Análisis comparativo: anticoagulantes clásicos frente a los nuevos anticoagulantes

En los últimos años ha aumentado considerablemente la utilización de anticoagulantes orales en la prevención de procesos tromboembólicos. El descubrimiento de los anticoagulantes clásicos como son los antagonistas de la vitamina K o la heparina no fraccionada fueron la única opción disponible para la terapia anticoagulante oral en la prevención y tratamiento de las enfermedades tromboembólicas venosas (ETV) durante un largo periodo de tiempo. Sin embargo, el uso de estos anticoagulantes siempre ha estado obstaculizado por la necesidad de llevar un control periódico de la coagulación y las posibles complicaciones hemorrágicas. Este tratamiento resulta muy complejo, por ello en los últimos años, la investigación se ha centrado en el desarrollo de un anticoagulante oral con amplio margen terapéutico y escasa variabilidad intra e interindividual que pueda administrarse con una dosis fija sin necesidad de monitorizar sistemáticamente la coagulación y que presente pocas interacciones. Actualmente, existen tres inhibidores directos del factor X activo (FXa) (rivaroxabán, apixabán y edoxabán) y un inhibidor directo de la trombina (dabigatrán), que han desarrollado un balance beneficio/riesgo favorable, comparable en eficacia y seguridad a los anticoagulantes tradicionales antagonistas de la vitamina K. No obstante, es necesario obtener una mayor experiencia con su utilización en la práctica clínica para solventar los problemas derivados de su reciente comercialización.In recent years, the use of oral anticoagulants in the prevention of thromboembolic processes has increased considerably. The Discovery of classic anticoagulants such as vitamin K antagonists or unfractionated heparin were the only available option for oral anticoagulant therapy in the prevention and treatment of venous thromboembolic diseases for a long period of time. However, the use of these anticoagulants has always been hampered by the need for regular monitoring of coagulation and potential bleeding complications. This treatment is very complex, wich is why in recent years, research has focused on the development of an oral anticoagulant with a wide therapeutic margin and Little intra and inter-individual variability that can be administered with a fixed dose without the need to systematically monitor coagulation and with few interactions. Currently, there are three direct inhibitors of active factor X (FXa) (Rivaroxaban, apixaban and edoxaban) and one direct thrombin inhibitor (dabigatran), wich have developed a favorable benefit/risk balance, comparable in efficacy anda safety to tradicional anticoagulants vitamin K antagonists. However, it is necessary to ontain more experience with their use in clinical practice to solve the problems arising from their recent marketing

<<DesrinconARTE>>

The project presented below is an educational proposal developed for the CIS Mercedes Pinto, located in Santa Cruz de Tenerife. The project is aimed specifically at women of the center. It has studied the need to implement a number of specific activities for women within the center. For this reason «DesrinconARTE» arises, in order to provide women a space where they can express themselves freely, to share experiences and work for social reintegration. This proposal has two educational strategies that are considered essential to work with women. On the one hand "the eighth art" in which aspects of sexuality work as it is considered an aspect that seriously affects the personality of persons deprived of their liberty. On the other hand, "FamiliARTE" issues related to family, especially mothers and exploitation that many women will make this work. All this through art work is considered a great method that allows freedom of expression and encourages creativity.El proyecto que se presenta a continuación es una propuesta educativa elaborada para el CIS Mercedes Pinto, situado en Santa Cruz de Tenerife. El proyecto está destinado específicamente a las mujeres de dicho centro. Se ha estudiado la necesidad de implantar una serie de actividades específicas para las mujeres dentro del centro. Por ese motivo surge «DesrinconARTE», con el fin de aportar a las mujeres un espacio en el que puedan expresarse libremente, compartir experiencias y trabajar para la reinserción social. Esta propuesta presenta dos estrategias educativas que se consideran fundamentales para trabajar con las mujeres. Por un lado “El octavo arte” en el cual se trabajaran aspectos de la sexualidad, ya que se considera un aspecto que influye gravemente en la personalidad de las personas privadas de libertad. Por otro lado, “FamiliARTE” se trabajaran temas relacionados con la familia, especialmente con la maternidad y la instrumentalización que muchas mujeres hacen de esta. Todo esto se trabajará a través del arte que se considera un gran método que permite la libertad de expresión y fomenta la creatividad

Local convexity for second order differential equations on a Lie algebroid

A theory of local convexity for a second order differential equation (SODE) on a Lie algebroid is developed. The particular case when the SODE is homogeneous quadratic is extensively discussed.Comment: 25 pages. To appear in Journal of Geometric Mechanics. arXiv admin note: substantial text overlap with arXiv:1608.0158

Perfil de personalidad del tenista

El presente trabajo intenta descubrir las características de personalidad del tenista grancanario a partir de la comparación con un grupo de sujetos que practican deportes individuales distintos al tenis y un grupo de sujetos no deportistas. El total de la muestra está constituida por 191 sujetos distribuidos en tres grupos. El grupo de tenistas está formado por 64 sujetos federados en la isla de Gran Canaria, de los cuales 43 son hombres y 21 mujeres; el grupo de deportistas individuales está formado por 63 sujetos, 42 hombres y 21 mujeres y el grupo de no deportistas está formado por 64 sujetos, 41 hombres y 23 mujeres, todos ellos en edades comprendidas entre los 14 y los 25 años de edad. El cuestionario utilizado fue el 16 PF-5 y en el análisis de varianza efectuado se observan tres diferencias significativas en las escalas Apertura-Cambio, Dureza y Manipulación de la imagen. Asimismo, se observan diferencias significativas atendiendo a la variable sexo.The present study sets out to examine the personality characteristics of the Grancanary tennis player through a comparison with a sports group of subjects who practice single sports different from tennis and a non-sports group of subjects. The totality of the sample is composed by 191 subjects separated in three groups. The tennis players group is composed by 64 federated subjects in Gran Canaria island, in which 43 are men and 21 are women; the single sportsmen group is composed by 63 subjects, 42 are men and 21 are women and the non-sports group is composed by 64 subjects, 41 are men and 23 are women, all of them between 14 and 25 years old. The 16 PF-5 was the questionnaire used and the variance analysis shows three meaningful differences: the opening-change, tough-mindedness and impression management scales. In the same way, it is noticed meaningful differences in sex variable

