Insurgency in Nepal

Insurgencies in the 21st century are different than the Cold War era ones that generated existing doctrine and strategy, and which shaped the way that most American strategists think about insurgency. The beast has mutated and evolved. So, too, must those who confront it. To help Army and Department of Defense leaders master these new challenges, the Strategic Studies Institute publishes a special series entitled Insurgency and Counterinsurgency in the 21st Century. This monograph, which assesses the growing insurgency in Nepal with its potential to further destabilize an already volatile region, is a path-breaking and an excellent inaugural effort in this new series.https://press.armywarcollege.edu/monographs/1778/thumbnail.jp

Sustainability of Colombian Military/Strategic Support for Democratic Security

For the first time in 40 years, cautious optimism pervades discussions of Bogota\u27s seemingly intractable situation. Drugs, terrorism, and insurgency continue in their explosive mix, but the current government of President Alvaro Uribe has fashioned a counterinsurgency approach that holds the strategic initiative and has a chance of negating a long-standing security threat to the state. Colombia has become synonymous in the popular mind with an intractable war waged against narco-terrorists. Not as understood is the strategic setting, wherein the illegal drug trade is not just linked to terrorism but rather is an integral part of a left-wing insurgency that continues to talk the language of the Cold War. This insurgency is the greatest threat to Bogota and to Washington\u27s interests in the region. Thus it is of particular moment to see an indigenously generated response succeed in turning the tide. What has been particularly remarkable has been a military reform movement engineered by Colombian officers committed to strengthening military professionalism and accountability to civilian authority.https://press.armywarcollege.edu/monographs/1737/thumbnail.jp

Colombian Army Adaptation to FARC Insurgency

The author points out that Revolutionary Armed Forces of Colombia (FARC) insurgents actively are pursuing a strategy to mobilize the disaffected and disposed people of Colombia, and to control the entire national territory. At the same time, he argues that no one in the national political establishment has taken the initiative to conduct an appropriate effort to deny FARC its objective. As a result, the Colombian Army has been left alone to direct the fight, without a coordinated and integrated national campaign plan or other resources that would allow for success. The author concludes that the Army has bought time, and there is still an opportunity for the United States to help Colombia deal with its insurgent threat in new ways.https://press.armywarcollege.edu/monographs/1827/thumbnail.jp

FreeContact: fast and free software for protein contact prediction from residue co-evolution

Background: 20 years of improved technology and growing sequences now renders residue-residue contact constraints in large protein families through correlated mutations accurate enough to drive de novo predictions of protein three-dimensional structure. The method EVfold broke new ground using mean-field Direct Coupling Analysis (EVfold-mfDCA); the method PSICOV applied a related concept by estimating a sparse inverse covariance matrix. Both methods (EVfold-mfDCA and PSICOV) are publicly available, but both require too much CPU time for interactive applications. On top, EVfold-mfDCA depends on proprietary software. Results: Here, we present FreeContact, a fast, open source implementation of EVfold-mfDCA and PSICOV. On a test set of 140 proteins, FreeContact was almost eight times faster than PSICOV without decreasing prediction performance. The EVfold-mfDCA implementation of FreeContact was over 220 times faster than PSICOV with negligible performance decrease. EVfold-mfDCA was unavailable for testing due to its dependency on proprietary software. FreeContact is implemented as the free C++ library “libfreecontact”, complete with command line tool “freecontact”, as well as Perl and Python modules. All components are available as Debian packages. FreeContact supports the BioXSD format for interoperability. Conclusions: FreeContact provides the opportunity to compute reliable contact predictions in any environment (desktop or cloud)

Two distinct age groups of melilitites, foidites, and basanites from the southern Central European Volcanic Province reflect lithospheric heterogeneity

Petrographic observations and in situ U–Pb ages of melilitites, foidites, basanites, phonolites, and trachytes from the southern part of the Central European Volcanic Province (CEVP) and related plutonic inclusions therein reveal two distinct age groups separated by a gap of ~ 20 Myr. A late Cretaceous to early Eocene group (~ 73–47 Ma; Taunus, Lower Main plain, Odenwald and Kraichgau area, Bonndorfer Graben and Freiburger Bucht area, Vosges and Pfälzerwald) is characterized by nephelinites and basanites mostly devoid of melilite and perovskite, and by rare haüynites, and trachytes. In contrast, a late Oligocene to late Miocene group (~ 27–9 Ma; Lorraine, southern Upper Rhine Graben, Urach, Hegau area) is dominated by melilitites, melilite-bearing nephelinites (both carrying perovskite), and phonolites. Both magmatic episodes are related to domal topographic uplift, erosion, and formation of major angular unconformities in the Upper Rhine Graben, suggesting an association with dynamic topography interrupted by phases of subsidence (or abatements of uplift). The investigated rocks in the southern CEVP (south of a line Eifel–Vogelsberg–Rhön–Heldburg), except for the Kaiserstuhl volcanic complex, mostly comprise small and isolated occurrences or monogenetic volcanic fields, whereas the northern CEVP is dominated by large volcanic complexes and dyke swarms, which are mostly SiO$_2$-saturated to weakly SiO$_2$-undersaturated. In the northern CEVP, evidence of spatially varying but recurrent volcanic activity exists since the Eocene, lacking the distinct 20 Myr gap as documented from the southern CEVP. While the temporal and spatial distribution of volcanism are a result of the Cretaceous to Miocene tectonic evolution in Central Europe, further studies are needed to explain the petrographic differences between the two age groups in the south

Neutron Correlations in the Decay of the First Excited State of 11Li

The decay of unbound excited 11Li was measured after being populated by a two-proton removal from a 13B beam at 71 MeV/nucleon. Decay energy spectra and Jacobi plots were obtained from measurements of the momentum vectors of the 9Li fragment and neutrons. A resonance at an excitation energy of ∼1.2 MeV was observed. The kinematics of the decay are equally well fit by a simple dineutron-like model or a phase-space model that includes final state interactions. A sequential decay model can be excluded

Structured States of Disordered Proteins from Genomic Sequences

Protein flexibility ranges from simple hinge movements to functional disorder. Around half of all human proteins contain apparently disordered regions with little 3D or functional information, and many of these proteins are associated with disease. Building on the evolutionary couplings approach previously successful in predicting 3D states of ordered proteins and RNA, we developed a method to predict the potential for ordered states for all apparently disordered proteins with sufficiently rich evolutionary information. The approach is highly accurate (79%) for residue interactions as tested in more than 60 known disordered regions captured in a bound or specific condition. Assessing the potential for structure of more than 1,000 apparently disordered regions of human proteins reveals a continuum of structural order with at least 50% with clear propensity for three-or two-dimensional states. Co-evolutionary constraints reveal hitherto unseen structures of functional importance in apparently disordered proteins. Keywords: Evolutionary couplings disorder; conformational flexibility; statistical physics; maximum entropy; EVfold; bioinformatics; computational biology; structure predictionNational Institutes of Health (U.S.) (Grant R01GM081871