample of 25 massive relaxed galaxy clusters observed with the Sunyaev-Zel'dovich Array (SZA), an 8-element interferometer that is part of the Combined Array for Research in Millimeter-wave Astronomy (CARMA). We perform an analysis of new SZA data and archival Chandra observations of this sample to investigate the integrated pressure -- a proxy for cluster mass -- determined from X-ray and SZ observations, two independent probes of the intra-cluster medium. This analysis makes use of a model for the intra-cluster medium introduced by Bulbul (2010) which can be applied simultaneously to SZ and X-ray data. With this model, we estimate the pressure profile for each cluster using a joint analysis of the SZ and X-ray data, and using the SZ data alone. We find that the integrated pressures measured from X-ray and SZ data are consistent. This conclusion is in agreement with recent results obtained using WMAP and Planck data, confirming that SZ and X-ray observations of massive clusters detect the same amount of thermal pressure from the intra-cluster medium. To test for possible biases introduced by our choice of model, we also fit the SZ data using the universal pressure profile proposed by Arnaud (2010), and find consistency between the two models out to r500 in the pressure profiles and integrated pressures.Comment: Accepted for New Journal of Physics, Focus Issue on Galaxy Cluster

The evolution of non-small cell lung cancer metastases in TRACERx

Metastatic disease is responsible for the majority of cancer-related deaths. We report the longitudinal evolutionary analysis of 126 non-small cell lung cancer (NSCLC) tumours from 421 prospectively recruited patients in TRACERx who developed metastatic disease, compared with a control cohort of 144 non-metastatic tumours. In 25% of cases, metastases diverged early, before the last clonal sweep in the primary tumour, and early divergence was enriched for patients who were smokers at the time of initial diagnosis. Simulations suggested that early metastatic divergence more frequently occurred at smaller tumour diameters (less than 8 mm). Single-region primary tumour sampling resulted in 83% of late divergence cases being misclassified as early, highlighting the importance of extensive primary tumour sampling. Polyclonal dissemination, which was associated with extrathoracic disease recurrence, was found in 32% of cases. Primary lymph node disease contributed to metastatic relapse in less than 20% of cases, representing a hallmark of metastatic potential rather than a route to subsequent recurrences/disease progression. Metastasis-seeding subclones exhibited subclonal expansions within primary tumours, probably reflecting positive selection. Our findings highlight the importance of selection in metastatic clone evolution within untreated primary tumours, the distinction between monoclonal versus polyclonal seeding in dictating site of recurrence, the limitations of current radiological screening approaches for early diverging tumours and the need to develop strategies to target metastasis-seeding subclones before relapse

Genomic–transcriptomic evolution in lung cancer and metastasis

Intratumour heterogeneity (ITH) fuels lung cancer evolution, which leads to immune evasion and resistance to therapy. Here, using paired whole-exome and RNA sequencing data, we investigate intratumour transcriptomic diversity in 354 non-small cell lung cancer tumours from 347 out of the first 421 patients prospectively recruited into the TRACERx study. Analyses of 947 tumour regions, representing both primary and metastatic disease, alongside 96 tumour-adjacent normal tissue samples implicate the transcriptome as a major source of phenotypic variation. Gene expression levels and ITH relate to patterns of positive and negative selection during tumour evolution. We observe frequent copy number-independent allele-specific expression that is linked to epigenomic dysfunction. Allele-specific expression can also result in genomic–transcriptomic parallel evolution, which converges on cancer gene disruption. We extract signatures of RNA single-base substitutions and link their aetiology to the activity of the RNA-editing enzymes ADAR and APOBEC3A, thereby revealing otherwise undetected ongoing APOBEC activity in tumours. Characterizing the transcriptomes of primary–metastatic tumour pairs, we combine multiple machine-learning approaches that leverage genomic and transcriptomic variables to link metastasis-seeding potential to the evolutionary context of mutations and increased proliferation within primary tumour regions. These results highlight the interplay between the genome and transcriptome in influencing ITH, lung cancer evolution and metastasis