145 research outputs found
Paesaggi agrari tardo-antichi e medievali della Sardegna settentrionale
Negli anni 2004-08 sono state condotte dalle Università di Sassari e di Pisa campagne di ricognizione sistematica in vaste aree della Sardegna nord-occidentale, nell’ambito di un più ampio progetto sui villaggi medievali abbandonati dell’isola. Le ricognizioni si sono svolte nei comuni di Sassari, Sorso, Sennori, Porto Torres, Osilo, Chiaramonti, Sedini, Monteleone Rocca Doria, Mores, Ozieri, Bessude,
Semestene, Bonorva e Siligo, dove sono state identificate decine di villaggi medievali abbandonati.
Le ricerche sono state inizialmente indirizzate all’identificazione sul terreno dei siti medievali noti da fonti scritte e da indicatori toponomastici, con la finalità di perimetrare le aree di effettiva potenzialitÃ
archeologica.
In quasi tutti i casi si è verificato che l’insediamento medievale insiste fisicamente su un sito rurale (in genere fattorie di diversa scala di estensione) di epoca romana e spesso anche di periodo nuragico, con attestazioni che si spingono fino alla tarda antichità , con aree di elevata densità e concentrazione di materiali.
In questa sede vengono sinteticamente presentati alcuni dati relativi a siti identificati nella valle del rio Mannu e nel territorio di Chiaramonti, dove è in corso di svolgimento un ampio progetto di ricerca sui villaggi medievali abbandonati del territorio
Refractory Status Epilepticus in Genetic Epilepsy-Is Vagus Nerve Stimulation an Option?
Refractory and super-refractory status epilepticus (RSE, SRSE) are severe conditions that can have long-term neurological consequences with high morbidity and mortality rates. The usefulness of vagus nerve-stimulation (VNS) implantation during RSE has been documented by anecdotal cases and in systematic reviews; however, the use of VNS in RSE has not been widely adopted. We successfully implanted VNS in two patients with genetic epilepsy admitted to hospital for SRSE; detailed descriptions of the clinical findings and VNS parameters are provided. Our patients were implanted 25 and 58 days after status epilepticus (SE) onset, and a stable remission of SE was observed from the seventh and tenth day after VNS implantation, respectively, without change in anti-seizure medication. We used a fast ramp-up of stimulation without evident side effects. Our results support the consideration of VNS implantation as a safe and effective adjunctive treatment for SRSE
Advanced active pixel architectures in standard CMOS technology
This paper aims at exploring and validating the adoption of standard fabrication processes for the realization of CMOS active pixel sensors, for particle detection purposes. The goal is to implement a single-chip, complete radiation sensor system, including on a CMOS integrated circuit the sensitive devices, read-out and signal processing circuits. A prototype chip (RAPS01) based on these principles has been already fabricated, and a chip characterization has been carried out; in particular, the evaluation of the sensitivity of the sensor response on the actual operating conditions was estimated, as well as the response uniformity. Optimization and tailoring of the sensor structures for High Energy Physics applications are being evaluated in the design of the next generation chip (RAPS02). Basic features of the new chip includes digitally configurable readout and multi-mode access (i.e., either sparse of line-scan readout). © 2005 IEEE
The miR-139-5p regulates proliferation of supratentorial paediatric low-grade gliomas by targeting the PI3K/AKT/mTORC1 signalling
Paediatric low-grade gliomas (pLGGs) are a heterogeneous group of brain tumours associated with a high overall survival: however, they are prone to recur and supratentorial lesions are difficult to resect, being associated with high percentage of disease recurrence. Our aim was to shed light on the biology of pLGGs
Epitaxial CdSe-Au Nanocrystal Heterostructures by Thermal Annealing
Abstract: The thermal evolution of a collection of heterogeneous CdSe−Au nanosystems (Au-decorated CdSe nanorods, networks, vertical assemblies) prepared by wet-chemical approaches was monitored in situ in the transmission electron microscope. In contrast to interfaces that are formed during kinetically controlled wet chemical synthesis, heating under vacuum conditions results in distinct and well-defined CdSe/Au interfaces, located at the CdSe polar surfaces. The high quality of these interfaces should make the heterostructures more suitable for use in nanoscale electronic devices
Risk stratification in individuals with the Brugadatype 1 ECG pattern without previous cardiacarrest: usefulness of a combined clinical andelectrophysiologic approach.
