Библиография и библиотековедение в информационную эпоху: возможности и перспективы. (Размышления о книге: Леонов В. П. Избранное / В. П. Леонов ; Библиотека РАН. Санкт-Петербург : БАН, 2021. 564 с.)

Review of the book: Leonov V. P. Selected works / V. P. Leonov ; RAS Library. Saint Petersburg : LAS, 2021. 564 p.The concepts examined in Leonov’s book are reviewed. The articles, lectures, interviews included in the book illustrate the evolution of knowledge on bibliography, books, library science being influenced by information technologies. The book also reflects the author’s intellectual evolution as well as the evolution of bibliography as the discipline to integrate the methodology of the human and natural sciences. This approach enables to explore these problems in many aspects. The book structure and contents of the sections are discussed, e. g. The book studies; New aspects of theory, The library studies and a fundamental disciplines, Bibliographic information and problems of its compression, Library and bibliographic processes as a social phenomenon, Bibliography: In search of new paradigm, The concept of exact bibliography, The Academy of Sciences Library: Attempting the biography, Association Internationale de Bibliophilie and the Library of Russian Academy of Sciences, The third era of reminiscences. The contents is grouped in accordance with the complex problems of modern bibliology, which enables to explore individual problems within the context of the changing general scientific knowledge substance and form. With the cognitive sciences metholdology, V. Leonov finds the ways to apply them to the humanities. The book author introduces into the wide range of problems and applies new methods to library science, bibliology and bibliography. The relevancy of Leonov’s book is emphasized.Рец. на кн.: Леонов В. П. Избранное / В. П. Леонов ; Библиотека РАН. Санкт-Петербург : БАН, 2021. 564 с.Собранные в издании статьи, выступления, интервью отражают эволюцию интересов научного сообщества к библиографии, книге, библиотековедению, которая происходила под влиянием развития информационных технологий. Комплекс представленных материалов отражает не только интеллектуально-мыслительную эволюцию автора, но и развитие библиографии как дисциплины, интегрирующей методы гуманитарных и естественных наук. Такой подход позволяет многоаспектно раскрыть обозначенные проблемы. В отзыве кратко освещены структура книги и содержание её разделов: «Книговедение: новые аспекты теории», «Библиотековедение как фундаментальная наука», «Библиографическая информация и проблемы её свёртывания», «Библиотечно-библиографические процессы как социальный феномен», «Библиография: в поисках новой парадигмы», «Концепция точного библиографоведения», «Библиотека Академии наук: опыт биографии», «Международная ассоциация библиофилов и Библиотека Российской академии наук», «Из третьей эпохи воспоминаний». Материал сгруппирован в соответствии с комплексными проблемами современного книговедения, что позволяет рассматривать частные вопросы в контексте изменений содержания и формы общенаучного знания. Используя методы когнитивных наук, В. П. Леонов находит способы их применения в цикле гуманитарных наук. Рецензент отмечает актуальность рассматриваемого издания, которое представляет интерес для читателя благодаря широкому кругу поставленных проблем и использованию новых подходов к изучению библиотековедческих, книговедческих и библиографоведческих наук

Ремоделирование сердца недоношенных детей

Epidemiological studies consistently have suggested an association between low birth weight and increased rate of cardiovascular morbidity and mortality in adult life. Preterm birth, as one of the leading causes of the low birth weight, is associated with cardiovascular remodeling which consists of changes in heart chambers geometry and contraction-relaxation mode, ventricular hypertrophy, arterial wall structure and density changes. Several types of preterm birth are discussed: prematurity, associated with placental insufficiency and fetal growth restriction, preterm leaking of amniotic fluid, and twin pregnancy. DNA methylation process under the influence of epigenetic factors of the intrauterine and early postnatal development is suggested as a one of the main mechanism of cardiovascular remodeling in preterm infants. The other mechanisms of cardiovascular remodeling are discussed in terms of the modern intrauterine programming concept. The early diagnostics and prevention of cardiovascular diseases in preterm born children are discussed. The treatment during prenatal and early postnatal periods as well as prevention of the remodeling causes could diminish and even reverse the development of the negative cardiovascular events and diseases in later life according to the so called concept of “one thousand days opportunities window”. © 2020 Izdatel'stvo Meditsina. All rights reserved.Работа выполнена при финансовой поддержке ФГБОУ ВО УГМУ Минздрава России в рамках госзадания ИИФ УрО РАН (тема № АААА-А18-118020590031-8) и поддержана постановлением Правительства РФ от 16.03.2013 № 211 (соглашение 02.A03.21.0006)

О себе, о жизни, о судьбе: интервью с В. П. Леоновым

.Валерий Павлович Леонов – библиографовед, библиотековед, известный библиотечный деятель, специалист в области информатики, доктор педагогических наук (1987), профессор (1988), научный руководитель Библиотеки Российской академии наук. В 2022 г. В. П. Леонов отметил свой 80-летний юбилей. В преддверии 300-летия Российской академии наук и 310-й годовщины со дня основания её Библиотеки (БАН) мы решили поговорить с научным руководителем БАН о жизни, о судьбе, о библиотеке

Left ventricular isovolumic relaxation and renin-angiotensin system in the growth restricted fetus

