341 research outputs found
Modeling of Hydrogen Storage Materials: A Reactive Force Field for NaH
Parameterization of a reactive force field for NaH is done using ab initio derived data. The parameterized force field(ReaxFFNaH) is used to study the dynamics governing hydrogen desorption in NaH. During the abstraction process of surface molecular hydrogen charge transfer is found to be well described by the parameterized force field. To gain more insight into the mechanism governing structural transformation of NaH during thermal decomposition a heating run in a molecular dynamics simulation is done. The result shows that a clear signature of hydrogen desorption is the fall in potential energy surface during heating
An analysis of Australia's carbon pollution reduction scheme
The authors review the decision-making since the Labour Government came into office (November 2007). The Australian Government’s ‘Carbon Pollution Reduction Scheme’ White Paper (15 December 2008) proposes that an Australian Emissions Trading Scheme (AETS) be implemented in mid-2010. Acknowledging that the scheme is comprehensive, the paper finds that in many cases, Australia will take a softer approach to climate change through the AETS than the European Union ETS(EUETS). The paper assesses key issues in the White Paper such as emissions reduction targets, GHG coverage, sectoral coverage, inclusion of unlimited quantities of offsets from Kyoto international markets and exclusion of deforestation activities
Spatio-temporal variability in accretion and erosion of coastal foredunes in the Netherlands: regional climate and local topography
Depending on the amount of aeolian sediment input and dune erosion, dune size and morphology change over time. Since coastal foredunes play an important role in the Dutch coastal defence, it is important to have good insight in the main factors that control these changes. In this paper the temporal variations in foredune erosion and accretion were studied in relation to proxies for aeolian transport potential and storminess using yearly elevation measurements from 1965 to 2012 for six sections of the Dutch coast. Longshore differences in the relative impacts of erosion and accretion were examined in relation to local beach width. The results show that temporal variability in foredune accretion and erosion is highest in narrow beach sections. Here, dune erosion alternates with accretion, with variability displaying strong correlations with yearly values of storminess (maximum sea levels). In wider beach sections, dune erosion is less frequent, with lower temporal variability and stronger correlations with time series of transport potential. In erosion dominated years, eroded volumes decrease from narrow to wider beaches. When accretion dominates, dune-volume changes are relatively constant alongshore. Dune erosion is therefore suggested to control spatial variability in dune-volume changes. On a scale of decades, the volume of foredunes tends to increase more on wider beaches. However, where widths exceed 200 to 300 m, this trend is no longer observed
Dystrophin Gene Mutation Location and the Risk of Cognitive Impairment in Duchenne Muscular Dystrophy
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88828.pdf (publisher's version ) (Open Access)BACKGROUND: A significant component of the variation in cognitive disability that is observed in Duchenne muscular dystrophy (DMD) is known to be under genetic regulation. In this study we report correlations between standardised measures of intelligence and mutational class, mutation size, mutation location and the involvement of dystrophin isoforms. METHODS AND RESULTS: Sixty two male subjects were recruited as part of a study of the cognitive spectrum in boys with DMD conducted at the Sydney Children's Hospital (SCH). All 62 children received neuropsychological testing from a single clinical psychologist and had a defined dystrophin gene (DMD) mutation; including DMD gene deletions, duplications and DNA point mutations. Full Scale Intelligence Quotients (FSIQ) in unrelated subjects with the same mutation were found to be highly correlated (r = 0.83, p = 0.0008), in contrast to results in previous publications. In 58 cases (94%) it was possible to definitively assign a mutation as affecting one or more dystrophin isoforms. A strong association between the risk of cognitive disability and the involvement of groups of DMD isoforms was found. In particular, improvements in the correlation of FSIQ with mutation location were identified when a new classification system for mutations affecting the Dp140 isoform was implemented. SIGNIFICANCE: These data represent one of the largest studies of FSIQ and mutational data in DMD patients and is among the first to report on a DMD cohort which has had both comprehensive mutational analysis and FSIQ testing through a single referral centre. The correlation between FSIQ results with the location of the dystrophin gene mutation suggests that the risk of cognitive deficit is a result of the cumulative loss of central nervous system (CNS) expressed dystrophin isoforms, and that correct classification of isoform involvement results in improved estimates of risk
Multi-modality curative treatment of salivary gland cancer liver metastases with drug-eluting bead chemoembolization, radiofrequency ablation, and surgical resection: a case report
<p>Abstract</p> <p>Introduction</p> <p>Liver metastases are rare in salivary gland tumors and have been reported only once to be the first manifestation of the disease. They are usually treated with surgical resection of the primary tumor and systemic chemotherapy. Drug-eluting bead chemoembolization has an evolving role in the treatment of hepatocellular carcinoma, as well as in the treatment of metastatic disease of the liver. Nevertheless, it has never been used in a patient with salivary gland liver metastases.</p> <p>Case presentation</p> <p>We report a case of a 51-year-old Caucasian Greek woman who presented to our hospital with liver metastases as the first manifestation of an adenoid cystic carcinoma of the left submandibular gland. The liver lesions were deemed inoperable because of their size and multi-focality and proved resistant to systemic chemotherapy. She was curatively treated with a combination of doxorubicin eluting bead (DC Beads) chemoembolization, intra-operative and percutaneous radiofrequency ablation, and radiofrequency-assisted surgical resection. The patient remained disease-free one year after the surgical resection.</p> <p>Conclusion</p> <p>In conclusion, this complex case is an example of inoperable liver metastatic disease from the salivary glands that was refractory to systemic chemotherapy but was curatively treated with a combination of locoregional therapies and surgery. A multi-disciplinary approach and the adoption of modern radiological techniques produced good results after conventional therapies failed and there were no other available treatment modalities.</p
The improved ARTEMIS IV multichannel solar radio spectrograph of the University of Athens
We present the improved solar radio spectrograph of the University of Athens
operating at the Thermopylae Satellite Telecommunication Station. Observations
now cover the frequency range from 20 to 650 MHz. The spectrograph has a
7-meter moving parabola fed by a log-periodic antenna for 100 650 MHz and a
stationary inverted V fat dipole antenna for the 20 100 MHz range. Two
receivers are operating in parallel, one swept frequency for the whole range
(10 spectrums/sec, 630 channels/spectrum) and one acousto-optical receiver for
the range 270 to 450 MHz (100 spectrums/sec, 128 channels/spectrum). The data
acquisition system consists of two PCs (equipped with 12 bit, 225 ksamples/sec
ADC, one for each receiver). Sensitivity is about 3 SFU and 30 SFU in the 20
100 MHz and 100 650 MHz range respectively. The daily operation is fully
automated: receiving universal time from a GPS, pointing the antenna to the
sun, system calibration, starting and stopping the observations at preset
times, data acquisition, and archiving on DVD. We can also control the whole
system through modem or Internet. The instrument can be used either by itself
or in conjunction with other instruments to study the onset and evolution of
solar radio bursts and associated interplanetary phenomena.Comment: Experimental Astronomy, Volume 21, Issue 1, pp.41-5
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