Inequivalent contact structures on Boothby-Wang 5-manifolds

We consider contact structures on simply-connected 5-manifolds which arise as circle bundles over simply-connected symplectic 4-manifolds and show that invariants from contact homology are related to the divisibility of the canonical class of the symplectic structure. As an application we find new examples of inequivalent contact structures in the same equivalence class of almost contact structures with non-zero first Chern class.Comment: 27 pages; to appear in Math. Zeitschrif

Wildfire, climate, and perceptions in northeast Oregon

Wildfire poses a rising threat in the western USA, fueled by synergies between historical fire suppression, changing land use, insects and disease, and shifts toward a drier, warmer climate. The rugged landscapes of northeast Oregon, with their historically forest- and resource-based economies, have been one of the areas affected. A 2011 survey found area residents highly concerned about fire and insect threats, but not about climate change. In 2014 we conducted a second survey that, to explore this apparent disconnect, included questions about past and future summertime (fire season) temperatures. Although regional temperatures have warmed in recent decades at twice the global rate, accompanied by increasing dryness and fire risks, the warming itself is recognized by only 40 % of our respondents. Awareness of recent warming proves unrelated to individual characteristics that might indicate experience on the land: old-timer versus newcomer status, year-round versus seasonal residence, and ownership of forested land. Perceptions of past warming and expectations of future warming are more common among younger respondents and less common among Tea Party supporters. The best-educated partisans stand farthest apart. Perceptions about local temperatures that are important for adaptation planning thus follow ideological patterns similar to beliefs about global climate change

Combination GLP-1 and Insulin Treatment Fails to Alter Myocardial Fuel Selection Versus Insulin Alone in Type 2 Diabetes

Context Glucagon-like peptide-1 (GLP-1) and the clinically available GLP-1 agonists have been shown to exert effects on the heart. It is unclear whether these effects occur at clinically used doses in vivo in humans, possibly contributing to CVD risk reduction. Objective To determine whether liraglutide at clinical dosing augments myocardial glucose uptake alone or in combination with insulin compared to insulin alone in metformin-treated Type 2 diabetes mellitus. Design Comparison of myocardial fuel utilization after 3 months of treatment with insulin detemir, liraglutide, or combination detemir+liraglutide. Setting Academic hospital Participants Type 2 diabetes treated with metformin plus oral agents or basal insulin. Interventions Insulin detemir, liraglutide, or combination added to background metformin Main Outcome Measures Myocardial blood flow, fuel selection and rates of fuel utilization evaluated using positron emission tomography, powered to demonstrate large effects. Results We observed greater myocardial blood flow in the insulin-treated groups (median[25th, 75th percentile]: detemir 0.64[0.50, 0.69], liraglutide 0.52[0.46, 0.58] and detemir+liraglutide 0.75[0.55, 0.77] mL/g/min, p=0.035 comparing 3 groups and p=0.01 comparing detemir groups to liraglutide alone). There were no evident differences between groups in myocardial glucose uptake (detemir 0.040[0.013, 0.049], liraglutide 0.055[0.019, 0.105], detemir+liraglutide 0.037[0.009, 0.046] µmol/g/min, p=0.68 comparing 3 groups). Similarly there were no treatment group differences in measures of myocardial fatty acid uptake or handling, and no differences in total oxidation rate. Conclusions These observations argue against large effects of GLP-1 agonists on myocardial fuel metabolism as mediators of beneficial treatment effects on myocardial function and ischemia protection

Atrial Fibrillation During an Exploration Class Mission

Background: A long-duration exploration class mission is fraught with numerous medical contingency plans. Herein, we explore the challenges of symptomatic atrial fibrillation (AF) occurring during an exploration class mission. The actions and resources required to ameliorate the situation, including the availability of appropriate pharmaceuticals, monitoring devices, treatment modalities, and communication protocols will be investigated. Challenges of Atrial Fibrillation during an Exploration Mission: Numerous etiologies are responsible for the initiation of AF. On Earth, we have the time and medical resources to evaluate and determine the causative situation for most cases of AF and initiate therapy accordingly. During a long-duration exploration class mission resources will be severely restricted. How is one to determine if new onset AF is due to recent myocardial infarction, pulmonary embolism, fluid overload, thyrotoxicosis, cardiac structural abnormalities, or CO poisoning? Which pharmaceutical therapy should be initiated and what potential side effects can be expected? Should anti-coagulation therapy be initiated? How would one monitor the therapeutic treatment of AF in microgravity? What training would medical officers require, and which communication strategies should be developed to enable the best, safest therapeutic options for treatment of AF during a long-duration exploration class mission? Summary: These questions will be investigated with expert opinion on disease elucidation, efficient pharmacology, therapeutic monitoring, telecommunication strategies, and mission cost parameters with emphasis on atrial fibrillation being just one illustration of the tremendous challenges that face a long-duration exploration mission. The limited crew training time, medical hardware, and drugs manifested to deal with such an event predicate that aggressive primary and secondary prevention strategies be developed to protect a multibillion-dollar asset like the International Space Station or a mission to the Moon or Mars. Learning Objectives: The audience will become familiar with the risks and challenges inherent to developing a therapeutic strategy for the treatment of atrial fibrillation during a long-term exploration class mission