To determine left ventricular isovolumic relaxation time (LV IRT) in normally developing and growth restricted fetuses (FGR) as an indicator of fetal cardiac afterload and neonatal systolic blood pressure

Substrate Cooperativity in Marine Luciferases

Marine luciferases are increasingly used as reporters to study gene regulation. These luciferases have utility in bioluminescent assay development, although little has been reported on their catalytic properties in response to substrate concentration. Here, we report that the two marine luciferases from the copepods, Gaussia princeps (GLuc) and Metridia longa (MLuc) were found, surprisingly, to produce light in a cooperative manner with respect to their luciferin substrate concentration; as the substrate concentration was decreased 10 fold the rate of light production decreased 1000 fold. This positive cooperative effect is likely a result of allostery between the two proposed catalytic domains found in Gaussia and Metridia. In contrast, the marine luciferases from Renilla reniformis (RLuc) and Cypridina noctiluca (CLuc) demonstrate a linear relationship between the concentration of their respective luciferin and the rate of light produced. The consequences of these enzyme responses are discussed

An individual patient-data comparison of combined modality therapy and ABVD alone for patients with limited-stage Hodgkin lymphoma

Background Treatment options for patients with nonbulky stage IA-IIA Hodgkin lymphoma include combined modality therapy (CMT) using doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD) plus involved-field radiation therapy (IFRT), and chemotherapy with ABVD alone. There are no mature randomized data comparing ABVD with CMT using modern radiation techniques. Patients and methods Using German Hodgkin Study Group HD10/HD11 and NCIC Clinical Trials Group HD.6 databases, we identified 588 patients who met mutually inclusive eligibility criteria from the preferred arms of HD10 or 11 (n = 406) and HD.6 (n = 182). We evaluated time to progression (TTP), progression-free (PFS) and overall survival, including in three predefined exploratory subset analyses. Results With median follow-up of 91 (HD10/11) and 134 (HD.6) months, respective 8-year outcomes were for TTP, 93% versus 87% [hazard ratio (HR) 0.44, 95% confidence interval (CI) 0.24-0.78]; for PFS, 89% versus 86% (HR 0.71, 95% CI 0.42-1.18) and for overall survival, 95% versus 95% (HR 1.09, 95% CI 0.49-2.40). In the exploratory subset analysis including HD10 eligible patients who achieved complete response (CR) or unconfirmed complete response (CRu) after two cycles of ABVD, 8-year PFS was 87% (HD10) versus 95% (HD.6) (HR 2.8; 95% CI 0.64-12.5) and overall survival 96% versus 100%. In contrast, among those without CR/CRu after two cycles of ABVD, 8-year PFS was 88% versus 74% (HR 0.35; 95% CI 0.16-0.79) and overall survival 95% versus 91%, respectively (HR 0.42; 95% CI 0.12-1.44). Conclusions In patients with nonbulky stage IA-IIA Hodgkin lymphoma, CMT provides better disease control than ABVD alone, especially among those not achieving complete response after two cycles of ABVD. Within the follow-up duration evaluated, overall survivals were similar. Longer follow-up is required to understand the implications of radiation and chemotherapy-related late effects. Clinical trials The trials included in this analysis were registered at ClinicalTrials.gov: HD10 - NCT00265018, HD11 - NCT00264953, HD.6 - NCT0000256

The Boltzmann equation for colourless plasmons in hot QCD plasma. Semiclassical approximation

Within the framework of the semiclassical approximation, we derive the Boltzmann equation describing the dynamics of colorless plasmons in a hot QCD plasma. The probability of the plasmon-plasmon scattering at the leading order in the coupling constant is obtained. This probability is gauge-independent at least in the class of the covariant and temporal gauges. It is noted that the structure of the scattering kernel possesses important qualitative difference from the corresponding one in the Abelian plasma, in spite of the fact that we focused our study on the colorless soft excitations. It is shown that four-plasmon decay is suppressed by the power of $g$ relative to the process of nonlinear scattering of plasmons by thermal particles at the soft momentum scale. It is stated that the former process becomes important in going to the ultrasoft region of the momentum scale.Comment: 41, LaTeX, minor changes, identical to published versio

Accurate reconstruction of insertion-deletion histories by statistical phylogenetics

The Multiple Sequence Alignment (MSA) is a computational abstraction that represents a partial summary either of indel history, or of structural similarity. Taking the former view (indel history), it is possible to use formal automata theory to generalize the phylogenetic likelihood framework for finite substitution models (Dayhoff's probability matrices and Felsenstein's pruning algorithm) to arbitrary-length sequences. In this paper, we report results of a simulation-based benchmark of several methods for reconstruction of indel history. The methods tested include a relatively new algorithm for statistical marginalization of MSAs that sums over a stochastically-sampled ensemble of the most probable evolutionary histories. For mammalian evolutionary parameters on several different trees, the single most likely history sampled by our algorithm appears less biased than histories reconstructed by other MSA methods. The algorithm can also be used for alignment-free inference, where the MSA is explicitly summed out of the analysis. As an illustration of our method, we discuss reconstruction of the evolutionary histories of human protein-coding genes.Comment: 28 pages, 15 figures. arXiv admin note: text overlap with arXiv:1103.434