A Neuroanatomical Signature for Schizophrenia Across Different Ethnic Groups

Schizophrenia is a disabling clinical syndrome found across the world. While the incidence and clinical expression of this illness are strongly influenced by ethnic factors, it is unclear whether patients from different ethnicities show distinct brain deficits. In this multicentre study, we used structural Magnetic Resonance Imaging to investigate neuroanatomy in 126 patients with first episode schizophrenia who came from 4 ethnically distinct cohorts (White Caucasians, African-Caribbeans, Japanese, and Chinese). Each patient was individually matched with a healthy control of the same ethnicity, gender, and age (±1 year). We report a reduction in the gray matter volume of the right anterior insula in patients relative to controls (P < .05 corrected); this reduction was detected in all 4 ethnic groups despite differences in psychopathology, exposure to antipsychotic medication and image acquisition sequence. This finding provides evidence for a neuroanatomical signature of schizophrenia expressed above and beyond ethnic variations in incidence and clinical expression. In light of the existing literature, implicating the right anterior insula in bipolar disorder, depression, addiction, obsessive-compulsive disorder, and anxiety, we speculate that the neuroanatomical deficit reported here may represent a transdiagnostic feature of Axis I disorders

Analysis of polymorphic membrane protein expression in cultured cells Identifies PmpA and PmpH of Chlamydia psittaci as candidate factors in pathogenesis and immunity to infection

The polymorphic membrane protein (Pmp) paralogous families of Chlamydia trachomatis, Chlamydia pneumoniae and Chlamydia abortus are putative targets for Chlamydia vaccine development. To determine whether this is also the case for Pmp family members of C. psittaci, we analyzed transcription levels, protein production and localization of several Pmps of C. psittaci. Pmp expression profiles were characterized using quantitative real-time PCR (RT-qPCR), immunofluorescence (IF) and immuno-electron microscopy (IEM) under normal and stress conditions. We found that PmpA was highly produced in all inclusions as early as 12 hpi in all biological replicates. In addition, PmpA and PmpH appeared to be unusually accessible to antibody as determined by both immunofluorescence and immuno-electron microscopy. Our results suggest an important role for these Pmps in the pathogenesis of C. psittaci, and make them promising candidates in vaccine development

An analytical model of transducer array arrangement for guided wave excitation and propagation on cylindrical structures

Ultrasonic guided wave (GW) inspection is one of the non-destructive testing (NDT) techniques available for the engineering structures. Compared with other NDT techniques, guided waves can propagate a long distance with a relatively high sensitivity to defects in the structure. In order to increase the performance for pipe inspections to meet higher requirements under different conditions, the optimisation of piezoelectric transducer array design is still a need, as the technique is currently subject to a complex analysis due to wide number of guided wave modes generated. This can be done by optimising the transducer array design. In this paper, it is described an analytical mode of a set of piezoelectric transducer arrays upon torsional wave mode T(0,1) excitation in a tubular structure. The proposed analytical model for predicting signal propagation is validated by using finite element analysis in ABAQUS and three-dimensional laser vibrometer experiments for transducer array characterisations. The proposed analytical model works well and very fast for simulating transducer excitation and wave propagation along cylindrical structures. This will significantly reduce the complexity of guided wave analysis, enhancing effectively the structural health of structures and subsequently reducing the industry maintenance cost

Experimental observation of fractional topological phases with photonic qudits

Geometrical and topological phases play a fundamental role in quantum theory. Geometric phases have been proposed as a tool for implementing unitary gates for quantum computation. A fractional topological phase has been recently discovered for bipartite systems. The dimension of the Hilbert space determines the topological phase of entangled qudits under local unitary operations. Here we investigate fractional topological phases acquired by photonic entangled qudits. Photon pairs prepared as spatial qudits are operated inside a Sagnac interferometer and the two-photon interference pattern reveals the topological phase as fringes shifts when local operations are performed. Dimensions $d = 2, 3$ and $4$ were tested, showing the expected theoretical values.Comment: 6 pages, 4 figure

Hermitian symmetric polynomials and CR complexity

Properties of Hermitian forms are used to investigate several natural questions from CR Geometry. To each Hermitian symmetric polynomial we assign a Hermitian form. We study how the signature pairs of two Hermitian forms behave under the polynomial product. We show, except for three trivial cases, that every signature pair can be obtained from the product of two indefinite forms. We provide several new applications to the complexity theory of rational mappings between hyperquadrics, including a stability result about the existence of non-trivial rational mappings from a sphere to a hyperquadric with a given signature pair.Comment: 19 pages, latex, fixed typos, to appear in Journal of Geometric Analysi

Young Galaxy Candidates in the Hubble Frontier Fields - III. MACSJ0717.5+3745

In this paper we present the results of our search for and study of $z \gtrsim 6$ galaxy candidates behind the third Frontier Fields (FF) cluster, MACSJ0717.5+3745, and its parallel field, combining data from Hubble and Spitzer. We select 39 candidates using the Lyman Break technique, for which the clear non-detection in optical make the extreme mid-$z$ interlopers hypothesis unlikely. We also take benefit from $z \gtrsim 6$ samples selected using previous Frontier Fields datasets of Abell 2744 and MACS0416 to improve the constraints on the properties of very high-redshift objects. We compute the redshift and the physical properties, such emission lines properties, star formation rate, reddening, and stellar mass for all Frontier Fields objects from their spectral energy distribution using templates including nebular emission lines. We study the relationship between several physical properties and confirm the trend already observed in previous surveys for evolution of star formation rate with galaxy mass, and between the size and the UV luminosity of our candidates. The analysis of the evolution of the UV Luminosity Function with redshift seems more compatible with an evolution of density. Moreover, no robust $z\ge$8.5 object is selected behind the cluster field, and few $z$$\sim$9 candidates have been selected in the two previous datasets from this legacy survey, suggesting a strong evolution in the number density of galaxies between $z$$\sim$8 and 9. Thanks to the use of the lensing cluster, we study the evolution of the star formation rate density produced by galaxies with L$>$0.03L$^{\star}$, and confirm the strong decrease observed between $z$$\sim$8 and 9.Comment: 21 pages - Accepted for publication in ApJ - v2: small correction

Compression modulus of macroscopic fiber bundles

We study dense, disordered stacks of elastic macroscopic fibers. These stacks often exhibit non-linear elasticity, due to the coupling between the applied stress and the internal distribution of fiber contacts. We propose a theoretical model for the compression modulus of such systems, and illustrate our method by studying the conical shapes frequently observed at the extremities of ropes and other fiber structures. studying the conical shapes frequently observed at theextremities of ropes and other fiber structures

Spin-orbit coupling and intrinsic spin mixing in quantum dots

Spin-orbit coupling effects are studied in quantum dots in InSb, a narrow-gap material. Competition between different Rashba and Dresselhaus terms is shown to produce wholesale changes in the spectrum. The large (and negative) $g$-factor and the Rashba field produce states where spin is no longer a good quantum number and intrinsic flips occur at moderate magnetic fields. For dots with two electrons, a singlet-triplet mixing occurs in the ground state, with observable signatures in intraband FIR absorption, and possible importance in quantum computation.Comment: REVTEX4 text with 3 figures (high resolution figs available by request). Submitted to PR