Forest Views: Shifting Attitudes Toward the Environment in Northeast Oregon

This brief reports on a telephone survey conducted in fall 2014 as part of the ongoing Communities and Forests in Oregon (CAFOR) project. CAFOR focuses on seven counties in the Blue Mountains of northeast Oregon (Baker, Crook, Grant, Umatilla, Union, Wallowa, and Wheeler), where the landscape and local livelihoods are changing in interconnected ways. In an effort to inform policy development around natural resource management, the study seeks to understand how public perceptions of climate change and forest management intersect. Authors Angela Boag, Joel Hartter, Lawrence Hamilton, Forrest Stevens, Mark Ducey, Michael Palace, Nils Christoffersen, and Paul Oester report that 65 percent of those surveyed believe that forests are less healthy than they were twenty years ago. Approximately half of residents support increased user fees to improve forest health on federal land, and a majority believes that climate change is happening, although opinion is split between those who believe it is human-caused and those who believe it is caused by natural forces. The authors conclude that innovative economic and policy solutions are needed across the Inland West to help people and forests regain a strong and productive relationship that both supports livelihoods and sustains working landscapes

Does it matter if people think climate change is human caused?

There is a growing consensus that climate is changing, but beliefs about the causal factors vary widely among the general public. Current research shows that such causal beliefs are strongly influenced by cultural, political, and identity-driven views. We examined the influence that local perceptions have on the acceptance of basic facts about climate change. We also examined the connection to wildfire by local people. Two recent telephone surveys found that 37% (in 2011) and 46% (in 2014) of eastern Oregon (USA) respondents accept the scientific consensus that human activities are now changing the climate. Although most do not agree with that consensus, large majorities (85–86%) do agree that climate is changing, whether by natural or human causes. Acceptance of anthropogenic climate change generally divides along political party lines, but acceptance of climate change more generally, and concerns about wildfire, transcend political divisions. Support for active forest management to reduce wildfire risks is strong in this region, and restoration treatments could be critical to the resilience of both communities and ecosystems. Although these immediate steps involve adaptations to a changing climate, they can be motivated without necessarily invoking human-caused climate change, a divisive concept among local landowners

A note on T-folds and T3 fibrations

We study stringy modifications of T-3-fibered manifolds, where the fiber undergoes a monodromy in the T-duality group. We determine the fibration data defining such T-folds from a geometric model, by using a map between the duality group and the group of large diffeomorphisms of a four-torus. We describe the monodromies induced around duality defects where such fibrations degenerate and we argue that local solutions receive corrections from the winding sector, dual to the symmetry-breaking modes that correct semi-flat metrics

Fluorinated benzalkylsilane molecular rectifiers

We report on the synthesis and electrical properties of nine new alkylated silane self-assembled monolayers (SAMs) – (EtO)3Si(CH2)nN = CHPhX where n = 3 or 11 and X = 4-CF[subscript 3], 3,5-CF[subscript 3], 3-F-4-CF[subscript 3], 4-F, or 2,3,4,5,6-F, and explore their rectification behavior in relation to their molecular structure. The electrical properties of the films were examined in a metal/insulator/metal configuration, with a highly-doped silicon bottom contact and a eutectic gallium-indium liquid metal (EGaIn) top contact. The junctions exhibit high yields (>90%), a remarkable resistance to bias stress, and current rectification ratios (R) between 20 and 200 depending on the structure, degree of order, and internal dipole of each molecule. We found that the rectification ratio correlates positively with the strength of the molecular dipole moment and it is reduced with increasing molecular length.National Science Foundation (U.S.) (Award ECCS 1254757)Wake Forest University (Pilot Research Grant