Industry 4.0 related innovation and firm growth

In this paper we explore the relationship between innovative firms that patent technology related to Industry 4.0 and their economic performance. By applying the new patent cartography developed by the EPO that identifies firm's 4.0 patents, this is one of the first large-scale, systematic studies on the impact of 4.0 technologies. Since 4.0 patents are more likely to be general purpose technologies, firms with 4.0 patents should be in a better position to increase their sales as 4.0 technology has on average a wider industrial applicability. Results of our Fixed Effects Least Squares regressions and Dynamic Panel Model suggest that 4.0 patent stock is positively associated to sales and that this effect is significantly larger than the effect of Non-4.0 patent stock. These effects are found to be decreasing with firm size

Innerverbandliche Heterogenität und die Vertretungswirksamkeit deutscher Arbeitgeberverbände

"Der vorliegende Beitrag analysiert die Auswirkungen der innerverbandlichen Heterogenität auf die Vertretungswirksamkeit von Arbeitgeberverbänden. Unter Rückgriff auf die Daten der Aachener Befragung 'Wirtschaftsverbände in Deutschland 2005/ 2006' wird der Frage nachgegangen, wie sich unterschiedliche Aspekte verbandlicher Heterogenität auf den Organisationsgrad, die Politikbeeinflussung und den tarifpolitischen Erfolg deutscher Arbeitgeberverbände auswirken. Die vorgenommene multivariate Analyse zeigt, dass Heterogenität unterschiedliche Wirkung entfaltet, je nachdem ob Heterogenität auf die Domänenabgrenzung oder die Mitgliederstruktur bezogen wird. Während sich eine höhere Homogenität der Interessendomäne positiv auf den Organisationsgrad von Arbeitgeberverbänden auswirkt, findet sich auf der Ebene der Zusammensetzung der Mitgliedschaft eine negative Assoziation zwischen der Homogenität und dem Organisationsgrad." (Autorenreferat)"Since the Eastern Enlargement of the EU, the conditions in which trade unions operate in Central Eastern Europe have changed considerably. The influence of the communist heritage and the dilemmas of the transformation period are losing their importance. Using the example of the Solidarity union, the article analyses the organisational change of unions in Central Eastern Europe. The failure of Solidarity's involvement in party politics has led to increasing attention being focused on workplace organizing activities following the Anglo-American model. The young union activists develop a different self-conception from older unionists. The reference to Solidarity's history is disappearing, which leads to conflicts about the union's identity and its goals. The new union organisations are born from resistance to abusive practices of employers and lack a strong collective identity which makes it difficult in the long term to stabilise membership. The introduction of works councils has had only a marginal influence on trade unions and industrial relations. The paper is based on qualitative semi-structured interviews with trade unionists in solidarity's headquarter and in four manufacturing plants in Poland." (author's abstract

In-Situ Wear Measurement of Hot Forging Dies Using Robot Aided Endoscopic Fringe Projection

According to the current state of the art, wear conditions of forging dies are assessed visually in the dismantled state, as there is no measuring procedure available for inline wear measurement of hot forging dies. This paper introduces a handling concept for automated loading and in-situ tool inspection for a hot forging process. An industrial robot with a quick-change system mounted on its endeffector is utilized to integrate both, a high-temperature gripper and an endoscopic 3D-measurement sensor. By adapting the measuring method of fringe projection to an endoscopic design, the measuring system can be navigated into the difficult-to-access geometry of the forge and take high-precision 3D-measurements of the forging die. The ambient air heated by the forming process creates an inhomogeneous refractive index field around the measuring system and the hot die, which deflects the light during the measurement and deteriorates the overall accuracy of the reconstructed point cloud. This can lead to strong deviations in the reconstructed point clouds and the functional geometries calculated from them. Using a compressed air actuator, the measuring system can be protected from the heat effects of the measuring object, as well as from dirt. Furthermore, the effect of the inhomogeneous refractive index field can be significantly reduced. With this approach the in-situ wear measurement at highly stressed regions using the example of the mandrel radius and the flash radius will be demonstrated. These functional elements are of particular interest, as the thermal stress is high and large material flow takes place. For the wear determination, the functional elements of the tool are examined in detail by fitting geometrical features into the reconstructed point clouds and determining the deviations from a reference geometry. In addition, the measurement data is validated with the aid of a commercially available state-of-the-art measurement system