Characteristics, limitations and possibilities of development of production and marketing of organic products in Peru

Universidad Nacional Agraria La Molina. Escuela de Posgrado. Maestría en AgronegociosLa investigación se realizó tomando como referencia el ámbito nacional del sector de productos agrícolas orgánicos entre el 2000 y 2009, comprende una evaluación nacional respecto al crecimiento y evolución del sector, hectáreas sembradas, productores y ventas en el mercado nacional e internacional. Su propósito consistió en el análisis de las posibilidades y limitaciones de la producción y comercialización de productos agrícolas orgánicos en el Perú, como alternativa para el desarrollo rural sostenible e identifica la estrategia genérica para el desarrollo competitivo del sector. El trabajo se justificó por no existir investigaciones anteriores respecto al sector, por su valor teórico y utilidad práctica. Se sustentó en el enfoque teórico de la competitividad a nivel nacional, sectorial y empresarial. La investigación se abordó de acuerdo al tipo de estudio descriptivo-longitudinal, se analizo y se midió la información cualitativa y cuantitativa de los determinantes del Diamante de Competitividad y de las Cinco Fuerzas de Porter, complementándose con el análisis de la matriz FODA del sector. Los resultados fueron: Entre el 2001 y el 2009, las exportaciones de productos orgánicos pasaron de 15,1 millones a 240 millones de dólares, las hectáreas de producción orgánica de 28,225 a 314,190 y los productores de 8,505 a 46,230. La demanda interna representa el 3% y el 97% de la producción se orienta al mercado internacional. El café, banano, cacao y el mango representan el 93.6% de las exportaciones en el sector. Concluyéndose, que la agricultura orgánica en el Perú se encuentra respaldada en los factores básicos como fuente esencial de la ventaja competitiva. La competitividad del sector está orientada principalmente a la aplicación de la estrategia de enfoque o alta segmentaciónThe research considered the National Organic Agricultural Products Sector among 2000 and 2009. It is related to a national evaluation process considering growing and sector development, crops in hectares, producers and national and international marketing. The purpose of the study was the analysis of advantages and disadvantages of organic agricultural production and marketing in Peru as a possible alternative for rural sustainable development and identifies the generic strategy for development competiviness of the sector mentioned. It is known that there is no previous research is this sector which focuses the theoretical value and practical usage. The study was based on the theoretical approach to the competiviness at the national, sectorial and enterprise levels. The research was about a cross -sectional and descriptive one. Qualitive and Quantitive information were determinats of the Diamond Competitiveness and Porter's Five Forces measured and complemented by a SWOT matrix sector analysis. Organic products exports, organic production in hectares increased from 15.1 to 240 million US Dollars, from 28, 225 to 314,190 ha and from 8,505 to 46,230 producers respectively among 2001 and 2009 were the results. The domestic demand has only a share of 3% and 97 % of the international marketing production. Main organic products are coffee, bananas, cocoa and mango and they represent 93% of total exports. In conclusion, organic agriculture is seen as an essential source of competitive advantage in Peru. The competiviness of the sector is mainly oriented to the implementation of the high segmentation approach strategyTesi

Environmental assessment model for scrubbers versus alternative mitigation systems for feeder vessels in liner shipping

[Abstract] Implementation of the Global Sulphur Cap (GSC), in January 2020, boosted scrubber installation in vessels to fulfill the new air emission limitations. This increase in scrubbers’ use has intensified concern about its environmental performance. Even though achievement of GSC requirements through this mitigation system has been widely proven, the impact of wash water discharge on the marine environment remains under discussion. In this paper, an assessment environmental model is introduced to quantify in monetary terms the performance of feeder vessels that operate with several mitigation systems. This model attempts to improve traditional air emission evaluations by including the impact of scrubbers’ discharges on the marine environmental. In this way, the analysis not only allows different mitigations systems to be ranked by considering their capacity to reduce air emissions, but also provides further information about the marine eutrophication and ecotoxicity impact from scrubbers’ discharge. Through the model’s application to a regular shipping line between the Canary Islands and the Iberian Peninsula, it was found that, the scrubber, regardless of its operation mode (open- or closed loop), is the most efficient mitigation option after the Liquefied Natural Gas (LNG) fuel shift. The impact of scrubbers’ discharge was not as significant as expected on the feeder vessel’s total pollution since this provides similar relative weight to the methane emissions from a dual-engine option by operating with LNG. The results also show the need to more closely research the marine eutrophication impact of closed-loop scrubbers. Finally, this paper warns about a significant dispersion on the monetary values of marine ecotoxicity and eutrophication, due to a high dependence of the results on the frameworks’ localization. Consequently, further research is needed on the homogenization of pollution monetization in the marine environment