Cerium Oxide Nanoparticle Administration to Skeletal Muscle Cells under Different Gravity and Radiation Conditions
For their remarkable biomimetic properties implying strong modulation of the intracellular and extracellular redox state, cerium oxide nanoparticles (also termed "nanoceria") were hypothesized to exert a protective role against oxidative stress associated with the harsh environmental conditions of spaceflight, characterized by microgravity and highly energetic radiations. Nanoparticles were supplied to proliferating C2C12 mouse skeletal muscle cells under different gravity and radiation levels. Biological responses were thus investigated at a transcriptional level by RNA next-generation sequencing. Lists of differentially expressed genes (DEGs) were generated and intersected by taking into consideration relevant comparisons, which led to the observation of prevailing effects of the space environment over those induced by nanoceria. In space, upregulation of transcription was slightly preponderant over downregulation, implying involvement of intracellular compartments, with the majority of DEGs consistently over- or under-expressed whenever present. Cosmic radiations regulated a higher number of DEGs than microgravity and seemed to promote increased cellular catabolism. By taking into consideration space physical stressors alone, microgravity and cosmic radiations appeared to have opposite effects at transcriptional levels despite partial sharing of molecular pathways. Interestingly, gene ontology denoted some enrichment in terms related to vision, when only effects of radiations were assessed. The transcriptional regulation of mitochondrial uncoupling protein 2 in space-relevant samples suggests perturbation of the intracellular redox homeostasis, and leaves open opportunities for antioxidant treatment for oxidative stress reduction in harsh environments
The Adaptive Gain Integrating Pixel Detector at the European XFEL
The Adaptive Gain Integrating Pixel Detector (AGIPD) is an x-ray imager,
custom designed for the European x-ray Free-Electron Laser (XFEL). It is a
fast, low noise integrating detector, with an adaptive gain amplifier per
pixel. This has an equivalent noise of less than 1 keV when detecting single
photons and, when switched into another gain state, a dynamic range of more
than 10 photons of 12 keV. In burst mode the system is able to store 352
images while running at up to 6.5 MHz, which is compatible with the 4.5 MHz
frame rate at the European XFEL. The AGIPD system was installed and
commissioned in August 2017, and successfully used for the first experiments at
the Single Particles, Clusters and Biomolecules (SPB) experimental station at
the European XFEL since September 2017. This paper describes the principal
components and performance parameters of the system.Comment: revised version after peer revie
Chest tuberculosis with mediastinal asymptomatic lymphadenitis without lung involvement in an immunocompetent patient
Megapixels @ Megahertz -- The AGIPD High-Speed Cameras for the European XFEL
The European XFEL is an extremely brilliant Free Electron Laser Source with a
very demanding pulse structure: trains of 2700 X-Ray pulses are repeated at 10
Hz. The pulses inside the train are spaced by 220 ns and each one contains up
to photons of 12.4 keV, while being fs in length. AGIPD,
the Adaptive Gain Integrating Pixel Detector, is a hybrid pixel detector
developed by DESY, PSI, and the Universities of Bonn and Hamburg to cope with
these properties. It is a fast, low noise integrating detector, with single
photon sensitivity (for keV) and a large dynamic
range, up to photons at 12.4 keV. This is achieved with a charge
sensitive amplifier with 3 adaptively selected gains per pixel. 352 images can
be recorded at up to 6.5 MHz and stored in the in-pixel analogue memory and
read out between pulse trains. The core component of this detector is the AGIPD
ASIC, which consists of pixels of . Control of the ASIC's image acquisition and analogue readout is
via a command based interface. FPGA based electronic boards, controlling ASIC
operation, image digitisation and 10 GE data transmission interface AGIPD
detectors to DAQ and control systems. An AGIPD 1 Mpixel detector has been
installed at the SPB experimental station in August 2017, while a second one is
currently commissioned for the MID endstation. A larger (4 Mpixel) AGIPD
detector and one to employ Hi-Z sensor material to efficiently register photons
up to keV are currently under construction.Comment: submitted to the proceedings of the ULITIMA 2018 conference, to be
published in NIM
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