Deep-learning-based identification, tracking, pose estimation and behaviour classification of interacting primates and mice in complex environments

The quantification of behaviors of interest from video data is commonly used to study brain function, the effects of pharmacological interventions, and genetic alterations. Existing approaches lack the capability to analyze the behavior of groups of animals in complex environments. We present a novel deep learning architecture for classifying individual and social animal behavior, even in complex environments directly from raw video frames, while requiring no intervention after initial human supervision. Our behavioral classifier is embedded in a pipeline (SIPEC) that performs segmentation, identification, pose-estimation, and classification of complex behavior, outperforming the state of the art. SIPEC successfully recognizes multiple behaviors of freely moving individual mice as well as socially interacting non-human primates in 3D, using data only from simple mono-vision cameras in home-cage setups

Strukturdaten des Naturkostfachhandels: Erhebung des Status quo und Aufbau eines Instrumentariums zur kontinuierlichen Strukturbeschreibung des Bio-Marktsegmentes Naturkostfachhandel

Der spezialisierte Naturkosthandel stellt in Deutschland traditionell einen wichtigen Absatzkanal für Öko-Lebensmittel dar. Zu Beginn des zweijährigen Projektes im Dezember 2009 lagen zu den Strukturen der Branche keine vollständigen und abgesicherten Daten vor. Dies galt insbesondere für den Naturkosteinzelhandel, aber auch den Naturkostgroßhandel. Es bestand eine relativ hohe Marktintransparenz. Vor diesem Hintergrund zielte das Vorhaben zunächst auf die Erhebung der Grundgesamtheit des Naturkosteinzelhandels ab. Zum Oktober 2010 wurden 2.346 Naturfachgeschäfte ermittelt. Aus der Grundgesamtheit wurde eine repräsentative Stichprobe von 319 Geschäften für die Durchführung von Face-to-Face-Interviews gezogen. Im Ergebnis lagen auswertbare Daten von 254 Geschäften vor, die detaillierte Auskünfte über u. a. Verkaufsflächen, Umsätze, Sortimentsstrukturen und Bezugsquellen der Einzelhändler ermöglichen. Zur Analyse der Großhandelsstrukturen wurden rund 131 Großhändler und Hersteller, die den Naturkosteinzelhandel direkt beliefern, telefonisch kontaktiert und nach bestimmten Kriterien befragt. Mit einer weitergehenden schriftlichen Befragung konnten auswertbare Ergebnisse von 28 Unternehmen erzielt werden, die erstmals vertiefte Einblicke in Umsätze sowie die Umsatzanteile verschiedener Kundengruppen und Sortimente geben. Auf der Grundlage der erhobenen Daten wurde ein Verfahren zur Hochrechnung des Marktvolumens der Naturkostbranche erarbeitet. Dazu wurden sechs verschiedene Varianten getestet und diskutiert. Die letztlich ausgewählte Variante kommt zu dem Ergebnis, dass das Marktvolumen des Naturkostfachhandels im Jahr 2009 1,77 Milliarden Euro betrug. Abschließend wurden mögliche Varianten für eine Datenfortschreibung (Strukturdaten und Hochrechnung des Marktvolumens) diskutiert. Dieses erfolgte sowohl auf der Basis der im Projekt erhobenen Daten als auch auf der Basis von bestehenden Datenquellen, die Teile der Naturkostbranche im Rahmen von Stichproben abbilden

Injectable calcium phosphate cement for augmentation around cancellous bone screws. In vivo biomechanical studies

In lower cancellous apparent bone density, it can be difficult to achieve adequate screw fixation and hence stable fracture fixation. Different strategies have been proposed, one of them is through augmentation using calcium phosphate cement in the region at or close to the screw thread itself. To support the hypothesis of an improved screw fixation technique by augmentation of the bone surrounding the implanted screw, in vivo biomechanical and densitometric studies are performed on rabbit specimen where normal and simulated weak bone quality are considered. In particular, the evolution of screw stability till 12 weeks following the implantation is quantified. A statistical significance in the pull out force for augmented versus non-augmented screws was found for the shorter time periods tested of ≤ 5 days whilst the pull out force was found to increase with time for both augmented and non-augmented screws during the 12 week course of the study. The results of the study demonstrate that the use of an injectable calcium phosphate cement which sets in vivo can significantly improve screw pull out strength at and after implantation for normal and simulated weak bone quality

Analysis of Lymphocytic DNA Damage in Early Multiple Sclerosis by Automated Gamma-H2AX and 53BP1 Foci Detection: A Case Control Study

Background In response to DNA double-strand breaks, the histone protein H2AX becomes phosphorylated at its C-terminal serine 139 residue, referred to as γ-H2AX. Formation of γ-H2AX foci is associated with recruitment of p53-binding protein 1 (53BP1), a regulator of the cellular response to DNA double-strand breaks. γ-H2AX expression in peripheral blood mononuclear cells (PBMCs) was recently proposed as a diagnostic and disease activity marker for multiple sclerosis (MS). Objective To evaluate the significance of γ-H2AX and 53BP1 foci in PBMCs as diagnostic and disease activity markers in patients with clinically isolated syndrome (CIS) and early relapsing-remitting MS (RRMS) using automated γ-H2AX and 53BP1 foci detection. Methods Immunocytochemistry was performed on freshly isolated PBMCs of patients with CIS/early RRMS (n = 25) and healthy controls (n = 27) with γ-H2AX and 53BP1 specific antibodies. Nuclear γ-H2AX and 53BP1 foci were determined using a fully automated reading system, assessing the numbers of γ-H2AX and 53BP1 foci per total number of cells and the percentage of cells with foci. Patients underwent contrast enhanced 3 Tesla magnetic resonance imaging (MRI) and clinical examination including expanded disability status scale (EDSS) score. γ-H2AX and 53BP1 were also compared in previously frozen PBMCs of each 10 CIS/early RRMS patients with and without contrast enhancing lesions (CEL) and 10 healthy controls. Results The median (range) number of γ-H2AX (0.04 [0–0.5]) and 53BP1 (0.005 [0–0.2]) foci per cell in freshly isolated PBMCs across all study participants was low and similar to previously reported values of healthy individuals. For both, γ-H2AX and 53BP1, the cellular focus number as well as the percentage of positive cells did not differ between patients with CIS/RRMS and healthy controls. γ-H2AX and 53BP1 levels neither correlated with number nor volume of T2-weighted lesions on MRI, nor with the EDSS. Although γ-H2AX, but not 53BP1, levels were higher in previously frozen PBMCs of patients with than without CEL, γ-H2AX values of both groups overlapped and γ-H2AX did not correlate with the number or volume of CEL. Conclusion γ-H2AX and 53BP1 foci do not seem to be promising diagnostic or disease activity biomarkers in patients with early MS. Lymphocytic DNA double-strand breaks are unlikely to play a major role in the pathophysiology of MS

Fringe Projection Profilometry in Production Metrology: A Multi-Scale Comparison in Sheet-Bulk Metal Forming

Fringe projection profilometry in combination with other optical measuring technologies has established itself over the last decades as an essential complement to conventional, tactile measuring devices. The non-contact, holistic reconstruction of complex geometries within fractions of a second in conjunction with the lightweight and transportable sensor design open up many fields of application in production metrology. Furthermore, triangulation-based measuring principles feature good scalability, which has led to 3D scanners for various scale ranges. Innovative and modern production processes, such as sheet-bulk metal forming, thus, utilize fringe projection profilometry in many respects to monitor the process, quantify possible wear and improve production technology. Therefore, it is essential to identify the appropriate 3D scanner for each application and to properly evaluate the acquired data. Through precise knowledge of the measurement volume and the relative uncertainty with respect to the specimen and scanner position, adapted measurement strategies and integrated production concepts can be realized. Although there are extensive industrial standards and guidelines for the quantification of sensor performance, evaluation and tolerancing is mainly global and can, therefore, neither provide assistance in the correct, application-specific positioning and alignment of the sensor nor reflect the local characteristics within the measuring volume. Therefore, this article compares fringe projection systems across various scale ranges by positioning and scanning a calibrated sphere in a high resolution grid